메뉴 건너뛰기




Volumn 179, Issue 8, 2007, Pages 5346-5357

The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; ESCHERICHIA COLI ENTEROTOXIN; IMMUNOLOGICAL ADJUVANT; LTK 63; LTK63; UNCLASSIFIED DRUG; BACTERIAL TOXIN; ENTEROTOXIN; ENTEROTOXIN LT; ESCHERICHIA COLI PROTEIN;

EID: 38449108512     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.8.5346     Document Type: Article
Times cited : (29)

References (43)
  • 2
    • 14744303986 scopus 로고    scopus 로고
    • Mucosal adjuvants
    • Freytag, L. C., and J. D. Clements. 2005. Mucosal adjuvants. Vaccine 23: 1804-1813.
    • (2005) Vaccine , vol.23 , pp. 1804-1813
    • Freytag, L.C.1    Clements, J.D.2
  • 4
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman, D. M. 2004. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4: 249-258.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 5
    • 0023916532 scopus 로고
    • Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb
    • Fukuta, S., J. L. Magnani, E. M. Twiddy, R. K. Holmes, and V. Ginsburg. 1988. Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb. Infect. Immun. 56: 1748-1753.
    • (1988) Infect. Immun , vol.56 , pp. 1748-1753
    • Fukuta, S.1    Magnani, J.L.2    Twiddy, E.M.3    Holmes, R.K.4    Ginsburg, V.5
  • 6
    • 0032748077 scopus 로고    scopus 로고
    • Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins
    • Rappuoli, R., M. Pizza, G. Douce, and G. Dougan. 1999. Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. Immunol. Today 20: 493-500.
    • (1999) Immunol. Today , vol.20 , pp. 493-500
    • Rappuoli, R.1    Pizza, M.2    Douce, G.3    Dougan, G.4
  • 7
    • 0242349115 scopus 로고    scopus 로고
    • Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA
    • Marinaro, M., A. Riccomi, R. Rappuoli, M. Pizza, V. Fiorelli, A. Tripiciano, A. Cafaro, B. Ensoli, and M. T. De Magistris. 2003. Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA. Vaccine 21: 3972-3981.
    • (2003) Vaccine , vol.21 , pp. 3972-3981
    • Marinaro, M.1    Riccomi, A.2    Rappuoli, R.3    Pizza, M.4    Fiorelli, V.5    Tripiciano, A.6    Cafaro, A.7    Ensoli, B.8    De Magistris, M.T.9
  • 8
    • 0031025178 scopus 로고    scopus 로고
    • Adjuvant activity of the heat-labile enterotoxin from enterotoxigenic Escherichia coli for oral administration of inactivated influenza virus vaccine
    • Katz, J. M., X. Lu, S. A. Young, and J. C. Galphin. 1997. Adjuvant activity of the heat-labile enterotoxin from enterotoxigenic Escherichia coli for oral administration of inactivated influenza virus vaccine. J. Infect. Dis. 175: 352-363.
    • (1997) J. Infect. Dis , vol.175 , pp. 352-363
    • Katz, J.M.1    Lu, X.2    Young, S.A.3    Galphin, J.C.4
  • 9
    • 0032489830 scopus 로고    scopus 로고
    • Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity
    • Giuliani, M. M., G. Del Giudice, V. Giannelli, G. Dougan, G. Douce, R. Rappuoli, and M. Pizza. 1998. Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity. J. Exp. Med. 187: 1123-1132.
    • (1998) J. Exp. Med , vol.187 , pp. 1123-1132
    • Giuliani, M.M.1    Del Giudice, G.2    Giannelli, V.3    Dougan, G.4    Douce, G.5    Rappuoli, R.6    Pizza, M.7
  • 12
    • 0033797049 scopus 로고    scopus 로고
    • Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55
    • Neidleman, J. A., M. Vajdy, M. Ugozzoli, G. Ott, and D. O'Hagan. 2000. Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55. Immunology 101: 154-160.
    • (2000) Immunology , vol.101 , pp. 154-160
    • Neidleman, J.A.1    Vajdy, M.2    Ugozzoli, M.3    Ott, G.4    O'Hagan, D.5
  • 13
    • 1542267689 scopus 로고    scopus 로고
    • Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system
    • Baudner, B. C., M. Morandi, M. M. Giuliani, J. C. Verhoef, H. E. Junginger, P. Costantino, R. Rappuoli, and G. Del Giudice. 2004. Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system. J. Infect. Dis. 189: 828-832.
