Rationale and timeliness for IL-1β-targeted therapy to reduce allogeneic organ injury at procurement and to diminish risk of rejection after transplantation

Clinical Transplantation

Volumn 24, Issue 3, 2010, Pages 307-311

  Wanderer, Alan A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Hyperuricemia; Interleukin 1 beta; Interleukin 1 beta targeted therapy; Ischemia reperfusion injury; NALP 3 inflammasome; Neutrophilic inflammation; Transplantation pathobiology

Indexed keywords

BLEOMYCIN; CALCIUM PHOSPHATE; CANAKINUMAB; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; PYROPHOSPHATE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR; URATE;

ALLOTRANSPLANTATION; ANAEROBIC METABOLISM; ARTERY OCCLUSION; ARTICLE; BIOLOGICAL THERAPY; COLD ISCHEMIA; CYTOKINE RELEASE; DEOXYGENATION; DNA POLYMORPHISM; GENE MUTATION; GRAFT REJECTION; HUMAN; INNATE IMMUNITY; ISCHEMIA; METABOLIC ACIDOSIS; MOLECULARLY TARGETED THERAPY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; RISK REDUCTION; DRUG ANTAGONISM; IMMUNOLOGY; INFLAMMATION; ORGAN TRANSPLANTATION; PATHOLOGY; SIGNAL TRANSDUCTION; TIME;

GRAFT REJECTION; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-1BETA; ORGAN TRANSPLANTATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 77954155781     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01256.x     Document Type: Article

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