Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Kallio, Heini ^a,b   Hilvo, Mika ^c   Rodriguez, Alejandra ^a,b   Lappalainen, Eeva Helena ^a,b   Lappalainen, Anna Maria ^a,b   Parkkila, Seppo ^a,b  

^a UNIVERSITY OF TAMPERE   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE 2A5; CARBONATE DEHYDRATASE IX; CARBOXYPEPTIDASE A1; CHYMOSIN; CHYMOTRYPSINOGEN B1; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 13; DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN; DERMOKINE; GASDERMIN C2; GROWTH DIFFERENTIATION FACTOR 9; INTERLEUKIN 1 RECEPTOR LIKE 1 PROTEIN; INVOLUCRIN; LORICRIN; LYMPHOCYTE ANTIGEN 6 COMPLEX D; NON SPECIFIC CYTOTOXIC CELL RECEPTOR PROTEIN 1; PLAKOPHILIN 4; SCLEROSTIN DOMAIN CONTAINING 1 PROTEIN; SERINE PROTEINASE INHIBITOR B12; SLC27A2 PROTEIN; SMALL PROLINE RICH PROTEIN 1A; SMALL PROLINE RICH PROTEIN 2D; SMALL PROLINE RICH PROTEIN 2I; SODIUM PROTON EXCHANGE PROTEIN 3; SURFACTANT PROTEIN D; TRANSMEMBRANE 4 SUPERFAMILY 5 PROTEIN; TRIACYLGLYCEROL LIPASE; TRYPSIN 4; UNCLASSIFIED DRUG; UNINDEXED DRUG; CARBONATE DEHYDRATASE; CARBONIC ANHYDRASE IX, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBONATE DEHYDRATASE IX DEFICIENCY; CELL DIFFERENTIATION; CONTROLLED STUDY; DEVELOPMENT; DOWN REGULATION; ENZYME DEFICIENCY; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE REPRESSION; IMMUNE RESPONSE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH; STOMACH MUCOSA; ANIMAL; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; GENOMICS; HUMAN; HYPERPLASIA; MALE; METABOLISM; PATHOLOGY; PHENOTYPE; PREGNANCY; REPRODUCIBILITY;

MUS;

ANIMALS; CARBONIC ANHYDRASES; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; HYPERPLASIA; MALE; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PREGNANCY; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH; TRANSCRIPTION, GENETIC;

EID: 77953712547     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-397     Document Type: Article

References (77)

1. Sly WS, Hu PY. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem 1995, 64:375-401. 10.1146/annurev.bi.64.070195.002111, 7574487.
2. Parkkila S. An overview of the distribution and function of carbonic anhydrase in mammals. Exs 2000, (90):79-93.
3. Hilvo M, Tolvanen M, Clark A, Shen B, Shah GN, Waheed A, Halmi P, Hanninen M, Hamalainen JM, Vihinen M, Sly WS, Parkkila S. Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. Biochem J 2005, 392(Pt 1):83-92. 1317667, 16083424.
4. Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S. Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J Biol Chem 2008, 283(41):27799-27809. 10.1074/jbc.M800938200, 18703501.
5. Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G. Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc Natl Acad Sci USA 2009, 106(38):16233-16238. 10.1073/pnas.0908301106, 2752527, 19805286.
6. Pastorekova S. Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Cancer Therapy 2004, 2:245-262.
7. Svastova E, Zilka N, Zat'ovicova M, Gibadulinova A, Ciampor F, Pastorek J, Pastorekova S. Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin. Exp Cell Res 2003, 290(2):332-345. 10.1016/S0014-4827(03)00351-3, 14567991.
8. Pastorekova S, Parkkila S, Parkkila AK, Opavsky R, Zelnik V, Saarnio J, Pastorek J. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 1997, 112(2):398-408. 10.1053/gast.1997.v112.pm9024293, 9024293.
9. Hilvo M, Rafajova M, Pastorekova S, Pastorek J, Parkkila S. Expression of carbonic anhydrase IX in mouse tissues. J Histochem Cytochem 2004, 52(10):1313-1322. 10.1369/jhc.3A6225.2004, 15385577.
