메뉴 건너뛰기




Volumn 34, Issue 1, 2008, Pages 115-143

Fibrosis in Systemic Sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; CHEMOKINE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 1; FRACTALKINE; GAMMA INTERFERON; INTEGRIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN PARC; RANTES; SMAD1 PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR FLI 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNINDEXED DRUG;

EID: 40149092637     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2007.11.002     Document Type: Review
Times cited : (70)

References (132)
  • 1
    • 0029048962 scopus 로고
    • Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages
    • Kraling B.M., Maul G.G., and Jimenez S.A. Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages. Pathobiology 63 1 (1995) 48-56
    • (1995) Pathobiology , vol.63 , Issue.1 , pp. 48-56
    • Kraling, B.M.1    Maul, G.G.2    Jimenez, S.A.3
  • 2
    • 0033788161 scopus 로고    scopus 로고
    • Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis
    • Jelaska A., and Korn J.H. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum 43 10 (2000) 2230-2239
    • (2000) Arthritis Rheum , vol.43 , Issue.10 , pp. 2230-2239
    • Jelaska, A.1    Korn, J.H.2
  • 3
    • 30744438818 scopus 로고    scopus 로고
    • The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
    • [Epub 2005 Dec 15]
    • Davies C.A., Jeziorska M., Freemont A.J., et al. The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis. Hum Pathol 37 2 (2006) 190-197 [Epub 2005 Dec 15]
    • (2006) Hum Pathol , vol.37 , Issue.2 , pp. 190-197
    • Davies, C.A.1    Jeziorska, M.2    Freemont, A.J.3
  • 4
    • 0028351248 scopus 로고
    • Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by TGF-ß
    • Rudnicka L., Varga J., Christiano A.M., et al. Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by TGF-ß. J Clin Invest 93 4 (1994) 1709-1715
    • (1994) J Clin Invest , vol.93 , Issue.4 , pp. 1709-1715
    • Rudnicka, L.1    Varga, J.2    Christiano, A.M.3
  • 5
    • 17044454221 scopus 로고    scopus 로고
    • Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis
    • [Epub 2003 Jul 24]
    • van der Slot A.J., Zuurmond A.M., Bardoel A.F., et al. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem 278 42 (2003) 40967-40972 [Epub 2003 Jul 24]
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 40967-40972
    • van der Slot, A.J.1    Zuurmond, A.M.2    Bardoel, A.F.3
  • 6
    • 33745042859 scopus 로고    scopus 로고
    • Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts
    • Gardner H., Shearstone J.R., Bandaru R., et al. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum 54 6 (2006) 1961-1973
    • (2006) Arthritis Rheum , vol.54 , Issue.6 , pp. 1961-1973
    • Gardner, H.1    Shearstone, J.R.2    Bandaru, R.3
  • 7
    • 0142059804 scopus 로고    scopus 로고
    • Systemic and cell type-specific gene expression patterns in scleroderma skin
    • Whitfield M.L., Finlay D.R., Murray J.I., et al. Systemic and cell type-specific gene expression patterns in scleroderma skin. Proc Natl Acad Sci U S A 100 21 (2003) 12319-12324
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.21 , pp. 12319-12324
    • Whitfield, M.L.1    Finlay, D.R.2    Murray, J.I.3
  • 8
    • 36849091820 scopus 로고    scopus 로고
    • TGF-beta regulates DNA-binding activity of transcription factor Fli1 by PCAF-dependent acetylation
    • Asano Y., Czuwara-Ladykowska J., and Trojanowska M. TGF-beta regulates DNA-binding activity of transcription factor Fli1 by PCAF-dependent acetylation. J Biol Chem 282 48 (2007) 34672-34683
    • (2007) J Biol Chem , vol.282 , Issue.48 , pp. 34672-34683
    • Asano, Y.1    Czuwara-Ladykowska, J.2    Trojanowska, M.3
  • 9
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y., Fan P.S., and Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54 7 (2006) 2271-2279
    • (2006) Arthritis Rheum , vol.54 , Issue.7 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 10
    • 0033000530 scopus 로고    scopus 로고
    • Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis
    • Atamas S.P., Yurovsky V.V., Wise R., et al. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum 42 6 (1999) 1168-1178
    • (1999) Arthritis Rheum , vol.42 , Issue.6 , pp. 1168-1178
    • Atamas, S.P.1    Yurovsky, V.V.2    Wise, R.3
  • 11
    • 0037098050 scopus 로고    scopus 로고
    • Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome
    • Bouros D., Wells A.U., Nicholson A.G., et al. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med 165 12 (2002) 1581-1586
    • (2002) Am J Respir Crit Care Med , vol.165 , Issue.12 , pp. 1581-1586
    • Bouros, D.1    Wells, A.U.2    Nicholson, A.G.3
  • 13
    • 0042361733 scopus 로고    scopus 로고
    • Cardiac remodeling in patients with systemic sclerosis with no signs or symptoms of heart failure: an endomyocardial biopsy study
    • Fernandes F., Ramires F.J., Arteaga E., et al. Cardiac remodeling in patients with systemic sclerosis with no signs or symptoms of heart failure: an endomyocardial biopsy study. J Card Fail 9 4 (2003) 311-317
    • (2003) J Card Fail , vol.9 , Issue.4 , pp. 311-317
    • Fernandes, F.1    Ramires, F.J.2    Arteaga, E.3
  • 14
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: paradigm multisystem fibrosing disorder
    • Varga J., and Abraham D.J. Systemic sclerosis: paradigm multisystem fibrosing disorder. J Clin Invest 117 3 (2007) 557-567
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 557-567
    • Varga, J.1    Abraham, D.J.2
  • 15
    • 0029199313 scopus 로고
    • Regulation of connective tissue synthesis in systemic sclerosis
    • Varga J., and Bashey R.I. Regulation of connective tissue synthesis in systemic sclerosis. Int Rev Immunol 12 2-4 (1995) 187-199
