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Volumn 29, Issue 24, 2010, Pages 3465-3476

Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma

Author keywords

Hedgehog; Medulloblastoma; Notch; RBP J; Therapy

Indexed keywords

CRE RECOMBINASE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; NOTCH RECEPTOR; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HES 5; TRANSCRIPTION FACTOR MATH1; UNCLASSIFIED DRUG;

EID: 77953767906     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.101     Document Type: Article
Times cited : (21)

References (71)
  • 1
    • 33644509505 scopus 로고    scopus 로고
    • Patched1 functions as a gatekeeper by promoting cell cycle progression
    • Adolphe C, Hetherington R, Ellis T, Wainwright B. (2006). Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 66: 2081-2088.
    • (2006) Cancer Res , vol.66 , pp. 2081-2088
    • Adolphe, C.1    Hetherington, R.2    Ellis, T.3    Wainwright, B.4
  • 2
    • 8444228878 scopus 로고    scopus 로고
    • An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
    • Adolphe C, Narang M, Ellis T, Wicking C, Kaur P, Wainwright B. (2004). An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131: 5009-5019.
    • (2004) Development , vol.131 , pp. 5009-5019
    • Adolphe, C.1    Narang, M.2    Ellis, T.3    Wicking, C.4    Kaur, P.5    Wainwright, B.6
  • 4
    • 54249163448 scopus 로고    scopus 로고
    • Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth
    • Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ et al. (2008). Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. Cancer Res 68: 7838-7845.
    • (2008) Cancer Res , vol.68 , pp. 7838-7845
    • Binning, M.J.1    Niazi, T.2    Pedone, C.A.3    Lal, B.4    Eberhart, C.G.5    Kim, K.J.6
  • 7
    • 33748542296 scopus 로고    scopus 로고
    • Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice
    • Dakubo GD, Mazerolle CJ, Wallace VA. (2006). Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 79: 221-227.
    • (2006) J Neurooncol , vol.79 , pp. 221-227
    • Dakubo, G.D.1    Mazerolle, C.J.2    Wallace, V.A.3
  • 9
    • 0034221629 scopus 로고    scopus 로고
    • Identification of PATCHED mutations in medulloblastomas by direct sequencing
    • Dong J, Gailani MR, Pomeroy SL, Reardon D, Bale AE. (2000). Identification of PATCHED mutations in medulloblastomas by direct sequencing. Hum Mutat 16: 89-90.
    • (2000) Hum Mutat , vol.16 , pp. 89-90
    • Dong, J.1    Gailani, M.R.2    Pomeroy, S.L.3    Reardon, D.4    Bale, A.E.5
  • 11
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM et al. (2006). Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 66: 7445-7452.
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6
  • 12
    • 7444224783 scopus 로고    scopus 로고
    • Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    • Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D et al. (2004). Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 64: 7787-7793.
    • (2004) Cancer Res , vol.64 , pp. 7787-7793
    • Fan, X.1    Mikolaenko, I.2    Elhassan, I.3    Ni, X.4    Wang, Y.5    Ball, D.6
  • 13
    • 34250001115 scopus 로고    scopus 로고
    • BRCA2 is required for neurogenesis and suppression of medulloblastoma
    • Frappart PO, Lee Y, Lamont J, McKinnon PJ. (2007). BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-2742.
    • (2007) EMBO J , vol.26 , pp. 2732-2742
    • Frappart, P.O.1    Lee, Y.2    Lamont, J.3    McKinnon, P.J.4
  • 14
    • 33645080922 scopus 로고    scopus 로고
    • Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
    • Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H et al. (2006). Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab 3: 59-65.
    • (2006) Cell Metab , vol.3 , pp. 59-65
    • Fujikura, J.1    Hosoda, K.2    Iwakura, H.3    Tomita, T.4    Noguchi, M.5    Masuzaki, H.6
  • 15
    • 0036333524 scopus 로고    scopus 로고
    • Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system
    • Galli R, Fiocco R, De Filippis L, Muzio L, Gritti A, Mercurio S et al. (2002). Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system. Development 129: 1633-1644.
    • (2002) Development , vol.129 , pp. 1633-1644
    • Galli, R.1    Fiocco, R.2    De Filippis, L.3    Muzio, L.4    Gritti, A.5    Mercurio, S.6
  • 16
    • 62749122684 scopus 로고    scopus 로고
    • Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors
    • Gao F, Zhang Q, Zheng MH, Liu HL, Hu YY, Zhang P et al. (2009). Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors. Mol Cell Neurosci 40: 442-450.