10. Leppilampi M, Saarnio J, Karttunen TJ, Kivela J, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S. Carbonic anhydrase isozymes IX and XII in gastric tumors. World J Gastroenterol 2003, 9(7):1398-1403.
11. Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000, 60(24):7075-7083.
12. Svastova E, Hulikova A, Rafajova M, Zat'ovicova M, Gibadulinova A, Casini A, Cecchi A, Scozzafava A, Supuran CT, Pastorek J, Pastorekova S. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004, 577(3):439-445. 10.1016/j.febslet.2004.10.043, 15556624.
13. Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002, 2(1):38-47. 10.1038/nrc704, 11902584.
14. Kaluz S, Kaluzova M, Chrastina A, Olive PL, Pastorekova S, Pastorek J, Lerman MI, Stanbridge EJ. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. Cancer Res 2002, 62(15):4469-4477.
15. Kopacek J, Barathova M, Dequiedt F, Sepelakova J, Kettmann R, Pastorek J, Pastorekova S. MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX. Biochim Biophys Acta 2005, 1729(1):41-49.
16. Ortova Gut MO, Parkkila S, Vernerova Z, Rohde E, Zavada J, Hocker M, Pastorek J, Karttunen T, Gibadulinova A, Zavadova Z, Knobeloch KP, Wiedenmann B, Svoboda J, Horak I, Pastorekova S. Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 2002, 123(6):1889-1903. 10.1053/gast.2002.37052, 12454846.
17. Leppilampi M, Karttunen TJ, Kivela J, Gut MO, Pastorekova S, Pastorek J, Parkkila S. Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C. Transgenic Res 2005, 14(5):655-663. 10.1007/s11248-005-7215-z, 16245156.
18. Morey JS, Ryan JC, Van Dolah FM. Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biol Proced Online 2006, 8:175-193. 10.1251/bpo126, 1779618, 17242735.
19. Lemercier C, To RQ, Swanson BJ, Lyons GE, Konieczny SF. Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol 1997, 182(1):101-113. 10.1006/dbio.1996.8454, 9073453.
20. Pin CL, Bonvissuto AC, Konieczny SF. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec 2000, 259(2):157-167. 10.1002/(SICI)1097-0185(20000601)259:2<157::AID-AR6>3.0.CO;2-0, 10820318.
21. Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF, Mills JC. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development 2007, 134(1):211-222. 10.1242/dev.02700, 17164426.
22. Heitz PU, Kasper M, van Noorden S, Polak JM, Gregory H, Pearse AG. Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands. Gut 1978, 19(5):408-413. 10.1136/gut.19.5.408, 1412104, 350728.
23. Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 2004, 59(2 Suppl):21-26.
24. Fujisawa T, Kamimura H, Hosaka M, Torii S, Izumi T, Kuwano H, Takeuchi T. Functional localization of proprotein-convertase furin and its substrate TGFbeta in EGF receptor-expressing gastric chief cells. Growth Factors 2004, 22(1):51-59. 10.1080/0897719042000201659, 15176459.
25. Kamimura H, Konda Y, Yokota H, Takenoshita S, Nagamachi Y, Kuwano H, Takeuchi T. Kex2 family endoprotease furin is expressed specifically in pit-region parietal cells of the rat gastric mucosa. Am J Physiol 1999, 277(1 Pt 1):G183-190.
26. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 1997, 17(1):32-39. 10.1038/ng0997-32, 9288095.
27. Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci USA 1999, 96(19):10794-10799. 10.1073/pnas.96.19.10794, 17962, 10485905.
28. De Lisle RC, Petitt M, Huff J, Isom KS, Agbas A. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. Gastroenterology 1997, 113(2):521-532. 10.1053/gast.1997.v113.pm9247472, 9247472.
29. Somerville RP, Shoshan Y, Eng C, Barnett G, Miller D, Cowell JK. Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene 1998, 17(13):1755-1757. 10.1038/sj.onc.1202066, 9796706.
30. Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard GF, Sugimachi K. Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br J Cancer 1999, 79(2):211-213. 10.1038/sj.bjc.6690035, 2362205, 9888459.
31. Takito J, Hikita C, Al-Awqati Q. Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. J Clin Invest 1996, 98(10):2324-2331. 10.1172/JCI119044, 507683, 8941650.
32. Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S. Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol 2007, 178(12):8203-8211.
