The programmable cell of monocytic origin (PCMO): A potential adult stem/progenitor cell source for the generation of islet cells

Advances in Experimental Medicine and Biology

Volumn 654, Issue , 2010, Pages 667-682

  Fändrich, Fred ^b   Ungefroren, Hendrik ^a  

^a UKS H   (Germany)

^b NONE

Author keywords

cell; Differentiation; NeoIslet cell; PCMO; Stem cell

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN; BETACELLULIN; C PEPTIDE; COLONY STIMULATING FACTOR 1; CYCLOPAMINE; EXENDIN 4; GLUCAGON; INSULIN; INTERLEUKIN 3; KERATINOCYTE GROWTH FACTOR; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 1; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ADULT STEM CELL; ARTICLE; CELL AGGREGATION; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CELL RENEWAL; CELL TYPE; COMBINATION CHEMOTHERAPY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SYNTHESIS; MESENCHYMAL STEM CELL; MONOCYTE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROGRAMMABLE CELL OF MONOCYTIC ORIGIN; ALLOTRANSPLANTATION; ANIMAL; BIOLOGICAL MODEL; BIOLOGICAL THERAPY; CYTOLOGY; METABOLISM; METHODOLOGY; PANCREAS ISLET; PHENOTYPE; REVIEW; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; MONOCYTES; PHENOTYPE; STEM CELLS; TISSUE THERAPY; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS;

EID: 77953953066     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-3271-3_29     Document Type: Article

References (56)

