Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain

BMC Medical Genomics

Volumn 3, Issue , 2010, Pages

  Martijn, Cécile ^a   Wiklund, Lars ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GUANYLATE CYCLASE; METHYLENE BLUE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN KINASE; CELL RECEPTOR; NEUROPROTECTIVE AGENT; SOLUBLE GUANYLYL CYCLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL MIGRATION; CELL PROTECTION; DOWN REGULATION; DRUG EFFICACY; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPLICATION; GENE SEQUENCE; HEART ARREST; MALE; MICROARRAY ANALYSIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REPERFUSION INJURY; RESUSCITATION; UPREGULATION; ANIMAL; BRAIN; CLUSTER ANALYSIS; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; GENOMICS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; SWINE; TIME;

SUIDAE; SUS;

ANIMALS; APOPTOSIS; BRAIN; CARDIOPULMONARY RESUSCITATION; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOMICS; GUANYLATE CYCLASE; HEART ARREST; MALE; METHYLENE BLUE; NEUROGENESIS; NEUROPROTECTIVE AGENTS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPERFUSION INJURY; SWINE; TIME FACTORS;

EID: 77954076439     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-3-27     Document Type: Article

References (107)

1. -2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Part 7.5: postresuscitation support. Circulation 2005 112 24 Suppl V84 IV88
2. Cerebral resuscitation potentials for cardiac arrest. P Safar W Behringer BW Bottiger F Sterz, Crit Care Med 2002 30 4 Suppl 140 144 10.1097/00003246- 200204001-00004 11940789
3. Post-resuscitation disease - a new nosological entity. Its reality and significance. VA Negovsky AM Gurvitch, Resuscitation 1995 30 1 23 27 10.1016/0300-9572(95)00861-M 7481099
4. Post-cardiac arrest syndrome: Epidemiology pathophysiology, treatment and prognostication A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. JP Nolan RW Neumar C Adrie M Aibiki RA Berg BW Bottiger C Callaway RS Clark RG Geocadin EC Jauch,, et al. Resuscitation 2008 79 3 350 379 10.1016/j.resuscitation.2008.09.017 18963350
5. Assessment of quality of life and cognitive function after out-of-hospital cardiac arrest with successful resuscitation. AP van Alem RA Waalewijn RW Koster R de Vos, Am J Cardiol 2004 93 2 131 135 10.1016/j.amjcard.2003.09.027 14715335
6. Cardiocerebral resuscitation improves neurologically intact survival of patients with out-of-hospital cardiac arrest. MJ Kellum KW Kennedy R Barney FA Keilhauer M Bellino M Zuercher GA Ewy, Ann Emerg Med 2008 52 3 244 252 10.1016/j.annemergmed.2008.02.006 18374452
7. European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. JP Nolan CD Deakin J Soar BW Bottiger G Smith, Resuscitation 2005 67 Suppl 1 39 86 10.1016/j.resuscitation.2005.10.009 16321716
8. Post resuscitation care: what are the therapeutic alternatives and what do we know? J Herlitz M Castren H Friberg J Nolan M Skrifvars K Sunde PA Steen, Resuscitation 2006 69 1 15 22 10.1016/j.resuscitation.2005.08.006 16488070
9. Normal physiological values for conscious pigs used in biomedical research. J Hannon C Bossone C Wade, Lab Anim Sci 1990 40 3 293 298 2162986
10. Cardiovascular and pulmonary effects of morphine in conscious pigs. JP Hannon CA Bossone, Am J Physiol 1991 261 5 Pt 2 1286 1293 1951777
11. Feasibility of a porcine adult intensive care model. SK Hanneman FJ Clubb Jr K McKay G Costas, Comp Med 2004 54 1 36 43 15027616
12. The use of pigs in neuroscience: modeling brain disorders. NM Lind A Moustgaard J Jelsing G Vajta P Cumming AK Hansen, Neurosci Biobehav Rev 2007 31 5 728 751 10.1016/j.neubiorev.2007.02.003 17445892
