Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease

Clinica Chimica Acta

Volumn 382, Issue 1-2, 2007, Pages 82-88

  Crosignani, Andrea ^a   Del Puppo, Marina ^c   Longo, Matteo ^a   De Fabiani, Emma ^b   Caruso, Donatella ^b   Zuin, Massimo ^a   Podda, Mauro ^a   Javitt, Norman B ^d   Kienle, Marzia Galli ^c  

^a School of Medicine San Paolo   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cholesterol catabolism; CYP27; CYP7A1; Primary biliary cirrhosis

Indexed keywords

26 HYDROXYCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; BILE ACID; OXYSTEROL; STEROL 27 HYDROXYLASE;

ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL BLOOD LEVEL; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEPATITIS C; HUMAN; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BILE ACIDS AND SALTS; BIOSYNTHETIC PATHWAYS; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOCHROME P-450 CYP27A1; FEMALE; HEPATITIS, CHRONIC; HUMANS; HYDROXYCHOLESTEROLS; HYDROXYLATION; LIVER CIRRHOSIS, BILIARY; MACROPHAGES; MALE; MIDDLE AGED;

HEPATITIS C VIRUS;

EID: 34249020156     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2007.03.025     Document Type: Article

References (36)

1. Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72 (2003) 137-174
2. Vlahcevic Z.R., Pandak W.M., and Stravitz R.T. Regulation of bile acid biosynthesis. Gastroenterol Clin North Am 28 (1999) 1-25 [v]
3. Lund E.G., Guileyardo J.M., and Russell D.W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A 96 (1999) 7238-7243
4. Lund E.G., Kerr T.A., Sakai J., Li W.P., and Russell D.W. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem 273 (1998) 34316-34327
5. Myant N.B., and Mitropoulos K.A. Cholesterol 7α-hydroxylase. J Lipid Res 18 (1977) 135-153
6. Stange E.F., Scheibner J., and Ditschuneit H. Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. J Clin Invest 84 (1989) 173-180
7. Reihner E., Bjorkhem I., Angelin B., Ewerth S., and Einarsson K. Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7α-hydroxylase activity. Gastroenterology 97 (1989) 1498-1505
8. Russell D.W. Nuclear orphan receptors control cholesterol catabolism. Cell 97 (1999) 539-542
9. Lu T.T., Makishima M., Repa J.J., et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6 (2000) 507-515
10. Goodwin B., Jones S.A., Price R.R., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6 (2000) 517-526
11. Li-Hawkins J., Gafvels M., Olin M., et al. Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest 110 (2002) 1191-1200
12. De Fabiani E., Mitro N., Anzulovich A.C., Pinelli A., Galli G., and Crestani M. The negative effects of bile acids and tumor necrosis factor-α on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. J Biol Chem 276 (2001) 30708-30716
13. Bjorkhem I., Araya Z., Rudling M., Angelin B., Einarsson C., and Wikvall K. Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1. J Biol Chem 277 (2002) 26804-26807
14. Bjorkhem I., and Diczfalusy U. Oxysterols: friends, foes, or just fellow passengers?. Arterioscler Thromb Vasc Biol 22 (2002) 734-742
15. Javitt N.B. 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. J Lipid Res 43 (2002) 665-670
16. Lund E., Andersson O., Zhang J., et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler Thromb Vasc Biol 16 (1996) 208-212
17. Duane W.C., and Javitt N.B. 27-hydroxycholesterol: production rates in normal human subjects. J Lipid Res 40 (1999) 1194-1199
18. Bertolotti M., Carulli L., Concari M., et al. Suppression of bile acid synthesis, but not of hepatic cholesterol 7α-hydroxylase expression, by obstructive cholestasis in humans. Hepatology 34 (2001) 234-242
19. Goldman M., Vlahcevic Z.R., Schwartz C.C., Gustafsson J., and Swell L. Bile acid metabolism in cirrhosis. VIII. Quantitative evaluation of bile acid synthesis from [7β-3H]7α-hydroxycholesterol and [G-3H]26-hydroxycholesterol. Hepatology 2 (1982) 59-66
20. Del Puppo M., Kienle M.G., Petroni M.L., Crosignani A., and Podda M. Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. J Lipid Res 39 (1998) 2477-2482
21. Talwalkar J.A., and Lindor K.D. Primary biliary cirrhosis. Lancet 362 (2003) 53-61
22. Longo M., Crosignani A., Battezzati P.M., et al. Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis. Gut 51 (2002) 265-269
23. Axelson M., Mork B., Aly A., Wisen O., and Sjovall J. Concentrations of cholestenoic acids in plasma from patients with liver disease. J Lipid Res 30 (1989) 1877-1882
24. Del Puppo M., Crosignani A., Longo M., et al. A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. Clin Chim Acta 355 (2005) 23-31
25. Babiker A., Andersson O., Lund E., et al. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. J Biol Chem 272 (1997) 26253-26261
26. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
27. Ciuffreda P., Casati S., Alessandrini L., Terraneo G., and Santaniello E. Synthesis of deuterated isotopomers of 7α- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. Steroids 68 (2003) 733-738
28. Javitt N.B., Kok E., Lloyd J., Benscath A., and Field F.H. Cholest-5-ene-3 beta, 26-diol: synthesis and biomedical use of a deuterated compound. Biomed Mass Spectrom 9 (1982) 61-63
29. Altman D.G. Practical statistics for medical research (1991), Chapman and Hall, London
30. Vlahcevic Z.R., Stravitz R.T., Heuman D.M., Hylemon P.B., and Pandak W.M. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. Gastroenterology 113 (1997) 1949-1957
31. Bjorkhem I., Muri Boberg K., and Leitersdorf E. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. The metabolic bases of inherited diseases (2001), McGraw-Hill, New York, NY 2961-2988
32. Leitersdorf E., Reshef A., Meiner V., et al. Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews or Moroccan origin. J Clin Invest 91 (1993) 2488-2496
33. Cali J.J., and Russell D.W. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J Biol Chem 266 (1991) 7774-7778
34. Pikuleva I.A., Babiker A., Waterman M.R., and Bjorkhem I. Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. J Biol Chem 273 (1998) 18153-18160
35. Duane W.C., Levitt D.G., Mueller S.M., and Behrens J.C. Regulation of bile acid synthesis in man. Presence of a diurnal rhythm. J Clin Invest 72 (1983) 1930-1936
36. Galman C., Angelin B., and Rudling M. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology 129 (2005) 1445-1453