    • (1995) Int Rev Immunol , vol.12 , Issue.2-4 , pp. 187-199
    • Varga, J.1    Bashey, R.I.2
  • 16
    • 33847392947 scopus 로고    scopus 로고
    • New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma
    • Abraham D.J., Eckes B., Rajkumar V., et al. New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep 9 2 (2007) 136-143
    • (2007) Curr Rheumatol Rep , vol.9 , Issue.2 , pp. 136-143
    • Abraham, D.J.1    Eckes, B.2    Rajkumar, V.3
  • 17
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechanoregulation of connective tissue remodeling
    • Tomasek J.J., Gabbiani G., Hinz B., et al. Myofibroblasts and mechanoregulation of connective tissue remodeling. Nat Rev Mol Cell Biol 3 5 (2002) 349-363
    • (2002) Nat Rev Mol Cell Biol , vol.3 , Issue.5 , pp. 349-363
    • Tomasek, J.J.1    Gabbiani, G.2    Hinz, B.3
  • 18
    • 28444434653 scopus 로고    scopus 로고
    • Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis
    • [Epub 2005 Jul 21]
    • Rajkumar V.S., Howell K., Csiszar K., et al. Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther 7 5 (2005) R1113-R1123 [Epub 2005 Jul 21]
    • (2005) Arthritis Res Ther , vol.7 , Issue.5
    • Rajkumar, V.S.1    Howell, K.2    Csiszar, K.3
  • 19
    • 3042589910 scopus 로고    scopus 로고
    • Hyperplasia of dermal microvascular pericytes in scleroderma
    • Helmbold P., Fiedler E., Fischer M., et al. Hyperplasia of dermal microvascular pericytes in scleroderma. J Cutan Pathol 31 6 (2004) 431-440
    • (2004) J Cutan Pathol , vol.31 , Issue.6 , pp. 431-440
    • Helmbold, P.1    Fiedler, E.2    Fischer, M.3
  • 20
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R., and Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112 12 (2003) 1776-1784
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 21
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: differentiation pathway and migration to wound sites
    • Abe R., Donnelly S.C., Peng T., et al. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 166 12 (2001) 7556-7562
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3
  • 22
    • 1542269059 scopus 로고    scopus 로고
    • Circulating fibrocytes: collagen-secreting cells of the peripheral blood
    • Quan T.E., Cowper S., Wu S.P., et al. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 36 4 (2004) 598-606
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.4 , pp. 598-606
    • Quan, T.E.1    Cowper, S.2    Wu, S.P.3
  • 23
    • 0347361659 scopus 로고    scopus 로고
    • Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation
    • Kuwana M., Okazaki Y., Kodama H., et al. Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 74 5 (2003) 833-845
    • (2003) J Leukoc Biol , vol.74 , Issue.5 , pp. 833-845
    • Kuwana, M.1    Okazaki, Y.2    Kodama, H.3
  • 24
    • 34547960749 scopus 로고    scopus 로고
    • The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
    • [Epub 2007 Jul 2]
    • Bellini A., and Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 87 9 (2007) 858-870 [Epub 2007 Jul 2]
    • (2007) Lab Invest , vol.87 , Issue.9 , pp. 858-870
    • Bellini, A.1    Mattoli, S.2
  • 25
    • 28444477739 scopus 로고    scopus 로고
    • Scleroderma: from cell and molecular mechanisms to disease models
    • Abraham D.J., and Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 26 11 (2005) 587-595
    • (2005) Trends Immunol , vol.26 , Issue.11 , pp. 587-595
    • Abraham, D.J.1    Varga, J.2
  • 26
    • 34948826895 scopus 로고    scopus 로고
    • Molecular pathways as novel therapeutic targets in systemic sclerosis
    • Varga J., and Trojanowska M. Molecular pathways as novel therapeutic targets in systemic sclerosis. Current Opin Rheumatol 19 6 (2007) 568-573
    • (2007) Current Opin Rheumatol , vol.19 , Issue.6 , pp. 568-573
    • Varga, J.1    Trojanowska, M.2
  • 27
    • 35848951176 scopus 로고    scopus 로고
    • The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis
    • Ghosh A.K., and Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol 213 3 (2007) 663-671
    • (2007) J Cell Physiol , vol.213 , Issue.3 , pp. 663-671
    • Ghosh, A.K.1    Varga, J.2
  • 28
    • 0037133596 scopus 로고    scopus 로고
    • Deficient Smad7 expression: a putative molecular defect in scleroderma
    • Dong C., Zhu S., Wang T., et al. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci U S A 99 6 (2002) 3908-3913
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.6 , pp. 3908-3913
    • Dong, C.1    Zhu, S.2    Wang, T.3
  • 29
    • 85047692249 scopus 로고    scopus 로고
    • Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., et al. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J Clin Invest 113 2 (2004) 253-264
    • (2004) J Clin Invest , vol.113 , Issue.2 , pp. 253-264
    • Asano, Y.1    Ihn, H.2    Yamane, K.3
  • 30
    • 9144233017 scopus 로고    scopus 로고
    • The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells
    • [Epub 2004 Sep 1]
    • Ghosh A.K., Bhattacharyya S., and Varga J. The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells. J Biol Chem 279 46 (2004) 47455-47463 [Epub 2004 Sep 1]
    • (2004) J Biol Chem , vol.279 , Issue.46 , pp. 47455-47463
    • Ghosh, A.K.1    Bhattacharyya, S.2    Varga, J.3
  • 31
    • 27744474113 scopus 로고    scopus 로고
    • Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts
    • [Epub 2005 Aug 4]
    • Svegliati S., Cancello R., Sambo P., et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem 280 43 (2005) 36474-36482 [Epub 2005 Aug 4]
    • (2005) J Biol Chem , vol.280 , Issue.43 , pp. 36474-36482
    • Svegliati, S.1    Cancello, R.2    Sambo, P.3
  • 32
    • 0042846026 scopus 로고    scopus 로고
    • Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin
    • Kubo M., Czuwara-Ladykowska J., Moussa O., et al. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163 2 (2003) 571-581
