메뉴 건너뛰기




Volumn 184, Issue 12, 2010, Pages 6695-6708

Dendritic cell-directed CTLA-4 engagement during pancreatic β cell antigen presentation delays type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; CYTOKINE; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; LEUKOCYTE ANTIGEN;

EID: 77953644388     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903130     Document Type: Article
Times cited : (19)

References (49)
  • 5
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 8
    • 0037141091 scopus 로고    scopus 로고
    • Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
    • Darlington, P. J., M. L. Baroja, T. A. Chau, E. Siu, V. Ling, B. M. Carreno, and J. Madrenas. 2002. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J. Exp. Med. 195: 1337-1347.
    • (2002) J. Exp. Med. , vol.195 , pp. 1337-1347
    • Darlington, P.J.1    Baroja, M.L.2    Chau, T.A.3    Siu, E.4    Ling, V.5    Carreno, B.M.6    Madrenas, J.7
  • 9
    • 4444369694 scopus 로고    scopus 로고
    • B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse
    • Pentcheva-Hoang, T., J. G. Egen, K. Wojnoonski, and J. P. Allison. 2004. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21: 401-413.
    • (2004) Immunity , vol.21 , pp. 401-413
    • Pentcheva-Hoang, T.1    Egen, J.G.2    Wojnoonski, K.3    Allison, J.P.4
  • 11
    • 0037406494 scopus 로고    scopus 로고
    • Targeted engagement of CTLA-4 prevents autoimmune thyroiditis
    • Vasu, C., S. R. Gorla, B. S. Prabhakar, and M. J. Holterman. 2003. Targeted engagement of CTLA-4 prevents autoimmune thyroiditis. Int. Immunol. 15: 641-654.
    • (2003) Int. Immunol. , vol.15 , pp. 641-654
    • Vasu, C.1    Gorla, S.R.2    Prabhakar, B.S.3    Holterman, M.J.4
  • 12
    • 4043140730 scopus 로고    scopus 로고
    • Targeted CTLA-4 engagement induces CD4+CD25+CTLA-4high T regulatory cells with target (allo)antigen specificity
    • Vasu, C., B. S. Prabhakar, and M. J. Holterman. 2004. Targeted CTLA-4 engagement induces CD4+CD25+CTLA-4high T regulatory cells with target (allo)antigen specificity. J. Immunol. 173: 2866-2876.
    • (2004) J. Immunol. , vol.173 , pp. 2866-2876
    • Vasu, C.1    Prabhakar, B.S.2    Holterman, M.J.3
  • 13
    • 0035181948 scopus 로고    scopus 로고
    • Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo
    • Rao, S., C. Vasu, O. Martinez, S. Kaithamana, B. S. Prabhakar, and M. J. Holterman. 2001. Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo. Clin. Immunol. 101: 136-145.
    • (2001) Clin. Immunol. , vol.101 , pp. 136-145
    • Rao, S.1    Vasu, C.2    Martinez, O.3    Kaithamana, S.4    Prabhakar, B.S.5    Holterman, M.J.6
  • 14
    • 0037100256 scopus 로고    scopus 로고
    • Cutting edge: Targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells
    • Hwang, K. W., W. B. Sweatt, I. E. Brown, C. Blank, T. F. Gajewski, J. A. Bluestone, and M. L. Alegre. 2002. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J. Immunol. 169: 633-637.
    • (2002) J. Immunol. , vol.169 , pp. 633-637
    • Hwang, K.W.1    Sweatt, W.B.2    Brown, I.E.3    Blank, C.4    Gajewski, T.F.5    Bluestone, J.A.6    Alegre, M.L.7
  • 15
    • 33746748176 scopus 로고    scopus 로고
    • Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist
    • Fife, B. T., M. D. Griffin, A. K. Abbas, R. M. Locksley, and J. A. Bluestone. 2006. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J. Clin. Invest. 116: 2252-2261.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2252-2261
    • Fife, B.T.1    Griffin, M.D.2    Abbas, A.K.3    Locksley, R.M.4    Bluestone, J.A.5
  • 16
    • 38449114545 scopus 로고    scopus 로고
    • Enhanced engagement of CTLA-4 induces antigen-specific CD4+ CD25+Foxp3+ and CD4+CD25- TGF-β 1+ adaptive regulatory T cells
    • Li, R., N. Perez, S. Karumuthil-Melethil, B. S. Prabhakar, M. J. Holterman, and C. Vasu. 2007. Enhanced engagement of CTLA-4 induces antigen-specific CD4+ CD25+Foxp3+ and CD4+CD25- TGF-β 1+ adaptive regulatory T cells. J. Immunol. 179: 5191-5203.
