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Volumn 7, Issue 3, 2006, Pages 311-329

Visualizing gene determinants of disease in drug discovery

Author keywords

Bayes; Case control study; Disease; Drug discovery; Filter; Gene; Individualization; Multivariate method; Population heterogeneity; Single nucleotide polymorphism; SNP; Subphenotype; Target visualization; Whole genome scan

Indexed keywords

CELL NUCLEUS RECEPTOR; NEW DRUG; PORPHOBILINOGEN SYNTHASE;

EID: 33646111432     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.7.3.311     Document Type: Review
Times cited : (18)

References (51)
  • 1
    • 13544270007 scopus 로고    scopus 로고
    • Disease-specific target selection: A critical first step down the right road
    • Roses AD, Burns DK, Chissoe S, Middleton LT, St Jean P: Disease-specific target selection: a critical first step down the right road. Drug Discov. Today 10(3), 177-189 (2005).
    • (2005) Drug Discov. Today , vol.10 , Issue.3 , pp. 177-189
    • Roses, A.D.1    Burns, D.K.2    Chissoe, S.3    Middleton, L.T.4    St Jean, P.5
  • 2
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • Roses AD: Pharmacogenetics and drug development: the path to safer and more effective drugs. Nature Rev. Genet. 5(9), 643-655 (2004).
    • (2004) Nature Rev. Genet. , vol.5 , Issue.9 , pp. 643-655
    • Roses, A.D.1
  • 3
    • 0037461782 scopus 로고    scopus 로고
    • The mosaic that is our genome
    • Pääbo S: The mosaic that is our genome. Nature 421(6921), 409-412 (2003).
    • (2003) Nature , vol.421 , Issue.6921 , pp. 409-412
    • Pääbo, S.1
  • 4
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard JK, Stephens M, Donnelly P: Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000).
    • (2000) Genetics , vol.155 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 5
    • 0033910724 scopus 로고    scopus 로고
    • Bayesian fine-scale mapping of disease loci, by hidden markov models
    • Morris AP, Whittaker JC, Balding DJ: Bayesian fine-scale mapping of disease loci, by hidden markov models. Am. J. Hum. Genet. 67, 155-169 (2000).
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 155-169
    • Morris, A.P.1    Whittaker, J.C.2    Balding, D.J.3
  • 7
    • 0035214299 scopus 로고    scopus 로고
    • Trimming, weighting and grouping SNPs in human case - Control association studies
    • Hoh J, Wille A, Ott J: Trimming, weighting and grouping SNPs in human case - control association studies. Genome Res. 11 (12), 2115-2119 (2001).
    • (2001) Genome Res. , vol.11 , Issue.12 , pp. 2115-2119
    • Hoh, J.1    Wille, A.2    Ott, J.3
  • 8
    • 0035084663 scopus 로고    scopus 로고
    • A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation
    • Nelson MR, Kardia SLR, Ferrell RE, Sing CF: A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. Genome Res. 11, 458-470 (2001).
    • (2001) Genome Res. , vol.11 , pp. 458-470
    • Nelson, M.R.1    Kardia, S.L.R.2    Ferrell, R.E.3    Sing, C.F.4
  • 9
    • 13544256549 scopus 로고    scopus 로고
    • Recursive partitioning analysis of complex disease pharmacogenetics studies. I. Motivation and overview
    • Young SS, Ge N: Recursive partitioning analysis of complex disease pharmacogenetics studies. I. Motivation and overview. Pharmacornonzics 6 (1), 65-75 (2005).
    • (2005) Pharmacornonzics , vol.6 , Issue.1 , pp. 65-75
    • Young, S.S.1    Ge, N.2
  • 12
    • 0034973569 scopus 로고    scopus 로고
    • Multifactor dimensionality reduction reveals high-order interactions amongst estrogen metabolism genes in sporadic breast cancer
    • Ritchie MD, Hahn LW, Roodi N et al.: Multifactor dimensionality reduction reveals high-order interactions amongst estrogen metabolism genes in sporadic breast cancer. Am. J. Hum. Genet. 69, 138-147 (2001).
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 138-147
    • Ritchie, M.D.1    Hahn, L.W.2    Roodi, N.3
  • 13
    • 0036363877 scopus 로고    scopus 로고
