Chemometric descriptors in modeling the carbonic anhydrase inhibition activity of sulfonamide and sulfamate derivatives

Molecular Diversity

Volumn 14, Issue 2, 2010, Pages 371-384

  Sharma, Brij Kishore ^a   Pilania, Pradeep ^a   Sarbhai, Kirti ^a   Singh, Prithvi ^a   Prabhakar, Yenamandra S ^b  

^a SK Government College   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Carbonic anhydrase; Combinatorial protocol in multiple linear regression; Inhibition activity; MOEdescriptors; Sulfonamide and sulfamate derivatives

Indexed keywords

AROMATIC COMPOUND; CARBONATE DEHYDRATASE; CHLORINE; HYDROGEN; SULFONAMIDE; SULFURIC ACID; CARBONATE DEHYDRATASE INHIBITOR; SULFAMIC ACID; SULFONIC ACID DERIVATIVE;

ARTICLE; CHEMOMETRICS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; PHARMACOPHORE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOMIZATION; SYNTHESIS; THEORETICAL MODEL; VALIDATION STUDY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ENZYMOLOGY; GENETICS; HELICOBACTER PYLORI; METABOLISM; PROTEIN BINDING; REPRODUCIBILITY; STATISTICAL MODEL;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DRUG DISCOVERY; HELICOBACTER PYLORI; HYDROPHOBICITY; LINEAR MODELS; MODELS, MOLECULAR; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SULFONAMIDES; SULFONIC ACIDS;

EID: 77953600039     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-009-9181-5     Document Type: Article

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