Molecular mechanisms of tissue fibrosis

Japanese Journal of Clinical Immunology

Volumn 32, Issue 3, 2009, Pages 160-167

  Kimura, Kuniko ^a   Iwano, Masayuki ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Epithelial mesenchymal transition; Fibroblast; Fibrosis; Hypoxia; Toll like receptor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRANSFORMING GROWTH FACTOR BETA;

B LYMPHOCYTE; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPITHELIUM CELL; FIBROBLAST; HUMAN; HYPOXEMIA; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; MESENCHYME CELL; MOLECULAR MECHANICS; PATHOGENESIS; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL HYPOXIA; ENDOTHELIAL CELLS; FIBROBLASTS; FIBROSIS; MICE;

EID: 77953664767     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.32.160     Document Type: Review

References (55)

1. Iwano M, Fischer A, Okada H, et al.: Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts. Mol Ther 3: 149-159, 2001.
2. Okada H, Danoff TM, Kalluri R, et al.: Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 273: F563-574, 1997.
3. Strutz F, Zeisberg M, Ziyadeh FN, et al.: Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61: 1714-1728, 2002.
4. Iwano M, Plieth D, Danoff TM, et al.: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341-350, 2002.
5. Grimm PC, Nickerson P, Jeffery J, et al.: Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection. N Engl J Med 345: 93-97, 2001.
6. Moore BB, Kolodsick JE, Thannickal VJ, et al.: CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 166: 675-684, 2005.
7. Phillips RJ, Burdick MD, Hong K, et al.: Circulating fikbrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114: 438-446, 2004.
8. Sakai N, Wada T, Yokoyama H, et al.: Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proc Natl Acad Sci USA 103: 14098-14103, 2006.
9. Hashimoto N, Jin H, Liu T, et al.: Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113: 243-252, 2004.
10. Zeisberg EM, Tarnavski O, Zeisberg M, et al.: Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13: 952-961, 2007.
11. Zeisberg EM, Potenta SE, Sugimoto H, et al.: Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 19: 2282-2287, 2008.
12. Lin SL, Kisseleva T, Brenner DA, et al.: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis ofthe kidney. Am J Pathol 173: 1617-1627, 2008.
13. Iwano M, Neilson EG.:Mechanisms of tubulointerstitial fibrosis. Curr Opin Nephrol Hypertens 13: 279-284, 2004.
14. Kalluri R, Neilson EG.: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003.
15. Lee JM, Dedhar S, Kalluri R, et al.: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172: 973-981, 2006.
16. Batlle E, Sancho E, Franci C, et al.: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2: 84-89, 2000.
17. Cano A, Perez-Moreno MA, Rodrigo I, et al.: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83, 2000.
18. Zavadil J, Bottinger EP.: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774, 2005.
19. Ikenouchi J, Matsuda M, Furuse M, et al.: Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116: 1959-1967, 2003.
20. McPhee TR, McDonald PC, Oloumi A, et al.: Integrin-linked kinase regulates E-cadherin expression through PARP-1. Dev Dyn 237: 2737-2747, 2008.
21. Schlessinger K, Hall A.: GSK-3beta sets Snail's pace. Nat Cell Biol 6: 913-915, 2004.
22. Ikeda S, Kishida S, Yamamoto H, et al.: Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. Embo J 17: 1371-1384, 1998.
23. Ozdamar B, Bose R, Barrios-Rodiles M, et al.: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307: 1603-1609, 2005.
24. Cheng S, Lovett DH.: Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162: 1937-1949, 2003.
25. Yang J, Shultz RW, Mars WM, et al.: Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 110: 1525-1538, 2002.
26. Radisky DC, Levy DD, Littlepage LE, et al.: Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436: 123-127, 2005.
27. Manotham K, Tanaka T, Matsumoto M, et al.: Evidence of tubular hypoxia in the early phase in the remnant kidney model. J Am Soc Nephrol 15: 1277-1288, 2004.
28. Varga J, Abraham D.: Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 117: 557-567, 2007.
29. Orphanides C, Fine LG, Norman JT.: Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism. Kidney Int 52: 637-647, 1997.
30. Higgins DF, Kimura K, Bernhardt WM, et al.: Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117: 3810-3820, 2007.
31. Kimura K, Iwano M, Higgins DF, et al.: Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol 295: F1023-1029, 2008.
32. Cramer T, Yamanishi Y, Clausen BE, et al.: HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112: 645-657, 2003.
33. Schofield CJ, Ratcliffe PJ.: Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5: 343-354, 2004.
34. Ding M, Cui S, Li C, et al.: Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med 12: 1081-1087, 2006.
35. Erler JT, Bennewith KL, Nicolau M, et al.: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226, 2006.
36. Higgins DF, Biju MP, Akai Y, et al.: Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol 287: F1223-1232, 2004.
37. Bernhardt WM, Campean V, Kany S, et al.: Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol 17: 1970-1978, 2006.
38. Tanaka T, Matsumoto M, Inagi R, et al.: Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis. Kidney Int 68: 2714-2725, 2005.
39. Gruber M, Hu CJ, Johnson RS, et al.:Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA 104: 2301-2306, 2007.
40. Haase VH.: Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol 291: F271-281, 2006.
41. Rankin EB, Biju MP, Liu Q, et al.: Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117: 1068-1077, 2007.
42. Anders HJ, Banas B, Schlondorff D.: Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867, 2004.
43. Marshak-Rothstein A.: Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 6: 823-835, 2006.
44. Schaefer L, Babelova A, Kiss E, et al.: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115: 2223-2233, 2005.
45. Tsung A, Sahai R, Tanaka H, et al.: The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201: 1135-1143, 2005.
46. Leemans JC, Stokman G, Claessen N, et al.: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 115: 2894-2903, 2005.
47. Wu H, Chen G, Wyburn KR, et al.: TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117: 2847-2859, 2007.
48. Seki E, DeMinicis S, Osterreicher CH, et al.: TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 13: 1324-1332, 2007.
49. Tan R, Zhang X, Yang J, et al.: Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor. J Am Soc Nephrol 18: 2340-2349, 2007.
50. Yang J, Dai C, Liu Y.: A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol 16: 68-78, 2005.
51. Zeisberg M, Hanai J, Sugimoto H, et al.: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003.
52. Hills CE, Al-Rasheed N, Al-Rasheed N, et al.: C-peptide reverses TGF-beta 1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. Am J Physiol Renal Physiol 296: F614-621, 2009.
53. Yang YL, Liu YS, Chuang LY, et al.: Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology 150: 727-740, 2009.
54. Petersen M, Thorikay M, Deckers M, et al.: Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int 73: 705-715, 2008.
55. Semenza GL.: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.