Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases
ACQUIRED IMMUNE DEFICIENCY SYNDROME;
ARTICLE;
DRUG DESIGN;
DRUG MECHANISM;
DRUG POTENCY;
DRUG SYNTHESIS;
HEAD AND NECK CARCINOMA;
HUMAN;
HUMAN CELL;
MYCOBACTERIUM AVIUM;
PNEUMOCYSTIS CARINII;
PNEUMOCYSTOSIS;
TOXOPLASMA GONDII;
TOXOPLASMOSIS;
TUMOR CELL LINE;
De Vita, V. T., Hellman, S., Rosenberg, S. A., Eds.; Lippincott Co.; Philadelphia
Falloon, J.; Masur, H. Infectious Complications of HIV. In Aids Etiology, Diagnosis, Treatment and Prevention, 3rd ed.; De Vita, V. T., Hellman, S., Rosenberg, S. A., Eds.; Lippincott Co.; Philadelphia, 1992.
Toxoplasma gondii Pneumonitis in Patients Infected with the Human Immunodeficiency Virus
Schnapp, L. M.; Geaghan, S. M.; Campagna, A.; Fahy, J.; Steiger, D.; Ng, V.; Hadley, W. K.; Hopwell, P. C.; Stansell, J. D. Toxoplasma gondii Pneumonitis in Patients Infected with the Human Immunodeficiency Virus. Arch. Intern. Med. 1992, 152, 1073-1077.
Toxoplasma Encephalitis in Patients with Acquired Immunodeficiency Syndrome: Diagnosis and Response to Therapy
Wanke, C.; Tuazon, C. U.; Kovacs, A.; Dina, D.; Davis, D. O.; Barton, N.; Katz, D.; Lunde, M.; Levy, C.; Conley, F. K.; Lane, H. C.; Fauci, A. S.; Masur, H. Toxoplasma Encephalitis in Patients with Acquired Immunodeficiency Syndrome: Diagnosis and Response to Therapy. Am. J. Trop. Med. Hyg. 1987, 36, 509-516.
Adverse Reactions to Trimethoprimsulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome
Gordin, F. M.; Simon, G. L.; Wofsy, C. B.; Mills, J. Adverse Reactions to Trimethoprimsulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome. Ann. Intern. Med. 1984, 100, 495-499.
Activity of Antifolates against Peumocystis carinii Dihydrofolate Reductase and Identification of a Potent New Agent
Allegra, C. J.; Kovacs, J. A.; Drake, J. C.; Swan, J. C.; Chabner, B. A.; Masur, H. Activity of Antifolates against Peumocystis carinii Dihydrofolate Reductase and Identification of a Potent New Agent. J. Exp. Med. 1987, 165, 926-931.
Activity of Lipid-soluble Inhibitors of Dihydrofolate Reductase Against Pneumocystis carinii in Culture and in a Rat Model of Infection
Queener, S. F.; Bartlett, M. S.; Jay, M. A.; Durkin, M. M.; Smith, J. W. Activity of Lipid-soluble Inhibitors of Dihydrofolate Reductase Against Pneumocystis carinii in Culture and in a Rat Model of Infection. Antimicrob. Agents Chemother. 1987, 31, 1323-1327.
Potent in vitro and in vivo Antitoxoplasma Activity of the Lipid-soluble Antifolate Trimetrexate
Allegra, C. J.; Kovacs, J. A.; Drake, J. C.; Swan, J. C.; Chabner, B. A.; Masur, H. Potent in vitro and in vivo Antitoxoplasma Activity of the Lipid-soluble Antifolate Trimetrexate. J. Clin. Invest. 1987, 79, 478-482.
Potent Effect of Trimetrexate, a Lipid-soluble Antifolates, on Toxoplasma gondii
Kovacs, J. A.; Chabner, B. A.; Swan, J.; Drake, M.; Lunde, M.; Parrillo, J. E.; Masur, H. Potent Effect of Trimetrexate, a Lipid-soluble Antifolates, on Toxoplasma gondii. J. Infect. Dis. 1987, 755, 1027-1032.
Potent Antipneumocystis and Antitoxoplasma Activities of Piritrexim, a Lipid- Soluble Antifolate
Kovacs, J. A.; Allegra, C. J.; Swan, J. C.; Drake, J. C.; Parrillo, J. E.; Chabner, B. A.; Masur, H. Potent Antipneumocystis and Antitoxoplasma Activities of Piritrexim, a Lipid- soluble Antifolate. Antimicrob. Agents Chemother. 1988, 32, 430-433.
