Release of short and proline-rich antihypertensive peptides from casein hydrolysate with an Aspergillus oryzae protease

Journal of Dairy Science

Volumn 87, Issue 10, 2004, Pages 3183-3188

  Mizuno, S ^a   Nishimura, S ^a   Matsuura, K ^a   Gotou, T ^a   Yamamoto, N ^a  

^a CALPIS Co Ltd   (Japan)

Author keywords

Angiotensin I converting enzyme; Antihypertensive peptide; Aspergillus oryzae protease; Casein hydrolysate

Indexed keywords

ASPERGILLUS; ASPERGILLUS ORYZAE;

EID: 6944241742     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(04)73453-0     Document Type: Article

References (22)

1. Abubakar, A., T. Saito, H. Kitazawa, Y. Kawai, and T. Itoh. 1998. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci. 81:3131-3138.
2. Chiou, R. Y., and S. L. Cheng. 2001. Isoflavone transformation during soybean koji preparation and subsequent miso fermentation supplemented with ethanol and NaCl. J. Agric. Food Chem. 49:3656-3660.
3. Church, F. C., D. H. Porter, G. L. Catignani, and H. Swaisgood. 1985. An o-phthalaldehyde spectrophotometric assay for proteinases. Anal. Biochem. 146:343-348.
4. Cushman, D. W., and H. S. Cheung. 1971. Spectrophotometric assay and properties of angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648.
5. Hata, Y., M. Yamamoto, M. Ohni, K. Nakajima, Y. Nakamura, and T. Takano. 1996. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am. J. Clin. Nutr. 64:767-771.
6. Kim, S. K., Y. T. Kim, H. G. Byun, K. S. Nam, D. S. Joo, and F. Shahide. 2001. Isolation and characterization of antioxidative peptides from gelatin hydrolyzate of Alaska pollack skin. J. Agric. Food Chem. 49:1984-1989.
7. Kodama, S., A. Yamamoto, A. Matsunaga, K. Nakagomi, and K. Hayakawa. 2002. Behaviors of D- and L-lactic acids during the brewing process of sake (Japanese rice wine). J. Agric. Food Chem. 50:767-770.
8. Lahov, E., and E. Regelson. 1996. Antibacterial and immunostimulating casein-derived substances from milk: Casecidin, isracidin peptides. Food Chem. Toxicol. 34:131-145.
9. Maruyama, S., K. Nakagomi, N. Tomizuka, and H. Suzuki. 1985. Angioten I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agric. Biol. Chem. 49:1405-1409.
10. Masuda, O., Y. Nakamura, and T. Takano. 1996. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J. Nutr. 126:3063-3068.
11. Matsumura, N., M. Fujii, Y. Takeda, K. Sugita, and T. Shimizu. 1993. Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci. Biotechnol. Biochem. 57:695-697.
12. Meisel, H., and W. Bockelmann. 1999. Bioactive peptides encrypted in milk proteins: Proteolytic activation and tropho-functional properties. Antonie van Leeuwenhoek 76:207-215.
13. Miyoshi, S., H. Ishikawa, T. Kaneko, F. Fukui, H. Tanaka, and S. Maruyama. 1991. Structures and activity of angiotensin-converting enzyme inhibitors in an alpha-zein hydrolysate. Agric. Biol. Chem. 55:1313-1318.
14. Nakamura, Y., N. Yamamoto, K. Sakai, A. Okubo, S. Yamazaki, and T. Takano. 1995a. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78:777-783.
15. Nakamura, Y., N. Yamamoto, K. Sakai, and T. Takano. 1995b. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J. Dairy Sci. 78:1253-1257.
16. O'Toole, D. K. 1999. Characteristics and use of okara, the soybean residue from soy milk production. J. Agric. Food Chem. 47:363-371.
17. Saito, T., T. Nakamura, H. Kitazawa, Y. Kawai, and T. Itoh. 2000. Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci. 83:1434-1440.
18. Seppo, L., O. Kerojoki, T. Suomalainen, and R. Korpela. 2002. The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension - A pilot study on humans. Milchwissenschaft 57:124-127.
19. Teschemacher, H., G. Kock, and V. Brantl. 1997. Milk protein-derived opioid receptor ligands. Biopolymers 43:99-117.
20. Yamamoto, N., M. Ejiri, and S. Mizuno. 2003 Biogenic peptides and their potential use. Curr. Pharm. Des. 9:1345-1355.
21. Yamamoto, N., M. Maeno, and T. Takano. 1999. Purification and characterization of an antihypertensive peptide derived from a yogurt-like product fermented by Lactobacillus helveticus CPN4. J. Dairy Sci. 82:1388-1393.
22. Yokoyama, K., H. Chiba, and M. Yoshikawa. 1992. Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotechnol. Biochem. 56:1541-1945.