13. Neurocognitive performance after cardiopulmonary resuscitation in pigs. M Fries K Nolte F Demir K Kottmann A Timper M Coburn J Weis R Rossaint, Crit Care Med 2008 36 3 842 847 10.1097/CCM.0B013E3181653041 18431271
14. Pharmacokinetics and organ distribution of intravenous and oral methylene blue. C Peter D Hongwan A Kupfer BH Lauterburg, Eur J Clin Pharmacol 2000 56 3 247 250 10.1007/s002280000124 10952480
15. Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy. A Kupfer C Aeschlimann T Cerny, Eur J Clin Pharmacol 1996 50 4 249 252 10.1007/s002280050102 8803513
16. Methylene Blue - a therapeutic dye for all seasons? M Wainwright KB Crossley, J Chemother 2002 14 5 431 443 12462423
17. A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manicdepressive psychosis. GJ Naylor B Martin SE Hopwood Y Watson, Biological Psychiatry 1986 21 10 915 920 10.1016/0006-3223(86)90265-9 3091097
18. Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue. L Wiklund S Basu A Miclescu P Wiklund G Ronquist HS Sharma, Ann N Y Acad Sci 2007 1122 231 244 10.1196/annals.1403.016 18077576
19. Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation. A Miclescu S Basu L Wiklund, Resuscitation 2007 75 1 88 97 10.1016/j.resuscitation.2007.03. 014 17482336
20. Potential of methylene blue to block oxygen radical generation in reperfusion injury. M Kelner R Bagnell B Hale A NM, Basic Life Sci 1988 49 895 898 2855011
21. Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrest. A Miclescu S Basu L Wiklund, Crit Care Med 2006 34 11 2806 2813 10.1097/01.CCM.0000242517.23324.27 16957637
22. Significance analysis of microarrays applied to the ionizing radiation response. VG Tusher R Tibshirani G Chu, Proc Natl Acad Sci USA 2001 98 9 5116 5121 10.1073/pnas.091062498 11309499
23. Ischemic cell death in brain neurons. P Lipton, Physiol Rev 1999 79 4 1431 1568 10508238
24. Expression of zinc transporter gene ZnT-1, is induced after transient forebrain ischemia in the gerbil. M Tsuda K Imaizumi T Katayama K Kitagawa A Wanaka M Tohyama T Takagi, J Neurosci 1997 17 17 6678 6684 9254680
25. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. M Seve F Chimienti S Devergnas A Favier, BMC Genomics 2004 5 1 32 10.1186/1471-2164-5-32 15154973
26. An antiport mechanism for a member of the cation diffusion facilitator family: divalent cations efflux in exchange for K+ and H+. AA Guffanti Y Wei SV Rood TA Krulwich, Mol Microbiol 2002 45 1 145 153 10.1046/j.1365-2958.2002. 02998.x 12100555
27. The role of zinc in cerebral ischemia. SL Galasso RH Dyck, Mol Med 2007 13 7-8 380 387 10.2119/2007-00044.Galasso 17622314
28. Genomic response of the rat brain to global ischemia and reperfusion. F Buttner C Cordes F Gerlach A Heimann B Alessandri U Luxemburger O Tureci T Hankeln O Kempski T Burmester, Brain Res 2009 1252 1 14 10.1016/j.brainres.2008. 10.045 19071098
29. DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. R Schmidt-Kastner B Zhang L Belayev L Khoutorova R Amin R Busto MD Ginsberg, Brain Res Mol Brain Res 2002 108 1-2 81 93 10.1016/S0169-328X(02)00516-8 12480181
30. Genomic responses of the brain to ischemic stroke intracerebral haemorrhage kainate seizures hypoglycemia, and hypoxia. Y Tang A Lu BJ Aronow KR Wagner FR Sharp, Eur J Neurosci 2002 15 12 1937 1952 10.1046/j.1460-9568.2002. 02030.x 12099900
31. Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion. XC Lu AJ Williams C Yao R Berti JA Hartings R Whipple MT Vahey RG Polavarapu KL Woller FC Tortella,, et al. J Neurosci Res 2004 77 6 843 857 10.1002/jnr.20218 15334602