Trimetrexate, a Novel and Effective Agent for the Treatment of Pneumocystis carinii Pneumonia in Patients with the Acquired Immunodeficiency Syndrome
Allegra, C. J.; Chabner, B. A.; Tuazon, C. U.; Ogata-Arakaki, D.; Baird, D.; Drake, J. C.; Simmons, J. T.; Lack, E. E.; Shelhamer, J., H.; Balis, F.; Walker, R.; Kovacs, J. A.; Lane, H. C.; Masur, H. Trimetrexate, a Novel and Effective Agent for the Treatment of Pneumocystis carinii Pneumonia in Patients with the Acquired Immunodeficiency Syndrome. N. Engl. J. Med. 1987, 377, 978-983.
Salvage Trial of Trimetrexate-Leucovorin for the Treatment of Cerebral Toxoplasmosis
Masur, H.; Polis, M. A.; Tuazon, C. U.; Ogata-Arakaki, D.; Kovacs, J. A.; Katz, D.; Hilt, D.; Simmons, T.; Feuerstein, I.; Lundgren, B.; Lane, H. C.; Chabner, B. A.; Allegra, C. J. Salvage Trial of Trimetrexate-Leucovorin for the Treatment of Cerebral Toxoplasmosis. J. Inefect. Dis. 1992, 167, 1422-1426.
2,4-Diamino- 5-methyl-6-[(3,4,5-trimethoxyanilino)-methyl]quinazoline (TMQ). A potent Non- classical Folate Antagonist Inhibitor-I
Bertino, J. R.; Sawicki, W. L.; Moroson, B. A.; Cashmore, A. R.; Elslager, E. F. 2,4-Diamino- 5-methyl-6-[(3,4,5-trimethoxyanilino)-methyl]quinazoline (TMQ). A potent Non- classical Folate Antagonist Inhibitor-I. Biochem. Pharmacol. 1979, 38, 1983-1987.
Classicaland Nonclassical Furo[2,3-d]-pyrimidines as Novel Antifolates: Synthesis and Biological Activities
Gangjee, A.; Devraj, R.; McGuire, J. J.; Kisliuk, R. L.; Queener, S. F.; Barrows, L. R.; Classicaland Nonclassical Furo[2,3-d]-pyrimidines as Novel Antifolates: Synthesis and Biological Activities. J. Med. Chem. 1994, 37, 1169-1176.
Novel 2,4-Diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases
Gangjee, A.; Mavandadi, F.; Queener, S. F.; McGuire, J. J.; Novel 2,4-Diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases. J. Med. Chem. 1995, 38, 2158-2165.
The Binding of Trimethoprim to Bacterial Dihydrofolate Reductase
Baker, D. J.; Bedell, C. R.; Champness, J. N.; Goodford, P.; Novrington, F. E.; Smith, D. R.; Stammers, D. N. The Binding of Trimethoprim to Bacterial Dihydrofolate Reductase. FEBS Lett. 1981, 126, 49-52.
Refined Crystal Structures of E. coli and Chicken Liver Dihydrofolate Reductase Containing Bound Trimethoprim
Mathews, D. A.; Bolin, J. T.; Burdge, J. M.; Filman, K. W.; Kaufman, B. T.; Bedell, C. R.; Champness, J. N.; Stammers, D. N.; Kraut, J. Refined Crystal Structures of E. coli and Chicken Liver Dihydrofolate Reductase Containing Bound Trimethoprim. J. Biol. Chem. 1985, 260, 381-391.
The Structure of Pneumocystis carinii Dihydrofolate Reductase to 1.9 Å Resolution
Champness, J. N.; Achari, A.; Ballantine, S. P.; Bryant, P. K.; Deleves, C. J.; Stammers, D. K. The Structure of Pneumocystis carinii Dihydrofolate Reductase to 1.9 Å Resolution. Structure, 1994, 915-924.
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Conformational Analysis of Human Dihydrofolate Reductase Inhibitor Complexes: Crystal Structure Determination of Wild-Type and F31 Mutant Binary and Ternary Inhibitor Complexes
Cody, V.; Wojtczak, A.; Kalman, T. I.; Freisheim, J. H.; Blakley, R. L.; Conformational Analysis of Human Dihydrofolate Reductase Inhibitor Complexes: Crystal Structure Determination of Wild-Type and F31 Mutant Binary and Ternary Inhibitor Complexes. Adv. Exp. Med. Biol. 1993, 338, 481-486.