    • (2003) Am J Pathol , vol.163 , Issue.2 , pp. 571-581
    • Kubo, M.1    Czuwara-Ladykowska, J.2    Moussa, O.3
  • 33
    • 24944463244 scopus 로고    scopus 로고
    • Transforming growth factor-beta: a key mediator of fibrosis
    • Mauviel A. Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med 117 (2005) 69-80
    • (2005) Methods Mol Med , vol.117 , pp. 69-80
    • Mauviel, A.1
  • 34
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massague J., Seoane J., and Wotton D. Smad transcription factors. Genes Dev 19 23 (2005) 2783-2810
    • (2005) Genes Dev , vol.19 , Issue.23 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 35
    • 17244371148 scopus 로고    scopus 로고
    • Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta
    • Bhattacharyya S., Ghosh A.K., Pannu J., et al. Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta. Arthritis Rheum 52 4 (2005) 1248-1258
    • (2005) Arthritis Rheum , vol.52 , Issue.4 , pp. 1248-1258
    • Bhattacharyya, S.1    Ghosh, A.K.2    Pannu, J.3
  • 36
    • 33746122263 scopus 로고    scopus 로고
    • Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo
    • [Epub 2006 Jun 1]
    • Ishida W., Mori Y., Lakos G., et al. Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol 126 8 (2006) 1733-1744 [Epub 2006 Jun 1]
    • (2006) J Invest Dermatol , vol.126 , Issue.8 , pp. 1733-1744
    • Ishida, W.1    Mori, Y.2    Lakos, G.3
  • 37
    • 10444259759 scopus 로고    scopus 로고
    • Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts
    • Mori Y., Ishida W., Bhattacharyya S., et al. Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Arthritis Rheum 50 12 (2004) 4008-4021
    • (2004) Arthritis Rheum , vol.50 , Issue.12 , pp. 4008-4021
    • Mori, Y.1    Ishida, W.2    Bhattacharyya, S.3
  • 38
    • 33646346588 scopus 로고    scopus 로고
    • Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts
    • Chen Y., Shi-wen X., Eastwood M., et al. Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts. Arthritis Rheum 54 4 (2006) 1309-1316
    • (2006) Arthritis Rheum , vol.54 , Issue.4 , pp. 1309-1316
    • Chen, Y.1    Shi-wen, X.2    Eastwood, M.3
  • 39
    • 35348940144 scopus 로고    scopus 로고
    • Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
    • Prud'homme G.J. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab Invest 87 11 (2007) 1077-1091
    • (2007) Lab Invest , vol.87 , Issue.11 , pp. 1077-1091
    • Prud'homme, G.J.1
  • 40
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A., and Heldin C.H. Non-Smad TGF-beta signals. J Cell Sci 118 (2005) 3573-3584
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 41
    • 0036226458 scopus 로고    scopus 로고
    • Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts
    • Sato M., Shegogue D., Gore E.A., et al. Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol 118 4 (2002) 704-711
    • (2002) J Invest Dermatol , vol.118 , Issue.4 , pp. 704-711
    • Sato, M.1    Shegogue, D.2    Gore, E.A.3
  • 42
    • 0042704734 scopus 로고    scopus 로고
    • Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta dependent responses in human mesangial cells
    • [Epub 2003 Jun 17]
    • Hayashida T., Decaestecker M., and Schnaper H.W. Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta dependent responses in human mesangial cells. FASEB J 17 11 (2003) 1576-1578 [Epub 2003 Jun 17]
    • (2003) FASEB J , vol.17 , Issue.11 , pp. 1576-1578
    • Hayashida, T.1    Decaestecker, M.2    Schnaper, H.W.3
  • 43
    • 38349011114 scopus 로고    scopus 로고
    • MAP kinase activity necessary for TGF-ß stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397
    • Hayashida T., Wu M., Pierce A., et al. MAP kinase activity necessary for TGF-ß stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397. J Cell Sci 120 Pt 23 (2007) 4230-4240
    • (2007) J Cell Sci , vol.120 , Issue.PART 23 , pp. 4230-4240
    • Hayashida, T.1    Wu, M.2    Pierce, A.3
  • 44
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • Daniels C.E., Wilkes M.C., Edens M., et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 114 (2004) 1308-1316
    • (2004) J Clin Invest , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3
  • 45
    • 34249845879 scopus 로고    scopus 로고
    • Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
    • Pannu J., Nakerakanti S., Smith E., et al. Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem 282 (2007) 10405-10413
    • (2007) J Biol Chem , vol.282 , pp. 10405-10413
    • Pannu, J.1    Nakerakanti, S.2    Smith, E.3
  • 46
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    • Goumans M.J., Valdimarsdottir G., Itoh S., et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 12 (2003) 817-828
    • (2003) Mol Cell , vol.12 , pp. 817-828
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3
  • 47
    • 1842639393 scopus 로고    scopus 로고
    • Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end product (AGE) stimulation
    • Abe H., Matsubara T., Iehara N., et al. Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end product (AGE) stimulation. J Biol Chem 279 (2004) 14201-14206
    • (2004) J Biol Chem , vol.279 , pp. 14201-14206
    • Abe, H.1    Matsubara, T.2    Iehara, N.3
  • 48
    • 33645286189 scopus 로고    scopus 로고
    • Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy
    • Matsubara T., Abe H., Arai H., et al. Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy. Lab Invest 86 (2006) 357-368
    • (2006) Lab Invest , vol.86 , pp. 357-368
    • Matsubara, T.1    Abe, H.2    Arai, H.3
  • 49
    • 20044376863 scopus 로고    scopus 로고
    • Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis
    • Takahashi T., Abe H., Arai H., et al. Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. J Biol Chem 280 (2005) 7100-7106
    • (2005) J Biol Chem , vol.280 , pp. 7100-7106
