메뉴 건너뛰기




Volumn 61, Issue 2, 2010, Pages 194-206

Neuroendocrine body weight regulation: Integration between fat tissue, gastrointestinal tract, and the brain

Author keywords

Central nerwous system; Obesity; Pancreas

Indexed keywords

AMYLIN; CHOLECYSTOKININ; ENDOCANNABINOID; ENTEROSTATIN; GHRELIN; GLUCAGON LIKE PEPTIDE 1; INTERLEUKIN 6; LEPTIN; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY;

EID: 77953527930     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (65)

References (71)
  • 1
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars: Molecular progress confronts an expanding epidemic
    • Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-350.
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 2
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • Morton GJ, Cummings DE, Baskin DG et al. Central nervous system control of food intake and body weight. Nature 2006; 443: 289-295.
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3
  • 4
    • 17844391500 scopus 로고    scopus 로고
    • The hardship of obesity: A soft-wired hypothalamus
    • Horvath TL. The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci 2005; 8: 561-565.
    • (2005) Nat Neurosci , vol.8 , pp. 561-565
    • Horvath, T.L.1
  • 5
    • 33845595901 scopus 로고    scopus 로고
    • Gut peptides in the regulation of food intake and energy homeostasis
    • DOI 10.1210/er.2006-0028
    • Murphy KG, Dhillo WS, Bloom SR. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 2006; 27: 719-727. (Pubitemid 44936055)
    • (2006) Endocrine Reviews , vol.27 , Issue.7 , pp. 719-727
    • Murphy, K.G.1    Dhillo, W.S.2    Bloom, S.R.3
  • 6
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007; 117: 13-23.
    • (2007) J Clin Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 7
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • DOI 10.1210/er.2005-0009
    • Pagotto U, Marsicano G, Cota D et al. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006; 27: 73-100. (Pubitemid 43228239)
    • (2006) Endocrine Reviews , vol.27 , Issue.1 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3    Lutz, B.4    Pasquali, R.5
  • 8
    • 33845588762 scopus 로고    scopus 로고
    • Emerging therapeutic strategies for obesity
    • Foster-Schubert KE, Cummings DE. Emerging therapeutic strategies for obesity. Endocr Rev 2006; 27: 779-793.
    • (2006) Endocr Rev , vol.27 , pp. 779-793
    • Foster-Schubert, K.E.1    Cummings, D.E.2
  • 9
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • Friedman JM. Modern science versus the stigma of obesity. Nat Med 2004; 10: 563-569.
    • (2004) Nat Med , vol.10 , pp. 563-569
    • Friedman, J.M.1
  • 10
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral EA, Simha V, Ruiz E et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002; 346: 570-578.
    • (2002) N Engl J Med , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 11
    • 33845567553 scopus 로고    scopus 로고
    • Genetics of obesity in humans
    • Farooqi S, O'Rahilly S. Genetics of obesity in humans. Endocr Rev 2006; 27: 710-718.
    • (2006) Endocr Rev , vol.27 , pp. 710-718
    • Farooqi, S.1    O'Rahilly, S.2
  • 13
    • 61449257382 scopus 로고    scopus 로고
    • Leptin in humans: Lessons from translational research
    • Bluher S, Mantzoros CS. Leptin in humans: lessons from translational research. Am J Clin Nutr 2009; 89: 991S-997S.
    • (2009) Am J Clin Nutr , vol.89
    • Bluher, S.1    Mantzoros, C.S.2
  • 14
    • 0037195916 scopus 로고    scopus 로고
    • Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
    • DOI 10.1074/jbc.M205825200
    • Ge H, Huang L, Pourbahrami T et al. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 2002; 277: 45898-45903. (Pubitemid 35417571)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 45898-45903
    • Ge, H.1    Huang, L.2    Pourbahrami, T.3    Li, C.4
  • 15
    • 0036168190 scopus 로고    scopus 로고
    • Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
    • DOI 10.1210/en.143.3.775
    • Hileman SM, Pierroz DD, Masuzaki H et al. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143: 775-783. (Pubitemid 34164025)
    • (2002) Endocrinology , vol.143 , Issue.3 , pp. 775-783
    • Hileman, S.M.1    Pierroz, D.D.2    Masuzaki, H.3    Bjorbk, C.4    El-Haschimi, K.5    Banks, W.A.6    Flier, J.S.7
  • 16
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6096.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 17
    • 0036720939 scopus 로고    scopus 로고
    • Brain stem is a direct target for leptin's action in the central nervous system