32. Gene expression profiling in the hippocampus of rats subjected to focal cerebral ischemia and enriched environment housing. R Sonninen T Virtanen J Sivenius J Jolkkonen, Restor Neurol Neurosci 2006 24 1 17 23 16518024
33. Genome-wide gene expression analysis for induced ischemic tolerance and delayed neuronal death following transient global ischemia in rats. N Kawahara Y Wang A Mukasa K Furuya T Shimizu T Hamakubo H Aburatani T Kodama T Kirino, J Cereb Blood Flow Metab 2004 24 2 212 223 10.1097/01.WCB.0000106012.33322.A2 14747748
34. Microarray analysis of hippocampal gene expression in global cerebral ischemia. K Jin XO Mao MW Eshoo T Nagayama M Minami RP Simon DA Greenberg, Ann Neurol 2001 50 1 93 103 10.1002/ana.1073 11456315
35. Inflammatory cell adhesion molecules in ischemic cerebrovascular disease. CJ Frijns LJ Kappelle, Stroke 2002 33 8 2115 2122 10.1161/01.STR.0000021902. 33129.69 12154274
36. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Y Cheng HT Zhang L Sun S Guo S Ouyang Y Zhang J Xu, Brain Res 2006 1110 1 193 200 10.1016/j.brainres.2006.06.065 16870162
37. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. T Hayashi K Abe H Suzuki Y Itoyama, Stroke 1997 28 10 2039 2044 9341716
38. Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. CE Marroquin PY Wai PC Kuo H Guo, Surgery 2005 138 1 93 99 10.1016/j.surg.2005.03.014 16003322
39. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. S Dore M Takahashi CD Ferris R Zakhary LD Hester D Guastella SH Snyder, Proc Natl Acad Sci USA 1999 96 5 2445 2450 10.1073/pnas.96.5.2445 10051662
40. Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. S Saleem H Zhuang S Biswal Y Christen S Dore, Stroke 2008 39 12 3389 3396 10.1161/STROKEAHA.108.523480 18845796
41. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. Y Ma JW Brewer JA Diehl LM Hendershot, J Mol Biol 2002 318 5 1351 1365 10.1016/S0022-2836(02)00234-6 12083523
42. Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. S Tajiri S Oyadomari S Yano M Morioka T Gotoh JI Hamada Y Ushio M Mori, Cell Death Differ 2004 11 4 403 415 10.1038/sj.cdd.4401365 14752508
43. Different effects of eNOS and nNOS inhibition on transient forebrain ischemia. MH Jiang T Kaku J Hada Y Hayashi, Brain Res 2002 946 1 139 147 10.1016/S0006-8993(02)02870-6 12133603
44. Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. MS Wolin PD Cherry JM Rodenburg EJ Messina G Kaley, J Pharmacol Exp Ther 1990 254 3 872 876 2168487
45. Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin sodium nitrite and amyl nitrite. CA Gruetter PJ Kadowitz LJ Ignarro, Can J Physiol Pharmacol 1981 59 2 150 156 6112057
46. Inhibition of nitric oxide synthesis by methylene blue. B Mayer F Brunner K Schmidt, Biochem Pharmacol 1993 45 2 367 374 10.1016/0006-2952(93)90072-5 7679577
47. Molecular biology of nitric oxide synthases. DA Geller TR Billiar, Cancer Metastasis Rev 1998 17 1 7 23 10.1023/A:1005940202801 9544420
48. Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. RC Venema VJ Venema H Ju MB Harris C Snead T Jilling C Dimitropoulou ME Maragoudakis JD Catravas, Am J Physiol Heart Circ Physiol 2003 285 2 69 678
49. Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. A Peri M Serio, J Mol Endocrinol 2008 41 5 251 261 10.1677/JME-08-0071 18768664
50. Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24(-/-) Mice. K Kuehnle MD Ledesma L Kalvodova AE Smith A Crameri F Skaanes-Brunner KM Thelen L Kulic D Lutjohann FL Heppner,, et al. Neurochem Res 2009 34 6 1167 1182 10.1007/s11064-008-9893-4 19115107
