Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists

Archives of Biochemistry and Biophysics

Volumn 461, Issue 2, 2007, Pages 263-274

  Gault, Victor A ^a   Hunter, Kerry ^a   Irwin, Nigel ^a   Green, Brian D ^a   Greer, Brett ^b   Harriott, Patrick ^b   O'Harte, Finbarr P M ^a   Flatt, Peter R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Diabetes; DPP IV; Gastrointestinal; GIP; Insulin secretion

Indexed keywords

ALANINE; CYCLIC AMP; DIPEPTIDYL PEPTIDASE IV; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE DERIVATIVE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR ANTAGONIST; GLUCOSE; HORMONE RECEPTOR BLOCKING AGENT; INSULIN; LYSINE; PHENYLALANINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

ADENOSINE DEAMINASE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD26; CRICETINAE; CRICETULUS; GASTRIC INHIBITORY POLYPEPTIDE; GLUTAMIC ACID; GLYCOPROTEINS; HUMANS; MICE; MICE, OBESE; RECEPTORS, GASTROINTESTINAL HORMONE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

MUS;

EID: 34247564632     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.03.001     Document Type: Article

References (46)

1. Gault V.A., O'Harte F.P.M., and Flatt P.R. Neuropeptides 37 (2003) 253-263
2. Gault V.A., Flatt P.R., and O'Harte F.P.M. Biochem. Biophys. Res. Commun. 308 (2003) 207-213
3. Amiranoff B., Vauclin-Jacques N., and Laburthe M. Biochem. Biophys. Res. Commun. 123 (1984) 671-676
4. Green B.D., Irwin N., Gault V.A., O'Harte F.P.M., and Flatt P.R. Br. J. Diabetes Vasc. Dis. 5 (2005) 134-140
5. Pospisilik J.A., Martin J., Doty T., Ehses J.A., Pamir N., Lynn F.C., Piteau S., Demuth H.U., McIntosh C.H.S., and Pederson R.A. Diabetes 52 (2003) 741-750
6. Trumper A., Trumper K., and Horsch D. J. Endocrinol. 174 (2002) 233-246
7. Trumper A., Trumper K., Trusheim H., Arnold R., Goke B., and Horsch D. Mol. Endocrinol. 15 (2001) 1559-1570
8. Ehses J.A., Casilla V.R., Doty T., Pospisilik J.A., Winter K.D., Demuth H.U., Pederson R.A., and McIntosh C.H.S. Endocrinology 144 (2003) 4433-4445
9. Kieffer T.J., McIntosh C.H.S., and Pederson R.A. Endocrinology 136 (1995) 3585-3596
10. Lambeir A.M., Durinx C., Sharpe S., and DeMeester I. Crit. Rev. Clin. Lab. Sci. 40 (2003) 209-294
11. Mentlein R. Reg. Pept. 85 (1999) 9-24
12. Drucker D.J. Exp. Opin. Invest. Drugs. 12 (2003) 87-100
13. Pospisilik J.A., Stafford S.G., Demuth H.U., McIntosh C.H.S., and Pederson R.A. Diabetes 51 (2002) 2677-2683
14. Pospisilik J.A., Stafford S.G., Demuth H.U., Brownsey R., Parkhouse W., Finegood D.T., McIntosh C.H.S., and Pederson R.A. Diabetes 51 (2002) 943-950
15. Pederson R.A., White H.A., Schlenzig D., Pauly R.P., McIntosh C.H.S., and Demuth H.U. Diabetes 47 (1998) 1253-1258
16. Ahren B., Simonsson E., Larsson H., Landin-Olsson M., Torgeirsson H., Jansson P.A., Sandqvist M., Bavenholm P., Efendic S., Eriksson J.W., Dickinson S., and Holmes D. Diabetes Care 25 (2002) 869-875
17. Shipp M.A., and Look A.T. Blood 82 (1993) 1052-1070
18. Holst J.J. Adv. Exp. Med. Biol. 524 (2003) 263-279
19. Lankas G., Leitning B., Roy R.S., Eiermann G., Beconi M.G., Biftu T., Chan C.C., Edmondson S., Feeney W.P., He H., Ippolito D.E., Kim D., Lyons K.A., Ok H.O., Patel R.A., Petrov A.N., Pryor K.A., Qian X., Reigle L., Woods A., Wu J.K., Zaller D., Zhang X., Zhu L., Weber A.E., and Thornberry N.A. Diabetes 54 (2005) 2988-2994