33. Kojouharova MS, Tsacheva IG, Tchorbadjieva MI, Reid KB, Kishore U. Localization of ligand-binding sites on human C1q globular head region using recombinant globular head fragments and single-chain antibodies. Biochim Biophys Acta 2003, 1652(1):64-74.
34. Cheng H, Bjerknes M, Chen H. CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts. Anat Rec 1996, 244(3):327-343. 10.1002/(SICI)1097-0185(199603)244:3<327::AID-AR5>3.0.CO;2-V, 8742698.
35. Mollenhauer J, Herbertz S, Holmskov U, Tolnay M, Krebs I, Merlo A, Schroder HD, Maier D, Breitling F, Wiemann S, Grone HJ, Poustka A. DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Res 2000, 60(6):1704-1710.
36. Kang W, Nielsen O, Fenger C, Madsen J, Hansen S, Tornoe I, Eggleton P, Reid KB, Holmskov U. The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester. Clin Exp Immunol 2002, 130(3):449-458. 10.1046/j.1365-2249.2002.01992.x, 1906537, 12452835.
37. Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frangsmyr L, Holmskov U, Leffler H, Nilsson C, Boren T, Wright JR, Stromberg N, Fisher SJ. Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem 2000, 275(51):39860-39866. 10.1074/jbc.M006928200, 11007786.
38. Stoddard E, Cannon G, Ni H, Kariko K, Capodici J, Malamud D, Weissman D. gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J Immunol 2007, 179(5):3126-3132.
39. White MR, Crouch E, van Eijk M, Hartshorn M, Pemberton L, Tornoe I, Holmskov U, Hartshorn KL. Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor. Am J Physiol Lung Cell Mol Physiol 2005, 288(5):L831-840. 10.1152/ajplung.00365.2004, 15608147.
40. Wu Z, Van Ryk D, Davis C, Abrams WR, Chaiken I, Magnani J, Malamud D. Salivary agglutinin inhibits HIV type 1 infectivity through interaction with viral glycoprotein 120. AIDS Res Hum Retroviruses 2003, 19(3):201-209. 10.1089/088922203763315704, 12689412.
41. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001, 291(5505):881-884. 10.1126/science.291.5505.881, 11157169.
42. Sun FJ, Kaur S, Ziemer D, Banerjee S, Samuelson LC, De Lisle RC. Decreased gastric bacterial killing and up-regulation of protective genes in small intestine in gastrin-deficient mouse. Dig Dis Sci 2003, 48(5):976-985. 10.1023/A:1023068116934, 12772799.
43. Norkina O, Kaur S, Ziemer D, De Lisle RC. Inflammation of the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol 2004, 286(6):G1032-1041. 10.1152/ajpgi.00473.2003, 14739145.
44. Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J. DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology 2007, 133(5):1499-1509. 10.1053/j.gastro.2007.08.007, 17983803.
45. Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, Bernal AL, Reid KB, Madan T, Chakraborty T. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol 2006, 43(9):1293-1315. 10.1016/j.molimm.2005.08.004, 16213021.
46. Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003, 115(1):13-23. 10.1016/S0092-8674(03)00758-X, 14531999.
47. Wang Y, Wang XY, Subjeck JR, Kim HL. Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant. Mol Cancer Ther 2008, 7(12):3867-3877. 10.1158/1535-7163.MCT-08-0603, 2676339, 19074859.
48. Gachter T, Werenskiold AK, Klemenz R. Transcription of the interleukin-1 receptor-related T1 gene is initiated at different promoters in mast cells and fibroblasts. J Biol Chem 1996, 271(1):124-129. 10.1074/jbc.271.1.124, 8550546.
49. Yanagisawa K, Naito Y, Kuroiwa K, Arai T, Furukawa Y, Tomizuka H, Miura Y, Kasahara T, Tetsuka T, Tominaga S. The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. J Biochem 1997, 121(1):95-103.
50. Xu D, Chan WL, Leung BP, Huang F, Wheeler R, Piedrafita D, Robinson JH, Liew FY. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 1998, 187(5):787-794. 10.1084/jem.187.5.787, 2212173, 9480988.
51. Lohning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A, Kamradt T. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA 1998, 95(12):6930-6935. 10.1073/pnas.95.12.6930, 22690, 9618516.
