메뉴 건너뛰기




Volumn 27, Issue 12, 1999, Pages 2766-2775

Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation

Author keywords

Carbon monoxide; Heat shock protein 32; Heme oxygenase 1; Hemorrhagic shock; Liver injury; Nitric oxide; Nitric oxide synthase II; S methylisothiourea; Tin protoporphyrin IX

Indexed keywords

CARBON MONOXIDE; HEAT SHOCK PROTEIN; HEME OXYGENASE; NITRIC OXIDE SYNTHASE; PROTOPORPHYRIN; TROLOX C;

EID: 0033400725     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199912000-00027     Document Type: Article
Times cited : (81)

References (50)
  • 1
    • 27144517300 scopus 로고
    • Trauma, shock and development of the organ in shock and early organ failure (SIRS): Response of the macrocirculation
    • Schlag R. and H. Redl (Eds). New York, Springer-Verlag
    • 1. Gutierrez G, Brown SD: Trauma, shock and development of the organ in shock and early organ failure (SIRS): Response of the macrocirculation. In: Pathophysiology of Shock, Sepsis, and Organ Failure. Schlag R. and H. Redl (Eds). New York, Springer-Verlag, 1993, pp 215-229
    • (1993) Pathophysiology of Shock, Sepsis, and Organ Failure , pp. 215-229
    • Gutierrez, G.1    Brown, S.D.2
  • 2
    • 0027511853 scopus 로고
    • The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis
    • 2. Palmer RMJ: The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis. Arch Surg 1993; 128: 396-401
    • (1993) Arch Surg , vol.128 , pp. 396-401
    • Palmer, R.M.J.1
  • 3
    • 0031093754 scopus 로고    scopus 로고
    • Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: Evidence that type II nitric oxide synthase does not regulate vascular decompensation
    • 3. Kelly E, Shah NS, Morgan NN, et al: Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: Evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock 1997; 7:157-163
    • (1997) Shock , vol.7 , pp. 157-163
    • Kelly, E.1    Shah, N.S.2    Morgan, N.N.3
  • 4
    • 0027472041 scopus 로고
    • Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide
    • 4. Tiemermann C, Szabo C, Mitchell JA, et al: Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci U S A 1993; 90: 267-271
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 267-271
    • Tiemermann, C.1    Szabo, C.2    Mitchell, J.A.3
  • 5
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • 5. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 6
    • 0030203367 scopus 로고    scopus 로고
    • The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury
    • 6. Szabo C: The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 1996; 6:79-88
    • (1996) Shock , vol.6 , pp. 79-88
    • Szabo, C.1
  • 7
    • 0028254620 scopus 로고
    • Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia
    • 7. Nishida J, McCuskey RS, McDonnell D, et al: Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 1994; 30:G1135-G1141
    • (1994) Am J Physiol , vol.30
    • Nishida, J.1    McCuskey, R.S.2    McDonnell, D.3
  • 8
    • 0029384468 scopus 로고
    • Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia
    • 8. Wang Y, Mathews WR, Guido DM, et al: Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia. Shock 1995; 4:282-288
    • (1995) Shock , vol.4 , pp. 282-288
    • Wang, Y.1    Mathews, W.R.2    Guido, D.M.3
  • 9
    • 0025181994 scopus 로고
    • Activation of soluble guanylate cyclase by carbon monoxide and inhibition by Superoxide anion
    • 9. Brüne B, Schmidt KU, Ulrich V: Activation of soluble guanylate cyclase by carbon monoxide and inhibition by Superoxide anion. Eur J Biochem 1990; 192:683-688
    • (1990) Eur J Biochem , vol.192 , pp. 683-688
    • Brüne, B.1    Schmidt, K.U.2    Ulrich, V.3
  • 10
    • 0028856163 scopus 로고
    • Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver
    • 10. Suematsu M, Goda N, Sano T, et al: Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest 1995; 96:2431-2437
    • (1995) J Clin Invest , vol.96 , pp. 2431-2437
    • Suematsu, M.1    Goda, N.2    Sano, T.3
  • 11
    • 0029848180 scopus 로고    scopus 로고
    • Evidence for a functional link between stress response and vascular control in hepatic portal circulation
    • 11. Bauer M, Pannen BHJ, Bauer I, et al: Evidence for a functional link between stress response and vascular control in hepatic portal circulation. Am J Physiol 1996; 271: G929-G935
    • (1996) Am J Physiol , vol.271
    • Bauer, M.1    Pannen, B.H.J.2    Bauer, I.3
  • 12
    • 0023731036 scopus 로고
    • Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
    • 12. Maines MD: Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 1988; 2:2557-2568
    • (1988) FASEB J , vol.2 , pp. 2557-2568
    • Maines, M.D.1
  • 13
    • 0030271238 scopus 로고    scopus 로고
    • Gaseous monoxides: A new class of microvascular regulator in the liver
    • 13. Suematsu M, Wakabayashi Y, Ishimura Y: Gaseous monoxides: a new class of microvascular regulator in the liver. Cardiovasc Res 1996; 32:679-686
    • (1996) Cardiovasc Res , vol.32 , pp. 679-686
    • Suematsu, M.1    Wakabayashi, Y.2    Ishimura, Y.3
  • 14
    • 0023854047 scopus 로고
    • Evidence suggesting that the two forms of heme oxygenase are products of different genes
    • 14. Cruse I, Maines MD: Evidence suggesting that the two forms of heme oxygenase are products of different genes. J Biol Chem 1988; 263:3348-3353
    • (1988) J Biol Chem , vol.263 , pp. 3348-3353
    • Cruse, I.1    Maines, M.D.2
  • 15
    • 0028357297 scopus 로고
    • Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model
    • 15. Villar J, Ribeiro SP, Mullen JBM, et al: Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 1994; 22:914-921
    • (1994) Crit Care Med , vol.22 , pp. 914-921
    • Villar, J.1    Ribeiro, S.P.2    Mullen, J.B.M.3
  • 16
    • 0030820387 scopus 로고    scopus 로고
    • Heat stress increases survival rates in lipopolysaccharide-stimulated rats
    • 16. Chu EK, Ribeiro SP, Slutsky AS: Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med 1997; 25: 1727-1732
    • (1997) Crit Care Med , vol.25 , pp. 1727-1732
    • Chu, E.K.1    Ribeiro, S.P.2    Slutsky, A.S.3
  • 17
    • 0027254809 scopus 로고
    • Induction of the heat shock response leads to apoptosis in endothelial cells previously exposed to endotoxin
    • 17. Buchman TG, Abello PA, Smith EH, et al: Induction of the heat shock response leads to apoptosis in endothelial cells previously exposed to endotoxin. Am J Physiol 1993; 265: H165-H170
    • (1993) Am J Physiol , vol.265
    • Buchman, T.G.1    Abello, P.A.2    Smith, E.H.3
  • 18
    • 0030865827 scopus 로고    scopus 로고
    • Some like it hot
    • 18. Buchman TG: Some like it hot. Crit Care Med 1997; 25:1636
    • (1997) Crit Care Med , vol.25 , pp. 1636
    • Buchman, T.G.1
  • 19
    • 0025182686 scopus 로고
    • Molecular biology of circulatory shock. II. Expression of four groups of hepatic genes is enhanced following resuscitation from cardiogenic shock
    • 19. Buchman TG, Cabin DE, Vickers S, et al: Molecular biology of circulatory shock. II. Expression of four groups of hepatic genes is enhanced following resuscitation from cardiogenic shock. Surgery 1990; 108:559-566
    • (1990) Surgery , vol.108 , pp. 559-566
    • Buchman, T.G.1    Cabin, D.E.2    Vickers, S.3
  • 20
    • 0031915553 scopus 로고    scopus 로고
    • Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress exposed rat liver
    • 20. Bauer I, Wanner CA, Rensing H, et al: Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress exposed rat liver. Hepatology 1998; 27:829-838
    • (1998) Hepatology , vol.27 , pp. 829-838
    • Bauer, I.1    Wanner, C.A.2    Rensing, H.3
