Role of the G-protein and tyrosine kinase - Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats

Journal of Biochemistry

Volumn 147, Issue 5, 2010, Pages 751-764

  Wang, Yali ^a   Liang, Di ^a   Wang, Shuang ^a   Qiu, Zhaoping ^a   Chu, Xiaojie ^a   Chen, Shuo ^a   Li, Lisha ^a   Nie, Xiaowei ^a   Zhang, Rong ^a   Wang, Zhigang ^a   Zhu, Daling ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

15 hydroxyeicosatetraenoic acid; hypoxia; pulmonary artery smooth muscle cells; pulmonary vasoconstriction; ROK

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; RHO KINASE; SMALL INTERFERING RNA; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; HYDROXYICOSATETRAENOIC ACID; PROTEIN TYROSINE KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME MECHANISM; ENZYME REGULATION; HYPOXIC LUNG VASOCONSTRICTION; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA INTERFERENCE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; UPREGULATION; WESTERN BLOTTING; WISTAR RAT; ANIMAL; ANOXIA; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; VASOCONSTRICTION;

RATTUS;

ANIMALS; ANOXIA; HYDROXYEICOSATETRAENOIC ACIDS; MALE; PROTEIN-TYROSINE KINASES; PULMONARY ARTERY; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; VASOCONSTRICTION;

EID: 77953719603     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvq010     Document Type: Article

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