TCDD suppresses insulin-responsive glucose transporter (GLUT-4) gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes

Journal of Biochemical and Molecular Toxicology

Volumn 20, Issue 2, 2006, Pages 79-87

  Liu, Phillip Chin Chen ^a   Matsumura, Fumio ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3T3 L1; DNA Deletion Analysis; GLUT4 Gene Promoter; Role of C EBP Proteins; Suppressive Effect of TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CHLORAMPHENICOL ACETYLTRANSFERASE; GLUCOSE TRANSPORTER 4; NUCLEAR PROTEIN; PHOSPHORUS 32;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; INSULIN RESPONSE; MOUSE; NONHUMAN; PLASMID; PROMOTER REGION; TRANSACTIVATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; GLUCOSE TRANSPORTER TYPE 4; MICE; PROMOTER REGIONS (GENETICS); TETRACHLORODIBENZODIOXIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 33645816542     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20120     Document Type: Article

References (45)

1. Schecter A, Birnbaum L, Ryan JJ, Constable JD. Dioxins: an overview. Environ Res 2006, Jan, 27. E-publication ahead of print.
2. Brewster DW, Matsumura F. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) reduces lipoprotein lipase activity in the adipose tissue of guinea pig. Biochem Biophys Res Commun 1984;122:810-817.
3. Enan E, Liu PCC, Matsumura F. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig. J Biol Chem 1992;67:19785-19791.
4. Liu PCC, Matsumura F. Differential effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin on the "adipose-type" and "brain-type" glucose transporters in mice. Mol Pharmacol 1995;47:65-73.
5. Brodie AE, Azarenko VA, Hu CY. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibition of fat cell differentiation Toxicol. Lett 1996;84:55-59.
6. Kaestner KH, Christy RJ, McLenithan JC, Braiterman LT, Cornelius P, Pekala PH, Lane MD. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1989;86:3150-3154.
7. Burant CF, Sivitz WI, Fukumoto H, Kayano T, Nagamatsu S, Seino S, Pessin JE, Bell GI. Mammalian glucose transporters: structure and molecular regulation. Recent Prog Hormone Res 1991;47:349-388.
8. Simpson IA, Cushman SW. Hormonal regulation of mammalian glucose transport. Ann Rev Biochem 1986;55:1059-1089.
9. Sivitz WI, DeSautel SL, Kayano T, Bell GI, Pessin JE. Regulation of glucose messenger RNA in insulin-deficient states. Nature 1989;340:72-74.
10. Berger J, Biswas C, Vicario PP, Strout HV, Saperstein R, Pilch PF. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature 1989;340:70-72.
11. Kahn BB. Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest 1992;89:1367-1374.
12. Kaestner KH, Flores-Riveros JR, McLenithan JC, Janicot M, Lane MD. Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP. Proc Natl Acad Sci USA 1991;88:1933-1937.
13. Stephens JM, Pekala PH. Transcriptional repression of the C/EBPα and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-α. J Biol Chem 1992;267:13580-13584.
14. Flores-Riveros JR, Kaestner KH, Thompson KS, Lane MD. Cyclic AMP-induced transcriptional regulation of the insulin-responsive glucoses transporter (GLUT4) gene: identification of a promoter region required for downregulation of transcription. Biochem Biophys Res Commun 1993;194:1148-1154.
15. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Khan BB. Adipose cell hyperplasia and enhance glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 1993;268:222243-222246.
16. Katz EB, Stenbit AE, Hatton K, DiPinho R, Charron MJ. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Science 1995;377:151-155.
17. Green H, Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975;5:19-27.
18. Green H, Keinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 1976;7:105-113.
19. Phillips M, Enan E, Liu PCC, Matsumura F. Inhibition of 3T3-L1 adipose differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Cell Sci 1995;108:395-402.
