Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Journal of Cellular Biochemistry

Volumn 110, Issue 4, 2010, Pages 960-967

  Dossa, Tanya ^a,b   Arabian, Alice ^a   Windle, Jolene J ^c   Dedhar, Shoukat ^d,e   Teitelbaum, Steven L ^f   Ross, F Patrick ^f   Roodman, G David ^g,h   St Arnaud, René ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d VANCOUVER GENERAL HOSPITAL   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Integrin linked kinase; Integrins; Osteoclast

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; INTEGRIN LINKED KINASE; ACID PHOSPHATASE; INTEGRIN-LINKED KINASE; ISOENZYME; PROTEIN SERINE THREONINE KINASE; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; DENTIN; ENZYME ANALYSIS; ENZYME INHIBITION; GENE INACTIVATION; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOMOGRAPHY;

MUS; MUS MUSCULUS;

ACID PHOSPHATASE; ANIMALS; BONE RESORPTION; ISOENZYMES; MICE; MICE, TRANSGENIC; OSTEOCLASTS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOMOGRAPHY;

EID: 77954132791     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22609     Document Type: Article

References (33)

1. An YH, Martin KL. 2003. Handbook of histology methods for bone and cartilage. Totowa, NJ: Humana Press. p. 587.
2. Attwell S, Mills J, Troussard A, Wu C, Dedhar S. 2003. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 14:4813-4825.
3. Boyle WJ, Simonet WS, Lacey DL. 2003. Osteoclast differentiation and activation. Nature 423:337-342.
4. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M. 1989. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109: 1817-1826.
5. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95:11211-11216.
6. Engleman VW, Nickols GA, Ross FP, Horton MA, Griggs DW, Settle SL, Ruminski PG, Teitelbaum SL. 1997. A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest 99:2284-2292.
7. Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, Teitelbaum SL. 2001. A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function. J Clin Invest 107:1137-1144. (Pubitemid 32422910)
8. Fielding AB, Dedhar S. 2009. The mitotic functions of integrin-linked kinase. Cancer Metastasis Rev 28:99-111.
9. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. 1996. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379:91-96.
10. Hannigan G, Troussard AA, Dedhar S. 2005. Integrin-linked kinase: A cancer therapeutic target unique among its ILK. Nat Rev Cancer 5:51-63.
11. Hynes R. 2002. Integrins: Bidirectional, allosteric signaling machines. Cell 110:673-687.
12. Kobayashi Y, Udagawa N, Takahashi N. 2009. Action of RANKL and OPG for osteoclastogenesis. Crit Rev Eukaryot Gene Expr 19:61-72.
13. Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R. 2009. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461:1002-1006.
14. Legate KR, Montanez E, Kudlacek O, Fassler R. 2006. ILK, PINCH and parvin: The tIPP of integrin signalling. Nat Rev Mol Cell Biol 7:20-31.
15. Legate KR, Wickstrom SA, Fassler R. 2009. Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23:397-418.
16. Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE. 2001. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. EMBO J 20:2160-2170.
17. McDonald PC, Fielding AB, Dedhar S. 2008. Integrin-linked kinase-Essential roles in physiology and cancer biology. J Cell Sci 121:3121-3132.
18. McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. 2000. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 105:433-440.
19. Meury T, Akhouayri O, Jafarov T, Mandic V, St-Arnaud R. 2010. Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo. Mol Cell Biol 30:43-53.
20. Nakrieko KA, Welch I, Dupuis H, Bryce D, Pajak A, St Arnaud R, Dedhar S, D'Souza SJ, Dagnino L. 2008. Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell 19:1462-1473.
21. Pan W, Mathews W, Donohue JM, Ramnaraine ML, Lynch C, Selski DJ, Walsh N, Cassady AI, Clohisy DR. 2005. Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice. J Biol Chem 280:4888-4893.
22. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. 2000. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 97:3207-3212.
23. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S., 2001a Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 276:27462-27469.
24. Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. 2001b. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 153:1161-1174.
25. Quelo I, Gauthier C, Hannigan GE, Dedhar S, St-Arnaud R. 2004. Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. J Biol Chem 279:43893-43899.
26. Reddy SV, Hundley JE, Windle JJ, Alcantara O, Linn R, Leach RJ, Boldt DH, Roodman GD. 1995. Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter. J Bone Miner Res 10:601-606.
27. Ross FP. 2008. Osteoclast biology and bone resorption. In: Rosen CJ, Compston JE, Lian JB, editors. Primer on the metabolic bone diseases and disorders of bone metabolism. Washington, DC: American Society for Bone and Mineral Research. pp. 16-22.
28. Ross FP, Teitelbaum SL. 2005. alphavbeta3 and macrophage colony-stimulating factor: Partners in osteoclast biology. Immunol Rev 208:88-105.
29. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
30. Susa M, Luong-Nguyen NH, Cappellen D, Zamurovic N, Gamse R. 2004. Human primary osteoclasts: In vitro generation and applications as pharmacological and clinical assay. J Transl Med 2:6.
31. Teitelbaum SL, Ross FP. 2003. Genetic regulation of osteoclast development and function. Nat Rev Genet 4:638-649.
32. Teitelbaum SL, Abu-Amer Y, Ross FP. 1995. Molecular mechanisms of bone resorption. J Cell Biochem 59:1-10.
33. Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R. 2003. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162:139-148.