52. Lecart S, Lecointe N, Subramaniam A, Alkan S, Ni D, Chen R, Boulay V, Pene J, Kuroiwa K, Tominaga S, Yssel H. Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol 2002, 32(10):2979-2987. 10.1002/1521-4141(2002010)32:10<2979::AID-IMMU2979>3.0.CO;2-5, 12355452.
53. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005, 23(5):479-490. 10.1016/j.immuni.2005.09.015, 16286016.
54. Oshikawa K, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Ohno S, Tominaga SI, Sugiyama Y. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med 2001, 164(2):277-281.
55. Oshikawa K, Yanagisawa K, Tominaga S, Sugiyama Y. Expression and function of the ST2 gene in a murine model of allergic airway inflammation. Clin Exp Allergy 2002, 32(10):1520-1526. 10.1046/j.1365-2745.2002.01494.x, 12372135.
56. Hayakawa H, Hayakawa M, Kume A, Tominaga S. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem 2007, 282(36):26369-26380. 10.1074/jbc.M704916200, 17623648.
57. Bachrati CZ, Hickson ID. RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J 2003, 374(Pt 3):577-606. 10.1042/BJ20030491, 1223634, 12803543.
58. German J. Bloom syndrome: a mendelian prototype of somatic mutational disease. Medicine (Baltimore) 1993, 72(6):393-406.
59. German J. Bloom's syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet 1997, 93(1):100-106. 10.1016/S0165-4608(96)00336-6, 9062585.
60. Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 2007, 27(5):1947-1959. 10.1128/MCB.01402-06, 1820471, 17210642.
61. Babbe H, McMenamin J, Hobeika E, Wang J, Rodig SJ, Reth M, Leder P. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol 2009, 182(1):347-360. 2742995, 19109166.
62. Baden HP, Kubilus J, Phillips SB, Kvedar JC, Tahan SR. A new class of soluble basic protein precursors of the cornified envelope of mammalian epidermis. Biochim Biophys Acta 1987, 925(1):63-73.
63. Tesfaigzi J, Carlson DM. Expression, regulation, and function of the SPR family of proteins. A review. Cell Biochem Biophys 1999, 30(2):243-265. 10.1007/BF02738069, 10356644.
64. Nozaki I, Lunz JG, Specht S, Stolz DB, Taguchi K, Subbotin VM, Murase N, Demetris AJ. Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. Lab Invest 2005, 85(1):109-123.
65. Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien KR. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J 2004, 23(22):4517-4525. 10.1038/sj.emboj.7600454, 526469, 15510217.
66. Mueller A, O'Rourke J, Grimm J, Guillemin K, Dixon MF, Lee A, Falkow S. Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proc Natl Acad Sci USA 2003, 100(3):1292-1297. 10.1073/pnas.242741699, 298766, 12552104.
67. Starkey ML, Davies M, Yip PK, Carter LM, Wong DJ, McMahon SB, Bradbury EJ. Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury. J Comp Neurol 2009, 513(1):51-68. 10.1002/cne.21944, 19107756.
68. He P, Yun CC. Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3. J Biomed Biotechnol 2010, 238080. 2789519, 20011065.
69. Hoogerwerf WA, Tsao SC, Devuyst O, Levine SA, Yun CH, Yip JW, Cohen ME, Wilson PD, Lazenby AJ, Tse CM, Donowitz M. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol 1996, 270(1 Pt 1):G29-41.
70. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30(1):207-210. 10.1093/nar/30.1.207, 99122, 11752295.
71. GEO. Gene Expression Omnibus. , http://www.ncbi.nlm.nih.gov/geo/
72. DAVID Bioinformatics Resources. , http://david.abcc.ncifcrf.gov/
73. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003, 4(5):P3.. 10.1186/gb-2003-4-5-p3, 12734009.
74. Primer3. , http://frodo.wi.mit.edu/primer3/
75. Quantitative PCR Primer Database. , http://web.ncifcrf.gov/rtp/gel/primerdb/
76. PrimerBank database. , http://pga.mgh.harvard.edu/primerbank/
77. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3(7):RESEARCH0034. 10.1186/gb-2002-3-7-research0034, 126239, 12184808.