Studies Directed Toward a Total Synthesis of Nucleoside Q. the Annulation of 2,4-Diaminopy- Rimidin-4-one with α-Halo Carbonyls to Form Pyrrolo[2,3-d]- pyrimidines and Furo[2,3-d]pyrimidines
Secrist, J. A., III.; Liu, P. S. Studies Directed Toward a Total Synthesis of Nucleoside Q. The Annulation of 2,4-Diaminopy- rimidin-4-one with α-Halo Carbonyls to Form Pyrrolo[2,3-d]- pyrimidines and Furo[2,3-d]pyrimidines. J. Org. Chem. 1978, 43, 3837-3941.
Pneumocystis carinii Dihydrofolate Reductase Used to Screen Potential Antipneumocystis Drugs
Broughton, M. C.; Queener, S. F. Pneumocystis carinii Dihydrofolate Reductase Used to Screen Potential Antipneumocystis Drugs. Antimicrob. Agents Chemother. 1991, 35, 1348-1355.
Identification of Highly Potent and Selective Inhibitors of Toxoplasma gondii Dihydrofolate Reductase
Chio, L.-C.; Queener, S. F. Identification of Highly Potent and Selective Inhibitors of Toxoplasma gondii Dihydrofolate Reductase. Antimicrob. Agents Chemother. 1993, 37, 1914-1923.
Decreased Folylpoly-glutamate Synthetase Activity as a Mechanism of Methotrexate Resistance in CCRF-CEM Human Leukemia Sublines
McCloskey, D. E.; McGuire, J. J.; Russell, C. A.; Rowan, B. G.; Bertino, J. R.; Pizzorno, G.; Mini, K. Decreased Folylpoly-glutamate Synthetase Activity as a Mechanism of Methotrexate Resistance in CCRF-CEM Human Leukemia Sublines. J. Biol. Chem. 1991, 266, 6181-6187.
Molecular and Karyological Analysis of Methotrexate-resistant and -selective Human Leukemic CCRF-CEM Cells
Mini, E.; Srimatkandada S.; Medina, W. D.; Moroson, B. A.; Carman, M. D.; Bertino, J. R. Molecular and Karyological Analysis of Methotrexate-resistant and -selective Human Leukemic CCRF-CEM Cells. Cancer Res. 1985, 45, 317-325.
Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines
Gangjee, A.; Devraj, R.; McGuire, J. J.; Kisliuk, R. L. Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines. J. Med. Chem. 1995, 38, 3798-3805.
Biochemical and Cellular Pharmacology of 1843U89, a Novel Benzoquinazoline Inhibition of Thymidylate Synthase
Duch, D.; Banks, S.; Dev, I. K.; Dickerson, S. H.; Ferone, R.; Heath, L. S.; Humphreys, J.; Knick, V.; Perdergast, W.; Singer, S.; Smith, G. K.; Waters, K.; Wilson, H. R. Biochemical and Cellular Pharmacology of 1843U89, a Novel Benzoquinazoline Inhibition of Thymidylate Synthase. Cancer Res. 1993, 53, 810-818.
Enzymatic Synthesis of Folylpolyglutamates. Characterization of the Reaction and its Products
McGuire, J. J.; Hsieh, P.; Coward, J. K.; Bertino, J. R. Enzymatic Synthesis of Folylpolyglutamates. Characterization of the Reaction and its Products. J. Biol. Chem. 1980, 255, 5776-5788.
Novel 6,5-fused-ring Heterocyclic Antifolates: Biochemical and Biological Characterization
McGuire, J. J.; Bergoltz, V. V.; Heitzman, K. J.; Haue, W. H.; Rüssell, C. A.; Bolanowska, W. E.; Kotake, Y.; Haneda, T.; Nomura, H. Novel 6,5-fused-ring Heterocyclic Antifolates: Biochemical and Biological Characterization. Cancer Res. 1994, 54, 2673-2679.
Continuous Culture of Lymphoblasts from Peripheral Blood of a Child with Acute Leukemia
Foley, G. F.; Lazarus, H.; Farber, S.; Uzman, B. G.; Boone, B. A.; McCarthy, R. E. Continuous Culture of Lymphoblasts from Peripheral Blood of a Child with Acute Leukemia. Cancer 1965, 18, 522-529.