    • Takahashi, T.1    Abe, H.2    Arai, H.3
  • 50
    • 33749320619 scopus 로고    scopus 로고
    • Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: a model of scleroderma
    • Pannu J., Gardner H., Shearstone J.R., et al. Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: a model of scleroderma. Arthritis Rheum 54 (2006) 3011-3021
    • (2006) Arthritis Rheum , vol.54 , pp. 3011-3021
    • Pannu, J.1    Gardner, H.2    Shearstone, J.R.3
  • 51
    • 0142211305 scopus 로고    scopus 로고
    • Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1
    • Holmes A., Abraham D.J., Chen Y., et al. Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1. J Biol Chem 278 (2003) 41728-41733
    • (2003) J Biol Chem , vol.278 , pp. 41728-41733
    • Holmes, A.1    Abraham, D.J.2    Chen, Y.3
  • 52
    • 33746374436 scopus 로고    scopus 로고
    • The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression
    • Chen S.J., Ning H., Ishida W., et al. The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression. J Biol Chem 281 (2006) 21183-21197
    • (2006) J Biol Chem , vol.281 , pp. 21183-21197
    • Chen, S.J.1    Ning, H.2    Ishida, W.3
  • 53
    • 3042801241 scopus 로고    scopus 로고
    • Coactivating factors p300 and CBP are transcriptionally cross-regulated by Egr1 in prostate cells, leading to divergent responses
    • Yu J., de Belle I., Liang H., et al. Coactivating factors p300 and CBP are transcriptionally cross-regulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell 15 (2004) 83-94
    • (2004) Mol Cell , vol.15 , pp. 83-94
    • Yu, J.1    de Belle, I.2    Liang, H.3
  • 54
    • 33646381116 scopus 로고    scopus 로고
    • Role of early growth response-1 (Egr-1) in interleukin-13 induced inflammation and remodeling
    • Cho S.J., Kang M.J., Homer R.J., et al. Role of early growth response-1 (Egr-1) in interleukin-13 induced inflammation and remodeling. J Biol Chem 281 (2006) 8161-8168
    • (2006) J Biol Chem , vol.281 , pp. 8161-8168
    • Cho, S.J.1    Kang, M.J.2    Homer, R.J.3
  • 55
    • 0035877684 scopus 로고    scopus 로고
    • Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway
    • Czuwara-Ladykowska J., Shirasaki F., Jackers P., et al. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 276 (2001) 20839-20848
    • (2001) J Biol Chem , vol.276 , pp. 20839-20848
    • Czuwara-Ladykowska, J.1    Shirasaki, F.2    Jackers, P.3
  • 56
    • 33748747707 scopus 로고    scopus 로고
    • Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program
    • Nakerakanti S.S., Kapanadze B., Yamasaki M., et al. Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program. J Biol Chem 281 (2006) 25259-25269
    • (2006) J Biol Chem , vol.281 , pp. 25259-25269
    • Nakerakanti, S.S.1    Kapanadze, B.2    Yamasaki, M.3
  • 57
    • 1842733168 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma
    • Ghosh A.K., Bhattacharyya S., Lakos G., et al. Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma. Arthritis Rheum 50 (2004) 1305-1318
    • (2004) Arthritis Rheum , vol.50 , pp. 1305-1318
    • Ghosh, A.K.1    Bhattacharyya, S.2    Lakos, G.3
  • 58
    • 2542491986 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1
    • Cheng S., Afif H., Martel-Pelletier J., et al. Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. J Biol Chem 279 (2004) 22057-22065
    • (2004) J Biol Chem , vol.279 , pp. 22057-22065
    • Cheng, S.1    Afif, H.2    Martel-Pelletier, J.3
  • 59
    • 33846209989 scopus 로고    scopus 로고
    • Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    • Distler J.H., Jungel A., Huber L.C., et al. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 56 1 (2007) 311-322
    • (2007) Arthritis Rheum , vol.56 , Issue.1 , pp. 311-322
    • Distler, J.H.1    Jungel, A.2    Huber, L.C.3
  • 60
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signaling through scaffolds and inhibitors
    • Kolch W. Coordinating ERK/MAPK signaling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6 (2005) 827-837
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 827-837
    • Kolch, W.1
  • 61
    • 0032589970 scopus 로고    scopus 로고
    • TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression
    • Hayashida T., Poncelet A.C., Hubchak S.C., et al. TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 56 5 (1999) 1710-1720
    • (1999) Kidney Int , vol.56 , Issue.5 , pp. 1710-1720
    • Hayashida, T.1    Poncelet, A.C.2    Hubchak, S.C.3
  • 62
    • 17144407933 scopus 로고    scopus 로고
    • Opposing effects of protein kinase C-alpha and protein kinase C-epsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling
    • Tourkina E., Gooz P., Pannu J., et al. Opposing effects of protein kinase C-alpha and protein kinase C-epsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling. J Biol Chem 280 (2005) 13879-13887
    • (2005) J Biol Chem , vol.280 , pp. 13879-13887
    • Tourkina, E.1    Gooz, P.2    Pannu, J.3
  • 63
    • 33745251100 scopus 로고    scopus 로고
    • Autoantibodies against PDGF receptor in scleroderma
    • Tan F.K. Autoantibodies against PDGF receptor in scleroderma. N Engl J Med 354 25 (2006) 2709-2711
    • (2006) N Engl J Med , vol.354 , Issue.25 , pp. 2709-2711
    • Tan, F.K.1
  • 64
    • 0034253938 scopus 로고    scopus 로고
    • Fibroblast-matrix interactions in wound healing and fibrosis
    • Eckes B., Zigrino P., Kessler D., et al. Fibroblast-matrix interactions in wound healing and fibrosis. Matrix Biol 19 (2000) 325-332
    • (2000) Matrix Biol , vol.19 , pp. 325-332
    • Eckes, B.1    Zigrino, P.2    Kessler, D.3
  • 65
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., et al. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J Immunol 175 (2005) 7708-7718
    • (2005) J Immunol , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3
