Topological descriptors in modeling the agonistic activity of human A3 adenosine receptor ligands: The derivatives of 2-chloro-N6-substituted-4′-thioadenosine-5′-uronamide

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1377-1382

  Sharma, Susheela ^a   Sharma, Brij K ^b   Sharma, Sanjeev K ^b   Singh, Prithvi ^b   Prabhakar, Yenamandra S ^c  

^a Sobhasaria Engineering College Sikar   (India)

^b SK Government College   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2 Chloro N6 substituted 4 thioadenosine 5 uronamide derivatives as human A3 receptor ligands; Combinatorial Protocol in Multiple Linear Regression (CP MLR); Quantitative structure activity relationship (QSAR)

Indexed keywords

2 CHLORO 4' THIOADENOSINE 5' URONAMIDE; ADENOSINE RECEPTOR STIMULATING AGENT; AMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG ACTIVITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ADENOSINE A3 RECEPTOR AGONISTS; DRUG DESIGN; HUMANS; LIGANDS; LINEAR MODELS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, ADENOSINE A3; THIONUCLEOSIDES;

EID: 61349134124     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.022     Document Type: Article

References (38)

1. Olah M.E., and Stiles G.L. Pharmacol. Ther. 85 (2000) 55-75
2. Liang B.T., and Jacobson K.A. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6995-6999
3. von Lubitz D.K.J.E., Ye W., McClellan J., and Lin R.C.-S. Ann. N.Y. Acad. Sci. 90 (1999) 93-106
4. Fishman P., Madi L., Bar-Yehuda S., Barer F., Del Valle L., and Khalili K. Oncogene 21 (2002) 4060-4064
5. Meade C.J., Mierau J., Leon I., and Ensinger H.A. J. Pharmacol. Exp. Ther. 279 (1996) 1148-1156
6. Avila M.Y., Stone R.A., and Civan M.M. Invest. Opthalmol. Vis. Sci. 43 (2002) 3021-3026
7. Sajjadi F.G., Takabayashi K., Foster A.C., Domingo R.C., and Firestein G.S. J. Immunol. 156 (1996) 3435-3442
8. Ramkumar V., Stiles G.L., Beaven M.A., and Ali H. J. Biol. Chem. 268 (1993) 16887-16890
9. Klotz K.-N. Naunyn Schmiedebergs Arch. Pharmacol. 362 (2000) 382-391
10. Baraldi P.G., Cacciari B., Romagnoli R., Merighi S., Varani K., Borea P.A., and Spalluto G. Med. Res. Rev. 20 (2000) 103-128
11. van Tilburg E.W., von Frijtag Drabbe Kunzel J., de Groote M., Vollinga R.C., Lorenzen A., and Ijzerman A.P. J. Med. Chem. 42 (1999) 1393-1400
12. van Tilburg E.W., van der Klein P.A.M., von Frijtag Drabbe Kunzel J., de Groote M., Stannek C., Lorenzen A., and Ijzerman A.P. J. Med. Chem. 44 (2001) 2966-2975
13. Gao Z.-G., Kim S.K., Biadatti T., Chen W., Lee K., Barak D., Kim S.G., Johnson C.R., and Jacobson K.A. J. Med. Chem. 45 (2002) 4471-4484
14. Gao Z.-G., Blaustein J.B., Gross A.S., Melman N., and Jacobson K.A. Biochem. Pharmacol. 65 (2003) 1675-1684
15. Gao Z.-G., Jeong L.S., Moon H.R., Kim H.O., Choi W.J., Shin D.H., Elhalem E., Comin M.J., Melaman N., Mamedova L., Gross A.S., Rodriguez J.B., and Jacobson K.A. Biochem. Pharmacol. 67 (2004) 893-901
16. Kim H.O., Ji X.-D., Siddiqi S.M., Olah M.E., Stiles G.L., and Jacobson K.A. J. Med. Chem. 37 (1994) 3614-3621
17. Jacobson K.A., and Knutsen L.J.S. In: Abbracchio M.P., and Williams M. (Eds). Handbook of Experimental Pharmacology vol. 151/I (2001), Springer-Verlag, Berlin, Germany 129-175
18. Jacobson K.A., Xi X.-D., Li A.-H., Melman N., Siddiqui M.A., Shin K.-J., Marquez V.E., and Ravi R.G. J. Med. Chem. 43 (2000) 2196-2203
19. Jeong L.S., Lee H.W., Jacobson K.A., Kim H.O., Shin D.H., Lee J.A., Gao Z.-G., Lu C., Duong H.T., Gunaga P., Lee S.K., Jin D.Z., Chun M.W., and Moon H.R. J. Med. Chem. 49 (2006) 273-281
20. González M.P., and Teran C. Bull. Math. Biol. 66 (2004) 907-920
21. González M.P., and Teran C. Bioorg. Med. Chem. 12 (2004) 2985-2993
22. González M.P., Teran C., Fall Y., Teijeira M., and Besada P. Bioorg. Med. Chem. 13 (2005) 601-618
23. González M.P., Teran C., Teijeira M., and Besada P. Bioorg. Med. Chem. Lett. 15 (2005) 2641-2645
24. González M.P., Teran C., Teijeira M., Besada P., and Gonzalez-Moa M.J. Eur. J. Med. Chem. 40 (2005) 1080-1086
25. González M.P., Teran C., Teijeira M., Besada P., and Helguera A.M. Bull. Math. Biol. 69 (2007) 347-359
26. González M.P., Teran C., Teijeira M., and Morales A.H. Curr. Med. Chem. 13 (2006) 2253-2266
27. González M.P., Teran C., Teijeira M., and Morales A.H. Eur. J. Med. Chem. 41 (2006) 56-62
28. González M.P., Teran C., Teijeira M., Besada P., and Gonzalez-Moa M.J. Bioorg. Med. Chem. Lett. 15 (2005) 3491-3495
29. ChemDraw Ultra 6.0 and Chem3D Ultra (2001), Cambridge Soft Corporation, Cambridge, USA
30. R. Todeschini, V. Consonni, DRAGON Software (version 1.11-2001), Milano, Italy, 2003.
31. Prabhakar Y.S. QSAR Comb. Sci. 22 (2003) 583-595
32. Gupta M.K., and Prabhakar Y.S. J. Chem. Inf. Model. 46 (2006) 93-102
33. Prabhakar Y.S., Solomon V.R., Rawal R.K., Gupta M.K., and Katti S.B. QSAR Comb. Sci. 23 (2004) 234-244
34. Prabhakar Y.S. Internet Electron J. Mol. Des. 3 (2004) 150-162.
35. Gupta M.K., Sagar R., Shaw A.K., and Prabhakar Y.S. Bioorg. Med. Chem. 13 (2005) 343-351
36. Saquib M., Gupta M.K., Sagar R., Prabhakar Y.S., Shaw A.K., Kumar R., Maulik P.R., Gaikwad A.N., Sinha S., Srivastava A.K., Chaturvedi V., Srivastava R., and Srivastava B.S. J. Med. Chem. 50 (2007) 2942-2950
37. So S.S., and Karplus M. J. Med. Chem. 40 (1997) 4347-4359
38. SYSTAT, Version 7.0, SPSS Inc., 444 North Michigan Avenue, Chicago, IL, 60611.