    • (2004) J. Infect. Dis , vol.189 , pp. 828-832
    • Baudner, B.C.1    Morandi, M.2    Giuliani, M.M.3    Verhoef, J.C.4    Junginger, H.E.5    Costantino, P.6    Rappuoli, R.7    Del Giudice, G.8
  • 14
    • 0031986493 scopus 로고    scopus 로고
    • Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant
    • Marchetti, M., M. Rossi, V. Giannelli, M. M. Giuliani, M. Pizza, S. Censini, A. Covacci, P. Massari, C. Pagliaccia, R. Manetti, et al. 1998. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine 16: 33-37.
    • (1998) Vaccine , vol.16 , pp. 33-37
    • Marchetti, M.1    Rossi, M.2    Giannelli, V.3    Giuliani, M.M.4    Pizza, M.5    Censini, S.6    Covacci, A.7    Massari, P.8    Pagliaccia, C.9    Manetti, R.10
  • 16
    • 0036182480 scopus 로고    scopus 로고
    • Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice
    • Jakobsen, H., S. Bjarnarson, G. Del Giudice, M. Moreau, C. A. Siegrist, and I. Jonsdottir. 2002. Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice. Infect. Immun. 70: 1443-1452.
    • (2002) Infect. Immun , vol.70 , pp. 1443-1452
    • Jakobsen, H.1    Bjarnarson, S.2    Del Giudice, G.3    Moreau, M.4    Siegrist, C.A.5    Jonsdottir, I.6
  • 17
    • 0141501124 scopus 로고    scopus 로고
    • Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses
    • Tierney, R., A. S. Beignon, R. Rappuoli, S. Muller, D. Sesardic, and C. D. Partidos. 2003. Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses. J. Infect. Dis. 188: 753-758.
    • (2003) J. Infect. Dis , vol.188 , pp. 753-758
    • Tierney, R.1    Beignon, A.S.2    Rappuoli, R.3    Muller, S.4    Sesardic, D.5    Partidos, C.D.6
  • 18
    • 33646447036 scopus 로고    scopus 로고
    • Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers
    • Stephenson, I., M. C. Zambon, A. Rudin, A. Colegate, A. Podda, R. Bugarini, G. Del Giudice, A. Minutello, S. Bonnington, J. Holmgren, et al. 2006. Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. J. Virol. 80: 4962-4970.
    • (2006) J. Virol , vol.80 , pp. 4962-4970
    • Stephenson, I.1    Zambon, M.C.2    Rudin, A.3    Colegate, A.4    Podda, A.5    Bugarini, R.6    Del Giudice, G.7    Minutello, A.8    Bonnington, S.9    Holmgren, J.10
  • 19
    • 33644746129 scopus 로고    scopus 로고
    • A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei
    • Waag, D. M., M. J. McCluskie, N. Zhang, and A. M. Krieg. 2006. A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei. Infect. Immun. 74: 1944-1948.
    • (2006) Infect. Immun , vol.74 , pp. 1944-1948
    • Waag, D.M.1    McCluskie, M.J.2    Zhang, N.3    Krieg, A.M.4
  • 20
    • 12344321508 scopus 로고    scopus 로고
    • Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner
    • Edwards, L., A. E. Williams, A. M. Krieg, A. J. Rae, R. J. Snelgrove, and T. Hussell. 2005. Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner. Eur. J. Immunol. 35: 273-281.
    • (2005) Eur. J. Immunol , vol.35 , pp. 273-281
    • Edwards, L.1    Williams, A.E.2    Krieg, A.M.3    Rae, A.J.4    Snelgrove, R.J.5    Hussell, T.6
  • 21
    • 10344265511 scopus 로고    scopus 로고
    • Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease
    • Williams, A. E., L. Edwards, I. R. Humphreys, R. Snelgrove, A. Rae, R. Rappuoli, and T. Hussell. 2004. Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease. J. Immunol. 173: 7435-7443.
    • (2004) J. Immunol , vol.173 , pp. 7435-7443
    • Williams, A.E.1    Edwards, L.2    Humphreys, I.R.3    Snelgrove, R.4    Rae, A.5    Rappuoli, R.6    Hussell, T.7
  • 22
    • 59849124921 scopus 로고
    • The ultrastructure of mouse lung: The alveolar macrophage
    • Karrer, H. E. 1958. The ultrastructure of mouse lung: the alveolar macrophage. J. Biophys. Biochem. Cytol. 4: 693-700.
