Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5377-5381

  Manikumar, Govindarajan ^a   Wadkins, Randy M ^b   Bearss, David ^c   Von Hoff, Daniel D ^c   Wani, Mansukhlal C ^a   Wall, Monroe E ^a  

^a RTI INTERNATIONAL   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Inhibitor; Kinetics; Poison; Topoisomerase I

Indexed keywords

10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 (4 CHLOROPHENYL) 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 (4 FLUOROPHENYL) 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 (4 TOLYL) 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 (4 TRIFLUOROMETHYLPHENYL) 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 BENZYL 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 BENZYLCAMPTOTHECIN; 7 CYCLOHEXYL 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 CYCLOPENTYL 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 ETHYLCAMPTOTHECIN; 7 N BUTYLCAMPTOTHECIN; 7 PHENYL 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 SEC BUTYLCAMPTOTHECIN; 7 TERT BUTYLCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; GRIGNARD REACTION; HYDROPHOBICITY; POLYMERIZATION; SUBSTITUTION REACTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KETONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344252359     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.010     Document Type: Article

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