Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes

Blood

Volumn 99, Issue 1, 2002, Pages 130-136

  Angchaisuksiri, Pantep ^a   Grigus, Shawn R ^a   Carlson, Patricia L ^a   Krystal, Geoffrey W ^a   Dessypris, Emmanuel N ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LYMPHOKINE; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBOPOIETIN;

ARTICLE; CELL MATURATION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MITOSIS; NATURAL KILLER CELL; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036095715     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.1.130     Document Type: Article

References (37)

1. Evaluation of bone marrow megakaryocyte ploidy distributions in persons with normal and abnormal platelet counts
2. Flow cytometric analysis of megakaryocytes from patients with abnormal platelet counts
3. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
4. cMpl ligand is a humoral regulator of megakaryocytopoiesis
5. + cells in a serum-free system
6. Replication and endoreplication in developing megakaryocytes in vitro
7. Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin
8. Depletion of stromal elements in human marrow grafts separated by soybean agglutinin
9. Biology of natural killer cells
10. Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions
11. Isolation and in vitro translation of the messenger RNA coding for pancreatic amylase
12. Biology and clinical relevance of human natural killer cells
13. Stromal cell-derived factor 1 increases polyploidization of megakaryocytes generated by human hemato-poietic progenitor cells
14. In vitro effects of hematopoietic growth factors on the proliferation, endoreplication, and maturation of human megakaryocytes
15. Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation
16. Thrombopoietin: The primary regulator of platelet production
17. Thrombopoietin requires additional megakaryo-cyte-active cytokines for optimal ex vivo expansion of megakaryocyte precursor cells
18. The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
19. Complementary and antagonistic effects of IL-3 in the early development of human megakaryocytes in culture
20. The hematologic toxicity of interleukin-2 inpatients with metastatic melanoma and renal cell carcinoma
21. Thrombocytopenia during immunotherapy with interleukin-2 by constant infusion
22. Increase of plasma transforming growth factor beta during immunotherapy with IL-2
23. Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro
24. Transforming growth factor beta inhibits megakaryocyte growth and endomitosis
25. Interleukin 2 induces increased platelet-endothelium interactions: A potential mechanism of toxicity
26. Thrombocytopenia in c-mpl deficient mice
27. Cytokine production and function in c-mpl deficient mice: No physiologic role for interleukin-3 in residual megakaryocyte and platelet production
28. The residual megakaryocyte and platelet production in c-mpl deficient mice is not dependent on the actions of interleukin 6, interleukin 11, or leukemia inhibitory factor
29. Serum interleukin-6 levels in patients with thrombocytosis
30. Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis
31. Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis
32. Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis
33. Thrombopoietin levels in patients with primary and reactive thrombocytosis
34. Differential effect of natural killer cells on modulating CFU-Meg and BFU-E proliferation in situ
35. Role of natural killer cells, in comparison with T lymphocytes and monocytes, in the regulation of normal human megakaryocytopoiesis in vitro
36. Enhancement of megakaryocytopoiesis by Campath-1G-treated natural killer cells
37. Activated natural killer cells and interleukin-2 promote granulocytic and megakaryocytic reconstitution after syngeneic bone marrow transplantation in mice