Key players for T-cell regeneration

Current Opinion in Hematology

Volumn 17, Issue 4, 2010, Pages 327-332

  Awong, Génève ^a   Lamotte Mohs, Ross ^a   Zúñiga Pflücker, Juan Carlos ^a  

^a Canada   (Canada)

Author keywords

delta like; hematopoietic stem cells; immune reconstitution; progenitor T cells; T cell development; thymus

Indexed keywords

INTERLEUKIN 7; KERATINOCYTE GROWTH FACTOR; SEX HORMONE;

CELL FUNCTION; CELL REGENERATION; CELL TRANSPLANTATION; CELLULAR IMMUNITY; HUMAN; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; ANIMAL; CLINICAL TRIAL (TOPIC); CYTOLOGY; DRUG EFFECTS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; PHYSIOLOGY; PROCEDURES; REGENERATION; THYMUS;

ANIMALS; CLINICAL TRIALS AS TOPIC; FIBROBLAST GROWTH FACTOR 7; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERLEUKIN-7; REGENERATION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 77954053475     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283395133     Document Type: Review

References (69)

1. Storek J, Gooley T, Witherspoon RP, et al. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol 1997; 54:131-138.
2. Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993; 73:147-157.
3. Macchi P, Villa A, Giliani S, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377:65-68.
4. Cowan MJ, Neven B, Cavazanna-Calvo M, et al. Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases. Biol Blood Marrow Transplant 2008; 14:73-75.
5. Russell SM, Tayebi N, Nakajima H, et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995; 270:797-800.
6. Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350-354.
7. Jones RB, Ndhlovu LC, Barbour JD, et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 2008; 205:2763-2779.
8. Welniak LA, Blazar BR, Murphy WJ. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol 2007; 25:139-170.
9. Douek DC, Vescio RA, Betts MR, et al. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell recon-stitution. Lancet 2000; 355:1875-1881.
10. van den Brink MR, Alpdogan O, Boyd RL. Strategies to enhance T-cell reconstitution in immunocompromised patients. Nat Rev Immunol 2004; 4:856-867.
11. Steinmann GG, Klaus B, Muller-Hermelink HK. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 1985; 22:563-575.
12. HaynesBF, Hale LP. The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. Immunol Res 1998; 18:175-192.
13. Hale JS, FinkPJ. Back to the thymus: peripheral T cells come home. Immunol Cell Biol 2009; 87:58-64.
14. Sprent J, Surh CD. Re-entry of mature T cells to the thymus: an epipheno-menon? Immunol Cell Biol 2009; 87:46-49.
15. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004; 5:133-139.
16. Hince M, Sakkal S, Vlahos K, et al. The role of sex steroids and gonadectomy in the control of thymic involution. Cell Immunol 2008; 252:122-138.
17. Fitzpatrick FT, Kendall MD, Wheeler MJ, et al. Reappearance of thymus of ageing rats after orchidectomy. J Endocrinol 1985; 106:R17-R19.
18. Greenstein BD, Fitzpatrick FT, Kendall MD, Wheeler MJ. Regeneration of the thymus in old male rats treated with a stable analogue of LHRH. J Endocrinol 1987; 112:345-350.
19. Windmill KF, Lee VW. Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes. Tissue Cell 1998; 30:104-111.
20. Chidgey AP, Seach N, Dudakov J, et al. Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: preclinical and clinical approaches. Semin Immunopathol 2008; 30:457-477.
21. Sutherland JS, Goldberg GL, Hammett MV, et al. Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol 2005; 175:2741-2753.
22. Goldberg GL, Alpdogan O, Muriglan SJ, etal. Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation. J Immunol 2007; 178:7473-7484.
23. Goldberg GL, Sutherland JS, Hammet MV, et al. Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Transplantation 2005; 80:1604-1613.
24. Heng TS, Goldberg GL, Gray DH, et al. Effects of castration on thymocyte development in two different models of thymic involution. J Immunol 2005; 175:2982-2993.
25. Petrie HT, Zuniga-Pflucker JC. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol 2007; 25:649-679.
26. Dudakov JA, Goldberg GL, Reiseger JJ, et al. Withdrawal of sex steroids reverses age-and chemotherapy-related defects in bone marrow lymphopoi esis. J Immunol 2009; 182:6247-6260.
27. Goldberg GL, King CG, Nejat RA, et al. Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow trans plantation. J Immunol 2009; 182:5846-5854.
28. Sutherland JS, Spyroglou L, Muirhead JL, et al. Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade. Clin Cancer Res 2008; 14:1138-1149.
29. Danilenko DM. Preclinical and early clinical development of keratinocyte growth factor, an epithelial-specific tissue growth factor. Toxicol Pathol 1999; 27:64-71.