  • 21
    • 0028406317 scopus 로고
    • Heme oxygenase does not protect human cells against oxidant stress
    • 21. Nutter LM, Sierra EE, Ngo EO: Heme oxygenase does not protect human cells against oxidant stress. J Lab Clin Med 1994; 123: 506-514
    • (1994) J Lab Clin Med , vol.123 , pp. 506-514
    • Nutter, L.M.1    Sierra, E.E.2    Ngo, E.O.3
  • 22
    • 0026716352 scopus 로고
    • Differential regulation of heme oxygenase isozymes by Sn-and Zn-protoporphyrins: Possible relevance to suppression of hyperbilirubinemia
    • 22. Maines MD, Trakshel GM: Differential regulation of heme oxygenase isozymes by Sn-and Zn-protoporphyrins: possible relevance to suppression of hyperbilirubinemia. Biochim Biophys Acta 1992; 1131:166-174
    • (1992) Biochim Biophys Acta , vol.1131 , pp. 166-174
    • Maines, M.D.1    Trakshel, G.M.2
  • 23
    • 0020479196 scopus 로고
    • Purfication and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation
    • 23. Yoshinaga T, Sassa S, Kappas A: Purfication and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem 1982; 257:7778-7785
    • (1982) J Biol Chem , vol.257 , pp. 7778-7785
    • Yoshinaga, T.1    Sassa, S.2    Kappas, A.3
  • 24
    • 0019883606 scopus 로고
    • Zinc-protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat
    • 24. Maines MD: Zinc-protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Biochim Biophys Acta 1981; 673:339-354
    • (1981) Biochim Biophys Acta , vol.673 , pp. 339-354
    • Maines, M.D.1
  • 25
    • 0030076587 scopus 로고    scopus 로고
    • A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: Comparison with two nonselective strategies
    • 25. Aranow SA, Zhuang J, Whang H, et al: A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: Comparison with two nonselective strategies. Shock 1996; 5:116-121
    • (1996) Shock , vol.5 , pp. 116-121
    • Aranow, S.A.1    Zhuang, J.2    Whang, H.3
  • 26
    • 0028848015 scopus 로고
    • Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • 26. Southan GJ, Szabo C, Thiemermann C: Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 1995; 114:510-516
    • (1995) Br J Pharmacol , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabo, C.2    Thiemermann, C.3
  • 27
    • 0027190038 scopus 로고
    • The contractional hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin-1 and nitric oxide in the regulation of sinusoidal tonus
    • 27. Kawada N, Tran-Thi TA, Klein H, et al: The contractional hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin-1 and nitric oxide in the regulation of sinusoidal tonus. Eur J Biochem 1993; 213:815-823
    • (1993) Eur J Biochem , vol.213 , pp. 815-823
    • Kawada, N.1    Tran-Thi, T.A.2    Klein, H.3
  • 28
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • 28. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-162
    • (1987) Anal Biochem , vol.162 , pp. 156-162
    • Chomczynski, P.1    Sacchi, N.2
  • 29
    • 0026755754 scopus 로고
    • Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
    • 29. Nath DA, Balla G, Vercelotti GM, et al: Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest 1992; 90:267-270
    • (1992) J Clin Invest , vol.90 , pp. 267-270
    • Nath, D.A.1    Balla, G.2    Vercelotti, G.M.3
  • 30
    • 0028830126 scopus 로고
    • Attenuation of shock induced hepatic microcirculatory disturbances by the use of a starchdeferoxamine conjugate for resuscitation
    • 30. Bauer M, Feucht K, Ziegenfuß T, et al: Attenuation of shock induced hepatic microcirculatory disturbances by the use of a starchdeferoxamine conjugate for resuscitation. Crit Care Med 1995; 23:316-322
    • (1995) Crit Care Med , vol.23 , pp. 316-322
    • Bauer, M.1    Feucht, K.2    Ziegenfuß, T.3
  • 31
    • 0027933447 scopus 로고
    • Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage
    • 31. Lesuy SF, Tomaro ML: Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1994; 1223:9-14
    • (1994) Biochim Biophys Acta , vol.1223 , pp. 9-14
    • Lesuy, S.F.1    Tomaro, M.L.2
  • 32
    • 0029982710 scopus 로고    scopus 로고
    • Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase
    • 32. Yamaguchi T, Terakado M, Horio F, et al: Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase. Biochem Biophys Res Commun 1996; 223:129-135
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 129-135
    • Yamaguchi, T.1    Terakado, M.2    Horio, F.3
  • 33
    • 0025027934 scopus 로고
    • The cytoprotective effect of Trolox demonstrated with three types of human cells
    • 33. Wu TW, Hashimoto N, Wu J, et al: The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol 1990; 68:1189-1194
    • (1990) Biochem Cell Biol , vol.68 , pp. 1189-1194
    • Wu, T.W.1    Hashimoto, N.2    Wu, J.3
  • 34
    • 0018174679 scopus 로고
    • Radioimmunoassay of plasma ligandin: A sensitive index of experimental hepatocellular necrosis
    • 34. Bass NM, Kirsch RE, Tuff SA, et al: Radioimmunoassay of plasma ligandin: A sensitive index of experimental hepatocellular necrosis. Gastroenterology 1978; 75:589-594
    • (1978) Gastroenterology , vol.75 , pp. 589-594
    • Bass, N.M.1    Kirsch, R.E.2    Tuff, S.A.3
  • 35
    • 0029315782 scopus 로고
    • Plasma gluthathione S-Transferase as an early marker of posttraumatic hepatic injury in non-human primates
    • 35. Redl H, Schlag G, Paul E, et al: Plasma Gluthathione S-Transferase as an early marker of posttraumatic hepatic injury in non-human primates. Shock 1995; 3:395-397
    • (1995) Shock , vol.3 , pp. 395-397
    • Redl, H.1    Schlag, G.2    Paul, E.3
  • 36
    • 0028814999 scopus 로고
    • A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats
    • 36. Johnson RA, Lavesa M, Askari B, et al: A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats. Hypertension 1995; 25:166-169
    • (1995) Hypertension , vol.25 , pp. 166-169
    • Johnson, R.A.1    Lavesa, M.2    Askari, B.3
  • 37
    • 0025945515 scopus 로고
    • Nitrogen oxide levels in patients after trauma and during sepsis
    • 37. Ochoa JB, Udekwu AO, Billiar TR, et al: Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991; 214: 621-626
    • (1991) Ann Surg , vol.214 , pp. 621-626
    • Ochoa, J.B.1    Udekwu, A.O.2    Billiar, T.R.3
  • 38
    • 33751268184 scopus 로고    scopus 로고
    • Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: Role of NO and endothelins
    • 38. Pannen BHJ, Bauer M, Nöldge-Schomburg GFE, et al: Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: Role of NO and endothelins. Am J Physiol 1997; 272:H2736-H2745
    • (1997) Am J Physiol , vol.272
    • Pannen, B.H.J.1    Bauer, M.2    Nöldge-Schomburg, G.F.E.3
  • 39
    • 0029401134 scopus 로고
    • Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury
    • 39. Harbrecht BG, Wu B, Watkins SC, et al: Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. Shock 1995; 4:332-337
    • (1995) Shock , vol.4 , pp. 332-337
    • Harbrecht, B.G.1    Wu, B.2    Watkins, S.C.3
  • 40
    • 0031306612 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil acccumulation in hemorrhaged rats
    • 40. Harbrecht BG, Wu B, Watkins SC, et al: Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil acccumulation in hemorrhaged rats. Shock 1997; 8:415-421
    • (1997) Shock , vol.8 , pp. 415-421
    • Harbrecht, B.G.1    Wu, B.2    Watkins, S.C.3
  • 41
    • 0032536875 scopus 로고    scopus 로고
    • Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock
    • 41. Hierholzer C, Harbrecht BG, Menezes JM, et al: Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 1998; 187:917-928
    • (1998) J Exp Med , vol.187 , pp. 917-928
