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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 13, 2010, Pages 4801-4811

Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway

(6) Mahindroo, Neeraj a Connelly, Michele C a Punchihewa, Chandanamali a Yang, Lei a Yan, Bing a Fujii, Naoaki a

a ST JUDE CHILDREN S RESEARCH HOSPITAL (United States)

Author keywords

Anticancer; Gli; Hedgehog; Metabolic stability

Indexed keywords

2 (3 BENZOYLPHENYL) N (1 PROPYL 1H INDOL 6 YL)PROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 4 YL) N (1H INDOL 6 YL) N PROPYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) 2 METHYLPENTANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N (2 MORPHOLINOETHYL) N PROPYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N (MORPHOLINOETHYL)PROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N [2 (PIPERIDIN 1 YL)ETHYL]PROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N [3 (DIMETHYLAMINO)PROPYL] N (1H INDOL 6 YL)PROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N ISOBUTYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N METHYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N PHENETHYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (1H INDOL 6 YL) N PROPYLPROPANAMIDE; 2 (3 BENZOYLPHENYL) N (CYCLOHEXYLMETHYL) N (1H INDOL 6 YL)PROPANAMIDE; AMIDE; INDOLE DERIVATIVE; KETOPROFEN DERIVATIVE; LUCIFERASE; N [(1H INDOL 5 YL)METHYL] 2 (3 BENZOYLPHENYL) N PROPYLPROPANAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 2 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 3 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 4 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 5 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 6 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 1H INDOL 7 CARBOXAMIDE; N [2 (3 BENZOYLPHENYL)PROPYL] 2 (1H INDOL 5 YL)ACETAMIDE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; IC 50; MEMBRANE PERMEABILITY; MEMBRANE STABILIZATION; MICROSOME MEMBRANE; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

AMIDES; CELL LINE; CELL MEMBRANE PERMEABILITY; GENES, REPORTER; HEDGEHOG PROTEINS; HUMANS; INDOLES; KETOPROFEN; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICROSOMES; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ERINACEIDAE;

EID: 77954213486 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.05.001 Document Type: Article

Times cited : (22)

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