  • 66
    • 1642329882 scopus 로고    scopus 로고
    • Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., et al. Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts. Am J Pathol 164 (2004) 1275-1292
    • (2004) Am J Pathol , vol.164 , pp. 1275-1292
    • Asano, Y.1    Ihn, H.2    Yamane, K.3
  • 67
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
    • Asano Y., Ihn H., Yamane K., et al. Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol 168 (2006) 499-510
    • (2006) Am J Pathol , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3
  • 68
    • 17844395977 scopus 로고    scopus 로고
    • Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts
    • Mimura Y., Ihn H., Jinnin M., et al. Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts. Am J Pathol 166 (2005) 1451-1463
    • (2005) Am J Pathol , vol.166 , pp. 1451-1463
    • Mimura, Y.1    Ihn, H.2    Jinnin, M.3
  • 69
    • 0033978653 scopus 로고    scopus 로고
    • Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
    • Sato S., Nagaoka T., Hasegawa M., et al. Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol 27 1 (2000) 149-154
    • (2000) J Rheumatol , vol.27 , Issue.1 , pp. 149-154
    • Sato, S.1    Nagaoka, T.2    Hasegawa, M.3
  • 70
    • 0029154782 scopus 로고
    • Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis
    • Igarashi A., Nashiro K., Kikuchi K., et al. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J Invest Dermatol 105 2 (1995) 280-284
    • (1995) J Invest Dermatol , vol.105 , Issue.2 , pp. 280-284
    • Igarashi, A.1    Nashiro, K.2    Kikuchi, K.3
  • 71
    • 34548843398 scopus 로고    scopus 로고
    • A polymorphism in the CTGF promoter region associated with systemic sclerosis
    • Fonseca C., Lindahl G.E., Ponticos M., et al. A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med 357 12 (2007) 1210-1220
    • (2007) N Engl J Med , vol.357 , Issue.12 , pp. 1210-1220
    • Fonseca, C.1    Lindahl, G.E.2    Ponticos, M.3
  • 72
    • 0442291674 scopus 로고    scopus 로고
    • The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology
    • Leask A., and Abraham D.J. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 81 6 (2003) 355-363
    • (2003) Biochem Cell Biol , vol.81 , Issue.6 , pp. 355-363
    • Leask, A.1    Abraham, D.J.2
  • 73
    • 16344369209 scopus 로고    scopus 로고
    • Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
    • Chujo S., Shirasaki F., Kawara S., et al. Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol 203 2 (2005) 447-456
    • (2005) J Cell Physiol , vol.203 , Issue.2 , pp. 447-456
    • Chujo, S.1    Shirasaki, F.2    Kawara, S.3
  • 74
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts
    • Grotendorst G.R. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8 3 (1997) 171-179
    • (1997) Cytokine Growth Factor Rev , vol.8 , Issue.3 , pp. 171-179
    • Grotendorst, G.R.1
  • 75
    • 39549119349 scopus 로고    scopus 로고
    • Mori Y, Hinchcliff M, Wu M, et al. Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res 2008, in press.
    • Mori Y, Hinchcliff M, Wu M, et al. Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res 2008, in press.
  • 76
    • 0025014021 scopus 로고
    • Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis
    • Klareskog L., Gustafsson R., Scheynius A., et al. Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis. Arthritis Rheum 33 10 (1990) 1534-1541
    • (1990) Arthritis Rheum , vol.33 , Issue.10 , pp. 1534-1541
    • Klareskog, L.1    Gustafsson, R.2    Scheynius, A.3
  • 77
    • 0028973641 scopus 로고
    • Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma
    • Ludwicka A., Ohba T., Trojanowska M., et al. Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol 22 10 (1995) 1876-1883
    • (1995) J Rheumatol , vol.22 , Issue.10 , pp. 1876-1883
    • Ludwicka, A.1    Ohba, T.2    Trojanowska, M.3
  • 78
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Baroni S.S., Santillo M., Bevilacqua F., et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 354 (2006) 2667-2676
    • (2006) N Engl J Med , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 79
    • 34347386226 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease
    • [Eppub 2007 Mar 15]
    • Svegliati S., Olivieri A., Campelli N., et al. Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease. Blood 110 1 (2007) 237-241 [Eppub 2007 Mar 15]
    • (2007) Blood , vol.110 , Issue.1 , pp. 237-241
    • Svegliati, S.1    Olivieri, A.2    Campelli, N.3
  • 80
    • 0026446005 scopus 로고
    • Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4
    • Postlethwaite A.E., Holness M.A., Katai H., et al. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 90 4 (1992) 1479-1485
    • (1992) J Clin Invest , vol.90 , Issue.4 , pp. 1479-1485
    • Postlethwaite, A.E.1    Holness, M.A.2    Katai, H.3
  • 81
    • 0031056613 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis
    • Hasegawa M., Fujimoto M., Kikuchi K., et al. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol 24 (1997) 328-332
    • (1997) J Rheumatol , vol.24 , pp. 328-332
    • Hasegawa, M.1    Fujimoto, M.2    Kikuchi, K.3
  • 82
    • 0032822463 scopus 로고    scopus 로고
    • Increased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis
    • Sakkas L.I., Tourtellotte C., Berney S., et al. Increased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis. Clin Diagn Lab Immunol 6 5 (1999) 660-664
    • (1999) Clin Diagn Lab Immunol , vol.6 , Issue.5 , pp. 660-664
    • Sakkas, L.I.1    Tourtellotte, C.2    Berney, S.3
  • 83
    • 0029941568 scopus 로고    scopus 로고
    • Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis
    • Salmon-Ehr V., Serpier H., Nawrocki B., et al. Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis. Arch Dermatol 132 7 (1996) 802-806
