Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways

Journal of Clinical Investigation

Volumn 100, Issue 8, 1997, Pages 2043-2053

  Blauvelt, Andrew ^a   Asada, Hideo ^a   Saville, M Wayne ^a   Klaus Kovtun, Vera ^a   Altman, David J ^a   Yarchoan, Robert ^a   Katz, Stephen I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CCR 5; CXCR 4; Dendritic cells; HIV AIDS; Immunopathogenesis

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL PROLIFERATION; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS TRANSMISSION;

EID: 0030777412     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119737     Document Type: Article

References (49)

1. Cameron, P., M. Pope, A. Granelli-Piperno, and R.M. Steinman. 1996. Dendritic cells and the replication of HIV-1. J. Leukocyte Biol. 59:158-171.
2. Knight, S.C. 1996. Bone-marrow-derived dendritic cells and the pathogenesis of AIDS. AIDS (Lond.). 10:807-817.
3. Blauvelt, A., and S.I. Katz. 1995. The skin as target, vector, and effector organ in human immunodeficiency virus disease. J. Investig. Dermatol. 105: 122S-126S.
4. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
5. Romani, N., and G. Schuler. 1992. The immunologic properties of epidermal Langerhans cells as part of the dendritic cell system. Springer Semin. Immunopathol. 13:265-279.
6. Spira, A.I., P.A. Marx, B.K. Patterson, J. Mahoney, R.A. Koup, S.M. Wolinsky, and D.D. Ho. 1996. Cellular targets of infection and route of viral domination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J. Exp. Med. 183:215-225.
7. Joag, S.V., I. Adany, Z. Li, L. Foresman, D.M. Pinson, C. Wang, E.B. Stephens, R. Raghavan, and O. Narayan. 1997. Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS. J. Virol. 71:4016-4023.
8. Macatonia, S.E., R. Lau, S. Patterson, A.J. Pinching, and S.C. Knight. 1989. Suppression of immune responses by dendritic cells infected with HIV. Immunology. 67:285-289.
9. Langhoff, E., E.F. Terwilliger, H.J. Bos, K.H. Kalland, M.C Poznansky, O.M.L. Bacon, and W.A. Haseltine. 1991. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc. Natl. Acad. Sci. USA. 88:7998-8002.
10. Berger, R., S. Gartner, K. Rappersberger, C.A. Foster, K. Wolff, and G. Stingl. 1992. Isolation of human immunodeficiency virus type 1 from human epidermis: virus replication and transmission studies. J. Investig. Dermatol. 99: 271-277.
11. Cameron, P.U., P.S. Freudenthal, J.M. Barker, S. Gezelter, K. Inaba, and R.M. Steinman. 1992. Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ cells. Science (Wash. DC). 257:383-387.
12. Cameron, P.U., M. Pope, S. Gezelter, and R.M. Steinman. 1994. Infection and apoptotic cell death of CD4+ T cells during an immune response to HIV-1-pulsed dendritic cells. AIDS Res. Hum. Retroviruses. 10:61-71.
13. Pinchuk, L.M., P.S. Polacino, M.B. Agy, S.J. Klaus, and E.A. Clark. 1994. The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Immunity. 1:317-325.
14. Ferbas, J.J., J.F. Toso, A.J. Logar, J.S. Navratil, and C.R. Rinaldo. 1994. CD4+ blood dendritic cells are potent producers of IFN-α in response to in vitro HIV-1 infection. J. Immunol. 152:4649-4662.
15. Pope, M., M.G.H. Betjes, N. Romani, P.U. Cameron, L. Hoffman, S. Gezelter, G. Schuler, and R.M. Steinman. 1994. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell. 78:389-398.
16. Pope, M., S. Gezelter, N. Gallo, L. Hoffman, and R.M. Steinman. 1995. Low levels of HIV-1 infection in cutaneous dendritic cells promote extensive viral replication upon binding to memory CD4+ T cells. J. Exp. Med. 182:2045-2056.
17. Weissman, D., Y. Li, J. Ananworanich, L.J. Zhou, J. Adelsberger, T.F. Tedder, M. Baseler, and A.S. Fauci. 1995. Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 92:826-830.
18. Weissman, D., Y. Li, J.M. Orenstein, and A.S. Fauci. 1995. Both a precursor and a mature population of dendritic cells can bind HIV. However, only the mature population that expresses CD80 can pass infection to unstimulated CD4+ T cells. J. Immunol. 155:4111-4117.
19. Ayehunie, S., R.W. Groves, A.M. Bruzzese, R.M. Ruprecht, T.S. Kupper, and E. Langhoff. 1995. Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact. AIDS Res. Hum. Retroviruses. 11:877-884.
20. Ramazzotti, E., A. Marconi, M.C. Re, G. Girolomoni, G. Cenacchi, M. Vignoli, G. Zambruno, G. Furlini, M.L. Placa, and A. Giannetti. 1995. In vitro infection of human epidermal Langerhans' cells with HIV-1. Immunology. 85: 94-98.
21. Soto-Ramirez, L.E., B. Renjifo, M.F. McLane, R. Marlink, C. O'Hara, R. Sutthent, C. Wasi, P. Vithayasai, V. Vithayasai, C. Apichartpiyakul, et al. 1996. HIV-1 Langerhan's cell tropism associated with heterosexual transmission of HIV. Science (Wash. DC). 271:1291-1293.
22. Ludewig, B., H.R. Gelderblom, Y. Becker, A. Schafer, and G. Pauli. 1996. Transmission of HIV-1 from productively infected mature Langerhans cells to primary CD4+ lymphocytes results in altered T cell responses with enhanced production of IFN-γ and IL-10. Virology. 215:51-60.
