The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery

BMC Structural Biology

Volumn 7, Issue , 2007, Pages

  Buetow, Lori ^a   Brown, Amanda C ^b   Parish, Tanya ^b   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL DEXTRO ERYTHRITOL 2,4 CYCLODIPHOSPHATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL PROTEIN; LIGAND; MAGNESIUM; PROTEIN SUBUNIT; WATER; ZINC;

AMINO ACID SEQUENCE; ARTICLE; DELETION MUTANT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; HYDROPHOBICITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; BACTERIAL GENE; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DNA SEQUENCE; DRUG DESIGN; ELECTROPORATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENE DELETION; GENE EXPRESSION; GENETICS; HYDROGEN BOND; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MYCOBACTERIUM SMEGMATIS; NUCLEOTIDE SEQUENCE; PLASMID; PLIABILITY; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CLONING, MOLECULAR; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA, BACTERIAL; DRUG DESIGN; ELECTROPORATION; GENE DELETION; GENE EXPRESSION; GENES, BACTERIAL; HYDROGEN BONDING; HYDROPHOBICITY; LIGANDS; MAGNESIUM; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PLASMIDS; PLIABILITY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; WATER; ZINC;

EID: 37349000949     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-7-68     Document Type: Article

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