    • (2009) Mol Cell Neurosci , vol.40 , pp. 442-450
    • Gao, F.1    Zhang, Q.2    Zheng, M.H.3    Liu, H.L.4    Hu, Y.Y.5    Zhang, P.6
  • 17
    • 63449135077 scopus 로고    scopus 로고
    • MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma
    • Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D et al. (2009). MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS One 4: e4998.
    • (2009) PLoS One , vol.4
    • Garzia, L.1    Andolfo, I.2    Cusanelli, E.3    Marino, N.4    Petrosino, G.5    De Martino, D.6
  • 18
    • 1442307700 scopus 로고    scopus 로고
    • Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
    • Gazit R, Krizhanovsky V, Ben-Arie N. (2004). Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development 131: 903-913.
    • (2004) Development , vol.131 , pp. 903-913
    • Gazit, R.1    Krizhanovsky, V.2    Ben-Arie, N.3
  • 19
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A et al. (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85: 841-851.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3    Gailani, M.R.4    Shanley, S.5    Chidambaram, A.6
  • 20
    • 7444228699 scopus 로고    scopus 로고
    • The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
    • Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA et al. (2004). The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 64: 7794-7800.
    • (2004) Cancer Res , vol.64 , pp. 7794-7800
    • Hallahan, A.R.1    Pritchard, J.I.2    Hansen, S.3    Benson, M.4    Stoeck, J.5    Hatton, B.A.6
  • 22
    • 50649085986 scopus 로고    scopus 로고
    • Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
    • Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R. (2008). Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 135: 2531-2541.
    • (2008) Development , vol.135 , pp. 2531-2541
    • Imayoshi, I.1    Shimogori, T.2    Ohtsuka, T.3    Kageyama, R.4
  • 23
    • 39849098719 scopus 로고    scopus 로고
    • Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling
    • Ingram WJ, McCue KI, Tran TH, Hallahan AR, Wainwright BJ. (2008). Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 27: 1489-1500.
    • (2008) Oncogene , vol.27 , pp. 1489-1500
    • Ingram, W.J.1    McCue, K.I.2    Tran, T.H.3    Hallahan, A.R.4    Wainwright, B.J.5
  • 24
    • 0842334506 scopus 로고    scopus 로고
    • Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells
    • Irvin DK, Nakano I, Paucar A, Kornblum HI. (2004). Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. J Neurosci Res 75: 330-343.
    • (2004) J Neurosci Res , vol.75 , pp. 330-343
    • Irvin, D.K.1    Nakano, I.2    Paucar, A.3    Kornblum, H.I.4
  • 27
    • 0037262305 scopus 로고    scopus 로고
    • Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    • Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH. (2003). Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130: 391-399.
    • (2003) Development , vol.130 , pp. 391-399
    • Kempermann, G.1    Gast, D.2    Kronenberg, G.3    Yamaguchi, M.4    Gage, F.H.5
  • 28
    • 0347722279 scopus 로고    scopus 로고
    • Murine numb regulates granule cell maturation in the cerebellum
    • Klein AL, Zilian O, Suter U, Taylor V. (2004). Murine numb regulates granule cell maturation in the cerebellum. Dev Biol 266: 161-177.
    • (2004) Dev Biol , vol.266 , pp. 161-177
    • Klein, A.L.1    Zilian, O.2    Suter, U.3    Taylor, V.4
  • 29
    • 35348852628 scopus 로고    scopus 로고
    • The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling
    • Komine O, Nagaoka M, Watase K, Gutmann DH, Tanigaki K, Honjo T et al. (2007). The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Dev Biol 311: 238-250.
    • (2007) Dev Biol , vol.311 , pp. 238-250
    • Komine, O.1    Nagaoka, M.2    Watase, K.3    Gutmann, D.H.4    Tanigaki, K.5    Honjo, T.6
  • 30
    • 43249100317 scopus 로고    scopus 로고
    • An obligatory role of mind bomb-1 in notch signaling of mammalian development
    • Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH et al. (2007). An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One 2: e1221.
    • (2007) PLoS One , vol.2
    • Koo, B.K.1    Yoon, M.J.2    Yoon, K.J.3    Im, S.K.4    Kim, Y.Y.5    Kim, C.H.6
  • 32
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P et al. (2004). Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341.