    • Hierholzer, C.1    Harbrecht, B.G.2    Menezes, J.M.3
  • 42
    • 0026316281 scopus 로고
    • Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated tumor necrosis factor and reactive nitrogen
    • 42. Ayala A, Perrin MM, Wang P, et al: Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated tumor necrosis factor and reactive nitrogen. J Immunol 1991; 147:4147-4154
    • (1991) J Immunol , vol.147 , pp. 4147-4154
    • Ayala, A.1    Perrin, M.M.2    Wang, P.3
  • 43
    • 0026490005 scopus 로고
    • Topographic dissociation between mitochondrial dysfunction and cell death during low-flow hypoxia in perfused rat liver
    • 43. Suematsu M, Suzuki H, Ishii H, et al: Topographic dissociation between mitochondrial dysfunction and cell death during low-flow hypoxia in perfused rat liver. Lab Invest 1992; 67:434-442
    • (1992) Lab Invest , vol.67 , pp. 434-442
    • Suematsu, M.1    Suzuki, H.2    Ishii, H.3
  • 44
    • 0030059360 scopus 로고    scopus 로고
    • Attenuation of shock induced inflammation in the rat liver depends on the time of TNF-α inhibition
    • 44. Bauer C, Roth W, Bahrami S, et al: Attenuation of shock induced inflammation in the rat liver depends on the time of TNF-α inhibition. J Mol Med 1996; 74:51-58
    • (1996) J Mol Med , vol.74 , pp. 51-58
    • Bauer, C.1    Roth, W.2    Bahrami, S.3
  • 45
    • 0027439440 scopus 로고
    • Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes
    • 45. Geller DA, Nussler AK, Di Silvio M, et al: Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A 1993; 90:522-526
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 522-526
    • Geller, D.A.1    Nussler, A.K.2    Di Silvio, M.3
  • 46
    • 0029400559 scopus 로고
    • Chronic ethanol consumption exacerbates liver injury following hemorrhagic shock: Role of sinusoidal perfusion failure
    • 46. Bauer I, Bauer M, Pannen BHJ, et al: Chronic ethanol consumption exacerbates liver injury following hemorrhagic shock: role of sinusoidal perfusion failure. Shock 1995; 4:324-331
    • (1995) Shock , vol.4 , pp. 324-331
    • Bauer, I.1    Bauer, M.2    Pannen, B.H.J.3
  • 47
    • 0028057021 scopus 로고
    • Hypertonie hydroxyethyl starch restores hepatic microvascular perfusion in hemorrhagic shock
    • 47. Vollmar B, Lang C, Menger MD, et al: Hypertonie hydroxyethyl starch restores hepatic microvascular perfusion in hemorrhagic shock. Am J. Physiol 1994; 35:H1927-H1934
    • (1994) Am J. Physiol , vol.35
    • Vollmar, B.1    Lang, C.2    Menger, M.D.3
  • 48
    • 0028044510 scopus 로고
    • Endothelin blockade lowers peripheral resistance in hemorrhagic shock recovery
    • 48. Zimmerman RS, Maymind M, Barbee RW: Endothelin blockade lowers peripheral resistance in hemorrhagic shock recovery. Hypertension 1994; 23:205-210
    • (1994) Hypertension , vol.23 , pp. 205-210
    • Zimmerman, R.S.1    Maymind, M.2    Barbee, R.W.3
  • 49
    • 0008923764 scopus 로고
    • Differential endothelin receptor gene expression as a mechanism for hepatic microvascular injury with sequential stresses
    • 49. Bauer M, Pannen BHJ, Barton DS, et al: Differential endothelin receptor gene expression as a mechanism for hepatic microvascular injury with sequential stresses. Shock 1995;4(Suppl 1):103
    • (1995) Shock , vol.4 , Issue.SUPPL. 1 , pp. 103
    • Bauer, M.1    Pannen, B.H.J.2    Barton, D.S.3
  • 50
    • 0031205733 scopus 로고    scopus 로고
    • Remodeling of hepatic microvascular responsiveness after ischemia/reperfusion
    • 50. Clemens MG, Bauer M, Pannen BHJ, et al. Remodeling of hepatic microvascular responsiveness after ischemia/reperfusion. Shock 1997; 8:80-85
    • (1997) Shock , vol.8 , pp. 80-85
    • Clemens, M.G.1    Bauer, M.2    Pannen, B.H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.