Specific primary sequence requirements for Aurora B kinase-mediated phosphorylation and subcellular localization of TMAP during mitosis

Cell Cycle

Volumn 9, Issue 10, 2010, Pages 2027-2036

  Kim, Hyun Jun ^a   Kwon, Hye Rim ^a   Bae, Chang Dae ^a   Park, Joobae ^a   Hong, Kyung U ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Aurora B; CKAP2; HMGN; Localization; Mitosis; Phosphorylation; TMAP

Indexed keywords

AMINO ACID; AURORA B KINASE; MICROTUBULE ASSOCIATED PROTEIN; SERINE; TUMOR ASSOCIATED MICROTUBULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CENTROSOME; CHROMOSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE; MITOSIS; MUTANT; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

EID: 77953634031     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.10.11753     Document Type: Article

References (44)

1. Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2:21-32.
2. Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol 2007; 8:798-812. (Pubitemid 47462135)
3. Giet R, Glover DM. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol 2001; 152:669-82.
4. Lipp JJ, Hirota T, Poser I, Peters JM. Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci 2007; 120:1245-55. (Pubitemid 46711843)
5. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 2004; 118:187-202. (Pubitemid 38962575)
6. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 2004; 166:179-91.
7. Cimini D, Wan X, Hirel CB, Salmon ED. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol 2006; 16:1711-8.
8. DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 2006; 127:969-82.
9. Kallio MJ, McCleland ML, Stukenberg PT, Gorbsky GJ. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol 2002; 12:900-5.
10. Terada Y, Tatsuka M, Suzuki F, Yasuda Y, Fujita S, Otsu M. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J 1998; 17:667-76. (Pubitemid 28062046)
11. Earnshaw WC, Cooke CA. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. J Cell Sci 1991; 98:443-61.
12. Zeitlin SG, Shelby RD, Sullivan KF. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 2001; 155:1147-57.
13. Resnick TD, Satinover DL, MacIsaac F, Stukenberg PT, Earnshaw WC, Orr-Weaver TL, et al. INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell 2006; 11:57-68. (Pubitemid 43964533)
14. Gadea BB, Ruderman JV. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/ Stathmin. Proc Natl Acad Sci USA 2006; 103:4493-8.
15. Guse A, Mishima M, Glotzer M. Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol 2005; 15:778-86. (Pubitemid 40599935)
16. Kawajiri A, Yasui Y, Goto H, Tatsuka M, Takahashi M, Nagata K, et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell 2003; 14:1489-500. (Pubitemid 36547417)
17. Knowlton AL, Lan W, Stukenberg PT. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol 2006; 16:1705-10. (Pubitemid 44691788)
18. Goto H, Yasui Y, Kawajiri A, Nigg EA, Terada Y, Tatsuka M, et al. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 2003; 278:8526-30.
19. Morrison C, Henzing AJ, Jensen ON, Osheroff N, Dodson H, Kandels-Lewis SE, et al. Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res 2002; 30:5318-27. (Pubitemid 36033051)
20. Meraldi P, Honda R, Nigg EA. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev 2004; 14:29-36. (Pubitemid 38167474)
21. Bae CD, Sung YS, Jeon SM, Suh Y, Yang HK, Kim YI, et al. Upregulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. J Cancer Res Clin Oncol 2003; 129:621-30. (Pubitemid 37452628)
22. Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, et al. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas. Oncogene 1998; 17:1245-51. (Pubitemid 28446164)
23. Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D. Serological detection of cutaneous T-cell lymphoma-associated antigens. Proc Natl Acad Sci USA 2001; 98:629-34.
24. Jeon SM, Choi B, Hong KU, Kim E, Seong YS, Bae CD, et al. A cytoskeleton-associated protein, TMAP/ CKAP2, is involved in the proliferation of human foreskin fibroblasts. Biochem Biophys Res Commun 2006; 348:222-8.
25. Hong KU, Park YS, Seong YS, Kang D, Bae CD, Park J. Functional importance of the anaphase-promoting complex- Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis. Mol Cell Biol 2007; 27:3667-81.
26. Jin Y, Murakumo Y, Ueno K, Hashimoto M, Watanabe T, Shimoyama Y, et al. Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule- stabilizing properties. Cancer Sci 2004; 95:815-21.
27. Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, et al. Ckap2 regulates aneuploidy, cell cycling and cell death in a p53-dependent manner. Cancer Res 2005; 65:6685-91.
28. Hong KU, Kim E, Bae CD, Park J. TMAP/CKAP2 is essential for proper chromosome segregation. Cell Cycle 2009; 8:314-24.
29. Seki A, Fang G. CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. J Biol Chem 2007; 282:15103-13.
30. Hong KU, Choi YB, Lee JH, Kim HJ, Kwon HR, Seong YS, et al. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/ cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis. Exp Mol Med 2008; 40:377-86.
31. Hong KU, Kim HJ, Bae CD, Park J. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. Exp Mol Med 2009; 41:832-40.
32. Hong KU, Kim HJ, Kim HS, Seong YS, Hong KM, Bae CD, et al. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/ cytoskeleton-associated protein 2 in mitosis. J Biol Chem 2009; 284:16501-12.
33. Ferrari S, Marin O, Pagano MA, Meggio F, Hess D, El-Shemerly M, et al. Aurora-A site specificity: a study with synthetic peptide substrates. Biochem J 2005; 390:293-302.
34. Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, et al. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 2003; 5:853-64.
35. Girdler F, Gascoigne KE, Eyers PA, Hartmuth S, Crafter C, Foote KM, et al. Validating Aurora B as an anticancer drug target. J Cell Sci 2006; 119:3664-75.
36. Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2 and Cenp-E to kinetochores. J Cell Biol 2003; 161:267-80.
37. Sugiyama K, Sugiura K, Hara T, Sugimoto K, Shima H, Honda K, et al. Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene 2002; 21:3103-11.
38. Eyers PA, Maller JL. Regulation of Xenopus Aurora A activation by TPX2. J Biol Chem 2004; 279:9008-15.
39. Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol 2007; 8:530-41.
40. Loog M, Morgan DO. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 2005; 434:104-8.
41. Kim SY, Ferrell JE Jr. Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 2007; 128:1133-45.
42. Ueda T, Catez F, Gerlitz G, Bustin M. Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells. Mol Cell Biol 2008; 28:2872-83.
43. Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. Protein Sci 2000; 9:170-9.
44. Klein UR, Nigg EA, Gruneberg U. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin and the N-terminal domain of INCENP. Mol Biol Cell 2006; 17:2547-58.