Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90-94) and (143-149) from αs1-casein

Food and Chemical Toxicology

Volumn 48, Issue 7, 2010, Pages 1836-1845

  Anadon A ^a   Martinez M A ^a   Ares, I ^a   Ramos, E ^a   Martinez Larranaga M R ^a   Contreras, M M ^b   Ramos, M ^b   Recio, I ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

Author keywords

Casein hydrolysate; RYLGY and AYFYPEL antihypertensive peptides; Safety evaluation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALANYLTYROSYLPHENYLALANYLTYROSYLPROLYLGLUTAMYLLEUCINE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA CASEIN; ALPHA S 1 CASEIN; ANTIHYPERTENSIVE AGENT; ARGINYLTYROSYLLEUCYLGLYCYLTYROSINE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CASEIN HYDROLYSATE; CHOLESTEROL; CREATININE; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; LOWPEPT; PEPTIDE FRAGMENT; POTASSIUM; SODIUM; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ACUTE TOXICITY; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOPHIL; BODY WEIGHT; CONTROLLED STUDY; DRUG SAFETY; EOSINOPHIL COUNT; ERYTHROCYTE COUNT; FEEDING; FEMALE; FOOD INTAKE; HEMATOCRIT; HISTOPATHOLOGY; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONOCYTE; MORTALITY; NEUTROPHIL COUNT; NONHUMAN; ORGAN WEIGHT; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; THROMBOCYTE COUNT; TOXICITY TESTING; WEIGHT GAIN;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; CASEINS; FEMALE; HYDROLYSIS; MALE; ORGAN SIZE; PEPTIDE FRAGMENTS; PROTEIN HYDROLYSATES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SEX CHARACTERISTICS; WEIGHT GAIN;

RATTUS;

EID: 77953610523     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.04.016     Document Type: Article

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