    • (1958) J. Biophys. Biochem. Cytol , vol.4 , pp. 693-700
    • Karrer, H.E.1
  • 23
    • 0037099005 scopus 로고    scopus 로고
    • Saal, L. H., C. Troein, J. Vallon-Christersson, S. Gruvberger, A. Borg, and C. Peterson. 2002. BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data. Genome Biol. 3: SOFTWARE0003.
    • Saal, L. H., C. Troein, J. Vallon-Christersson, S. Gruvberger, A. Borg, and C. Peterson. 2002. BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data. Genome Biol. 3: SOFTWARE0003.
  • 25
    • 2942617055 scopus 로고    scopus 로고
    • A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma
    • van Rijt, L. S., H. Kuipers, N. Vos, D. Hijdra, H. C. Hoogsteden, and B. N. Lambrecht. 2004. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J. Immunol. Methods 288: 111-121.
    • (2004) J. Immunol. Methods , vol.288 , pp. 111-121
    • van Rijt, L.S.1    Kuipers, H.2    Vos, N.3    Hijdra, D.4    Hoogsteden, H.C.5    Lambrecht, B.N.6
  • 27
    • 0141888552 scopus 로고    scopus 로고
    • Reactions that generate aromatic molecules: Is aromatic stabilization less or more advanced than bond changes at the transition state? Kinetic and thermodynamic acidities of rhenium carbene complexes
    • Bernasconi, C. F., M. L. Ragains, and S. Bhattacharya. 2003. Reactions that generate aromatic molecules: is aromatic stabilization less or more advanced than bond changes at the transition state? Kinetic and thermodynamic acidities of rhenium carbene complexes. J. Am. Chem. Soc. 125: 12328-12336.
    • (2003) J. Am. Chem. Soc , vol.125 , pp. 12328-12336
    • Bernasconi, C.F.1    Ragains, M.L.2    Bhattacharya, S.3
  • 28
    • 33745158157 scopus 로고
    • A simple method of estimating fifty per cent endpoints
    • Reed, L. J., and J. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27: 493-497.
    • (1938) Am. J. Hyg , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, J.2
  • 29
    • 0035863580 scopus 로고    scopus 로고
    • Potency of a genetically detoxified mucosal adjuvant derived from the heat-labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of preexisting immunity to the adjuvant
    • Ugozzoli, M., G. Santos, J. Donnelly, and D. T. O'Hagan. 2001. Potency of a genetically detoxified mucosal adjuvant derived from the heat-labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of preexisting immunity to the adjuvant. J. Infect. Dis. 183: 351-354.
    • (2001) J. Infect. Dis , vol.183 , pp. 351-354
    • Ugozzoli, M.1    Santos, G.2    Donnelly, J.3    O'Hagan, D.T.4
  • 30
    • 0030066516 scopus 로고    scopus 로고
    • Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant
    • Di Tommaso, A., G. Saletti, M. Pizza, R. Rappuoli, G. Dougan, S. Abrignani, G. Douce, and M. T. De Magistris. 1996. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect. Immun. 64: 974-979.
    • (1996) Infect. Immun , vol.64 , pp. 974-979
    • Di Tommaso, A.1    Saletti, G.2    Pizza, M.3    Rappuoli, R.4    Dougan, G.5    Abrignani, S.6    Douce, G.7    De Magistris, M.T.8
  • 31
    • 0036716434 scopus 로고    scopus 로고
    • Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles
    • Baudner, B. C., O. Balland, M. M. Giuliani, P. Von Hoegen, R. Rappuoli, D. Betbeder, and G. Del Giudice. 2002. Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles. Infect. Immun. 70: 4785-4790.
    • (2002) Infect. Immun , vol.70 , pp. 4785-4790
    • Baudner, B.C.1    Balland, O.2    Giuliani, M.M.3    Von Hoegen, P.4    Rappuoli, R.5    Betbeder, D.6    Del Giudice, G.7
  • 32
    • 0242317689 scopus 로고    scopus 로고
    • The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines
    • Baudner, B. C., M. M. Giuliani, J. C. Verhoef, R. Rappuoli, H. E. Junginger, and G. D. Giudice. 2003. The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines. Vaccine 21: 3837-3844.