    • DOI 10.1210/en.2002-220077
    • Hosoi T, Kawagishi T, Okuma Y et al. Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology 2002; 143: 3498-3504. (Pubitemid 34925724)
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3498-3504
    • Hosoi, T.1    Kawagishi, T.2    Okuma, Y.3    Tanaka, J.4    Nomura, Y.5
  • 20
    • 33645746168 scopus 로고    scopus 로고
    • Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    • Chen K, Li F, Li J et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 2006; 12: 425-432
    • (2006) Nat Med , vol.12 , pp. 425-432
    • Chen, K.1    Li, F.2    Li, J.3
  • 21
    • 0036281128 scopus 로고    scopus 로고
    • The cerebrospinal fluid/serum leptin ratio during pharmacological therapy for obesity
    • Rodrigues AM, Radominski RB, Suplicy Hde L et al. The cerebrospinal fluid/serum leptin ratio during pharmacological therapy for obesity. J Clin Endocrinol Metab 2002; 87: 1621-1626
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1621-1626
    • Rodrigues, A.M.1    Radominski, R.B.2    Suplicy Hde, L.3
  • 22
    • 0035957791 scopus 로고    scopus 로고
    • Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents
    • DOI 10.1016/S0006-8993(01)02242-9, PII S0006899301022429
    • Banks WA. Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents. Brain Res 2001; 899: 209-217. (Pubitemid 32324162)
    • (2001) Brain Research , vol.899 , Issue.1-2 , pp. 209-217
    • Banks, W.A.1
  • 24
    • 77149153389 scopus 로고    scopus 로고
    • Leptin production by the adipose tissue is decreased in obesity associated with severe metabolic syndrome
    • in press
    • Paz-Filho G, Volaco A, Suplicy HL et al. Leptin production by the adipose tissue is decreased in obesity associated with severe metabolic syndrome. Arq Bras Endocr Metabol 2009; (in press).
    • (2009) Arq Bras Endocr Metabol
    • Paz-Filho, G.1    Volaco, A.2    Suplicy, H.L.3
  • 26
    • 0037392395 scopus 로고    scopus 로고
    • Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men
    • Hukshorn CJ, Westerterp-Plantenga MS, Saris WH. Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men. Am J Clin Nutr 2003; 77: 771-776.
    • (2003) Am J Clin Nutr , vol.77 , pp. 771-776
    • Hukshorn, C.J.1    Westerterp-Plantenga, M.S.2    Saris, W.H.3
  • 28
    • 44449175729 scopus 로고    scopus 로고
    • Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies
    • Roth JD, Roland BL, Cole RL et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci USA 2008; 105: 7257-7262.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7257-7262
    • Roth, J.D.1    Roland, B.L.2    Cole, R.L.3
  • 29
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science 2005; 307: 375-379.
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 30
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning JC, Gautam D, Burks DJ et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289: 2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 31
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • DOI 10.1038/nn861
    • Obici S, Feng Z, Karkanias G et al. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 2002; 5: 566-572. (Pubitemid 34568999)
    • (2002) Nature Neuroscience , vol.5 , Issue.6 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 32
    • 33646530498 scopus 로고    scopus 로고
    • Tissue selectivity of insulin detemir action in vivo
    • Hennige AM, Sartorius T, Tschritter O et al. Tissue selectivity of insulin detemir action in vivo. Diabetologia 2006; 49: 1274-1282.
    • (2006) Diabetologia , vol.49 , pp. 1274-1282
    • Hennige, A.M.1    Sartorius, T.2    Tschritter, O.3
  • 33
    • 0034699544 scopus 로고    scopus 로고
    • IRS-2 pathways integrate female reproduction and energy homeostasis
    • Burks DJ, Font de Mora J, Schubert M et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000; 407: 377-382.
    • (2000) Nature , vol.407 , pp. 377-382
    • Burks, D.J.1    Font De Mora, J.2    Schubert, M.3
  • 34
    • 0029786390 scopus 로고    scopus 로고
    • Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat
    • Saad MJ, Carvalho CR, Thirone AC et al. Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem 19; 271: 22100-22104.
    • J Biol Chem , vol.19 , Issue.271 , pp. 22100-22104
    • Saad, M.J.1    Carvalho, C.R.2    Thirone, A.C.3
  • 37
    • 4344645299 scopus 로고    scopus 로고
    • Molecular evolution of NPY receptor subtypes
    • DOI 10.1016/j.npep.2004.06.002, PII S014341790400054X
