Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway

Free Radical Biology and Medicine

Volumn 42, Issue 12, 2007, Pages 1858-1865

  Probin, Virginia ^a   Wang, Yong ^a   Zhou, Daohong ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Alkylating agent; Erk; p38; p53; Reactive oxygen species; Senescence

Indexed keywords

ACETYLCYSTEINE; BUSULFAN; DNA; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CELL AGING; CONTROLLED STUDY; CROSS LINKING; DIPLOIDY; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS, ALKYLATING; BETA-GALACTOSIDASE; BLOTTING, WESTERN; BROMODEOXYURIDINE; BUSULFAN; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GLUTATHIONE; HUMANS; LUNG; MITOGEN-ACTIVATED PROTEIN KINASES; NADPH OXIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34248579873     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.03.020     Document Type: Article

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