51. A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. JR Halstead J van Rheenen MH Snel S Meeuws S Mohammed CS D'Santos AJ Heck K Jalink N Divecha, Curr Biol 2006 16 18 1850 1856 10.1016/j.cub.2006.07. 066 16979564
52. p21(waf1) mRNA contains a conserved element in its 3'-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins. B Joseph M Orlian H Furneaux, J Biol Chem 1998 273 32 20511 20516 10.1074/jbc.273.32.20511 9685407
53. Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility. R De Giorgio M Bovara G Barbara M Canossa G Sarnelli F De Ponti V Stanghellini M Tonini S Cappello E Pagnotta,, et al. Gastroenterology 2003 125 1 70 79 10.1016/S0016-5085(03)00664-4 12851872
54. Function and regulation of Rnd proteins. P Chardin, Nat Rev Mol Cell Biol 2006 7 1 54 62 10.1038/nrm1788 16493413
55. Unr, a cytoplasmic RNA-binding protein with cold-shock domains is involved in control of apoptosis in ES and HuH7 cells. V Dormoy-Raclet J Markovits Y Malato S Huet P Lagarde D Montaudon A Jacquemin-Sablon H Jacquemin-Sablon, Oncogene 2007 26 18 2595 2605 10.1038/sj.onc.1210068 17086213
56. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Y Cang J Zhang SA Nicholas J Bastien B Li P Zhou SP Goff, Cell 2006 127 5 929 940 10.1016/j.cell.2006.09.045 17129780
57. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. M Muda A Theodosiou N Rodrigues U Boschert M Camps C Gillieron K Davies A Ashworth S Arkinstall, J Biol Chem 1996 271 44 27205 27208 10.1074/jbc.271.44.27205 8910287
58. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. H Ichijo E Nishida K Irie P ten Dijke M Saitoh T Moriguchi M Takagi K Matsumoto K Miyazono Y Gotoh, Science 1997 275 5296 90 94 10.1126/science.275.5296.90 8974401
59. Association of 14-3-3gamma and phosphorylated bad attenuates injury in ischemic astrocytes. XQ Chen YW Fung AC Yu, J Cereb Blood Flow Metab 2005 25 3 338 347 10.1038/sj.jcbfm.9600032 15660102
60. Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons. V See AL Boutillier H Bito JP Loeffler, FASEB J 2001 15 1 134 144 10.1096/fj.00- 0106com 11149901
61. The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. Y Xu J Zhang X Chen, J Biol Chem 2007 282 52 37429 37435 10.1074/jbc.M706039200 17938176
62. RGM and its receptor neogenin regulate neuronal survival. E Matsunaga S Tauszig-Delamasure PP Monnier BK Mueller SM Strittmatter P Mehlen A Chedotal, Nat Cell Biol 2004 6 8 749 755 10.1038/ncb1157 15258591
63. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. A Ropolo D Grasso R Pardo ML Sacchetti C Archange A Lo Re M Seux J Nowak CD Gonzalez JL Iovanna,, et al. J Biol Chem 2007 282 51 37124 37133 10.1074/jbc.M706956200 17940279
64. SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. A Madeira JM Pommet A Prochiantz B Allinquant, FASEB J 2005 19 13 1905 1907 16162853
65. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. M Zamora M Granell T Mampel O Vinas, FEBS Lett 2004 563 1-3 155 160 10.1016/S0014-5793(04)00293-5 15063741
66. SAFB re-distribution marks steps of the apoptotic process. YB Lee S Colley M Norman G Biamonti JB Uney, Exp Cell Res 2007 313 18 3914 3923 10.1016/j.yexcr.2007.06.023 17643427
67. Cerebral protein synthesis and ischemia. W Bodsch K Takahashi A Barbier BG Ophoff KA Hossmann, Prog Brain Res 1985 63 197 210 full-text 3835579
68. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. R Thilmann Y Xie P Kleihues M Kiessling, Acta Neuropathol 1986 71 1-2 88 93 10.1007/BF00687967 3776478
69. Shutdown of translation: lethal or protective? Unfolded protein response versus apoptosis. W Paschen, J Cereb Blood Flow Metab 2003 23 7 773 779 10.1097/01.WCB.0000075009.47474.F9 12843781