30. Erickson M, Morkowski S, Lehar S, et al. Regulation of thymic epithelium by keratinocyte growth factor. Blood 2002; 100:3269-3278.
31. Min D, Taylor PA, Panoskaltsis-Mortari A, et al. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood 2002; 99:4592-4600.
32. Min D, Panoskaltsis-Mortari A, Kuro OM, et al. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood 2007; 109:2529-2537.
33. Alpdogan O, Hubbard VM, Smith OM, et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood 2006; 107:2453-2460.
34. Panoskaltsis-Mortari A, Lacey DL, Vallera DA, Blazar BR. Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood 1998; 92:3960-3967.
35. Chung B, Barbara-Burnham L, Barsky L, Weinberg K. Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation. Blood 2001; 98:1601-1606.
36. Farrell CL, Bready JV, Rex KL, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998; 58:933-939.
37. Rossi SW, Jeker LT, UenoT,et al. Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood 2007; 109:3803-3811.
38. Seggewiss R, LoreK, Guenaga FJ, etal. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 2007; 110:441-449. (Pubitemid 47026867)
39. Kelly RM, Highfill SL, Panoskaltsis-Mortari A, et al. Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation. Blood 2008; 111:5734-5744.
40. Bernstein ID, Boyd RL, van den Brink MR. Clinical strategies to enhance post-transplant immune reconstitution. Biol Blood Marrow Transplant 2008; 14:94-99.
41. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002; 99:3892-3904.
42. Link A, Vogt TK, Favre S, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007; 8:1255-1265.
43. von Freeden-Jeffry U, Vieira P, Lucian LA, et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995; 181:1519-1526.
44. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174:6571-6576.
45. Jameson SC. Maintaining the norm: T-cell homeostasis. Nat Rev Immunol 2002; 2:547-556.
46. Surh CD, Sprent J. Homeostasis of naive and memoryT cells. Immunity 2008; 29:848-862.
47. Boyman O, Ramsey C, Kim DM, et al. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T cell expansion without lympho-penia. J Immunol 2008; 180:7265-7275.
48. Alpdogan O, Muriglan SJ, Eng JM, et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest 2003; 112:1095-1107.
49. Mackall CL, Fleisher TA, Brown MR, et al. Distinctions between CD8\+ and CD4\+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood 1997; 89:3700-3707.
50. Bolotin E, Smogorzewska M, Smith S, et al. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 1996; 88:1887-1894.
51. Aspinall R, Pido-Lopez J, Imami N, et al. Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. Rejuvenation Res 2007; 10:5-17.
52. Goldberg GL, Zakrzewski JL, Perales MA, van den Brink MR. Clinical strategies to enhance T cell reconstitution. Semin Immunol 2007; 19:289-296.
53. Tanigaki K, Honjo T. Regulation of lymphocyte development by Notch signaling. Nat Immunol 2007; 8:451-456. (Pubitemid 46605909)
54. Pui JC, Allman D, Xu L, et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999; 11:299-308.
55. Radtke F, Wilson A, Stark G, et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999; 10:547-558.
56. Koch U, Fiorini E, Benedito R, etal. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med 2008; 205:2515-2523.
57. Hozumi K, Mailhos C, Negishi N, etal. Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med 2008; 205:2507-2513.
58. Schmitt TM, Zuniga-Pflucker JC. T-cell development, doing it in a dish. Immunol Rev 2006; 209:95-102.
59. Schmitt TM, Zuniga-Pflucker JC. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 2002; 17:749-756.
60. Jaleco AC, Neves H, Hooijberg E, et al. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med 2001; 194:991-1002.
61. La Motte-Mohs RN, Herer E, Zuñiga-Pflucker JC. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 2005; 105:1431-1439.
62. Awong G, Herer E, Surh CD, etal. Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood 2009; 114:972-982.
63. Schmitt TM, de Pooter RF, Gronski MA, et al. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat Immunol 2004; 5:410-417.
64. Zuniga-Pflucker JC. T-cell development made simple. Nat Rev Immunol 2004; 4:67-72.
65. Haddad R, Guimiot F, Six E, etal. Dynamics of thymus-colonizing cells during human development. Immunity 2006; 24:217-230.
66. Zakrzewski JL, Kochman AA, Lu SX, et al. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med 2006; 12:1039-1047.
67. Zakrzewski JL, Suh D, Markley JC, et al. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol 2008; 26:453-461.
68. Dallas MH, Varnum-Finney B, Martin PJ, Bernstein ID. Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1. Blood 2007; 109:3579-3587.
69. DelaneyC, Heimfeld S, Brashem-Stein C, etal. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010; 16:232-236.