    • (1996) Arch Dermatol , vol.132 , Issue.7 , pp. 802-806
    • Salmon-Ehr, V.1    Serpier, H.2    Nawrocki, B.3
  • 84
    • 34247586091 scopus 로고    scopus 로고
    • Induction of IL-13 triggers TGF-beta1 dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis
    • Fichtner-Feigl S., Fuss I.J., Young C.A., et al. Induction of IL-13 triggers TGF-beta1 dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J Immunol 178 9 (2007) 5859-5870
    • (2007) J Immunol , vol.178 , Issue.9 , pp. 5859-5870
    • Fichtner-Feigl, S.1    Fuss, I.J.2    Young, C.A.3
  • 85
    • 4744362174 scopus 로고    scopus 로고
    • Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblasts
    • Jinnin M., Ihn H., Yamane K., et al. Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblasts. J Biol Chem 279 40 (2004) 41783-41791
    • (2004) J Biol Chem , vol.279 , Issue.40 , pp. 41783-41791
    • Jinnin, M.1    Ihn, H.2    Yamane, K.3
  • 86
    • 33746350138 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in scleroderma
    • Yamamoto T. Chemokines and chemokine receptors in scleroderma. Int Arch Allergy Immunol 140 4 (2006) 345-356
    • (2006) Int Arch Allergy Immunol , vol.140 , Issue.4 , pp. 345-356
    • Yamamoto, T.1
  • 87
    • 29144490583 scopus 로고    scopus 로고
    • Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
    • Yanaba K., Komura K., Kodera M., et al. Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. Ann Rheum Dis 65 1 (2006) 124-126
    • (2006) Ann Rheum Dis , vol.65 , Issue.1 , pp. 124-126
    • Yanaba, K.1    Komura, K.2    Kodera, M.3
  • 88
    • 0027397988 scopus 로고
    • Demonstration of interleukin-8 and autoantibodies to interleukin-8 in the serum of patients with systemic sclerosis and related disorders
    • Reitamo S., Remitz A., Varga J., et al. Demonstration of interleukin-8 and autoantibodies to interleukin-8 in the serum of patients with systemic sclerosis and related disorders. Arch Dermatol 129 2 (1993) 189-193
    • (1993) Arch Dermatol , vol.129 , Issue.2 , pp. 189-193
    • Reitamo, S.1    Remitz, A.2    Varga, J.3
  • 89
    • 29144443977 scopus 로고    scopus 로고
    • Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation
    • Carulli M.T., Ong V.H., Ponticos M., et al. Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation. Arthritis Rheum 52 12 (2005) 3772-3782
    • (2005) Arthritis Rheum , vol.52 , Issue.12 , pp. 3772-3782
    • Carulli, M.T.1    Ong, V.H.2    Ponticos, M.3
  • 90
    • 33746173341 scopus 로고    scopus 로고
    • Diminished induction of skin fibrosis in mice with MCP-1 deficiency
    • Ferreira A.M., Takagawa S., Fresco R., et al. Diminished induction of skin fibrosis in mice with MCP-1 deficiency. J Invest Dermatol 126 8 (2006) 1900-1908
    • (2006) J Invest Dermatol , vol.126 , Issue.8 , pp. 1900-1908
    • Ferreira, A.M.1    Takagawa, S.2    Fresco, R.3
  • 91
    • 0038004791 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse
    • Ong V.H., Evans L.A., Shiwen X., et al. Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis Rheum 48 7 (2003) 1979-1991
    • (2003) Arthritis Rheum , vol.48 , Issue.7 , pp. 1979-1991
    • Ong, V.H.1    Evans, L.A.2    Shiwen, X.3
  • 92
    • 34248547174 scopus 로고    scopus 로고
    • CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis
    • Prasse A., Pechkovsky D.V., Toews G.B., et al. CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. Arthritis Rheum 56 5 (2007) 1685-1693
    • (2007) Arthritis Rheum , vol.56 , Issue.5 , pp. 1685-1693
    • Prasse, A.1    Pechkovsky, D.V.2    Toews, G.B.3
  • 93
    • 13244254138 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
    • Pilewski J.M., Liu L., Henry A.C., et al. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol 166 2 (2005) 399-407
    • (2005) Am J Pathol , vol.166 , Issue.2 , pp. 399-407
    • Pilewski, J.M.1    Liu, L.2    Henry, A.C.3
  • 94
    • 0028118592 scopus 로고
    • Insulin-like growth factor-I is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis
    • Harrison N.K., Cambrey A.D., Myers A.R., et al. Insulin-like growth factor-I is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis. Clin Sci (Lond) 86 2 (1994) 141-148
    • (1994) Clin Sci (Lond) , vol.86 , Issue.2 , pp. 141-148
    • Harrison, N.K.1    Cambrey, A.D.2    Myers, A.R.3
  • 95
    • 0033503210 scopus 로고    scopus 로고
    • Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis
    • Feghali C.A., and Wright T.M. Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis. Arthritis Rheum 42 7 (1999) 1451-1457
    • (1999) Arthritis Rheum , vol.42 , Issue.7 , pp. 1451-1457
    • Feghali, C.A.1    Wright, T.M.2
  • 96
    • 33947171101 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration
    • Yasuoka H., Zhou Z., Pilewski J.M., et al. Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol 169 5 (2006) 1633-1642
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1633-1642
    • Yasuoka, H.1    Zhou, Z.2    Pilewski, J.M.3
  • 97
    • 0021162097 scopus 로고
    • Selective inhibition of human diploid fibroblast collagen synthesis by interferons
    • Jimenez S.A., Freundlich B., and Rosenbloom J. Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest 74 3 (1984) 1112-1116
    • (1984) J Clin Invest , vol.74 , Issue.3 , pp. 1112-1116
    • Jimenez, S.A.1    Freundlich, B.2    Rosenbloom, J.3
  • 98
    • 0022260875 scopus 로고
    • Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation
    • Duncan M.R., and Berman B. Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med 162 2 (1985) 516-527
    • (1985) J Exp Med , vol.162 , Issue.2 , pp. 516-527
    • Duncan, M.R.1    Berman, B.2
  • 99
    • 0032901003 scopus 로고    scopus 로고
    • Selective inhibition of collagen gene expression in fibroblasts by an interferon-gamma transgene