23. Granelli-Piperno, A., B. Moser, M. Pope, D. Chen, Y. Wei, F. Isdell, U. O'Doherty, W. Paxton, R. Koup, S. Mojsov, et al. 1996. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J. Exp. Med. 184:2433-2438.
24. Wood, G.S., N.L. Warner, and R. Warnke. 1983. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J. Immunol. 131:212-216.
25. Romani, N., A. Lenz, H. Glassel, H. Stossel, U. Stanzl, O. Majdic, P. Fritsch, and G. Schuler. 1989. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J. Investig. Dermatol. 93:600-609.
26. O'Doherty, U., M. Peng, S. Gezelter, W.J. Swiggard, M. Betjes, N. Bhardwaj, and R.M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature, and the other immature. Immunology. 82:487-493.
27. Cameron, P.U., M.G. Lowe, S.M. Crowe, U. O'Doherty, M. Pope, S. Gezelter, and R.M. Steinman. 1994. Susceptibility of dendritic cells to HIV-1 infection. J. Leukocyte Biol. 56:257-265.
28. Wei, X., S.K. Ghosh, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Deutsch. J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B.H. Hahn, et al. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond). 373:117-122.
29. Ho, D.D., A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, and M. Markovitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (Lond.). 373:123-126.
30. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature (Lond.). 360:258-261.
31. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109-1118.
32. Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P.O. Fritsch, R.M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83-93.
33. Blauvelt, A., H. Asada, V. Klaus-Kovtun, D.J. Altman, D.R. Lucey, and S.I. Katz. 1996. Interleukin-15 mRNA is expressed by human keratinocytes, Langerhans cells, and blood-derived dendritic cells and is downregulated by ultraviolet B radiation. J. Investig. Dermatol. 106:1047-1052.
34. Enk, C.D., D. Sredni, A. Blauvelt, and S.I. Katz. 1995. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J. Immunol. 154:4851-4856.
35. Saville, M.W., K. Taga, A. Foli, S. Broder, G. Tosato, and R. Yarchoan. 1994. Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage. Blood. 83:3591-3599.
36. Tang, S., and J.A. Levy. 1991. Inactivation of HIV-1 by trypsin and its use in demonstrating specific virus infection of cells. J. Virol. Methods. 33:39-46.
37. Benkirane, M., P. Corbeau, V. Housset, and C. Devaux. 1993. An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells. EMBO (Eur. Mol. Biol. Organ.) J. 12:4909-4921.
38. Feng, Y., C.C. Broder, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (Wash. DC). 272:872-877.
39. Alkhatib, G., C. Combadiere, C.C. Broder, Y. Feng, P.E. Kennedy, P.M. Murphy, and E.A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science (Wash. DC). 272:1955-1958.
40. Tsunetsugu-Yokota, Y., K. Akagawa, H. Kimoto, K. Suzuki, M. Iwasaki, S. Yasuda, G. Hausser, C. Hultgren, A. Meyerhans, and T. Takemori. 1995. Monocyte-derived cultured dendritic cells are susceptible to human immunodeficiency virus infection and transmit virus to resting T cells in the process of nominal antigen presentation. J. Virol. 69:4544-4547.
41. Charbonnier, A.S., B. Verrier, C. Jacquet, C. Massacrier, M.M. Fiers, F. Mallet, C. Dezutter-Dambuyant, and D. Schmitt. 1996. In vitro HIV1 infection of CD34+ progenitor-derived dendritic/Langerhans cells at different stages of their differentiation in the presence of GM-CSFA/TNF alpha. Res. Virol. 147:89-95.
42. Biti, R., R. French, J. Young, B. Bennetts, G. Stewart, and T. Liang. 1997. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat. Med. 3:252-253.
43. O'Brien, T.R., C. Winkler, M. Dean, J.A.E. Nelson, M. Carrington, N.L. Michael, and G.C. White. 1997. HIV-1 infection in a man homozygous for CCR5Δ32. Lancet. 349:1219.
44. Theodorou, L. L. Meyer, M. Magierowska, C. Katlama, and C. Rouzioux. 1997. HIV-1 infection in an individual homozygous for CCR5Δ32. Seroco Study Group. Lancet. 349:1219-1220.
45. Claydon, E.J., J. Bennet, D. Gor, and S.M. Forster. 1991. Transient elevations of serum HIV-1 antigen levels associated with intercurrent infection. AIDS (Lond.). 5:113-114.
46. Ho, D. 1992. HIV-1 viraemia and influenza. Lancet. 339:1549.
47. Staprans, S.I., B.L. Hamilton, S.E. Follansbee, T. Elbeik, P. Barbosa, R.M. Grant, and M.B. Feinberg. 1995. Activation of virus replication after vaccination of HIV-1-infected individuals. J. Exp. Med. 182:1727-1737.
48. Stanley, S.K., M.A. Ostrowski, J.S. Justement, K. Gantt, S. Hedayati, M. Mannix, K. Roche, D.J. Schwartzcntruber, C.H. Fox, and A.S. Fauci. 1996. Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N. Engl. J. Med. 334: 1222-1230.
49. Goletti, D., D. Weissman, R.W. Jackson, N.M. Graham, D. Vlahov, R.S. Klein, S.S. Munsiff, L. Ortona, R. Cauda, and A.S. Fauci. 1996. Effect of Mycobacterium tuberculosis on HIV replication: role of immune activation. J. Immunol. 157:1271-1278.