20. Olsen H, Enan E, Matsumura F. Regulation of glucose transport in the NIH 3T3 L1 preadipocyte cell line by TCDD. Environ Health Perspect 1994;102:454-458.
21. Liu PCC, Dunlap DY, Matsumura F. Suppression of C/EBPα and induction of C/EBβ by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse adipose tissue and liver. Biochem Pharmacol 1998;55:1647-1655.
22. Lavery DJ, Schigbler U. Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver enriched bZIP protein DBP. Genes Dev 1993;7:1871-1884.
23. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
24. Kaestner KH, Christy RJ, Lane MD. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. Proc Natl Acad Sci USA 1990;87:251-255.
25. Graves RA, Tontonoz P, Spiegelman BA. Analysis of a tissue-specific enhancer: AFR6 regulates adipogenic gene expression. Mol Cell Biol 1992;12:1202-1208.
26. Seed B, Sheen JY. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 1998;67:271-277.
27. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 1991;5:1538-1552.
28. Wang ZX, Jiang CS, Liu L, Wang XH, Jin HJ, Wu Q, Chen Q. The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Res 2005;15:379-386.
29. Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr 2002;132:904-910.
30. Engelman JA, Lisanti MP, Scherer PE. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem 1998;273:32111-32120.
31. Bortell R, Owen TA, Ignotz R, Stein GS, Stein JL. TGF beta 1 prevents the down-regulation of type I procollagen, fibronectin, and TGF beta 1 gene expression associated with 3T3-L1 pre-adipocyte differentiation. J Cell Biochem 1994;54:256-263.
32. Moreno-Aliaga MJ, Matsumura F. Endrin inhibits adipocyte differentiation by selectively altering expression pattern of CCAAT/enhancer binding protein-alpha in 3T3-L1 cells. Mol Pharmacol 1999;56:91-101.
33. Vasiliou V, Reuter SF, Williams S, Puga A, Nebert DW. Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin inducible expression. Pharmacogenetics 1999;9:569-580.
34. Kiningham KK, Xu Y, Daosukho C, Popova B, St Clair DK. Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2. Biochem J 2001;353:147-156.
35. Vogel CF, Zhao Y, Wong P, Young NF, Matsumura F. The use of c-src knockout mice for the identification of the main toxic signaling pathway of TCDD to induce wasting syndrome. J Biochem Mol Toxicol 2003;17:305-315.
36. Jain R, Police S, Phelps K, Pekala PH. Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer binding proteins (C/EBPs) alpha and beta determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes. Biochem J 1999;338:737-743.
37. Liu PCC, Phillips MA, Matsumura F. Alterations by 2,3,7,8- tetrachlorodibenzo-p-dioxin on C/EBP correlate to suppressed adipocyte differentiation in 3T3-L1 cells. Mol Pharmacol 1996;49:989-997.
38. Vogel CF, Sciullo E, Park S, Liedtke C, Trautwein C, Matsumura F. Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A J Biol Chem 2004;279:8886-8894.
39. Liu PCC, Moreno-Aliaga MJ, Dunlap DY, Hu XM, Denison MS, Matsumura F. Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells. J Biochem Mol Toxicol 2002;16:70-83.
40. Kern PA, Dicker-Brown A, Said ST, Kennedy R, Fonseca VA. The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Metabolism 2002;51:65-68.
41. Gorgoni B, Maritano D, Marthyn P, Righi M, Poli V. C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages. J Immunol 2002;168:4055-4062.
42. Bertazzi PA, Consonni D, Bachetti S, Rubagotti M, Baccarelli A, Zochetti C, Pesatori AC. Health effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001;153:1031-1044.
43. Michalek JE, Ketchum NS, Tripathi RC. Diabetes mellitus and 2,3,7,8-tetrachlorodibenzo-p-dioxin elimination in veterans of Operation Ranch Hand. J Toxicol Environ Health A 2003;66:211-221.
44. Fierens S, Mairesse H, Heilier JF, De Burbure C, Focant JF, Eppe G, De Pauw E, Bernard A. Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium. Biomarkers 2003;8:529-534.
45. Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem 2003;278:33609-33612.