    • (2007) J. Immunol. , vol.179 , pp. 5191-5203
    • Li, R.1    Perez, N.2    Karumuthil-Melethil, S.3    Prabhakar, B.S.4    Holterman, M.J.5    Vasu, C.6
  • 18
    • 0034161702 scopus 로고    scopus 로고
    • Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation
    • Dahlén, E., G. Hedlund, and K. Dawe. 2000. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. J. Immunol. 164: 2444-2456. (Pubitemid 30115473)
    • (2000) Journal of Immunology , vol.164 , Issue.5 , pp. 2444-2456
    • Dahlen, E.1    Hedlund, G.2    Dawe, K.3
  • 19
    • 45549090382 scopus 로고    scopus 로고
    • Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation
    • Perez, N., S. Karumuthil-Melethil, R. Li, B. S. Prabhakar, M. J. Holterman, and C. Vasu. 2008. Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J. Immunol. 180: 6566-6576.
    • (2008) J. Immunol. , vol.180 , pp. 6566-6576
    • Perez, N.1    Karumuthil-Melethil, S.2    Li, R.3    Prabhakar, B.S.4    Holterman, M.J.5    Vasu, C.6
  • 21
    • 0031010513 scopus 로고    scopus 로고
    • Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice
    • Chao, C. C., and H. O. McDevitt. 1997. Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice. Immunogenetics 46: 29-34.
    • (1997) Immunogenetics , vol.46 , pp. 29-34
    • Chao, C.C.1    McDevitt, H.O.2
  • 22
    • 0035434657 scopus 로고    scopus 로고
    • T-cell epitope analysis on the autoantigen phogrin (IA-2β) in the nonobese diabetic mouse
    • Kelemen, K., D. R. Wegmann, and J. C. Hutton. 2001. T-cell epitope analysis on the autoantigen phogrin (IA-2β) in the nonobese diabetic mouse. Diabetes 50: 1729-1734.
    • (2001) Diabetes , vol.50 , pp. 1729-1734
    • Kelemen, K.1    Wegmann, D.R.2    Hutton, J.C.3
  • 23
    • 0030175329 scopus 로고    scopus 로고
    • T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD(524-543)
    • Quinn, A., and E. E. Sercarz. 1996. T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD(524-543). J. Autoimmun. 9: 365-370.
    • (1996) J. Autoimmun. , vol.9 , pp. 365-370
    • Quinn, A.1    Sercarz, E.E.2
  • 24
    • 17844365884 scopus 로고    scopus 로고
    • + T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: A novel beta cell autoantigen in type 1 diabetes
    • Mukherjee, R., D. Wagar, T. A. Stephens, E. Lee-Chan, and B. Singh. 2005. Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes. J. Immunol. 174: 5306-5315. (Pubitemid 40593169)
    • (2005) Journal of Immunology , vol.174 , Issue.9 , pp. 5306-5315
    • Mukherjee, R.1    Wagar, D.2    Stephens, T.A.3    Lee-Chan, E.4    Singh, B.5
  • 25
  • 26
    • 0035863724 scopus 로고    scopus 로고
    • Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice
    • Judkowski, V., C. Pinilla, K. Schroder, L. Tucker, N. Sarvetnick, and D. B. Wilson. 2001. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J. Immunol. 166: 908-917.
