DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer

Cancer Research

Volumn 60, Issue 6, 2000, Pages 1704-1710

  Mollenhauer, Jan ^a   Herbertz, Stephan ^a   Holmskov, Uffe ^b   Tolnay, Markus ^c   Krebs, Inge ^a   Merlo, Adrian ^d   Daa Schrøder, Henrik ^b   Maier, Daniel ^d   Breitling, Frank ^a   Wiemann, Stefan ^a   Gröne, Hermann Josef ^a   Poustka, Annemarie ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TUMOR; GENE DELETION; GENE REARRANGEMENT; GENETIC STABILITY; GLIOBLASTOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR SUPPRESSOR GENE;

AGGLUTININS; BRAIN; BRAIN CHEMISTRY; BRAIN NEOPLASMS; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIFFERENTIATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HL-60 CELLS; HUMANS; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; JURKAT CELLS; LOSS OF HETEROZYGOSITY; NEOPLASMS; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 0034654634     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Mollenhauer, J., Wiemann, S., Scheurlen, W., Korn, B., Hayashi, Y., Wilgenbus, K. K., von Deimling, A., and Poustka, A. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours. Nat. Genet., 17: 32-39, 1997.
2. Somerville, R. P. T., Shoshan, Y., Eng, C., Barnett, G., Miller, D., and Cowell, J. K. Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene, 17: 1755-1757, 1998.
3. Mori, M., Shiraishi, T., Tanaka, S., Yamagata, M., Mafune, K., Tanaka, Y., Ueo, H., Barnard, G. F., Akiyoshi, T., and Sugimachi, K. Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br. J. Cancer, 79: 211-213, 1999.
4. Wu, W., Kemp, B. L., Proctor, M. L., Gazdar, A. F., Minna, J. D., Hong, W. K., and Mao, L. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. Cancer Res., 59: 1846-1851, 1999.
5. Koths, K., Taylor, E., Halenbeck, R., Casipit, C., and Wans, A. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. J. Biol. Chem., 268: 14245-14249, 1993.
6. Fornarini, B., Iacobelli, S., Tinari, N., Natoli, C., De Martino, M., and Sabatino, G. Human milk 90K (Mac-2 BP): possible protective effects against acute respiratory infections. Clin. Exp. Immunol., 115: 91-94, 1999.
7. Ullrich, A., Sures, I., D'Egidio, M., Jallal, B., Powell, T. J., Herbst, R., Dreps, A., Azam, M., Rubinstein, M., Natoli, C., Shawver, L. K., Schlessinger, J., and Iacobelli, S. The secreted tumor-associated antigen 90K is a potent immune stimulator. J. Biol. Chem., 269: 18401-18407, 1994.
8. Jallal, B., Powell, J., Zachwieja, J., Brakebush, C., Germain, L., Jacobs, J., Iacobelli, S., and Ullrich, A. Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Res., 55: 3223-3227, 1995.
9. Inohara, H., Akahani, S., Koths, K., and Raz, A. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Res., 56; 4530-4534, 1996.
10. Sasaki, T., Brakebush, C., Engel, J., and Timpl, R. Mac-2-binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds 81 integrins, collagens and fibronectin. EMBO J., 17: 1606-1613, 1998.
11. Holmskov, U., Lawson, P., Teisner, B., Tornøe, I., Willis, A. C., Morgan, C., Koch, C., and Reid, K. B. M. Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule. J. Biol. Chem., 272: 13743-13749, 1997.
12. Tino, M. J., and Wright, J. R. Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A independent manner. Am. J. Respir. Cell Mol. Biol., 20: 759-768, 1999.
13. Li, X. J., and Snyder, S. H. Molecular cloning of Ebnerin, a von Ebner's Gland protein associated with taste buds. J. Biol. Chem., 270: 17674-17679, 1995.
14. Cheng, H., Bjerknes, M., and Chen, H. CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts. Anat. Rec., 244: 327-343, 1996.
15. Takito, J., Hikita, C., and Al-Awqati, Q. Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. J. Clin. Invest., 98: 2324-2331, 1996.
16. Vijayakumar, S., Takito, J., Hikita, C., and Al-Awqati, Q. Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation. J. Cell Biol., 144: 1057-1067, 1999.
17. Aruffo, A., Bowen, M. A., Patel, D. D., Haynes, B. F., Starling, G. C., Gebe, J. A., and Bajorath, J. CD6-ligand interactions: a paradigm for SRCR domain function? Immunol. Today, 18: 498-504, 1997.
18. Bork, P., and Sander, C. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-β type III receptor. FEBS Lett., 300: 237-240, 1992.
19. Bork, P., and Beckmann, G. The CUB domain a widespread module in developmentally regulated proteins. J. Mol. Biol., 231: 539-545, 1993.
20. Mollenhauer, J., Holmskov, U., Wiemann, S., Krebs, I., Herbertz, S., Madsen, J., Kioschis, P., Coy, J. F., and Poustka, A. The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene, 18: 6233-6240, 1999.
21. Crouch, E. C. Collectins and pulmonary host defense. Am. J. Respir. Cell Mol. Biol., 19: 177-201, 1998.
22. Holmskov, U., Mollenhauer, J., Madsen, J., Vitved, L., Grønlund, J., Tornøe, I., Kliem, A., Reid, K. B. M., Poustka, A., and Skjødt, K. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc. Natl. Acad. Sci. USA, 96: 10794-10799, 1999.
23. Fujita, T., Taira, S., Kodama, N., Matsushita, M., and Fujita, T. Mannose-binding protein recognizes glioma cells: in vitro analysis of complement activation on glioma cells via the lectin pathway. Jpn. J. Cancer Res., 86: 187-192, 1995.
24. Ma, Y., Uemura, K., Oka, S., Kozutsumi, Y., Kawasaki, N., and Kawasaki, T. Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding protein-dependent cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA, 96: 371-375, 1999.
25. Fusco, O., Querzoli, P., Nenci, I., Natoli, C., Brakebush, C., Ullrich, A., and Iacobelli, S. 90K (Mac-2 bp) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells. Int. J. Cancer, 79: 23-26, 1998.
26. Iacobelli, S., Arno, E., Sismondi, P., Natoli, C., Gentiloni, N., Scambia, G., Giai, M., Cortese, P., Benedetti Panici, P., and Mancuso, S. Measurement of breast cancer associated antigen detected by monoclonal antibody SP-2 in sera of cancer patients. Breast Cancer Res. Treat., 11: 19-30, 1988.
27. Taktio, J., Yan, L., Ma, J., Hikita, C., Vijayakumar, S., Warburton, D., and Al-Awqati, Q. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am. J. Physiol., 277: F277-F289, 1999.
28. Hikita, C., Takito, J., Vijayakumar, S., and Al-Awqati, Q. Only multimeric hensin located in the extracellular matrix can induce apical endocytosis and reverse the polarity of intercalated cells. J. Biol. Chem., 274: 17671-17676, 1999.