1. Best M, Carroll M, Hanley NA, Piper Hanley K. Embryonic stem cells to beta-cells by understanding pancreas development. Mol Cell Endocrinol 2008;288:86-94.
2. Bonner-Weir S, Weir GC. New sources of pancreatic β-cells. Nat Biotechnol 2005;23:857-61.
3. Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans 2008;36:353-6. (Pubitemid 351839330)
4. Bouwens L. Beta cell regeneration. Curr Diabetes Rev 2006;2:3-9. (Pubitemid 44082946)
5. Boumaza I, Srinivasan S, Witt WT, Feghali-Bostwick C, Dai Y, Garcia-Ocana A, Feili-Hariri M. Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia. J Autoimmun 2009;32:33-42.
6. Brem-Exner BG, Sattler C, Hutchinson JA, Koehl GE, Kronenberg K, Farkas S, Inoue S, Blank C, Knechtle SJ, Schlitt HJ, Fändrich F, Geissler EK. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol 2008;180:335-49.
7. Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004;145: 2653-9. (Pubitemid 38686211)
8. Burns CJ, Persaud SJ, Jones PM. Diabetes mellitus: a potential target for stem cell therapy. Curr Stem Cell Res Ther 2006;1:255-66.
9. Dai C, Huh CG, Thorgeirsson SS, Liu Y. Betα-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol 2005;167:429-36. (Pubitemid 43026099)
10. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006;24:1392-401. (Pubitemid 44722103)
11. Eberhard D, Tosh D, Slack JM: Origin of pancreatic endocrine cells from biliary duct epithelium. Cell Mol Life Sci 2008;65:3467-80.
12. Ehnert S, Nussler AK, Lehmann A, Dooley S. Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism. Drug Metab Dispos 2008;36:1922-9.
13. Glanemann M, Gaebelein G, Nussler N, Hao L, Kronbach Z, Shi B, Neuhaus P, Nussler AK. Transplantation of monocyte-derived hepatocyte-like cells (NeoHeps) improves survival in a model of acute liver failure. Ann Surg 2009;249:149-54.
14. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005;5:953-64. (Pubitemid 41746764)
15. Guillemain G, Filhoulaud G, Da Silva-Xavier G, Rutter GA, Scharfmann R. Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem 2007;282: 15228-37. (Pubitemid 47093387)
16. Gurdon JB, Melton DA. Nuclear reprogramming in cells. Science 2008;322:1811-5.
17. Hutchinson JA, Riquelme P, Wundt J, Hengstler JG, Fändrich F, Ungefroren H, Clement B. Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease? Am J Hematol 2007;82:947-8. (Pubitemid 350004383)
18. Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74. (Pubitemid 34680517)
19. Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M, Schöler HR. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008;454:646-50.
20. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, Young H, Richardson M, Smart NG, Cunningham J, Agulnick AD, D'Amour KA, Carpenter MK, Baetge EE. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008;26:443-52. (Pubitemid 351501814)
21. Kuwana M, Kuwana M, Okazaki Y, Kodama H, Izumi K, Yasuoka H, Ogawa Y, Kawakami Y, Ikeda Y. Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 2003;74:833-45. (Pubitemid 38040360)
22. Levine F, Itkin-Ansari P. Beta-cell Regeneration: neogenesis, replication or both? J Mol Med 2008;86:247-58. (Pubitemid 351311421)
23. Li L, Li F, Qi H, Feng G, Yuan K, Deng H, Zhou H. Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Stem Cells Dev 2008;815-23.
24. Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T. Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 2000;127:2617-27. (Pubitemid 30426809)
25. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander ES, Bernstein BE: Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007;448:548-9.
26. Möller B, Ungefroren H, Acil Y, Springer I, Schulze M, Warnke PH, Fändrich F, Wiltfang J. Transdifferentiation of human monocytes to osteoblast-like cells - a comparison to human osteoblasts, SaOS-2 osteosarcoma cells and human mesenchymal stem cells. In press
27. Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi S. Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviralmediated gene transfer technology. Cell Transplant 2006;15:929-38. (Pubitemid 46174543)
28. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, Morishita Y, Watabe T, Niwa H, Miyazono K. Activin-Nodal signaling is involved in propagation ofmouse embryonic stem cells. J Cell Sci 2006;120:55-65.
29. Oliver-Krasinski JM, Stoffers DA. On the origin of the beta cell. Genes Dev 2008;22: 1998-2021.
30. Pufe T, Petersen W, Fändrich F, Varoga D, Wruck CJ, Mentlein R, Helfenstein A, Hoseas D, Dressel S, Tillmann B, Ruhnke M. Programmable cells of monocytic origin (PCMO): A source of peripheral blood stem cells that generate collagen type II-producing chondrocytes. J Orthop Res 2008;26:304-13.
31. Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes 2005;54:2090-102. (Pubitemid 40911272)
32. Romagnani P, Annunziato F, Liotta F, Lazzeri E, Mazzinghi B, Frosali F, Cosmi L, Maggi L, Lasagni L, Scheffold A, Kruger M, Dimmeler S, Marra F, Gensini G, Maggi E, Romagnani S. CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res 2005;97:314-22. (Pubitemid 41216135)
33. Ruau D, Ensenat-Waser R, Dinger TC, Vallabhapurapu DS, Rolletschek A, Hacker C, Hieronymus T, Wobus AM, Müller AM, Zenke M. Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells 2008;26:920-6.
34. Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler JG, Klapper W, Ulrichs K, Hutchinson JA, Soria B, Parwaresch RM, Heeckt P, Kremer B, Fändrich F. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 2005;128:1774-86. (Pubitemid 40824688)
35. Ruhnke M, Nussler AK, Ungefroren H, Hengstler JG, Kremer B, Hoeckh W, Gottwald T, Heeckt P, Fändrich F. Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy. Transplantation 2005;79:1097-103. (Pubitemid 40664004)
36. Sanvito F, Herrera PL, Huarte J, Nichols A, Montesano R, Orci L, Vassalli JD. TGFbeta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 1994;120:3451-62. (Pubitemid 24366990)
37. Schulze M, Fändrich F, Ungefroren H, Kremer B. Adult stem cells - perspectives in treatment of metabolic diseases. Acta Gastro-Enterologica Belgica 2005;68:461-5. (Pubitemid 43067254)
38. Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A: Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells 2008;26:3-16.
39. Silva J, Barrandon O, Nichols J, Kawaguchi J, Theunissen TW, Smith A. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 2008;6:e253.
40. Soria B, Bedoya FJ, Tejedo JR, Hmadcha A, Ruiz-Salmerón R, Lim S, Martin F. Cell therapy for diabetes mellitus: an opportunity for stem cells? Cells Tissues Organs 2008;188:70-7. (Pubitemid 351962231)
41. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008;322:945-9.
42. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76. (Pubitemid 44233629)
43. Tang DQ, Cao LZ, Burkhardt BR, Xia CQ, Litherland SA, Atkinson MA, Yang LJ. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004;53:1721-32. (Pubitemid 38857030)
44. Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol 2004;220:59-65. (Pubitemid 38757881)
45. Vaca P, Berná G, Araujo R, Carneiro EM, Bedoya FJ, Soria B, Martín F. Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells. Exp Cell Res 2008;314:969-74.
46. Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004;116:639-48. (Pubitemid 38326723)
47. Xiao L, Yuan X, Sharkis SJ. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenetic protein pathways in human embryonic stem cells. Stem Cells 2006;24:1476-86. (Pubitemid 44464664)
48. Xie H, Ye M, Feng R, Graf T: Stepwise reprogramming of B cells into macrophages. Cell 2004;117:663-76. (Pubitemid 38692531)
49. Yan L, Han Y, Wang J, Liu J, Hong L, Fan D. Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes. Am J Hematol 2007;82:949-54. (Pubitemid 350004384)
50. Yang L, Li S, Hatch H, Ahrens K, Cornelius JG, Petersen BE, Peck AB: In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A 2002;99:8078-83. (Pubitemid 34651008)
51. Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H: Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008;132: 197-207. (Pubitemid 351181232)
52. Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet 2008;9:329-40. (Pubitemid 351556060)
53. Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008;322:1490-4.
54. Zhao Y, Glesne D, Huberman E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Natl Acad Sci U S A 2003;100:2426-31. (Pubitemid 36297515)
55. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta cells. Nature 2008;455:627-32.
56. Zulewski H. Differentiation of embryonic and adult stem cells into insulin producing cells. Panminerva Med 2008;50:73-9.