Discovery of new 1,3,5-triazine scaffolds with potent activityagainst Mycobacterium tuberculosis H37Rv

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3335-3345

  Sunduru, Naresh ^a   Gupta, Leena ^a   Chaturvedi, Vinita ^a   Dwivedi, Richa ^a   Sinha, Sudhir ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

1,3,5 Triazine; Anti tubercular; Isoniazid; Pyrimidine

Indexed keywords

1 (4,6 DICHLORO 1,3,5 TRIAZIN 2 YL) 1,2,3,4 TETRAHYDROQUINOLINE; 1,10 (6 CHLORO 1,3,5 TRIAZINE 2,4 DIYL)BIS(1,2,3,4 TETRAHYDROQUINOLINE); 1,10 [6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZINE 2,4 DIYL]BIS(1,2,3,4 TETRAHYDROQUINOLINE); 2 (4,6 DICHLORO 1,3,5 TRIAZIN 2 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 2,2' (6 CHLORO 1,3,5 TRIAZINE 2,4 DIYL)BIS(1,2,3,4 TETRAHYDROISOQUINOLINE); 2,2' [6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZINE 2,4 DIYL]BIS(1,2,3,4 TETRAHYDROISOQUINOLINE); 2,4 DICHLORO 6 (PIPERIDIN 1 YL) 1,3,5-TRIAZINE; 4 [4,6 BIS(3,4 DIHYDROISOQUINOLIN 2(1H) YL) 1,3,5 TRIAZIN 2 YL]MORPHOLINE; 4 [4,6 BIS(3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZIN 2 YL]MORPHOLINE; 4,6 BIS(3,4 DIHYDROISOQUINOLIN 2(1H) YL) N (2 MORPHOLINOETHYL) 1,3,5 TRIAZIN 2 AMINE; 4,6 BIS(3,4 DIHYDROISOQUINOLIN 2(1H) YL) N (3 MORPHOLINOPROPYL) 1,3,5 TRIAZIN 2 AMINE; 4,6 BIS(3,4 DIHYDROQUINOLIN 1(2H) YL) N (2 MORPHOLINOETHYL) 1,3,5 TRIAZIN 2 AMINE; 4,6 BIS(3,4 DIHYDROQUINOLIN 1(2H) YL) N (3 MORPHOLINOPROPYL) 1,3,5 TRIAZIN 2 AMINE; 4,6 DICHLORO N PHENYL 1,3,5 TRIAZIN 2 AMINE; 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) N 2,N 4 BIS(2 MORPHOLINOETHYL) 1,3,5 TRIAZINE 2,4 DIAMINE; 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) N 2,N 4 BIS(3 MORPHOLINOPROPYL) 1,3,5 TRIAZINE 2,4 DIAMINE; 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) N 2,N 4 DIETHYL 1,3,5 TRIAZINE 2,4 DIAMINE; 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) N 2,N 4 DIISOPROPYL 1,3,5 TRIAZINE 2,4 DIAMINE; 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) N 2,N 4 DIPROPYL 1,3,5 TRIAZINE 2,4 DIAMINE; 6 (PIPERIDIN 1 YL) N 2,N 4 DIPROPYL 1,3,5 TRIAZINE 2,4 DIAMINE; N 1 [4,6 BIS(3,4 DIHYDROISOQUINOLIN 2(1H) YL) 1,3,5 TRIAZIN 2 YL] N 2,N 2 DIETHYLETHANE 1,2 DIAMINE; N 1 [4,6 BIS(3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZIN 2 YL] N 2,N 2 DIETHYLETHANE 1,2 DIAMINE; N 1,N 1' [6 (3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZINE 2,4 DIYL]BIS(N 2,N 2 DIETHYLETHANE 1,2 DIAMINE); N 1,N 1' [6 (3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZINE 2,4 DIYL]BIS(N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE); N 2,N 4 DI TERT BUTYL 6 (3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZINE 2,4 DIAMINE; N 2,N 4 DIETHYL 6 (PIPERIDIN 1 YL) 1,3,5 TRIAZINE 2,4 DIAMINE; N TERT BUTYL 4,6 BIS(3,4 DIHYDROISOQUINOLIN 2(1H) YL) 1,3,5 TRIAZIN 2 AMINE; N TERT BUTYL 4,6 BIS(3,4 DIHYDROQUINOLIN 1(2H) YL) 1,3,5 TRIAZIN 2 AMINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VERO CELL;

EID: 77954316167     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.017     Document Type: Article

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