    • A cellular automata approach to detecting interactions amongst single-nucleotide polymorphisms in complex multifactorial diseases
    • Moore JH, Hahn LW: A cellular automata approach to detecting interactions amongst single-nucleotide polymorphisms in complex multifactorial diseases. Pac. Symp. Biocomput. 53-64 (2002).
    • (2002) Pac. Symp. Biocomput. , pp. 53-64
    • Moore, J.H.1    Hahn, L.W.2
  • 14
    • 0344837170 scopus 로고    scopus 로고
    • Cellular automata and genetic algorithms for parallel problem solving in human genetics
    • Merelo JJ, Panagiotis A, Beyer H-G (Eds), Springer-Verlag, Berlin, Germany
    • Moore JH, Hahn LW: Cellular automata and genetic algorithms for parallel problem solving in human genetics. In: Lecture Notes in Computer Science. Merelo JJ, Panagiotis A, Beyer H-G (Eds), Springer-Verlag, Berlin, Germany, 2439, 821-830 (2002).
    • (2002) Lecture Notes in Computer Science , vol.2439 , pp. 821-830
    • Moore, J.H.1    Hahn, L.W.2
  • 15
    • 0036260234 scopus 로고    scopus 로고
    • New strategies for identifying gene-gene interactions in hypertension
    • Moore JH, Williams SM: New strategies for identifying gene-gene interactions in hypertension. Ann, Med. 34, 1-8 (2002).
    • (2002) Ann, Med. , vol.34 , pp. 1-8
    • Moore, J.H.1    Williams, S.M.2
  • 16
    • 2942519521 scopus 로고    scopus 로고
    • Evolutionary algorithms for the selection of single nucleotide polymorphisms
    • Hubley R, Zitzler E, Roach J: Evolutionary algorithms for the selection of single nucleotide polymorphisms. BMC Bioinformatics 4, 30 (2004).
    • (2004) BMC Bioinformatics , vol.4 , pp. 30
    • Hubley, R.1    Zitzler, E.2    Roach, J.3
  • 18
    • 33646084345 scopus 로고    scopus 로고
    • Visualization of gene and pathway determinants of disease
    • Barber S, Baxter PD, Mardia KV, Walls RE (Eds), University of Leeds, Leeds, UK
    • Delrieu O, Bowman CE: Visualization of gene and pathway determinants of disease. In: Quantitative Biology, Shape Analysis and Wavelets. Barber S, Baxter PD, Mardia KV, Walls RE (Eds), University of Leeds, Leeds, UK, 21-24 (2005).
    • (2005) Quantitative Biology, Shape Analysis and Wavelets , pp. 21-24
    • Delrieu, O.1    Bowman, C.E.2
  • 27
    • 0035257025 scopus 로고    scopus 로고
    • At the interfaces of epidemiology, genetics and genomics
    • Potter JD: At the interfaces of epidemiology, genetics and genomics. Nature Rev. Genet. 2, 142-146 (2001).
    • (2001) Nature Rev. Genet. , vol.2 , pp. 142-146
    • Potter, J.D.1
  • 28
    • 33646111880 scopus 로고
    • The botryology of botryology
    • van Ryzin J (Ed.), Academic Press, New York, NY, USA
    • Good IJ: The botryology of botryology. In: Classification and clustering. van Ryzin J (Ed.), Academic Press, New York, NY, USA, 73-94 (1977).
    • (1977) Classification and Clustering , pp. 73-94
    • Good, I.J.1
  • 29
    • 0003752712 scopus 로고
    • Sinauer Associates Incorporated, Sunderland, MA, USA
    • Weir BS: Genetic Data Analysis II. Sinauer Associates Incorporated, Sunderland, MA, USA (1966).
    • (1966) Genetic Data Analysis II
    • Weir, B.S.1
  • 30
    • 33646090581 scopus 로고
    • Cluster analysis applied to a study of race mixture in human populations
    • van Ryzin J (Ed.), Academic Press, New York, NY, USA
    • Rao CR: Cluster analysis applied to a study of race mixture in human populations. In: Classification and clustering. van Ryzin J (Ed.), Academic Press, New York, NY, USA 175-197 (1977).
    • (1977) Classification and Clustering , pp. 175-197
    • Rao, C.R.1
  • 31
    • 0001276815 scopus 로고
    • Distance between populations on the basis of attribute data
    • Balakrishnan V, Sanghvi LD: Distance between populations on the basis of attribute data. Biometrics 24, 859-865 (1968).
    • (1968) Biometrics , vol.24 , pp. 859-865
    • Balakrishnan, V.1    Sanghvi, L.D.2
  • 32
    • 0000156374 scopus 로고
    • Phylogenetic analysis: Models and estimation procedures