20. Green B.D., Gault V.A., O'Harte F.P.M., and Flatt P.R. Curr. Pharm. Des. 10 (2004) 3651-3662
21. Holst J.J., and Deacon C.F. Curr. Opin. Pharmacol. 4 (2004) 589-596
22. Kolterman O., Buse J., Fineman M., Gaines E., Heintz S., Bicsak T., Taylor K., Kim D., Aisporna M., Wang Y., and Baron A. J. Clin. Endocrinol. Metab. 88 (2003) 3082-3089
23. Hinke S.A., Lynn F., Ehses J., Pamir N., Manhart S., Kuhn-Wache K., Rosche F., Demuth H.U., Pederson R.A., and McIntosh C.H.S. Adv. Exp. Med. Biol. 524 (2003) 293-301
24. O'Harte F.P.M., Gault V.A., Parker J.C., Harriott P., Mooney M.H., Bailey C.J., and Flatt P.R. Diabetologia 45 (2002) 1281-1291
25. Gault V.A., Flatt P.R., Bailey C.J., Harriott P., Greer B., Mooney M.H., and O'Harte F.P.M. Biochem. J. 367 (2002) 913-920
26. Gault V.A., O'Harte F.P.M., Harriott P., and Flatt P.R. Metabolism 52 (2003) 679-687
27. Gault V.A., Flatt P.R., Harriott P., Mooney M.H., Bailey C.J., and O'Harte F.P.M. J. Endocrinol. 176 (2003) 133-141
28. Hinke S.A., Gelling R.W., Pederson R.A., Manhart S., Nian C., Demuth H.U., and McIntosh C.H.S. Diabetes 51 (2002) 652-661
29. Hinke S.A., Gelling R., Manhart S., Lynn F., Pederson R.A., Kuhn-Wache K., Rosche F., Demuth H.U., Coy D., and McIntosh C.H.S. Biol. Chem. 384 (2003) 403-407
30. Hinke S.A., Manhart S., Kuhn-Wache K., Nian C., Demuth H.U., Pederson R.A., and McIntosh C.H.S. J. Biol. Chem. 279 (2004) 3998-4006
31. Juhl C.B., Hollingdal M., Sturis J., Jakobsen G., Agerso H., Veldhuis J., Porksen M., and Schmitz O. Diabetes 51 (2002) 424-429
32. Meier J.J., Goetze O., Anstipp J., Hagemann D., Holst J.J., Schmidt W.E., Gallwitz B., and Nauck M.A. Am. J. Physiol. Endocrinol. Metab. 286 (2004) E621-E625
33. Gault V.A., O'Harte F.P.M., Harriott P., and Flatt P.R. Biochem. Biophys. Res. Commun. 290 (2002) 1420-1426
34. Gault V.A., O'Harte F.P.M., Harriott P., Mooney M.H., Green B.D., and Flatt P.R. Diabetologia 46 (2003) 222-230
35. Miyawaki K., Yamada Y., Ban N., Ihara Y., Tsukiyama K., Zhou H., Fujimoto S., Oku A., Tsuda K., Toyokuni S., Hiai H., Mizunoya W., Fushiki T., Holst J.J., Makino M., Tashita A., Kobara Y., Tsubamoto Y., Jinnouchi T., Jomori T., and Seino Y. Nat. Med. 8 (2002) 738-742
36. Gault V.A., Irwin N., Green B.D., McCluskey J.T., Greer B., Bailey C.J., Harriott P., O'Harte F.P.M., and Flatt P.R. Diabetes 54 (2005) 2436-2446
37. Gremlich S., Porret A., Hani E.H., Cherif D., Vionnet N., Froguel P., and Thorens B. Diabetes 44 (1995) 1202-1208
38. McClenaghan N.H., Barnett C.R., Ah-Sing E., Abdel-Wahab Y.H.A., O'Harte F.P.M., Yoon T.W., Swanston-Flatt S.K., and Flatt P.R. Diabetes 45 (1996) 1132-1140
39. Flatt P.R., and Bailey C.J. Diabetologia 20 (1981) 573-577
40. Bailey C.J., Flatt P.R., and Atkins T.W. Int. J. Obes. 6 (1982) 11-21
41. Stevens J.F. Clin. Chem. Acta. 32 (1971) 199-201
42. Ehses J.A., Lee S.S., Pederson R., and McIntosh C.H.S. J. Biol. Chem. 276 (2001) 23667-23673
43. Bailey C.J., and Flatt P.R. Textbook of diabetes. third ed. (2003), Blackwell Science, Oxford, UK
44. Flatt P.R., Bailey C.J., Kwasowski P., Swanston-Flatt S.K., and Marks V. Diabetes 32 (1983) 433-435
45. Yip R.G., and Wolfe M.M. Life Sci. 66 (2000) 91-103
46. O'Harte F.P.M., Gray A.M., and Flatt P.R. J. Endocrinol. 156 (1998) 237-243