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Volumn 5, Issue 7, 2010, Pages 1092-1101

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

(16) Geist, Julie G a Lauw, Susan b Illarionova, Victoria c Illarionov, Boris d Fischer, Markus c Gräwert, Tobias b Rohdich, Felix b Eisenreich, Wolfgang b Kaiser, Johannes b Groll, Michael b Scheurer, Christian e Wittlin, Sergio e Alonso Gómez, José L a Schweizer, W Bernd a Bacher, Adelbert b Diederich, François a

a ETH ZURICH (Switzerland)

b TECHNICAL UNIVERSITY OF MUNICH (Germany)

c UNIVERSITY OF HAMBURG (Germany)

d Ikosatec GmbH (Germany)

e SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Switzerland)

Author keywords

Anti infective agents; Inhibitors; Non mevalonate pathway; Thiazolopyrimidines

Indexed keywords

2 METHYLERYTHRITOL 2,4 CYCLODIPHOSPHATE SYNTHASE; ARTESUNATE; CHLOROQUINE; PYRIMIDINE DERIVATIVE; SYNTHETASE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; ISPF PROTEIN, ARABIDOPSIS; LYASE; MOLECULAR LIBRARY; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ANTIBACTERIAL ACTIVITY; ANTIMALARIAL ACTIVITY; ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HIGH THROUGHPUT SCREENING; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOTOMETRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIMALARIALS; ARABIDOPSIS; BACTERIAL PROTEINS; ENZYME INHIBITORS; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORUS-OXYGEN LYASES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PYRIMIDINES; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 77954108524 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000083 Document Type: Article

Times cited : (72)

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