Similarities and differences between selective and nonselective BAFF blockade in murine SLE

Journal of Clinical Investigation

Volumn 116, Issue 3, 2006, Pages 724-734

  Ramanujam, Meera ^a   Wang, Xiaobo ^b   Huang, Weiqing ^a   Liu, Zheng ^a   Schiffer, Lena ^a   Tao, Haiou ^a   Frank, Daniel ^a   Rice, Jeffrey ^a   Diamond, Betty ^a   Yu, Karl O A ^b   Porcelli, Steven ^b   Davidson, Anne ^a,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; APRIL PROTEIN; B CELL ACTIVATING FACTOR OF THE TUMOR NECROSIS FACTOR FAMILY RECEPTOR IMMUNOGLOBULIN; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IMMUNOLOGIC AGENT; TRANSMEMBRANE ACTIVATOR AND CALCIUM MODULATOR LIGAND INTERACTOR IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; SPLEEN; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE PROTEINS; MICE; MICE, INBRED NZB; MICE, SCID; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33644660402     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI26385     Document Type: Article

References (50)

1. Lipsky, P.E. 2001. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat. Immunol. 2:764-766.
2. Cassese, G., et al. 2001. Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur. J. Immunol. 31:2726-2732.
3. Takemura, S., et al. 2001. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 167:1072-1080.
4. Mackay, F., Schneider, P., Rennert, P., and Browning, J. 2003. BAFF and APRIL: a tutorial on B cell survival. Annu. Rev. Immunol. 21:231-264.
5. Crowley, J.E., Treml, L.S., Stadanlick, J.E., Carpenter, E., and Cancro, M.P. 2005. Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin. Immunol. 17:193-199.
6. Zhang, J., et al. 2001. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166:6-10.
7. Cheema, G.S., Roschke, V., Hilbert, D.M., and Stohl, W. 2001. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 44:1313-1319.
8. Gross, J.A., et al. 2000. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 404:995-999.
9. Kayagaki, N., et al. 2002. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 17:515-524.
10. Ramanujam, M., et al. 2004. Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus. J. Immunol. 173:3524-3534.
11. Wang, H., et al. 2001. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat. Immunol. 2:632-637.
12. Ramanujam, M., and Davidson, A. 2004. The current status of targeting BAFF/BLyS for autoimmune diseases. Arthritis. Res. Ther. 6:197-202.
13. Avery, D.T., et al. 2003. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J. Clin. Invest. 112:286-297. doi:10.1172/JCI200318025.
14. Zhang, X., et al. 2005. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors. Int. Immunol. 17:779-788.
15. Pelletier, M., et al. 2003. Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. J. Biol. Chem. 278:33127-33133.
16. Martin, F., Oliver, A.M., and Kearney, J.F. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity. 14:617-629.
17. Storb, U., et al. 1986. Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J. Exp. Med. 164:627-641.
18. Erickson, L.D., Lin, L.L., Duan, B., Morel, L., and Noelle, R.J. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc. Natl. Acad. Sci. U. S. A. 100:12905-12910.
19. Cancro, M.P. 2004. The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Immunol. Rev. 202:237-249.
20. Yu, G., et al. 2000. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 1:252-256.
21. Lesley, R., et al. 2004. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 20:441-453.
22. Thien, M., et al. 2004. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 20:785-798.
23. Gorelik, L., et al. 2004. Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function. J. Immunol. 172:762-766.
24. Ngo, V.N., Cornall, R.J., and Cyster, J.G. 2001. Splenic T zone development is B cell dependent. J. Exp. Med. 194:1649-1660.
25. Grammer, A.C., and Lipsky, P.E. 2003. B cell abnormalities in systemic lupus erythematosus. Arthritis Res. Ther. 5:S22-S27.
26. Shlomchik, M.J., Craft, J.E., and Mamula, M.J. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1:147-153.
27. Ng, L.G., et al. 2004. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173:807-817.
28. Schiffer, L., et al. 2003. Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J. Immunol. 171:489-497.
29. Hoyer, B.F., et al. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J. Exp. Med. 199:1577-1584.
30. Ingold, K., et al. 2005. Identification of proteoglycans as the APRIL-specific binding partners. J. Exp. Med. 201:1375-1383.
31. Groom, J., et al. 2002. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J. Clin. Invest. 109:59-68. doi:10.1172/JCI200214121.
32. Gavin, A.L., et al. 2005. DeltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models. J. Immunol. 175:319-328.
33. Gross, J.A., et al. 2001. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity. 15:289-302.
34. Planelles, L., et al. 2004. APRIL promotes B-1 cell-associated neoplasm. Cancer Cell. 6:399-408.
35. Balazs, M., Martin, F., Zhou, T., and Kearney, J. 2002. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity. 17:341-352.
36. von Bulow, G.U., van Deursen, J.M., and Bram, R.J. 2001. Regulation of the T-independent humoral response by TACI. Immunity. 14:573-582.
37. Shulga-Morskaya, S., et al. 2004. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J. Immunol. 173:2331-2341.
38. Varfolomeev, E., et al. 2004. APRIL-deficient mice have normal immune system development. Mol. Cell. Biol. 24:997-1006.
39. Tumang, J.R., Hastings, W.D., Bai, C., and Rothstein, T.L. 2004. Peritoneal and splenic B-1 cells are separable by phenotypic, functional, and transcriptomic characteristics. Eur. J. Immunol. 34:2158-2167.
40. Rahman, Z.S., Rao, S.P., Kalled, S.L., and Manser, T. 2003. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J. Exp. Med. 198:1157-1169.
41. Vora, K.A., et al. 2003. Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function. J. Immunol. 171:547-551.
42. O'Connor, B.P., et al. 2004. BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 199:91-98.
43. Schneider, P., et al. 2001. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J. Exp. Med. 194:1691-1697.
44. Bernasconi, N.L., Traggiai, E., and Lanzavecchia, A. 2002. Maintenance of serological memory by polyclonal activation of human memory B cells. Science. 298:2199-2202.
45. Salzer, U., et al. 2005. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 37:820-828.
46. Mihara, M., et al. 2000. CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus. J. Clin. Invest. 106:91-101.
47. Chan, O., Madaio, M.P., and Shlomchik, M.J. 1997. The roles of B cells in MRL/lpr murine lupus. Ann. N. Y. Acad. Sci. 815:75-87.
48. Steinbrink, K., Sorg, C., and Macher, E. 1996. Low zone tolerance to contact allergens in mice: a functional role for CD8+ T helper type 2 cells. J. Exp. Med. 183:759-768.
49. Wang, X., Huang, W., Mihara, M., Sinha, J., and Davidson, A. 2002. Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J. Immunol. 168:2046-2053.
50. Sieckmann, D.G., Martin, E., Guelde, G., Longo, D.L., and Kenny, J.J. 1997. Anti-idiotype monoclonal antibodies specific for the MOPC167 anti-phosphocholine transgene-encoded antibody. Hybridoma. 16:503-511.