70. PERK and PKR: old kinases learn new tricks. JF Raven AE Koromilas, Cell Cycle 2008 7 9 1146 1150 18418049
71. EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Y Oda N Hosokawa I Wada K Nagata, Science 2003 299 5611 1394 1397 10.1126/science.1079181 12610305
72. MDG1/ERdj4, an ER-resident DnaJ family member suppresses cell death induced by ER stress. J Kurisu A Honma H Miyajima S Kondo M Okumura K Imaizumi, Genes Cells 2003 8 2 189 202 10.1046/j.1365-2443.2003.00625.x 12581160
73. Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis. JD Lane J Lucocq J Pryde FA Barr PG Woodman VJ Allan M Lowe, J Cell Biol 2002 156 3 495 509 10.1083/jcb.200110007 11815631
74. Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis. M Lowe JD Lane PG Woodman VJ Allan, J Cell Sci 2004 117 Pt 7 1139 1150 10.1242/jcs.00950 14970262
75. Subunit structure of a mammalian ER/Golgi SNARE complex. D Xu AP Joglekar AL Williams JC Hay, J Biol Chem 2000 275 50 39631 39639 10.1074/jbc.M007684200 11035026
76. Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates. T Rowe C Dascher S Bannykh H Plutner WE Balch, Science 1998 279 5351 696 700 10.1126/science.279.5351.696 9445473
77. Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles. JA Martinez-Menarguez HJ Geuze JW Slot J Klumperman, Cell 1999 98 1 81 90 10.1016/S0092-8674(00)80608-X 10412983
78. Emerging aspects of membrane traffic in neuronal dendrite growth. BL Tang, Biochim Biophys Acta 2008 1783 2 169 176 10.1016/j.bbamcr.2007.11.011 18155172
79. Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. BY Kim M Ueda E Kominami K Akagawa S Kohsaka C Akazawa, Biochem Biophys Res Commun 2003 311 3 577 582 10.1016/j.bbrc.2003.10. 030 14623309
80. GGA function is required for maturation of neuroendocrine secretory granules. O Kakhlon P Sakya B Larijani R Watson SA Tooze, EMBO J 2006 25 8 1590 1602 10.1038/sj.emboj.7601067 16601685
81. Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins. E Orzech L Livshits J Leyt H Okhrimenko V Reich S Cohen A Weiss N Melamed-Book M Lebendiker Y Altschuler,, et al. J Biol Chem 2001 276 33 31340 31348 10.1074/jbc.M101054200 11418592
82. Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons. C Gonzalez-Billault R Owen PR Gordon-Weeks J Avila, Brain Res 2002 943 1 56 67 10.1016/S0006- 8993(02)02534-9 12088839
83. The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. IE Vega SC Hsu, J Neurosci 2001 21 11 3839 3848 11356872
84. Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. X Wang WR Shaw HT Tsang E Reid CJ O'Kane, Nat Neurosci 2007 10 2 177 185 10.1038/nn1841 17220882
85. Regulation of microtubule dynamics by Ca2 +/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. H Melander Gradin U Marklund N Larsson TA Chatila M Gullberg, Mol Cell Biol 1997 17 6 3459 3467 9154845
86. From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. S Prislei S Mozzetti F Filippetti M De Donato G Raspaglio L Cicchillitti G Scambia C Ferlini, Mol Cancer Ther 2008 7 1 233 241 10.1158/1535-7163.MCT-07- 0390 18187809
87. Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. F Suto K Ito M Uemura M Shimizu Y Shinkawa M Sanbo T Shinoda M Tsuboi S Takashima T Yagi,, et al. J Neurosci 2005 25 14 3628 3637 10.1523/JNEUROSCI.4480-04.2005 15814794
88. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. BE Kremer T Haystead IG Macara, Mol Biol Cell 2005 16 10 4648 4659 10.1091/mbc.E05-03-0267 16093351
89. Shared and unique roles of CAP23 and GAP43 in actin regulation neurite outgrowth and anatomical plasticity. D Frey T Laux L Xu C Schneider P Caroni, J Cell Biol 2000 149 7 1443 1454 10.1083/jcb.149.7.1443 10871284
90. Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. CS Stipp ME Hemler, J Cell Sci 2000 113 Pt 11 1871 1882 10806098
91. Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions. OD Gil G Zanazzi AF Struyk JL Salzer, J Neurosci 1998 18 22 9312 9325 9801370
92. Isolation of human NURF: a regulator of Engrailed gene expression. O Barak MA Lazzaro WS Lane DW Speicher DJ Picketts R Shiekhattar, EMBO J 2003 22 22 6089 6100 10.1093/emboj/cdg582 14609955
93. Singar1, a novel RUN domain-containing protein suppresses formation of surplus axons for neuronal polarity. T Mori T Wada T Suzuki Y Kubota N Inagaki, J Biol Chem 2007 282 27 19884 19893 10.1074/jbc.M700770200 17439943
94. Identification and characterization of a novel gene (neurorep 1) expressed in nerve cells and up-regulated after axotomy. K Uwabe Y Gahara H Yamada T Miyake T Kitamura, Neuroscience 1997 80 2 501 509 10.1016/S0306- 4522(97)00112-7 9284352
95. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. BA Samuels YP Hsueh T Shu H Liang HC Tseng CJ Hong SC Su J Volker RL Neve DT Yue,, et al. Neuron 2007 56 5 823 837 10.1016/j.neuron.2007.09.035 18054859
96. Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. M Hattori H Adachi M Tsujimoto H Arai K Inoue, Nature 1994 370 6486 216 218 10.1038/370216a0 8028668
97. Interaction of reelin signaling and Lis1 in brain development. AH Assadi G Zhang U Beffert RS McNeil AL Renfro S Niu CC Quattrocchi BA Antalffy M Sheldon DD Armstrong,, et al. Nat Genet 2003 35 3 270 276 10.1038/ng1257 14578885
98. Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration. M Yoshizawa T Kawauchi M Sone YV Nishimura M Terao K Chihama Y Nabeshima M Hoshino, J Neurosci 2005 25 17 4406 4419 10.1523/JNEUROSCI.4955-04.2005 15858067
99. Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. A Buffo MR Vosko D Erturk GF Hamann M Jucker D Rowitch M Gotz, Proc Natl Acad Sci USA 2005 102 50 18183 18188 10.1073/pnas.0506535102 16330768
100. Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon. MDA Piper C Lindwall G Barry C Plachez LJ Richards, Novartis Found Symp 2007 288 230 242 full-text 18494262
101. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. T Nakase S Fushiki CC Naus, Stroke 2003 34 8 1987 1993 10.1161/01.STR.0000079814.72027.34 12843358
102. A central role of connexin 43 in hypoxic preconditioning. JH Lin N Lou N Kang T Takano F Hu X Han Q Xu D Lovatt A Torres K Willecke,, et al. J Neurosci 2008 28 3 681 695 10.1523/JNEUROSCI.3827-07.2008 18199768
103. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. M Thiyagarajan JA Fernandez SM Lane JH Griffin BV Zlokovic, J Neurosci 2008 28 48 12788 12797 10.1523/JNEUROSCI.3485-08.2008 19036971
104. Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat. M Taniguchi T Yamashita E Kumura M Tamatani A Kobayashi T Yokawa M Maruno A Kato T Ohnishi E Kohmura,, et al. Brain Res Mol Brain Res 2000 78 1-2 131 137 10.1016/S0169-328X(00)00084-X 10891592
105. Neuregulin attenuated cerebral ischemia-Creperfusion injury via inhibiting apoptosis and upregulating aquaporin-4. Q Li Z Li Y Mei Y Guo, Neurosci Lett 2008 443 3 155 159 10.1016/j.neulet.2008.07.064 18680785
106. CART protects brain from damage through ERK activation in ischemic stroke. J Jia X Chen W Zhu Y Luo Z Hua Y Xu, Neuropeptides 2008 42 5-6 653 661 10.1016/j.npep.2008.05.006 18644622
107. Mitochondrial mechanism of neuroprotection by CART. P Mao A Ardeshiri R Jacks S Yang PD Hurn NJ Alkayed, Eur J Neurosci 2007 26 3 624 632 10.1111/j.1460-9568.2007.05691.x 17634068