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1    Lingbeek, M.2    Shakhova, O.3    Liu, J.4    Tanger, E.5    Saremaslani, P.6
  • 33
    • 31444447881 scopus 로고    scopus 로고
    • Notch signalling in vertebrate neural development
    • Louvi A, Artavanis-Tsakonas S. (2006). Notch signalling in vertebrate neural development. Nat Rev Neurosci 7: 93-102.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 93-102
    • Louvi, A.1    Artavanis-Tsakonas, S.2
  • 34
    • 0036023380 scopus 로고    scopus 로고
    • Notch1 is required for neuronal and glial differentiation in the cerebellum
    • Lutolf S, Radtke F, Aguet M, Suter U, Taylor V. (2002). Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129: 373-385.
    • (2002) Development , vol.129 , pp. 373-385
    • Lutolf, S.1    Radtke, F.2    Aguet, M.3    Suter, U.4    Taylor, V.5
  • 35
    • 11844301282 scopus 로고    scopus 로고
    • Medulloblastoma: Developmental mechanisms out of control
    • Marino S. (2005). Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 11: 17-22.
    • (2005) Trends Mol Med , vol.11 , pp. 17-22
    • Marino, S.1
  • 36
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. (2000). Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14: 994-1004.
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 37
    • 33646203458 scopus 로고    scopus 로고
    • Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability
    • Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD et al. (2006). Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem 281: 5106-5119.
    • (2006) J Biol Chem , vol.281 , pp. 5106-5119
    • Ong, C.T.1    Cheng, H.T.2    Chang, L.W.3    Ohtsuka, T.4    Kageyama, R.5    Stormo, G.D.6
  • 38
    • 0028223958 scopus 로고
    • Diagnosis, treatment, and outcome of primary central nervous system tumors of childhood
    • Packer RJ. (1994). Diagnosis, treatment, and outcome of primary central nervous system tumors of childhood. Curr Opin Oncol 6: 240-246.
    • (1994) Curr Opin Oncol , vol.6 , pp. 240-246
    • Packer, R.J.1
  • 40
    • 0030913169 scopus 로고    scopus 로고
    • Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
    • Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J et al. (1997). Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 57: 2085-2088.
    • (1997) Cancer Res , vol.57 , pp. 2085-2088
    • Pietsch, T.1    Waha, A.2    Koch, A.3    Kraus, J.4    Albrecht, S.5    Tonn, J.6
  • 41
    • 65549140334 scopus 로고    scopus 로고
    • Notch inhibitors as a new tool in the war on cancer: A pathway to watch
    • Purow B. (2009). Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Curr Pharm Biotechnol 10: 154-160.
    • (2009) Curr Pharm Biotechnol , vol.10 , pp. 154-160
    • Purow, B.1
  • 42
    • 4444273153 scopus 로고    scopus 로고
    • Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
    • Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, Fults DW. (2004). Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 23: 6156-6162.
    • (2004) Oncogene , vol.23 , pp. 6156-6162
    • Rao, G.1    Pedone, C.A.2    Del Valle, L.3    Reiss, K.4    Holland, E.C.5    Fults, D.W.6
  • 43
    • 20444468917 scopus 로고    scopus 로고
    • Targeting medulloblastoma: Small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
    • Romer J, Curran T. (2005). Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res 65: 4975-4978.
    • (2005) Cancer Res , vol.65 , pp. 4975-4978
    • Romer, J.1    Curran, T.2
  • 45
    • 73249116358 scopus 로고    scopus 로고
    • Medulloblastoma: Role of developmental pathways, dna repair signaling, and other players
    • Saran A. (2009). Medulloblastoma: role of developmental pathways, dna repair signaling, and other players. Curr Mol Med 9: 1046-1057.
    • (2009) Curr Mol Med , vol.9 , pp. 1046-1057
    • Saran, A.1
  • 46
    • 34248573807 scopus 로고    scopus 로고
    • Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor
    • Sasai K, Romer JT, Kimura H, Eberhart DE, Rice DS, Curran T. (2007). Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res 67: 3871-3877.
    • (2007) Cancer Res , vol.67 , pp. 3871-3877
    • Sasai, K.1    Romer, J.T.2    Kimura, H.3    Eberhart, D.E.4    Rice, D.S.5    Curran, T.6
  • 47
    • 33646231995 scopus 로고    scopus 로고
    • Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
    • Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ et al. (2006). Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 66: 4215-4222.
    • (2006) Cancer Res , vol.66 , pp. 4215-4222
    • Sasai, K.1    Romer, J.T.2    Lee, Y.3    Finkelstein, D.4    Fuller, C.5    McKinnon, P.J.6
  • 48
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • Schuller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG et al. (2008). Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14: 123-134.