    • Jaffe H.A., Gao Z., Mori Y., et al. Selective inhibition of collagen gene expression in fibroblasts by an interferon-gamma transgene. Exp Lung Res 25 3 (1999) 199-215
    • (1999) Exp Lung Res , vol.25 , Issue.3 , pp. 199-215
    • Jaffe, H.A.1    Gao, Z.2    Mori, Y.3
  • 100
    • 0035815696 scopus 로고    scopus 로고
    • Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators
    • Ghosh A.K., Yuan W., Mori Y., et al. Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem 276 14 (2001) 11041-11048
    • (2001) J Biol Chem , vol.276 , Issue.14 , pp. 11041-11048
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3
  • 101
    • 0031734246 scopus 로고    scopus 로고
    • Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts
    • Chizzolini C., Rezzonico R., Ribbens C., et al. Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts. Arthritis Rheum 41 11 (1998) 2039-2047
    • (1998) Arthritis Rheum , vol.41 , Issue.11 , pp. 2039-2047
    • Chizzolini, C.1    Rezzonico, R.2    Ribbens, C.3
  • 102
    • 0026804662 scopus 로고
    • Treatment of systemic sclerosis with recombinant interferon-gamma. A phase I/II clinical trial
    • Freundlich B., Jimenez S.A., Steen V.D., et al. Treatment of systemic sclerosis with recombinant interferon-gamma. A phase I/II clinical trial. Arthritis Rheum 35 10 (1992) 1134-1142
    • (1992) Arthritis Rheum , vol.35 , Issue.10 , pp. 1134-1142
    • Freundlich, B.1    Jimenez, S.A.2    Steen, V.D.3
  • 103
    • 7844237877 scopus 로고    scopus 로고
    • Interferon-gamma in the treatment of systemic sclerosis: a randomized controlled multicentre trial
    • Grassegger A., Schuler G., Hessenberger G., et al. Interferon-gamma in the treatment of systemic sclerosis: a randomized controlled multicentre trial. Br J Dermatol 139 4 (1998) 639-648
    • (1998) Br J Dermatol , vol.139 , Issue.4 , pp. 639-648
    • Grassegger, A.1    Schuler, G.2    Hessenberger, G.3
  • 104
    • 0030992808 scopus 로고    scopus 로고
    • Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma
    • Hunzelmann N., Anders S., Fierlbeck G., et al. Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma. Arch Dermatol 133 5 (1997) 609-613
    • (1997) Arch Dermatol , vol.133 , Issue.5 , pp. 609-613
    • Hunzelmann, N.1    Anders, S.2    Fierlbeck, G.3
  • 105
    • 4444223567 scopus 로고    scopus 로고
    • What did we learn by studying scleroderma fibroblasts?
    • Trojanowska M. What did we learn by studying scleroderma fibroblasts?. Clin Exp Rheumatol 22 3 Suppl 33 (2004) S59-S63
    • (2004) Clin Exp Rheumatol , vol.22 , Issue.3 SUPPL. 33
    • Trojanowska, M.1
  • 106
    • 18244368698 scopus 로고    scopus 로고
    • Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts
    • Mimura Y., Ihn H., Jinnin M., et al. Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts. J Invest Dermatol 124 5 (2005) 886-892
    • (2005) J Invest Dermatol , vol.124 , Issue.5 , pp. 886-892
    • Mimura, Y.1    Ihn, H.2    Jinnin, M.3
  • 107
    • 12944286451 scopus 로고    scopus 로고
    • Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ
    • Jun J.B., Kuechle M., Min J., et al. Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ. J Invest Dermatol 124 2 (2005) 298-303
    • (2005) J Invest Dermatol , vol.124 , Issue.2 , pp. 298-303
    • Jun, J.B.1    Kuechle, M.2    Min, J.3
  • 108
    • 37349113805 scopus 로고    scopus 로고
    • Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis
    • Ihn H. Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis. J Dermatol Sci 49 2 (2008) 103-113
    • (2008) J Dermatol Sci , vol.49 , Issue.2 , pp. 103-113
    • Ihn, H.1
  • 109
    • 0036745067 scopus 로고    scopus 로고
    • Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts
    • Yamane K., Ihn H., Kubo M., et al. Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts. Arthritis Rheum 46 9 (2002) 2421-2428
    • (2002) Arthritis Rheum , vol.46 , Issue.9 , pp. 2421-2428
    • Yamane, K.1    Ihn, H.2    Kubo, M.3
  • 110
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype
    • Kawakami T., Ihn H., Xu W., et al. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 110 1 (1998) 47-51
    • (1998) J Invest Dermatol , vol.110 , Issue.1 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3
  • 111
    • 0036894848 scopus 로고    scopus 로고
    • Up-regulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis
    • Kubo M., Ihn H., Yamane K., et al. Up-regulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis. J Rheumatol 29 12 (2002) 2558-2564
    • (2002) J Rheumatol , vol.29 , Issue.12 , pp. 2558-2564
    • Kubo, M.1    Ihn, H.2    Yamane, K.3
  • 112
    • 0038004796 scopus 로고    scopus 로고
    • Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
    • Mori Y., Chen S.J., and Varga J. Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum 48 7 (2003) 1964-1978
    • (2003) Arthritis Rheum , vol.48 , Issue.7 , pp. 1964-1978
    • Mori, Y.1    Chen, S.J.2    Varga, J.3
  • 113
    • 0036064618 scopus 로고    scopus 로고
    • SSc and Smads: dysfunctional Smad family dynamics culminating in fibrosis
    • Varga J. SSc and Smads: dysfunctional Smad family dynamics culminating in fibrosis. Arthritis Rheum 46 7 (2002) 1703-1713
    • (2002) Arthritis Rheum , vol.46 , Issue.7 , pp. 1703-1713
    • Varga, J.1
  • 114
    • 34347231354 scopus 로고    scopus 로고
    • Skin involvement in scleroderma-where histological and clinical scores meet
    • [Epub 2007 Jan 25]
    • Verrecchia F., Laboureau J., Verola O., et al. Skin involvement in scleroderma-where histological and clinical scores meet. Rheumatology (Oxford) 46 5 (2007) 833-841 [Epub 2007 Jan 25]
    • (2007) Rheumatology (Oxford) , vol.46 , Issue.5 , pp. 833-841
    • Verrecchia, F.1    Laboureau, J.2    Verola, O.3
  • 115
    • 31544442502 scopus 로고    scopus 로고
    • Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts
    • [Epub 2005 Nov 30]
    • Ihn H., Yamane K., Asano Y., et al. Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts. Rheumatology (Oxford) 45 2 (2006) 157-165 [Epub 2005 Nov 30]
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.2 , pp. 157-165
    • Ihn, H.1    Yamane, K.2    Asano, Y.3
  • 116
    • 23644440113 scopus 로고    scopus 로고
    • Animal models in scleroderma
    • Clark S.H. Animal models in scleroderma. Curr Rheumatol Rep 7 2 (2005) 150-155
    • (2005) Curr Rheumatol Rep , vol.7 , Issue.2 , pp. 150-155
    • Clark, S.H.1
  • 117
    • 0017250167 scopus 로고
    • Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton
    • Green M.C., Sweet H.O., and Bunker L.E. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am J Pathol 82 3 (1976) 493-512
    • (1976) Am J Pathol , vol.82 , Issue.3 , pp. 493-512
    • Green, M.C.1    Sweet, H.O.2    Bunker, L.E.3
  • 118
    • 40649105572 scopus 로고    scopus 로고
    • Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    • [epub ahead of print]
    • Bayle J., Fitch J., Jacobsen K., et al. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol (2007) [epub ahead of print]
    • (2007) J Invest Dermatol
    • Bayle, J.1    Fitch, J.2    Jacobsen, K.3
  • 119
    • 0021359715 scopus 로고
    • Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse
    • Jimenez S.A., Millan A., and Bashey R.I. Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse. Arthritis Rheum 27 2 (1984) 180-185
    • (1984) Arthritis Rheum , vol.27 , Issue.2 , pp. 180-185
    • Jimenez, S.A.1    Millan, A.2    Bashey, R.I.3
  • 120
    • 25144523631 scopus 로고    scopus 로고
    • Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents
    • Baxter R.M., Crowell T.P., McCrann M.E., et al. Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents. Lab Invest 85 10 (2005) 1199-1209
    • (2005) Lab Invest , vol.85 , Issue.10 , pp. 1199-1209
    • Baxter, R.M.1    Crowell, T.P.2    McCrann, M.E.3
  • 121
    • 0029941445 scopus 로고    scopus 로고
    • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation
    • Siracusa L.D., McGrath R., Ma Q., et al. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res 6 4 (1996) 300-313
    • (1996) Genome Res , vol.6 , Issue.4 , pp. 300-313
    • Siracusa, L.D.1    McGrath, R.2    Ma, Q.3
  • 122
    • 0029610915 scopus 로고
    • The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration
    • Christner P.J., Peters J., Hawkins D., et al. The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration. Arthritis Rheum 38 12 (1995) 1791-1798
    • (1995) Arthritis Rheum , vol.38 , Issue.12 , pp. 1791-1798
    • Christner, P.J.1    Peters, J.2    Hawkins, D.3
  • 123
    • 0032907817 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. I: local injections of bleomycin induce sclerotic skin mimicking scleroderma
    • Yamamoto T., Takagawa S., Katayama I., et al. Animal model of sclerotic skin. I: local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 112 4 (1999) 456-462
    • (1999) J Invest Dermatol , vol.112 , Issue.4 , pp. 456-462
    • Yamamoto, T.1    Takagawa, S.2    Katayama, I.3
  • 124
    • 33847377509 scopus 로고    scopus 로고
    • Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet
    • Lakos G., Melichian D., Wu M., et al. Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet. Pathobiology 73 5 (2006) 224-237
    • (2006) Pathobiology , vol.73 , Issue.5 , pp. 224-237
    • Lakos, G.1    Melichian, D.2    Wu, M.3
  • 125
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G., Takagawa S., Chen S.J., et al. Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 165 1 (2004) 203-217
    • (2004) Am J Pathol , vol.165 , Issue.1 , pp. 203-217
    • Lakos, G.1    Takagawa, S.2    Chen, S.J.3
  • 127
    • 0036546603 scopus 로고    scopus 로고
    • Animal models for scleroderma: an update
    • Zhang Y., and Gilliam A.C. Animal models for scleroderma: an update. Curr Rheumatol Rep 4 2 (2002) 150-162
    • (2002) Curr Rheumatol Rep , vol.4 , Issue.2 , pp. 150-162
    • Zhang, Y.1    Gilliam, A.C.2
  • 128
    • 0037087318 scopus 로고    scopus 로고
    • Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation
    • Zhang Y., McCormick L.L., Desai S.R., et al. Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. J Immunol 168 6 (2002) 3088-3098
    • (2002) J Immunol , vol.168 , Issue.6 , pp. 3088-3098
    • Zhang, Y.1    McCormick, L.L.2    Desai, S.R.3
  • 129
    • 1842783757 scopus 로고    scopus 로고
    • A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease
    • Ruzek M.C., Jha S., Ledbetter S., et al. A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease. Arthritis Rheum 50 4 (2004) 1319-1331
    • (2004) Arthritis Rheum , vol.50 , Issue.4 , pp. 1319-1331
    • Ruzek, M.C.1    Jha, S.2    Ledbetter, S.3
  • 130
    • 33846247466 scopus 로고    scopus 로고
    • Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
    • Sonnylal S., Denton C.P., Zheng B., et al. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 56 (2007) 334-344
    • (2007) Arthritis Rheum , vol.56 , pp. 334-344
    • Sonnylal, S.1    Denton, C.P.2    Zheng, B.3
  • 131
    • 20944449564 scopus 로고    scopus 로고
    • Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II TGF-ß receptor
    • Denton C.P., Lindahl G.E., Khan K., et al. Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II TGF-ß receptor. J Biol Chem 280 16 (2005) 16053-16065
    • (2005) J Biol Chem , vol.280 , Issue.16 , pp. 16053-16065
    • Denton, C.P.1    Lindahl, G.E.2    Khan, K.3
  • 132
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynne T. Cellular and molecular mechanisms of fibrosis. J Pathol 214 2 (2008) 199-210
    • (2008) J Pathol , vol.214 , Issue.2 , pp. 199-210
    • Wynne, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.