    • Larhammar D, Salaneck E: Molecular evolution of NPY receptor subtypes. Neuropeptides 2004; 38: 141-151. (Pubitemid 39158855)
    • (2004) Neuropeptides , vol.38 , Issue.4 , pp. 141-151
    • Larhammar, D.1    Salaneck, E.2
  • 38
    • 0036552411 scopus 로고    scopus 로고
    • Diverse functions of neuropeptide Y revealed using genetically modified animals
    • Thorsell A, Heilig M. Diverse functions of neuropeptide Y revealed using genetically modified animals. Neuropeptides 2002; 36: 182-193.
    • (2002) Neuropeptides , vol.36 , pp. 182-193
    • Thorsell, A.1    Heilig, M.2
  • 39
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • Cone RD. Studies on the physiological functions of the melanocortin system. Endocr Rev 2006; 27: 736-749.
    • (2006) Endocr Rev , vol.27 , pp. 736-749
    • Cone, R.D.1
  • 40
    • 0034456398 scopus 로고    scopus 로고
    • A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
    • Butler AA, Kesterson RA, Khong K et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000; 141: 3518-3521.
    • (2000) Endocrinology , vol.141 , pp. 3518-3521
    • Butler, A.A.1    Kesterson, R.A.2    Khong, K.3
  • 41
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen AS, Marsh DJ, Trumbauer ME et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26: 97-102.
    • (2000) Nat Genet , vol.26 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3
  • 43
    • 33845592201 scopus 로고    scopus 로고
    • Adipose tissue-derived factors: Impact on health and disease
    • DOI 10.1210/er.2006-0033
    • Trujillo ME, Scherer PE. Adipose tissue-derived factors: impact on health and disease. Endocr Rev 2006; 27: 762-778. (Pubitemid 44936059)
    • (2006) Endocrine Reviews , vol.27 , Issue.7 , pp. 762-778
    • Trujillo, M.E.1    Scherer, P.E.2
  • 44
    • 43049096057 scopus 로고    scopus 로고
    • Adipokines and the peripheral and neural control of energy balance
    • Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol 2008; 22: 1023-1031.
    • (2008) Mol Endocrinol , vol.22 , pp. 1023-1031
    • Ahima, R.S.1    Lazar, M.A.2
  • 47
    • 42049101804 scopus 로고    scopus 로고
    • AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
    • Coope A, Milanski M, Araújo EP et al. AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 2008; 582: 1471-1476.
    • (2008) FEBS Lett , vol.582 , pp. 1471-1476
    • Coope, A.1    Milanski, M.2    Araújo, E.P.3
  • 48
    • 10744225368 scopus 로고    scopus 로고
    • Regulation of fasted blood glucose by resistin
    • Banerjee RR, Rangwala SM, Shapiro JS et al. Regulation of fasted blood glucose by resistin. Science 2004; 303: 1195-1198.
    • (2004) Science , vol.303 , pp. 1195-1198
    • Banerjee, R.R.1    Rangwala, S.M.2    Shapiro, J.S.3
  • 49
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • DOI 10.1016/S1043-2760(00)00272-1, PII S1043276000002721
    • Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000; 11: 212-217. (Pubitemid 30603166)
    • (2000) Trends in Endocrinology and Metabolism , vol.11 , Issue.6 , pp. 212-217
    • Moller, D.E.1
  • 50
    • 0142087565 scopus 로고    scopus 로고
    • The therapeutic potential of interleukin-6 in treating obesity
    • DOI 10.1517/14712598.3.7.1061
    • Wallenius K, Jansson JO, Wallenius V. The therapeutic potential of interleukin-6 in treating obesity. Expert Opin Biol Ther 2003; 3: 1061-1070. (Pubitemid 37295762)
    • (2003) Expert Opinion on Biological Therapy , vol.3 , Issue.7 , pp. 1061-1070
    • Wallenius, K.1    Jansson, J.-O.2    Wallenius, V.3
  • 51
    • 66649134711 scopus 로고    scopus 로고
    • Minireview: Gut peptides: Targets for anti-obesity drug development?
    • Moran TH, Dailey MJ. Minireview: Gut peptides: targets for anti-obesity drug development? Endocrinology 2009; 150: 2526-2530.
    • (2009) Endocrinology , vol.150 , pp. 2526-2530
    • Moran, T.H.1    Dailey, M.J.2
  • 52
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005; 85: 495-522.
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 53
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • DOI 10.1210/er.2002-0029
    • van der Lely AJ, Tschop M, Heiman ML et al. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004; 25: 426-457. (Pubitemid 38780667)
    • (2004) Endocrine Reviews , vol.25 , Issue.3 , pp. 426-457
    • Van Der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 54
    • 27744600963 scopus 로고    scopus 로고
    • Medicine: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • DOI 10.1126/science.1117255
    • Zhang JV, Ren PG, Avsian-Kretchmer O et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-999. (Pubitemid 41611907)
