T cells with multiple fine specificities are used by non-obese diabetic (NOB) mice in the response to GAD(524-543)

Journal of Autoimmunity

Volumn 9, Issue 3, 1996, Pages 365-370

  Quinn, Anthony ^a   Sercarz, Eli E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti GAD T cells; IDDM; NOD mice

Indexed keywords

GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; INTERLEUKIN 2; INTERLEUKIN 5; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; HYBRIDOMA; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

EID: 0030175329     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0049     Document Type: Conference Paper

References (19)

1. 1. Castano L., Eisenbarth G.S. 1990. Type-1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8: 647-679
2. + T cells. J. Exp. Med. 166: 823-832
3. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140: 52-58
4. 4. Katz J., Benoist C., Mathis D. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23: 3358-3360
5. 5. Kaufman D.L., Clare-Salzler M., Tian J., Forsthuber T., Ting G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
6. 6. Tisch R., Yang X., Singer S.M., Liblau R.S., Fugger L., McDevitt H.O. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
7. 7. Bowman M.A., Leiter E.H., Atkinson M.A. 1994. Prevention of diabetes in the NOD mouse: implications for the therapeutic intervention in human disease. Immunol. Today 15: 115-120
8. 8. Nicholson L.B., Greer J.M., Sobel R.A., Lees M.B., Kuchroo V.K. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3: 397-405
9. 9. Kumar V., Bhardwaj V., Soares L., Alexander J., Sette A., Sercarz E. 1995. MHC-binding affinity of an antigenic determinant is crucial for the differential secretion of IL-4 or IFN-γ by T cells. Proc. Natl. Acad. Sci. USA 92: 9510-9514
10. 10. Maeji N.J., Bray A.M., Geysen H.M. 1990. Multi-pin peptide synthesis strategy for T cell determinant analysis. J. Immunol. Methods 134: 23
11. 11. Deng H., Apple R., Clare-Salzler M., Trembleau S., Mathis D., Adorini L., Sercarz E. 1993. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 178: 1675-1680
12. 12. England R.D., Kullberg M.C., Cornette J.L., Berzofsky J.A. 1995. Molecular analysis of a heteroclitic T cell response to the immunodominant epitope of sperm whale myoglobin: Implications for peptide partial agonist. J. Immunol. 155: 4295-4306
13. 13. Nanda N., Arzoo K.K., Sercarz E.E. 1992. In a small multideterminant peptide, each determinant is recognized by a different Vβ gene segment. J. Exp. Med. 176: 297-302
14. 14. Sloan-Lancaster J., Evavold B.D., Allen P.M. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363: 156-159
15. 15. Karin N., Mitchell D.J., Brocke S., Ling N., Steinman L. 1994. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor α production. J. Exp. Med. 180: 2227-2237
16. 16. Candeias S., Katz J., Benoist C., Mathis D., Haskins K. 1991. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc. Natl. Acad. Sci. USA 88: 6167-6170
17. 17. Sarukhan A., Gombert J.M., Olivi M., Bach J.F., Carnaud C., Garchon H.J. 1994. Anchored polymerase chain reaction based analysis of the Vβ repertoire in the non-obese diabetic (NOD) mouse. Eur. J. Immunol. 24: 1750-1756
18. 18. Yang Y., Charlton B., Shimada A., Dal Canto R., Fathman C.G. 1996. Monoclonal T cells identified in NOD islet infiltrates. Immunity 4: 189-194
19. 19. Manca F., Clarke J., Shastri N., Miller A., Sercarz E.E. 1984. A limited region within hen eggwhite lysozyme serves as the focus for a diversity of T cell clones. J. Immunol. 133: 2075-2078