    • Cavalli-Sforza LL, Edwards AWF: Phylogenetic analysis: Models and estimation procedures. Evolution 32, 550-570 (1967).
    • (1967) Evolution , vol.32 , pp. 550-570
    • Cavalli-Sforza, L.L.1    Edwards, A.W.F.2
  • 33
    • 0000655270 scopus 로고
    • Genetic distance between populations
    • Nei M: Genetic distance between populations. Am. Nat. 106(949), 283-292 (1972).
    • (1972) Am. Nat. , vol.106 , Issue.949 , pp. 283-292
    • Nei, M.1
  • 34
    • 0000413758 scopus 로고
    • Measures of genetic similarity and genetic distance
    • University of Texas Publishing, Austin, TX, USA
    • Rogers JS: Measures of genetic similarity and genetic distance. Studies in Genetics. University of Texas Publishing, Austin, TX, USA 7(7213), 145-153 (1972).
    • (1972) Studies in Genetics , vol.7 , Issue.7213 , pp. 145-153
    • Rogers, J.S.1
  • 38
    • 6444240010 scopus 로고    scopus 로고
    • A generalized Mahatanobis distance for mixed data
    • de Leon AR, Carrière KC: A generalized Mahatanobis distance for mixed data. J. Multivariate Anal. 92, 174-185 (2005).
    • (2005) J. Multivariate Anal. , vol.92 , pp. 174-185
    • de Leon, A.R.1    Carrière, K.C.2
  • 40
    • 85015054307 scopus 로고    scopus 로고
    • Nature, nurture and human disease
    • Chakravarti A, Little P: Nature, nurture and human disease. Nature 421(6921), 412-414 (2003).
    • (2003) Nature , vol.421 , Issue.6921 , pp. 412-414
    • Chakravarti, A.1    Little, P.2
  • 41
    • 0000263797 scopus 로고
    • Projection pursuit
    • Huber PJ: Projection pursuit. Ann. Stat. 13(2), 435-475 (1985).
    • (1985) Ann. Stat. , vol.13 , Issue.2 , pp. 435-475
    • Huber, P.J.1
  • 42
    • 0035986213 scopus 로고    scopus 로고
    • Treasure hunting in a new era: Genotyping of single nucleotide polymorphisms and the search for complex disease genes by association scans
    • McGinnis R: Treasure hunting in a new era: genotyping of single nucleotide polymorphisms and the search for complex disease genes by association scans. Psychiatric Genet. 12(2), 63-66 (2002).
    • (2002) Psychiatric Genet. , vol.12 , Issue.2 , pp. 63-66
    • McGinnis, R.1
  • 44
    • 77956887176 scopus 로고
    • The biplot graphic display of matrices with application to principal components analysis
    • Gabriel KR: The biplot graphic display of matrices with application to principal components analysis. Biometrika 58, 453-467 (1971).
    • (1971) Biometrika , vol.58 , pp. 453-467
    • Gabriel, K.R.1
  • 47
    • 0037433052 scopus 로고    scopus 로고
    • Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    • Hahn LW, Ritchie MD, Moore JH: Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 19(3), 376-382 (2003)
    • (2003) Bioinformatics , vol.19 , Issue.3 , pp. 376-382
    • Hahn, L.W.1    Ritchie, M.D.2    Moore, J.H.3
  • 48
    • 8444221177 scopus 로고    scopus 로고
    • Computational analysis of gene-gene interactions using multifactor dimension reduction
    • Moore JH: Computational analysis of gene-gene interactions using multifactor dimension reduction. Expert Rev. Mol. Diagn. 4(6), 795-803 (2004)
    • (2004) Expert Rev. Mol. Diagn. , vol.4 , Issue.6 , pp. 795-803
    • Moore, J.H.1
  • 50
    • 4344659001 scopus 로고    scopus 로고
    • Detecting epistatic interactions contributing to quantitative traits
    • Culverhouse R, Klein T, Shannon W: Detecting epistatic interactions contributing to quantitative traits. Genet. Epidemiol. 27(2), 141-152 (2004)
    • (2004) Genet. Epidemiol. , vol.27 , Issue.2 , pp. 141-152
    • Culverhouse, R.1    Klein, T.2    Shannon, W.3
  • 51
    • 0035992220 scopus 로고    scopus 로고
    • Symbolic discriminant analysis of microarray data in autoimmune disease
    • Moore JH, Parker JS, Oisen NJ, Aune,TM: Symbolic discriminant analysis of microarray data in autoimmune disease. Genet. Epidemiol. 23(l), 57-69 (2002).
    • (2002) Genet. Epidemiol. , vol.23 , Issue.1 , pp. 57-69
    • Moore, J.H.1    Parker, J.S.2    Oisen, N.J.3    Aune, T.M.4


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