    • (2003) Vaccine , vol.21 , pp. 3837-3844
    • Baudner, B.C.1    Giuliani, M.M.2    Verhoef, J.C.3    Rappuoli, R.4    Junginger, H.E.5    Giudice, G.D.6
  • 33
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma, G. C., R. P. Custer, and M. J. Bosma. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301: 527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 34
    • 23244454436 scopus 로고    scopus 로고
    • CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen
    • Osterholzer, J. J., T. Ames, T. Polak, J. Sonstein, B. B. Moore, S. W. Chensue, G. B. Toews, and J. L. Curtis. 2005. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J. Immunol. 175: 874-883.
    • (2005) J. Immunol , vol.175 , pp. 874-883
    • Osterholzer, J.J.1    Ames, T.2    Polak, T.3    Sonstein, J.4    Moore, B.B.5    Chensue, S.W.6    Toews, G.B.7    Curtis, J.L.8
  • 35
    • 0142031430 scopus 로고    scopus 로고
    • Role of Toll-like receptors in pathogen recognition
    • Janssens, S., and R. Beyaert. 2003. Role of Toll-like receptors in pathogen recognition. Clin. Microbiol. Rev. 16: 637-646.
    • (2003) Clin. Microbiol. Rev , vol.16 , pp. 637-646
    • Janssens, S.1    Beyaert, R.2
  • 36
    • 0036748197 scopus 로고    scopus 로고
    • Pulmonary innate immune proteins and receptors that interact with gram-positive bacterial ligands
    • Palaniyar, N., J. Nadesalingam, and K. B. Reid. 2002. Pulmonary innate immune proteins and receptors that interact with gram-positive bacterial ligands. Immunobiology 205: 575-594.
    • (2002) Immunobiology , vol.205 , pp. 575-594
    • Palaniyar, N.1    Nadesalingam, J.2    Reid, K.B.3
  • 37
    • 33645978992 scopus 로고    scopus 로고
    • Emerging patterns in complement-mediated pathogen recognition
    • Roozendaal, R., and M. C. Carroll. 2006. Emerging patterns in complement-mediated pathogen recognition. Cell 125: 29-32.
    • (2006) Cell , vol.125 , pp. 29-32
    • Roozendaal, R.1    Carroll, M.C.2
  • 38
    • 0041524018 scopus 로고    scopus 로고
    • Inflammatory response to infectious pulmonary injury
    • Delclaux, C., and E. Azoulay. 2003. Inflammatory response to infectious pulmonary injury. Eur. Respir. J. Suppl. 42:10s-14s.
    • (2003) Eur. Respir. J. Suppl , vol.42
    • Delclaux, C.1    Azoulay, E.2
  • 39
    • 33644838001 scopus 로고    scopus 로고
    • Modulation of dendritic cell trafficking to and from the airways
    • Jakubzick, C., F. Tacke, J. Llodra, N. van Rooijen, and G. J. Randolph. 2006. Modulation of dendritic cell trafficking to and from the airways. J. Immunol. 176: 3578-3584.
    • (2006) J. Immunol , vol.176 , pp. 3578-3584
    • Jakubzick, C.1    Tacke, F.2    Llodra, J.3    van Rooijen, N.4    Randolph, G.J.5
  • 40
    • 0034613727 scopus 로고    scopus 로고
    • Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology
    • Walzl, G., S. Tafuro, P. Moss, P. J. Openshaw, and T. Hussell. 2000. Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J. Exp. Med. 192: 1317-1326.
    • (2000) J. Exp. Med , vol.192 , pp. 1317-1326
    • Walzl, G.1    Tafuro, S.2    Moss, P.3    Openshaw, P.J.4    Hussell, T.5
  • 43
    • 0037037542 scopus 로고    scopus 로고
    • CD4 effector T cell subsets in the response to influenza: Heterogeneity, migration, and function
    • Roman, E., E. Miller, A. Harmsen, J. Wiley, U. H. Von Andrian, G. Huston, and S. L. Swain. 2002. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196: 957-968.
    • (2002) J. Exp. Med , vol.196 , pp. 957-968
    • Roman, E.1    Miller, E.2    Harmsen, A.3    Wiley, J.4    Von Andrian, U.H.5    Huston, G.6    Swain, S.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.