The role of IL-1β in reduced IL-7 production by stromal and epithelial cells: A model for impaired T-cell numbers in the gut during HIV-1 infection

Journal of Internal Medicine

Volumn 268, Issue 2, 2010, Pages 181-193

  Thang, P H ^a,b   Ruffin, N ^a   Brodin, D ^a   Rethi, B ^a   Cam, P D ^b   Hien, N T ^b   Lopalco, L ^c   Vivar, N ^a   Chiodi, F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Viet Nam)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

apoptosis; gene profile; HIV; IL 1 ; IL 7; T cells

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; TOLL LIKE RECEPTOR; CHEMOKINE RECEPTOR; CYTOKINE; FAS ANTIGEN; MESSENGER RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFLAMMATION; INTESTINE EPITHELIUM CELL; KERATINOCYTE; LYMPHOCYTE HOMING; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE; BIOLOGICAL MODEL; BIOSYNTHESIS; BONE MARROW CELL; DNA MICROARRAY; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; METABOLISM; METHODOLOGY; MUCOSAL IMMUNITY; TUMOR CELL CULTURE;

ANTIGENS, CD95; APOPTOSIS; BONE MARROW CELLS; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, MUCOSAL; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-7; MODELS, IMMUNOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CHEMOKINE; RNA, MESSENGER; STROMAL CELLS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 77954321039     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2010.02241.x     Document Type: Article

References (59)

