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Volumn 31, Issue 7, 2010, Pages 306-311

Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHRONOTHERAPY; CIRCADIAN RHYTHM; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG SENSITIVITY; GENE IDENTIFICATION; GENE MAPPING; GENE REGULATORY NETWORK; GENOME ANALYSIS; GENOTYPE ENVIRONMENT INTERACTION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MATHEMATICAL MODEL; METABOLOMICS; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENETICS; PHARMACOGENOMICS; PREDICTION; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE TRAIT LOCUS MAPPING; SYSTEMS BIOLOGY; TRANSCRIPTION REGULATION; ADVERSE DRUG REACTION; BIOLOGICAL MODEL; COMPUTER SIMULATION; METABOLISM; PHARMACOKINETICS; PHARMACOLOGY; QUANTITATIVE TRAIT LOCUS; TREATMENT OUTCOME;

EID: 77954028167     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2010.04.004     Document Type: Article
Times cited : (29)

References (48)
  • 1
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics - Five decades of therapeutic lessons from genetic diversity
    • Meyer U.A. Pharmacogenetics - Five decades of therapeutic lessons from genetic diversity. Nat. Rev. Genet. 2004, 5:669-676.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 669-676
    • Meyer, U.A.1
  • 2
    • 14344258388 scopus 로고    scopus 로고
    • Pharmacogenetics and geographical ancestry: implications for drug development and global health
    • Daar A.S., Singer P.A. Pharmacogenetics and geographical ancestry: implications for drug development and global health. Nat. Rev. Genet. 2005, 6:241-246.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 241-246
    • Daar, A.S.1    Singer, P.A.2
  • 3
    • 34447122644 scopus 로고    scopus 로고
    • Pharmacogenomics: challenges and opportunities
    • Roden D.M., et al. Pharmacogenomics: challenges and opportunities. Ann. Intern. Med. 2006, 145:749-757.
    • (2006) Ann. Intern. Med. , vol.145 , pp. 749-757
    • Roden, D.M.1
  • 4
    • 52149099016 scopus 로고    scopus 로고
    • Disability and genetics in the era of genomic medicine
    • Scully J.L. Disability and genetics in the era of genomic medicine. Nat. Rev. Genet. 2008, 9:797-802.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 797-802
    • Scully, J.L.1
  • 5
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D., et al. Genetic mapping in human disease. Science 2008, 322:881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1
  • 6
    • 58149328829 scopus 로고    scopus 로고
    • Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
    • Mohlke K.L., et al. Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum. Mol. Genet. 2008, 17:R102-R108.
    • (2008) Hum. Mol. Genet. , vol.17
    • Mohlke, K.L.1
  • 7
    • 44349167229 scopus 로고    scopus 로고
    • Multiple genetic loci for bone mineral density and fractures
    • Styrkarsdottir U., et al. Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 2008, 358:2355-2365.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2355-2365
    • Styrkarsdottir, U.1
  • 8
    • 0032974197 scopus 로고    scopus 로고
    • Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives
    • Derendorf H., Meibohm B. Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharm. Res. 1999, 16:176-185.
    • (1999) Pharm. Res. , vol.16 , pp. 176-185
    • Derendorf, H.1    Meibohm, B.2
  • 9
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho D.D., et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1
  • 10
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time
    • Perelson A.S., et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996, 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1
  • 11
    • 18844452358 scopus 로고    scopus 로고
    • Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
    • Mouton J.W., et al. Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update. J. Antimicrob. Chemother. 2005, 55:601-607.
    • (2005) J. Antimicrob. Chemother. , vol.55 , pp. 601-607
    • Mouton, J.W.1
  • 12
    • 0036671301 scopus 로고    scopus 로고
    • Functional mapping of quantitative trait loci underlying the character process: a theoretical framework
    • Ma C.-X., et al. Functional mapping of quantitative trait loci underlying the character process: a theoretical framework. Genetics 2002, 161:1751-1762.
    • (2002) Genetics , vol.161 , pp. 1751-1762
    • Ma, C.-X.1
  • 13
    • 1942530537 scopus 로고    scopus 로고
    • Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model
    • Wu R., et al. Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model. Biometrics 2004, 60:729-738.
    • (2004) Biometrics , vol.60 , pp. 729-738
    • Wu, R.1
  • 14
    • 33644845428 scopus 로고    scopus 로고
    • Functional mapping - how to map and study the genetic architecture of dynamic complex traits
    • Wu R.L., Lin M. Functional mapping - how to map and study the genetic architecture of dynamic complex traits. Nat. Rev. Genet. 2006, 7:229-237.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 229-237
    • Wu, R.L.1    Lin, M.2
  • 15
    • 33646111432 scopus 로고    scopus 로고
    • Visualizing gene determinants of disease in drug discovery
    • Delrieu O., Bowman C. Visualizing gene determinants of disease in drug discovery. Pharmacogenomics 2006, 7:311-329.
