Suramin disrupts receptor-G protein coupling by blocking association of G protein α and βγ subunits

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 191-198

  Chung, Wen Cheng ^a   Kermode, John C ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; SURAMIN; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CROSS LINKING; DRUG MECHANISM; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; BINDING, COMPETITIVE; CROSS-LINKING REAGENTS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); KINETICS; LUNG; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECOMBINANT PROTEINS; SURAMIN;

EID: 15744364676     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.078311     Document Type: Article

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