    • (2001) J. Immunol. , vol.166 , pp. 908-917
    • Judkowski, V.1    Pinilla, C.2    Schroder, K.3    Tucker, L.4    Sarvetnick, N.5    Wilson, D.B.6
  • 27
    • 34548408335 scopus 로고    scopus 로고
    • Bone marrow is a preferential homing site for autoreactive T-cells in type 1 diabetes
    • DOI 10.2337/db07-0502
    • Li, R., N. Perez, S. Karumuthil-Melethil, and C. Vasu. 2007. Bone marrow is a preferential homing site for autoreactive T-cells in type 1 diabetes. Diabetes 56: 2251-2259. (Pubitemid 47358232)
    • (2007) Diabetes , vol.56 , Issue.9 , pp. 2251-2259
    • Li, R.1    Perez, N.2    Karumuthil-Melethil, S.3    Vasu, C.4
  • 28
    • 58849145188 scopus 로고    scopus 로고
    • Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes
    • Karumuthil-Melethil, S., N. Perez, R. Li, and C. Vasu. 2008. Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes. J. Immunol. 181: 8323-8334.
    • (2008) J. Immunol. , vol.181 , pp. 8323-8334
    • Karumuthil-Melethil, S.1    Perez, N.2    Li, R.3    Vasu, C.4
  • 29
    • 0037025990 scopus 로고    scopus 로고
    • Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice
    • Gagnerault, M. C., J. J. Luan, C. Lotton, and F. Lepault. 2002. Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J. Exp. Med. 196: 369-377.
    • (2002) J. Exp. Med. , vol.196 , pp. 369-377
    • Gagnerault, M.C.1    Luan, J.J.2    Lotton, C.3    Lepault, F.4
  • 30
    • 0029030974 scopus 로고
    • Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice
    • Fabien, N., I. Bergerot, V. Maguer-Satta, J. Orgiazzi, and C. Thivolet. 1995. Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice. J. Autoimmun. 8: 323-334.
    • (1995) J. Autoimmun. , vol.8 , pp. 323-334
    • Fabien, N.1    Bergerot, I.2    Maguer-Satta, V.3    Orgiazzi, J.4    Thivolet, C.5
  • 31
    • 0032538819 scopus 로고    scopus 로고
    • Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
    • Chen, W., W. Jin, and S. M. Wahl. 1998. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J. Exp. Med. 188: 1849-1857.
    • (1998) J. Exp. Med. , vol.188 , pp. 1849-1857
    • Chen, W.1    Jin, W.2    Wahl, S.M.3
  • 32
    • 1642525993 scopus 로고    scopus 로고
    • Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity
    • Jovasevic, V. M., L. Gorelik, J. A. Bluestone, and M. B. Mokyr. 2004. Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity. J. Immunol. 172: 1449-1454.
    • (2004) J. Immunol. , vol.172 , pp. 1449-1454
    • Jovasevic, V.M.1    Gorelik, L.2    Bluestone, J.A.3    Mokyr, M.B.4
  • 33
    • 44449162734 scopus 로고    scopus 로고
    • Regulation of CD28 expression on CD8+ T cells by CTLA-4
    • Berg, M., and N. Zavazava. 2008. Regulation of CD28 expression on CD8+ T cells by CTLA-4. J. Leukoc. Biol. 83: 853-863.
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 853-863
    • Berg, M.1    Zavazava, N.2
  • 34
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng, S. G., J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz. 2007. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 178: 2018-2027.
    • (2007) J. Immunol. , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 35
    • 34547774699 scopus 로고    scopus 로고
    • TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets
    • Pyzik, M., and C. A. Piccirillo. 2007. TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets. J. Leukoc. Biol. 82: 335-346.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 335-346
    • Pyzik, M.1    Piccirillo, C.A.2
  • 36
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
    • Zheng, S. G., J. H. Wang, J. D. Gray, H. Soucier, and D. A. Horwitz. 2004. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol. 172: 5213-5221.
    • (2004) J. Immunol. , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 37
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., W. Jin, N. Hardegen, K. J. Lei, L. Li, N. Marinos, G. McGrady, and S. M. Wahl. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 38
    • 33644835247 scopus 로고    scopus 로고
    • TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    • Zheng, S. G., J. H. Wang, W. Stohl, K. S. Kim, J. D. Gray, and D. A. Horwitz. 2006. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 176: 3321-3329.