1. Jiang Q, Li WQ, Aiello FB et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev 2005 16 : 513 533.
2. Fry TJ, Connick E, Falloon J et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 2001 97 : 2983 2990.
3. Fry TJ, Mackall CL. Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol 2001 22 : 564 571.
4. Schluns KS, Kieper WC, Jameson SC, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000 1 : 426 432.
5. Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med 2003 198 : 1797 1806.
6. Tan JT, Dudl E, LeRoy E et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci USA 2001 98 : 8732 8737.
7. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002 99 : 3892 3904.
8. Sudo T, Ito M, Ogawa Y et al. Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 1989 170 : 333 338.
9. + B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol 1994 22 : 321 328.
10. Madrigal-Estebas L, McManus R, Byrne B et al. Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation. Hum Immunol 1997 58 : 83 90.
11. Watanabe M, Ueno Y, Yajima T et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 1995 95 : 2945 2953.
12. Link A, Vogt TK, Favre S et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007 8 : 1255 1265.
13. Heufler C, Topar G, Grasseger A et al. Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 1993 178 : 1109 1114.
14. Sorg RV, McLellan AD, Hock BD, Fearnley DB, Hart DN. Human dendritic cells express functional interleukin-7. Immunobiology 1998 198 : 514 526.
15. Kroncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol 1996 26 : 2541 2544.
16. Sawa Y, Arima Y, Ogura H et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity 2009 30 : 447 457.
17. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995 373 : 123 126.
18. Weiss RA. How does HIV cause AIDS? Science 1993 260 : 1273 1279.
19. Napolitano LA, Grant RM, Deeks SG et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001 7 : 73 9.
20. Fluur C, Rethi B, Thang PH et al. Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. AIDS 2007 21 : 1048 1050.
21. Albuquerque AS, Cortesao CS, Foxall RB, Soares RS, Victorino RM, Sousa AE. Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes. J Immunol 2007 178 : 3252 3259.
22. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005 174 : 6571 6576.
23. Rethi B, Fluur C, Atlas A et al. Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. AIDS 2005 19 : 2077 2086.
24. Sasson SC, Zaunders JJ, Zanetti G et al. Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis 2006 193 : 505 514.
25. Oshima S, Nakamura T, Namiki S et al. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol 2004 24 : 6298 6310.
26. Tang J, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN, Ryan DH. TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J Immunol 1997 159 : 117 125.
27. Yoshioka A, Okamoto R, Oshima S et al. Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine 2008 44 : 57 64.
28. Dinarello CA. Blocking IL-1 in systemic inflammation. J Exp Med 2005 201 : 1355 1359.
29. Daheshia M, Yao JQ. The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol 2008 35 : 2306 2312.
30. Sinicco A, Biglino A, Sciandra M et al. Cytokine network and acute primary HIV-1 infection. AIDS 1993 7 : 1167 1172. (Pubitemid 23270962)
31. Cheung R, Ravyn V, Wang L, Ptasznik A, Collman RG. Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. J Immunol 2008 180 : 6675 6684.
32. Weitzmann MN, Cenci S, Rifas L, Brown C, Pacifici R. Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines. Blood 2000 96 : 1873 1878.
33. + T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004 200 : 761 770.
34. + T cells. Nature 2005 434 : 1148 1152.
35. Guadalupe M, Sankaran S, George MD et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol 2006 80 : 8236 8247.
36. Brenchley JM, Price DA, Schacker TW et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006 12 : 1365 1371.
37. Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol 2007 178 : 7516 7519.
38. Jarry A, Bossard C, Bou-Hanna C et al. Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants. J Clin Invest 2008 118 : 1132 1142.
39. Angchaisuksiri P, Grigus SR, Carlson PL, Krystal GW, Dessypris EN. Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes. Blood 2002 99 : 130 136.
40. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 408.
41. Sabbagh L, Snell LM, Watts TH. TNF family ligands define niches for T cell memory. Trends Immunol 2007 28 : 333 339.
42. Alves NL, Richard-Le Goff O, Huntington ND et al. Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci USA 2009 106 : 1512 1517.
43. Boulassel MR, Smith GH, Edwardes MD et al. Influence of RANTES, SDF-1 and TGF-beta levels on the value of interleukin-7 as a predictor of virological response in HIV-1-infected patients receiving double boosted protease inhibitor-based therapy. HIV Med 2005 6 : 268 277.
44. Kerdiles YM, Beisner DR, Tinoco R et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol 2009 10 : 176 184.
45. Crawley AM, Vranjkovic A, Young C, Angel JB. Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8(+) T-cells. Eur J Immunol. 2010 [Epub ahead of print].
46. Rethi B, Vivar N, Sammicheli S et al. Priming of T cells to Fas-mediated proliferative signals by interleukin-7. Blood 2008 112 : 1195 1204.
47. Aigner T, McKenna L, Zien A, Fan Z, Gebhard PM, Zimmer R. Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes - a molecular analysis based on chondrocytes isolated from one donor. Cytokine 2005 31 : 227 240.
48. Ozinsky A, Underhill DM, Fontenot JD et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000 97 : 13766 13771.
49. Tan MC, Goedegebuure PS, Belt BA et al. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol 2009 182 : 1746 1755.
50. Oyama T, Miura S, Watanabe C et al. CXCL12 and CCL20 play a significant role in mucosal T-lymphocyte adherence to intestinal microvessels in mice. Microcirculation 2007 14 : 753 766.
51. Mikhak Z, Fleming CM, Medoff BD et al. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol 2006 176 : 4959 4967.
52. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998 161 : 5909 5917.
53. Li WQ, Jiang Q, Khaled AR, Keller JR, Durum SK. Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J Biol Chem 2004 279 : 29160 29166.
54. Blauvelt A, Asada H, Saville MW et al. Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways. J Clin Invest 1997 100 : 2043 2053.
55. + T cells in gut mucosa but enhances their rapid restoration through central memory T cells. J Virol 2008 82 : 4016 4027.
56. Nilsson J, Kinloch-de-Loes S, Granath A, Sonnerborg A, Goh LE, Andersson J. Early immune activation in gut-associated and peripheral lymphoid tissue during acute HIV infection. AIDS 2007 21 : 565 574.
57. + T cells. Nat Immunol 2009 10 : 149 157.
58. Molenaar R, Greuter M, van der Marel AP et al. Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol 2009 183 : 6395 6402.
59. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001 413 : 732 738.