    • (2005) Science , vol.310 , Issue.5750 , pp. 996-999
    • Zhang, J.V.1    Ren, P.-G.2    Avsian-Kretchmer, O.3    Luo, C.-W.4    Rauch, R.5    Klein, C.6    Hsueh, A.J.W.7
  • 55
    • 2942558193 scopus 로고    scopus 로고
    • Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- And food-related cues
    • Cummings DE, Frayo RS, Marmonier C et al. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 2004; 287: E297-304.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Cummings, D.E.1    Frayo, R.S.2    Marmonier, C.3
  • 56
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings DE, Purnell JQ, Frayo RS et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-1719.
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3
  • 57
    • 29344464362 scopus 로고    scopus 로고
    • Effects of a fixed meal pattern on ghrelin secretion: Evidence for a learned response independent of nutrient status
    • Drazen DL, Vahl TP, D'Alessio DA et al. Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology 2006; 147: 23-30.
    • (2006) Endocrinology , vol.147 , pp. 23-30
    • Drazen, D.L.1    Vahl, T.P.2    D'Alessio, D.A.3
  • 59
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of Ghrelin Impairs neither Growth nor Appetite
    • DOI 10.1128/MCB.23.22.7973-7981.2003
    • Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 2003; 23: 7973-7981. (Pubitemid 37377491)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 62
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK et al. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 2006; 3: 379-386.
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3
  • 63
    • 12144291698 scopus 로고    scopus 로고
    • Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
    • Challis BG, Coll AP, Yeo GS et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci USA 2004; 101: 4695-4700.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4695-4700
    • Challis, B.G.1    Coll, A.P.2    Yeo, G.S.3
  • 64
    • 34249682591 scopus 로고    scopus 로고
    • Beta-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg BL. Beta-cell failure in diabetes and preservation by clinical treatment. Endocr Rev 2007; 28: 187-218.
    • (2007) Endocr Rev , vol.28 , pp. 187-218
    • Wajchenberg, B.L.1
  • 65
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • DOI 10.1038/sj.ijo.0803344, PII 0803344
    • Wynne K, Park AJ, Small CJ et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controUed trial. Int J Obes (Lond) 2006; 30: 1729-1736. (Pubitemid 44863404)
    • (2006) International Journal of Obesity , vol.30 , Issue.12 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 67
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • DOI 10.1038/nn1457
    • Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005; 8: 585-589. (Pubitemid 40594198)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 585-589
    • Di Marzo, V.1    Matias, I.2
  • 68
    • 85047691827 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of body fat: The smoke is clearing
    • DOI 10.1172/JCI200319376
    • Horvath TL. Endocannabinoids and the regulation of body fat: the smoke is clearing. J Clin Invest 2003; 112: 323-326. (Pubitemid 38063759)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.3 , pp. 323-326
    • Horvath, T.L.1
  • 69
    • 1842866963 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
    • DOI 10.1038/sj.ijo.0802583
    • Ravinet Trillou C, Delgorge C, Menet C et al. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 2004; 28: 640-648. (Pubitemid 38491158)
    • (2004) International Journal of Obesity , vol.28 , Issue.4 , pp. 640-648
    • Ravinet Trillou, C.1    Delgorge, C.2    Menet, C.3    Arnone, M.4    Soubrie, P.5
  • 70
    • 33748937876 scopus 로고    scopus 로고
    • Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: Overview of RIO studies
    • Scheen AJ, Van Gaal LG, Despres JP et al. Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: overview of RIO studies. Rev Med Suisse 2006; 2: 1916-1923.
    • (2006) Rev Med Suisse , vol.2 , pp. 1916-1923
    • Scheen, A.J.1    Van Gaal, L.G.2    Despres, J.P.3
  • 71
    • 68949209293 scopus 로고    scopus 로고
    • The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents
    • Lee HK, Choi EB, Pak CS. The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents. Curr Top Med Chem 2009; 9: 482-503.
    • (2009) Curr Top Med Chem , vol.9 , pp. 482-503
    • Lee, H.K.1    Choi, E.B.2    Pak, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.