    • (2006) J. Immunol. , vol.176 , pp. 3321-3329
    • Zheng, S.G.1    Wang, J.H.2    Stohl, W.3    Kim, K.S.4    Gray, J.D.5    Horwitz, D.A.6
  • 41
    • 1942539121 scopus 로고    scopus 로고
    • Defective maturation of myeloid dendritic cell (DC) in NOD mice is controlled by IDD10/17/18
    • Peng, R., K. Bathjat, Y. Li, and M. J. Clare-Salzler. 2003. Defective maturation of myeloid dendritic cell (DC) in NOD mice is controlled by IDD10/17/18. Ann. N. Y. Acad. Sci. 1005: 184-186.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1005 , pp. 184-186
    • Peng, R.1    Bathjat, K.2    Li, Y.3    Clare-Salzler, M.J.4
  • 42
    • 0036700932 scopus 로고    scopus 로고
    • Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities
    • Marleau, A. M., and B. Singh. 2002. Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities. J. Autoimmun. 19: 23-35.
    • (2002) J. Autoimmun. , vol.19 , pp. 23-35
    • Marleau, A.M.1    Singh, B.2
  • 43
    • 63749109591 scopus 로고    scopus 로고
    • Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function
    • Cheatem, D., B. B. Ganesh, E. Gangi, C. Vasu, and B. S. Prabhakar. 2009. Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function. Clin. Immunol. 131: 260-270.
    • (2009) Clin. Immunol. , vol.131 , pp. 260-270
    • Cheatem, D.1    Ganesh, B.B.2    Gangi, E.3    Vasu, C.4    Prabhakar, B.S.5
  • 44
    • 0037851960 scopus 로고    scopus 로고
    • Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis
    • Vasu, C., R. N. Dogan, M. J. Holterman, and B. S. Prabhakar. 2003. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J. Immunol. 170: 5511-5522.
    • (2003) J. Immunol. , vol.170 , pp. 5511-5522
    • Vasu, C.1    Dogan, R.N.2    Holterman, M.J.3    Prabhakar, B.S.4
  • 45
    • 18944379171 scopus 로고    scopus 로고
    • IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis
    • Gangi, E., C. Vasu, D. Cheatem, and B. S. Prabhakar. 2005. IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J. Immunol. 174: 7006-7013.
    • (2005) J. Immunol. , vol.174 , pp. 7006-7013
    • Gangi, E.1    Vasu, C.2    Cheatem, D.3    Prabhakar, B.S.4
  • 46
    • 61349134275 scopus 로고    scopus 로고
    • GM-CSF-induced CD11c+CD8a - Dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis
    • Ganesh, B. B., D. M. Cheatem, J. R. Sheng, C. Vasu, and B. S. Prabhakar. 2009. GM-CSF-induced CD11c+CD8a - dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int. Immunol. 21: 269-282.
    • (2009) Int. Immunol. , vol.21 , pp. 269-282
    • Ganesh, B.B.1    Cheatem, D.M.2    Sheng, J.R.3    Vasu, C.4    Prabhakar, B.S.5
  • 47
    • 36849089218 scopus 로고    scopus 로고
    • The vicious cycle of apoptotic beta-cell death in type 1 diabetes
    • Kaminitz, A., J. Stein, I. Yaniv, and N. Askenasy. 2007. The vicious cycle of apoptotic beta-cell death in type 1 diabetes. Immunol. Cell Biol. 85: 582-589.
    • (2007) Immunol. Cell Biol. , vol.85 , pp. 582-589
    • Kaminitz, A.1    Stein, J.2    Yaniv, I.3    Askenasy, N.4
  • 49
    • 33748168720 scopus 로고    scopus 로고
    • Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand
    • Glinka, Y., Y. Chang, and G. J. Prud'homme. 2006. Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand. Mol. Ther. 14: 578-587.
    • (2006) Mol. Ther. , vol.14 , pp. 578-587
    • Glinka, Y.1    Chang, Y.2    Prud'homme, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.