A high dimensional QSAR study on the aldose reductase inhibitory activity of some flavones: Topological descriptors in modeling the activity

Journal of Chemical Information and Modeling

Volumn 46, Issue 1, 2006, Pages 86-92

  Prabhakar, Yenamandra S ^a   Gupta, Manish K ^a   Roy, Nobendu ^b   Venkateswarlu, Yenamandra ^c  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b Strand Genomics Ltd ^*  (India)

^c INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DESCRIBING FUNCTIONS; LEAST SQUARES APPROXIMATIONS; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; REGRESSION ANALYSIS; TOPOLOGY;

ALDOSE REDUCTASE (AR); MULTIPLE LINEAR REGRESSION (CP-MLR); PARTIAL LEAST SQUARES (PLS); QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSAR);

ENZYMES;

ALDEHYDE REDUCTASE; FLAVONE DERIVATIVE;

ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; METABOLISM; MULTIVARIATE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; REGRESSION ANALYSIS; STATISTICAL MODEL;

ALDEHYDE REDUCTASE; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; FLAVONES; LEAST-SQUARES ANALYSIS; LINEAR MODELS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

EID: 33244477896     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci050060u     Document Type: Conference Paper

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