2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines

Archives of Toxicology

Volumn 76, Issue 7, 2002, Pages 404-413

  Son, Deok Soo ^a   Rozman, Karl K ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin (TCDD); Aryl hydrocarbon receptor; Hepa1c1c7 cells; Plasminogen activator inhibitor 1; Transforming growth factor

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; CYCLOHEXIMIDE; CYTOCHROME P450 1A1; HYDROCARBON NUCLEAR TRANSLOCATOR; LUCIFERASE; MESSENGER RNA; PHENANTHROLINE; PLASMINOGEN ACTIVATOR INHIBITOR 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ARNT PROTEIN, MOUSE; DNA BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1BETA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HEPATOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; GENETICS; LIVER CELL CARCINOMA; METABOLISM; NORTHERN BLOTTING; POLLUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; MICE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DNA-BINDING PROTEINS;

ANIMALIA;

EID: 0036020365     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0354-6     Document Type: Article

References (80)

1. Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice
2. Targets of transcriptional regulation by transforming growth factor-beta: Expression profile analysis using oligonucleotide arrays
3. Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity
4. The urokinase-type plasminogen activator system in cancer metastasis: A review
5. Organization and characterization of the rat class 3 aldehyde dehydrogenase gene
6. Plasma plasminogen activator inhibitor 1, insulin resistance and android obesity
7. Promotion of N-nitrosodimethylamine-initiated mouse lung tumors following single or multiple low dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
8. Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-α expression in embryonic mouse urinary tract
9. Plasminogen activator inhibitor type 1 in ischemic cardiomyopathy
10. Plasminogen activator inhibitor-1 is an independent poor prognostic factor for survival in advanced stage epithelial ovarian cancer patients
11. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1β, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells
12. Negative regulation of rat GST-Ya gene via antioxidant/electrophile response element is directed by a C/EBP-like site
13. Dioxin induces transforming growth factor-α in human keratinocytes
14. Plasminogen activators, tissue degradation, and cancer
15. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-β-induced physical and functional interactions between Smads and Sp1
16. Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: Correlation with increased transforming growth factor α production
17. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
18. Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells
19. Differential gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Noncoordinate regulation of a TCDD-induced aldehyde dehydrogenase and cytochrome P-450c in the rat
20. Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-α
21. Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression
22. Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin
23. Post-transcriptional stabilization of urokinase plasminogen activator mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a human keratinocyte cell line
24. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-α and -β2 expression in a human keratinocyte cell line involves both transcriptional and posttranscriptional control
25. Toxic equivalency (TEQ) of polychlorinated dibenzo-p-dioxins (PCDDs) in an ovulation model: Validation of the TEQ concept for endocrine disruption
26. Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P): Menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity
27. Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD)
28. TGF-β1 modulation of urokinase and PAI-1 expression in human bronchial epithelial cells
29. TCDD-inducible plasminogen activator inhibitor type 2 (PAI-2) in human hepatocytes, HepG2 and monocytic U937 cells
30. Inducibility of glutathione S-transferases in hamsters
31. Plasminogen activator inhibitor type 1 in cytosolic tumor extracts predicts prognosis in low-risk breast cancer patients
32. Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line
33. Dietary selenium, glutathione peroxidase activity, and toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
34. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: Possible mechanism
35. Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
36. Carcinogenicity of TCDD: Experimental, mechanistic, and epidemiologic evidence
37. The plasminogen activator system: Biology and regulation
38. Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin
39. Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16
40. Induction of rat liver cytoplasmic aldehyde dehydrogenase by phenobarbital and polycyclic hydrocarbons. Comparison of different isoenzyme types
41. Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells
42. Cytokine gene expression during ontogeny in murine thymus on activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin
43. Expression of plasminogen activator inhibitors type-1 and type-2 in the mouse lung after administration of crystalline silica
44. Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: Functional redundancy among physiological plasminogen activators
45. Aryl hydrocarbon receptor-associated genes in rat liver: Regional coinduction of aldehyde dehydrogenase 3 and glutathione transferase Ya
46. Superinduction of CYP1A1 gene expression. Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide
47. Increase of hepatic and serum aldehyde dehydrogenase activity after TCDD treatment
48. Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
49. Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cells
50. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons
51. A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci
52. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models
53. The transcriptional signature of dioxin in human hepatoma HepG2 cells
54. Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression
55. Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor
56. The regulatory region of the human plasminogen activator inhibitor type-1 (PAI-1) gene
57. Transforming growth factor β1-responsive element: Closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene
58. PAI-1 secretion and matrix deposition in human peritoneal mesothelial cell cultures: Transcriptional regulation by TGF-β1
59. Histopathology of interscapular brown adipose tissue, thyroid, and pancreas in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats
60. The fat mouse: A powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM
61. Detection and analysis of proteins expressed from cloned genes
62. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-αa, and transforming growth factor-β
63. IL-1β mediates induction of hepatic type 1 plasminogen activator inhibitor in response to local tissue injury
64. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: Lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro
65. NAD(P)H: Quinone oxidoreductase (DT-diaphorase) in chick embryo liver. Comparison to activity in rat and guinea pig liver and differences in co-induction with 7-ethoxyresorufin deethylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin
66. Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β
67. Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase in hepatoma cells
68. Quantitative analysis of dose-and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats
69. Induction of class 3 aldehyde dehydrogenase in the mouse hepatoma cell line Hepa-1 by various chemicals
70. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced ethoxyresorufin-O-deethylase (EROD) and aldehyde dehydrogenase (ALDH3) activities in the brain and liver. A comparison between the most TCDD-susceptible and the most TCDD-resistant rat strain
71. Quantification of transforming growth factor-β in biological material using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
72. Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins
73. Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels
74. Mouse dioxin-inducible NAD(P)H: Menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels
75. Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): Gene structure and regulation of constitutive and dioxin-inducible expression
76. Subchronic/chronic toxicity of a mixture of four chlorinated dibenzo-p-dioxins in rats. I. Design, general observations, hematology, and liver concentrations
77. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7
78. Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: Possible c-Src-mediated pathway
79. Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin
80. A malignant transformation of human cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits altered expressions of growth regulatory factors