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1    Heine, V.M.2    Mao, J.3    Kho, A.T.4    Dillon, A.K.5    Han, Y.G.6
  • 49
    • 0035974898 scopus 로고    scopus 로고
    • Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
    • Solecki DJ, Liu XL, Tomoda T, Fang Y, Hatten ME. (2001). Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron 31: 557-568.
    • (2001) Neuron , vol.31 , pp. 557-568
    • Solecki, D.J.1    Liu, X.L.2    Tomoda, T.3    Fang, Y.4    Hatten, M.E.5
  • 50
    • 33746090935 scopus 로고    scopus 로고
    • Stem cell marker expression in the Bergmann glia population of the adult mouse brain
    • Sottile V, Li M, Scotting PJ. (2006). Stem cell marker expression in the Bergmann glia population of the adult mouse brain. Brain Res 1099: 8-17.
    • (2006) Brain Res , vol.1099 , pp. 8-17
    • Sottile, V.1    Li, M.2    Scotting, P.J.3
  • 51
    • 0036011255 scopus 로고    scopus 로고
    • Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain
    • Stump G, Durrer A, Klein AL, Lutolf S, Suter U, Taylor V. (2002). Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev 114: 153-159.
    • (2002) Mech Dev , vol.114 , pp. 153-159
    • Stump, G.1    Durrer, A.2    Klein, A.L.3    Lutolf, S.4    Suter, U.5    Taylor, V.6
  • 52
    • 9444261891 scopus 로고    scopus 로고
    • Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway
    • Sweeney C, Morrow D, Birney YA, Coyle S, Hennessy C, Scheller A et al. (2004). Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J 18: 1421-1423.
    • (2004) FASEB J , vol.18 , pp. 1421-1423
    • Sweeney, C.1    Morrow, D.2    Birney, Y.A.3    Coyle, S.4    Hennessy, C.5    Scheller, A.6
  • 53
    • 49349097988 scopus 로고    scopus 로고
    • Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes
    • Talora C, Campese AF, Bellavia D, Felli MP, Vacca A, Gulino A et al. (2008). Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes. Biochim Biophys Acta 1782: 489-497.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 489-497
    • Talora, C.1    Campese, A.F.2    Bellavia, D.3    Felli, M.P.4    Vacca, A.5    Gulino, A.6
  • 54
    • 0032737574 scopus 로고    scopus 로고
    • Notch2 expression negatively correlates with glial differentiation in the postnatal mouse brain
    • Tanaka M, Kadokawa Y, Hamada Y, Marunouchi T. (1999). Notch2 expression negatively correlates with glial differentiation in the postnatal mouse brain. J Neurobiol 41: 524-539.
    • (1999) J Neurobiol , vol.41 , pp. 524-539
    • Tanaka, M.1    Kadokawa, Y.2    Hamada, Y.3    Marunouchi, T.4
  • 55
    • 0036094254 scopus 로고    scopus 로고
    • Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
    • Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K et al. (2002). Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3: 443-450.
    • (2002) Nat Immunol , vol.3 , pp. 443-450
    • Tanigaki, K.1    Han, H.2    Yamamoto, N.3    Tashiro, K.4    Ikegawa, M.5    Kuroda, K.6
  • 56
    • 53349153003 scopus 로고    scopus 로고
    • PARP-1 cooperates with Ptc1 to suppress medullo-blastoma and basal cell carcinoma
    • Tanori M, Mancuso M, Pasquali E, Leonardi S, Rebessi S, Di Majo V et al. (2008). PARP-1 cooperates with Ptc1 to suppress medullo-blastoma and basal cell carcinoma. Carcinogenesis 29: 1911-1919.
    • (2008) Carcinogenesis , vol.29 , pp. 1911-1919
    • Tanori, M.1    Mancuso, M.2    Pasquali, E.3    Leonardi, S.4    Rebessi, S.5    Di Majo, V.6
  • 58
    • 64049091468 scopus 로고    scopus 로고
    • Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression
    • Thomas WD, Chen J, Gao YR, Cheung B, Koach J, Sekyere E et al. (2009). Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression. Oncogene 28: 1605-1615.
    • (2009) Oncogene , vol.28 , pp. 1605-1615
    • Thomas, W.D.1    Chen, J.2    Gao, Y.R.3    Cheung, B.4    Koach, J.5    Sekyere, E.6
  • 59
    • 33646362581 scopus 로고    scopus 로고
    • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    • Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC et al. (2006). Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 24: 1924-1931.
