Synthesis and antitumor activity of 9-methyl-10-hydroxycamptothecin

Chinese Chemical Letters

Volumn 19, Issue 8, 2008, Pages 918-920

  Wang, Sheng ^a   Li, Yu Yan ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

10 Hydroxycamptothecin; Camptothecin; Cytotoxicity; Synthesis

Indexed keywords

EID: 46349105443     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2008.05.042     Document Type: Article

References (9)

1. Wall M.E., Wani M.C., Cook C.E., et al. J. Am. Chem. Soc. 88 (1966) 3888
2. Cragg G.M., and Newman D.J. J. Nat. Prod. 67 (2004) 232
3. Kingsbury W.D., Boehm C.J., Jakas D.R., et al. J. Med. Chem. 34 (1991) 98
4. Sawada S., Okajima S., Aiyama R., et al. Chem. Pharm. Bull. 39 (1991) 1446
5. W. Lu, H. Gao, X. Zhang, et al., PCT/CN2004/000490, 2003.
6. Gao H., Zhang X., Chen Y., et al. Bioorg. Med. Chem. Lett. 15 (2005) 2003
7. Y.Y. Li, A.J. Lu, Q.D. Y, Chinese Patent Application: CN 200710132953.3 (2007).
8. 5: C 70.01, H 5.47, N 8.45; found: C 69.82, H 5.65, N 8.74.
9. Kim D., Ryu D.H., Lee J.Y., et al. J. Med. Chem. 44 (2001) 1594