DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo

European Journal of Immunology

Volumn 39, Issue 4, 2009, Pages 1129-1135

  Tassi, Ilaria ^a   Le Friec, Gaelle ^a   Gilfillan, Susan ^a   Takai, Toshiyuki ^b   Yokohama, Wayne M ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cytomegalovirus; Innate immunity; Signaling

Indexed keywords

GAMMA INTERFERON; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LYSINE; MEMBRANE PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN DAP10; UNCLASSIFIED DRUG; HCST PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; KLRA4 PROTEIN, MOUSE; KLRA8 PROTEIN, MOUSE; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY A; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROBP PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; IN VIVO STUDY; INFECTION CONTROL; INNATE IMMUNITY; KNOCKOUT MOUSE; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; BETAHERPESVIRINAE; C57BL MOUSE; CYTOTOXICITY; GENETICS; HERPES VIRUS INFECTION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; VIROLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; HERPESVIRIDAE INFECTIONS; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MUROMEGALOVIRUS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY A; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 65449185938     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838972     Document Type: Article

References (25)

1. Arase, H., Mocarski, E. S., Campbell, A. E., Hill, A. B. and Lanier, L. L., Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 2002. 296: 1323-1326.
2. Smith, H. R., Heusel, J. W., Mehta, I. K., Kim, S., Dorner, B. G., Naidenko, O. V., Iizuka, K. et al., Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc. Natl. Acad. Sci. USA 2002. 99: 8826-8831.
3. Furukawa, H., Iizuka, K., Poursine-Laurent, J., Shastri, N. and Yokoyama, W. M., A ligand for the murine NK activation receptor Ly-49D: Activation of tolerized NK cells from beta 2-microglobulin-deficient mice. J. Immunol. 2002. 169: 126-136.
4. Eagle, R. A., Traherne, J. A., Ashiru, O., Wills, M. R. and Trowsdale, J., Regulation of NKG2D ligand gene expression. Hum. Immunol. 2006. 67: 159-169.
5. Lanier, L. L., Up on the tightrope: Natural killer cell activation and inhibition. Nat. Immunol. 2008. 9: 495-502.
6. Tassi, I., Klesney-Tait, J. and Colonna, M., Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse. Immunol. Rev. 2006. 214: 92-105.
7. Anderson, S. K., Ortaldo, J. R. and McVicar, D. W., The everexpanding Ly49 gene family: Repertoire and signaling. Immunol. Rev. 2001. 181: 79-89.
8. Giurisato, E., Cella, M., Takai, T., Kurosaki, T., Feng, Y., Longmore, G. D., Colonna, M. and Shaw, A. S., Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol. Cell. Biol. 2007. 27: 8583-8599.
9. Upshaw, J. L., Arneson, L. N., Schoon, R. A., Dick, C. J., Billadeau, D. D. and Leibson, P. J., NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat. Immunol. 2006. 7: 524-532.
10. Billadeau, D. D., Upshaw, J. L., Schoon, R. A., Dick, C. J. and Leibson, P. J., NKG2D-DAP10 triggers human NK cell-mediated killing via a Sykindependent regulatory pathway. Nat. Immunol. 2003. 4: 557-564.
11. Graham, D. B., Cella, M., Giurisato, E., Fujikawa, K., Miletic, A. V., Kloeppel, T., Brim, K. et al., Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J. Immunol. 2006. 177: 2349-2355.
12. Zompi, S., Hamerman, J. A., Ogasawara, K., Schweighoffer, E., Tybulewicz, V. L., Di Santo, J. P., Lanier, L. L. and Colucci, F., NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 2003. 4: 565-572.
13. Smith, K. M., Wu, J., Bakker, A. B., Phillips, J. H. and Lanier, L. L., Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 1998. 161: 7-10.
14. Mason, L. H., Willette-Brown, J., Anderson, S. K., Gosselin, P., Shores, E. W., Love, P. E., Ortaldo, J. R. and McVicar, D. W., Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J. Immunol. 1998. 160: 4148-4152.
15. Wu, J., Song, Y., Bakker, A. B., Bauer, S., Spies, T., Lanier, L. L. and Phillips, J. H., An activating immunoreceptor complex formed by NKG2D and DAP10. Science 1999. 285: 730-732.
16. Diefenbach, A., Tomasello, E., Lucas, M., Jamieson, A. M., Hsia, J. K., Vivier, E. and Raulet, D. H., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 2002. 3: 1142-1149.
17. Gilfillan, S., Ho, E. L., Cella, M., Yokoyama, W. M. and Colonna, M., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 2002. 3: 1150-1155.
18. Coudert, J. D., Scarpellino, L., Gros, F., Vivier, E. and Held, W., Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. Blood 2008. 111: 3571-3578.
19. Bakker, A. B., Hoek, R. M., Cerwenka, A., Blom, B., Lucian, L., McNeil, T., Murray, R. et al., DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity 2000. 13: 345-353.
20. Tomasello, E., Desmoulins, P. O., Chemin, K., Guia, S., Cremer, H., Ortaldo, J., Love, P. et al., Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 2000. 13: 355-364.
21. + T cells. J. Exp. Med. 1997. 186: 1957-1963.
22. Dokun, A. O., Kim, S., Smith, H. R., Kang, H. S., Chu, D. T. and Yokoyama, W. M., Specific and nonspecific NK cell activation during virus infection. Nat. Immunol. 2001. 2: 951-956.
23. Sjolin, H., Tomasello, E., Mousavi-Jazi, M., Bartolazzi, A., Karre, K., Vivier, E. and Cerboni, C., Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection. J. Exp. Med. 2002. 195: 825-834.
24. Tassi, I., Presti, R., Kim, S., Yokoyama, W. M., Gilfillan, S. and Colonna, M., Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J. Immunol. 2005. 175: 749-754.
25. Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T. et al., Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004. 428: 758-763.