    • (2006) J Clin Oncol , vol.24 , pp. 1924-1931
    • Thompson, M.C.1    Fuller, C.2    Hogg, T.L.3    Dalton, J.4    Finkelstein, D.5    Lau, C.C.6
  • 60
    • 0030874617 scopus 로고    scopus 로고
    • Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours
    • Vorechovsky I, Tingby O, Hartman M, Stromberg B, Nister M, Collins VP et al. (1997). Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours. Oncogene 15: 361-366.
    • (1997) Oncogene , vol.15 , pp. 361-366
    • Vorechovsky, I.1    Tingby, O.2    Hartman, M.3    Stromberg, B.4    Nister, M.5    Collins, V.P.6
  • 61
    • 59849104344 scopus 로고    scopus 로고
    • Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity
    • Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y et al. (2009). Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184: 101-112.
    • (2009) J Cell Biol , vol.184 , pp. 101-112
    • Wall, D.S.1    Mears, A.J.2    McNeill, B.3    Mazerolle, C.4    Thurig, S.5    Wang, Y.6
  • 62
    • 65949098368 scopus 로고    scopus 로고
    • Hedgehog to Hes1: The heist of a Notch target
    • Wall DS, Wallace VA. (2009). Hedgehog to Hes1: the heist of a Notch target. Cell Cycle 8: 1301-1302.
    • (2009) Cell Cycle , vol.8 , pp. 1301-1302
    • Wall, D.S.1    Wallace, V.A.2
  • 63
    • 0141497028 scopus 로고    scopus 로고
    • Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain
    • Wang J, Pham-Mitchell N, Schindler C, Campbell IL. (2003). Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain. J Clin Invest 112: 535-543.
    • (2003) J Clin Invest , vol.112 , pp. 535-543
    • Wang, J.1    Pham-Mitchell, N.2    Schindler, C.3    Campbell, I.L.4
  • 64
    • 33644610874 scopus 로고    scopus 로고
    • Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia
    • Weller M, Krautler N, Mantei N, Suter U, Taylor V. (2006). Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia. Dev Neurosci 28: 70-80.
    • (2006) Dev Neurosci , vol.28 , pp. 70-80
    • Weller, M.1    Krautler, N.2    Mantei, N.3    Suter, U.4    Taylor, V.5
  • 65
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T. (2001). Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61: 513-516.
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 66
    • 0033590110 scopus 로고    scopus 로고
    • The hedgehog signalling pathway in tumorigenesis and development
    • Wicking C, Smyth I, Bale A. (1999). The hedgehog signalling pathway in tumorigenesis and development. Oncogene 18: 7844-7851.
    • (1999) Oncogene , vol.18 , pp. 7844-7851
    • Wicking, C.1    Smyth, I.2    Bale, A.3
  • 67
    • 0037452751 scopus 로고    scopus 로고
    • Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells
    • Yamamoto N, Tanigaki K, Han H, Hiai H, Honjo T. (2003). Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Curr Biol 13: 333-338.
    • (2003) Curr Biol , vol.13 , pp. 333-338
    • Yamamoto, N.1    Tanigaki, K.2    Han, H.3    Hiai, H.4    Honjo, T.5
  • 68
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M et al. (2008). Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14: 135-145.
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3    Read, T.A.4    Kessler, J.D.5    Bourboulas, M.6
  • 69
    • 2442720109 scopus 로고    scopus 로고
    • Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
    • Yokota N, Mainprize TG, Taylor MD, Kohata T, Loreto M, Ueda S et al. (2004). Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 23: 3444-3453.
    • (2004) Oncogene , vol.23 , pp. 3444-3453
    • Yokota, N.1    Mainprize, T.G.2    Taylor, M.D.3    Kohata, T.4    Loreto, M.5    Ueda, S.6
  • 70
    • 0035170704 scopus 로고    scopus 로고
    • HGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
    • Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A. (2001). hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31: 85-94.
    • (2001) Genesis , vol.31 , pp. 85-94
    • Zhuo, L.1    Theis, M.2    Alvarez-Maya, I.3    Brenner, M.4    Willecke, K.5    Messing, A.6
  • 71
    • 34047263220 scopus 로고    scopus 로고
    • Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    • Zindy F, Uziel T, Ayrault O, Calabrese C, Valentine M, Rehg JE et al. (2007). Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67: 2676-2684.
    • (2007) Cancer Res , vol.67 , pp. 2676-2684
    • Zindy, F.1    Uziel, T.2    Ayrault, O.3    Calabrese, C.4    Valentine, M.5    Rehg, J.E.6


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