The importance of serum bile acid level analysis and treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: A case series from central Europe

Archives of Dermatology

Volumn 143, Issue 6, 2007, Pages 757-762

  Ambros Rudolph, Christina M ^a   Glatz, Martin ^a   Trauner, Michael ^a   Kerl, Helmut ^a   Müllegger, Robert R ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; BILE ACID; COLESTYRAMINE; CORTICOSTEROID; STEROID; URSODEOXYCHOLIC ACID;

ADOLESCENT; ADULT; ARTICLE; BILE ACID BLOOD LEVEL; CASE STUDY; CHEMICAL ANALYSIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CORRELATION FUNCTION; DERMATOLOGY; DIARRHEA; EUROPE; FEMALE; FETUS DISTRESS; HEALTH SURVEY; HUMAN; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; LIVER FUNCTION TEST; MALE; NEWBORN ASSESSMENT; OBSTETRICS; PHYSICIAN; PREGNANCY; PREGNANCY DISORDER; PREMATURE LABOR; PRIORITY JOURNAL; PROGNOSIS; PRURITUS; RETROSPECTIVE STUDY; SKIN DEFECT; SKIN DISEASE; SYMPTOM; UNIVERSITY HOSPITAL;

ADOLESCENT; ADULT; AUSTRIA; BILE ACIDS AND SALTS; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS, INTRAHEPATIC; FEMALE; HUMANS; INFANT, NEWBORN; MEDICAL RECORDS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PRENATAL DIAGNOSIS; RETROSPECTIVE STUDIES; URSODEOXYCHOLIC ACID;

EID: 34250707309     PISSN: 0003987X     EISSN: 0003987X     Source Type: Journal    
DOI: 10.1001/archderm.143.6.757     Document Type: Article

References (32)

1. Ambros-Rudolph CM, Müllegger RR, Vaughan-Jones SA, et al. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol. 2006;54:395-404.
2. Lammert F, Marschall HU, Glantz A, Matern S. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol. 2000;33:1012-1021.
3. Girling JC, Dow E, Smith JH. Liver function tests in pre-eclampsia: importance of comparison with a reference range derived for normal pregnancy. Br J Obstet Gynaecol. 1997;104:246-250.
4. Carter J. Serum bile acids in normal pregnancy. Br J Obstet Gynaecol. 1991;98:540-543.
5. Kreek MJ. Female sex steroids and cholestasis. Semin Liver Dis. 1987;7:8-23.
6. Reyes H. The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy. Gastroenterol Clin North Am. 1992;21:905-921.
7. Ropponen A, Sund R, Riikionen S, et al. Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. Hepatology. 2006;43:723-728.
8. Reyes H, Sjövall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Ann Med. 2000;32:94-106.
9. Milkiewicz P, Williamson C, Weaver J, Elias E. Obstetric cholestasis. BMJ. 2002;324:123-124.
10. Berg B, Helm G, Petersohn L, Tryding N. Cholestasis of pregnancy: clinical and laboratory studies. Acta Obstet Gynecol Scand. 1986;65:107-113.
11. Reyes H, Báez ME, González MC, et al. Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals in Chile. J Hepatol. 2000;32:542-549.
12. Reyes H, Zapata R, Hernández I, et al. Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy? Hepatology. 2006;43:715-722.
13. Rioseco AJ, Ivankovic MB, Manzur A, et al. Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. Am J Obstet Gynecol. 1994;170:890-895.
14. Shornick JK. Dermatoses of pregnancy. Semin Cutan Med Surg. 1998;17:172-181.
15. Kroumpouzos G. Intrahepatic cholestasis of pregnancy: what's new. J Eur Acad Dermatol Venereol. 2002;16:316-318.
16. Brites D, Rodrigues CM, Oliveira N, et al. Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy. J Hepatol. 1998;28:91-98.
17. Milkiewicz P, Gallagher R, Chambers J, et al. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol. 2003;18:1283-1286.
18. Zapata R, Sandoval L, Palma J, et al. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a 12-year experience. Liver Int. 2005;25:548-554.
19. Reid R, Ivey KJ, Rencoret RH, Storey B. Fetal complications of obstetric cholestasis. Br Med J. 1976;1:870-872.
20. Sepúlveda WH, Gonzalez C, Cruz MA, Rudolph MI. Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynecol Reprod Biol. 1991;42:211-215.
21. Williamson C, Gorelik J, Eaton BM, et al. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin Sci (Lond). 2001;100:363-369.
22. Heikkinen J, Mäentausta O, Ylöstalo P, Janne O. Changes in serum bile acid concentrations during normal pregnancy, in patients with intrahepatic cholestasis of pregnancy, and in patients with itching. Br J Obstet Gynaecol. 1981;88:240-245.
23. Serrano MA, Brites D, Larena MG, et al. Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatol. 1998;28:829-839.
24. Laatikainen TJ. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Am J Obstet Gynecol. 1975;122:852-856.
25. Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology. 2004;40:467-474.
26. Williamson C, Hems LM, Goulis DG, et al. Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group. BJOG. 2004;111:676-681.
27. Davies MH, da Silva RC, Jones SR, et al. Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut. 1995;37:580-584.
28. Roncaglia N, Arreghini A, Locatelli A, et al. Obstetric cholestasis: outcome with active management. Eur J Obstet Gynecol Reprod Biol. 2002;100:167-170.
29. Hirvioja ML, Tuimala R. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. Br J Obstet Gynaecol. 1992;99:109-111.
30. Sadler LC, Lane M, North R. Severe fetal intracranial haemorrhage during treatment with cholestyramine for intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol. 1995;102:169-170.
31. Palma J, Reyes H, Ribalta J, et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J Hepatol. 1997;27:1022-1028.
32. Kondrackiene J, Beuers U, Kupcinskas L. Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. Gastroenterology. 2005;129:894-901.