    • (2006) Pharmacogenomics , vol.7 , pp. 311-329
    • Delrieu, O.1    Bowman, C.2
  • 16
    • 65849431826 scopus 로고    scopus 로고
    • Joint functional mapping of quantitative trait loci for HIV-1 and CD4+ dynamics
    • 5, Article 9
    • Wang, Z. et al. (2009) Joint functional mapping of quantitative trait loci for HIV-1 and CD4+ dynamics. Int. J. Biostat. 5, Article 9.
    • (2009) Int. J. Biostat.
    • Wang, Z.1
  • 17
    • 0032967837 scopus 로고    scopus 로고
    • Population HIV-1 dynamics in vivo: applicable models and inferential tools for virological data from AIDS clinical trials
    • Wu H., Ding A.A. Population HIV-1 dynamics in vivo: applicable models and inferential tools for virological data from AIDS clinical trials. Biometrics 1999, 55:410-418.
    • (1999) Biometrics , vol.55 , pp. 410-418
    • Wu, H.1    Ding, A.A.2
  • 18
    • 17344364659 scopus 로고    scopus 로고
    • Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy
    • Marschner I.C., et al. Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy. J. Infect. Dis. 1998, 177:40-47.
    • (1998) J. Infect. Dis. , vol.177 , pp. 40-47
    • Marschner, I.C.1
  • 19
    • 0036970596 scopus 로고    scopus 로고
    • A joint model for nonlinear mixed-effects models with censoring and covariates measured with error, with application to AIDS studies
    • Wu L. A joint model for nonlinear mixed-effects models with censoring and covariates measured with error, with application to AIDS studies. J. Am. Stat. Assoc. 2002, 97:955-964.
    • (2002) J. Am. Stat. Assoc. , vol.97 , pp. 955-964
    • Wu, L.1
  • 20
    • 46049115677 scopus 로고    scopus 로고
    • Modeling the genetic control of HIV-1 dynamics after highly active antiretroviral therapy
    • Ma C.-X., et al. Modeling the genetic control of HIV-1 dynamics after highly active antiretroviral therapy. Curr. Genomics 2008, 9:208-211.
    • (2008) Curr. Genomics , vol.9 , pp. 208-211
    • Ma, C.-X.1
  • 22
    • 57749101107 scopus 로고    scopus 로고
    • Using spline-enhanced ordinary differential equations for PK/PD model development
    • Wang Y., et al. Using spline-enhanced ordinary differential equations for PK/PD model development. J. Pharmacokinet. Pharmacodyn. 2008, 35:553-571.
    • (2008) J. Pharmacokinet. Pharmacodyn. , vol.35 , pp. 553-571
    • Wang, Y.1
  • 23
    • 77952292257 scopus 로고    scopus 로고
    • A differential equation model for functional mapping of a virus-cell dynamic system
    • Luo, et al. A differential equation model for functional mapping of a virus-cell dynamic system. J. Math. Biol. 2010, 61:1-15.
    • (2010) J. Math. Biol. , vol.61 , pp. 1-15
    • Luo1
  • 25
    • 0035988625 scopus 로고    scopus 로고
    • Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity
    • Johnson J.A., Evans W.E. Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity. Trends Mol. Med. 2002, 8:300-305.
    • (2002) Trends Mol. Med. , vol.8 , pp. 300-305
    • Johnson, J.A.1    Evans, W.E.2
  • 26
    • 35148831322 scopus 로고    scopus 로고
    • Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance
    • Clairambault J. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance. Adv. Drug Deliv. Rev. 2007, 59:1054-1068.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 1054-1068
    • Clairambault, J.1
  • 27
    • 72449164580 scopus 로고    scopus 로고
    • Circadian timing in cancer treatments
    • Lévi F., et al. Circadian timing in cancer treatments. Annu. Rev. Pharmacol. Toxicol. 2010, 50:377-421.
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 377-421
    • Lévi, F.1
  • 28
    • 33847075354 scopus 로고    scopus 로고
    • Circadian rhythms: mechanisms and therapeutic implications
    • Lévi F., Schibler U. Circadian rhythms: mechanisms and therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 2007, 47:593-628.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 593-628
    • Lévi, F.1    Schibler, U.2
  • 29
    • 77949503379 scopus 로고    scopus 로고
    • The role of clock genes in pharmacology
    • Paschos G.K., et al. The role of clock genes in pharmacology. Annu. Rev. Pharmacol. Toxicol. 2010, 50:187-214.
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 187-214
    • Paschos, G.K.1
  • 31
    • 0035106940 scopus 로고    scopus 로고
    • Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
    • Ohdo S., et al. Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Nat. Med. 2001, 7:356-360.
    • (2001) Nat. Med. , vol.7 , pp. 356-360
    • Ohdo, S.1
  • 32
    • 0026235914 scopus 로고
    • Biological rhythms in the absorption, distribution, metabolism and excretion of drugs
    • Labrecque G., Bélanger P.M. Biological rhythms in the absorption, distribution, metabolism and excretion of drugs. Pharmacol. Ther. 1991, 52:95-107.
