2,3,7,8-Tetrachlorodibenzo-p-dioxin activates ERK and p38 mitogen-activated protein kinases in RAW 264.7 cells

Anticancer Research

Volumn 25, Issue 4, 2005, Pages 2831-2836

  Park, Sang Joon ^a   Yoon, Won Kee ^b   Kim, Ho Jun ^c   Son, Hwa Young ^c   Cho, Sung Whan ^c   Jeong, Kyu Shik ^a   Kim, Tae Hwan ^a   Kim, Sung Ho ^d   Kim, Se Ra ^d   Ryu, Si Yun ^c  

^a Kyungpook National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chungnam National University   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Caspase 3; ERK; JNK; p38; RAW 264.7 cells

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CASPASE 3; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CELL SURVIVAL; DNA FRAGMENTATION; ENVIRONMENTAL POLLUTANTS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TETRACHLORODIBENZODIOXIN;

EID: 22944468782     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Nohara K, Fujimaki H, Tsukumo SI, Ushio H, Miyabara Y, Kijima M, Tohyama C and Yonemoto J: The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats. Toxicology 154: 123-133, 2000.
2. Prell RA, Oughton JA and Kerkvliet NI: Effect of 2,3,7,8- tetrachlorodibenzo-p-dioxin on anti-CD3-induced changes in T-cell subsets and cytokine production. Int J Immunopharmac 17: 951-961, 1995.
3. Badesha JS, Maliji G and Flaks B: Immunotoxic effects of prolonged dietary exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Eur J Pharmacol 293: 429-437, 1995.
4. Dearstyne EA and Kerkvliet NI: Mechanism of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD)-induced decrease in anti-CD3-activated CD+4 T cells: the roles of apoptosis, Fas, and TNF. Toxicology 170: 139-151, 2002.
5. Huff J, Lucier G and Tritscher A: Carcinogenicity of TCDD: experimental, mechanistic, and epidemiologic evidence. Annu Rev Pharmacol Toxicol 34: 343-372, 1994.
6. Tan Z, Chang X, Puga A and Xia Y: Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 64: 771-780, 2002.
7. Thurmond TS and Gasiewicz TA: A single dose of 2,3,7,8- tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile. Toxicol Sci 58: 88-95, 2000.
8. Yellon SM, Singh D, Garrett TM, Fagoaga OR and Nehlsen-Cannarella SL: Reproductive, neuroendocrine, and immune consequences of acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Siberian hamster. Biol Reprod 63: 538-543, 2000.
9. Fujimaki H, Nohara K, Kobayashi T, Suzuki K, Eguchi-kasai K, Tsukumo S, Kijima M and Tohyama C: Effect of a single oral dose of 2,3,7,8- tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice. Toxicol Sci 66: 117-124, 2002.
10. Komura K, Hayashi SI, Makino I, Poellinger L and Tanaka H: Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages. Mol Cell Biochem 226: 107-117, 2001.
11. Moos AB, Oughton JA and Kerkvliet NI:. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on tumor necrosis factor (TNF) production by peritoneal cells. Toxicol Lett 90: 145-153, 1997.
12. Holsapple MP, Snyder NK, Wood SC and Morris DL: A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update. Toxicology 69: 219-255, 1991.
13. El-Sabeawy F, Wang S, Overstreet J, Miller M, Lasley B and Enan E: Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-p- dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reaction of sperm. Toxicol Appl Pharmacol 150: 427-442, 1998.
14. Hossain A, Tsuchiya S, Minegish M, Osada M, Ikawa S, Tesuka F, Kaji M, Konno T, Watanabe M and Kikuchi H: The Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in human leukemic T cell lines. J Biol Chem 273: 19853-19858, 1998.
15. Kerkvliet NI, Steppan LB, Brauner JA, Deyo JA, Henderson MC, Tomar RS and Buhler DR: Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression. Toxicol Appl Pharmacol 105: 26-36, 1990.
16. Kwon MJ, Jeong KS, Choi EJ and Lee BH: 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in Jurkat T cells. Pharmacol Toxicol 93: 186-190, 2003.
17. Stadheim TA and Kucera GL: c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells. Leukemia Res 26: 55-65, 2002.
18. Yang GH, Jarvis BB, Chung YJ and Pestka JJ: Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. Toxicol Appl Pharmacol 164: 149-160, 2000.
19. Hanelt M, Gareis M and Kollarczik B: Cytotoxicity of mycotoxins evaluated by the MTT-cell culture assay. Mycopathologica 128: 167-174, 1994.
20. Hermann M, Lorenz H-M, Voll R, Grunke M, Woith W and Kalden JR: A rapid and simple method for isolation of apoptotic DNA fragments. Nucleic Acids Res 22: 5506-5507, 1994.
21. Budihardjo I, Oliver H, Lutter M, Luo X and Wang X: Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 260-290, 1999.
22. Chao JI and Yang JL: Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem Res Toxicol 14: 1193-1202, 2001.
23. Jarvis WD, Fornari FA, Tombes RM, Erukulla RK, Bittman R, Schwartz GK, Dent P and Grant S: Evidence for involvement of mitogen-activated kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D- arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase signaling. Mol Pharmacol 54: 844-856, 1998.
24. Lenczowski JM, Dominguez L, Eder AM, King LB, Zacharchuk CM and Ashwell JD: Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol Cell Biol 17: 170-181, 1997.
25. Craxton A, Shu G, Graves J, Saklatlava J, Krebs EG and Clark EA: P38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol 161: 3225-3236, 1998.
26. Sethi G and Sodhi A: Role of p38 mitogen-activated protein kinase and caspases in UV-B-induced apoptosis of murine peritoneal macrophages. Photochem Photobiol 79: 48-54, 2004.
27. Nicholson DW, Ali A, Thornberry NA, Valliancourt JP, Ding CK, Gallank M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yami T, Yu VL and Miller DK: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43, 1995
28. Xaus J, Comalada M, Valledor AF, Cardo M, Herrero C, Soler C, Lloberas J and Celada A: Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis. Immunobiol 204: 543-550, 2002.