    • (1991) Pharmacol. Ther. , vol.52 , pp. 95-107
    • Labrecque, G.1    Bélanger, P.M.2
  • 33
    • 0033593306 scopus 로고    scopus 로고
    • Molecular bases for circadian clocks
    • Dunlap J.C. Molecular bases for circadian clocks. Cell 1999, 96:271-290.
    • (1999) Cell , vol.96 , pp. 271-290
    • Dunlap, J.C.1
  • 34
    • 0035458732 scopus 로고    scopus 로고
    • Time zones: a comparative genetics of circadian clocks
    • Young M.W., Kay S.A. Time zones: a comparative genetics of circadian clocks. Nat. Rev. Genet. 2001, 2:702-715.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 702-715
    • Young, M.W.1    Kay, S.A.2
  • 35
    • 0037079015 scopus 로고    scopus 로고
    • Computational approaches to cellular rhythms
    • Goldbeter A. Computational approaches to cellular rhythms. Nature 2002, 420:238-245.
    • (2002) Nature , vol.420 , pp. 238-245
    • Goldbeter, A.1
  • 36
    • 10844239981 scopus 로고    scopus 로고
    • A unifying statistical model for QTL mapping of genotype×sex interaction for developmental trajectories
    • Zhao W., et al. A unifying statistical model for QTL mapping of genotype×sex interaction for developmental trajectories. Physiol. Genomics 2004, 19:218-227.
    • (2004) Physiol. Genomics , vol.19 , pp. 218-227
    • Zhao, W.1
  • 37
    • 10844256588 scopus 로고    scopus 로고
    • A unified statistical model for functional mapping of environment-dependent genetic expression and genotype×environment interactions for ontogenetic development
    • Zhao W., et al. A unified statistical model for functional mapping of environment-dependent genetic expression and genotype×environment interactions for ontogenetic development. Genetics 2004, 168:1751-1762.
    • (2004) Genetics , vol.168 , pp. 1751-1762
    • Zhao, W.1
  • 38
    • 0035775486 scopus 로고    scopus 로고
    • Pharmacogenomics: the inherited basis for interindividual differences in drug response
    • Evans W.E., Johnson J.A. Pharmacogenomics: the inherited basis for interindividual differences in drug response. Annu. Rev. Genomics Hum. Genet. 2001, 2:9-39.
    • (2001) Annu. Rev. Genomics Hum. Genet. , vol.2 , pp. 9-39
    • Evans, W.E.1    Johnson, J.A.2
  • 39
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans W.E., McLeod H.L. Pharmacogenomics - Drug disposition, drug targets, and side effects. N. Engl. J. Med. 2003, 348:538-549.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 40
    • 0242348747 scopus 로고    scopus 로고
    • Pharmacogenetics: potential for individualized drug therapy through genetics
    • Johnson J.A. Pharmacogenetics: potential for individualized drug therapy through genetics. Trends Genet. 2003, 19:660-666.
    • (2003) Trends Genet. , vol.19 , pp. 660-666
    • Johnson, J.A.1
  • 41
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N. Engl. J. Med. 2003, 348:529-537.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 42
    • 58149352685 scopus 로고    scopus 로고
    • Pharmacogenomics: candidate gene identification, functional validation and mechanisms
    • Wang L., Weinshilboum R.M. Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Hum. Mol. Genet. 2008, 17:R174-R179.
    • (2008) Hum. Mol. Genet. , vol.17
    • Wang, L.1    Weinshilboum, R.M.2
  • 43
    • 0035805255 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
    • Ideker T., et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 2001, 292:929-934.
    • (2001) Science , vol.292 , pp. 929-934
    • Ideker, T.1
  • 44
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: a brief overview
    • Kitano H. Systems biology: a brief overview. Science 2002, 295:1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 45
    • 33750204290 scopus 로고    scopus 로고
    • Genetics of global gene expression
    • Rockman M.V., Kruglyak L. Genetics of global gene expression. Nat. Rev. Genet. 2006, 7:862-872.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 862-872
    • Rockman, M.V.1    Kruglyak, L.2
  • 46
    • 62549110855 scopus 로고    scopus 로고
    • Personalizing medicine: a systems biology perspective
    • Deisboeck T.S. Personalizing medicine: a systems biology perspective. Mol. Syst. Biol. 2009, 5:249.
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 249
    • Deisboeck, T.S.1
  • 48
    • 28044473632 scopus 로고    scopus 로고
    • Structured antedependence models for functional mapping of multiple longitudinal traits
    • 4, Article 33
    • Zhao, W. et al. (2005) Structured antedependence models for functional mapping of multiple longitudinal traits. Stat. Appl. Genet. Mol. Biol. 4, Article 33.
    • (2005) Stat. Appl. Genet. Mol. Biol.
    • Zhao, W.1


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