-
1
-
-
0031739939
-
Introduction: the role of innate immunity in the adaptive immune response
-
Janeway, C. A. Jr. and Medzhitov, R. (1998) Introduction: the role of innate immunity in the adaptive immune response. Semin. Immunol. 10, 349-350.
-
(1998)
Semin. Immunol.
, vol.10
, pp. 349-350
-
-
Janeway C.A., Jr.1
Medzhitov, R.2
-
2
-
-
0034680145
-
Toll-like receptors in the induction of the innate immune response
-
Aderem, A. and Ulevitch, R. J. (2000) Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787.
-
(2000)
Nature
, vol.406
, pp. 782-787
-
-
Aderem, A.1
Ulevitch, R.J.2
-
3
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
4
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg, A. M. (2006) Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug. Discov. 5, 471-484.
-
(2006)
Nat. Rev. Drug. Discov.
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
5
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
-
Tokunaga, T., Yamamoto, H., Shimada, S., Abe, S. H., Fukuda, T., Fujisawa, Y., Furutani, Y., Yano, O., Kataoka, T., Sudo, T., Makiguchi, N. and Suganuma, T. (1984) Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72, 955-962.
-
(1984)
J. Natl. Cancer Inst.
, vol.72
, pp. 955-962
-
-
Tokunaga, T.1
Yamamoto, H.2
Shimada, S.3
Abe, S.H.4
Fukuda, T.5
Fujisawa, Y.6
Furutani, Y.7
Yano, O.8
Kataoka, T.9
Sudo, T.10
Makiguchi, N.11
Suganuma, T.12
-
6
-
-
0026006734
-
Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
-
Messina, J. P., Gilkeson, G. S. and Pisetsky, D. S. (1991) Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA . J. Immunol. 147, 1759-1764.
-
(1991)
J. Immunol.
, vol.147
, pp. 1759-1764
-
-
Messina, J.P.1
Gilkeson, G.S.2
Pisetsky, D.S.3
-
7
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B cell activation
-
Krieg, A. M., Yi, A. K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A. and Klinman, D. M. (1995) CpG motifs in bacterial DNA trigger direct B cell activation. Nature 374, 546-549.
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
8
-
-
0030239828
-
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
-
Ballas, Z. K., Rasmussen, W. L. and Krieg, A. M. (1996) Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157, 1840-1845.
-
(1996)
J. Immunol.
, vol.157
, pp. 1840-1845
-
-
Ballas, Z.K.1
Rasmussen, W.L.2
Krieg, A.M.3
-
9
-
-
0029984358
-
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ
-
Klinman, D. M., Yi, A. K., Beaucage, S. L., Conover, J. and Krieg, A. M. (1996) CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ. Proc. Natl. Acad. Sci. U.S.A. 93, 2879-2883.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 2879-2883
-
-
Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
10
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg, A. M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760.
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
11
-
-
0142122479
-
NF-κB-dependent regulation of tumor necrosis factor-α gene expression by CpG-oligodeoxynucleotides
-
Kwon, H. J., Lee, K. W., Yu, S. H., Han, J. H. and Kim, D. S. (2003) NF-κB-dependent regulation of tumor necrosis factor-α gene expression by CpG-oligodeoxynucleotides. Biochem. Biophys. Res. Commun. 311, 129-138.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.311
, pp. 129-138
-
-
Kwon, H.J.1
Lee, K.W.2
Yu, S.H.3
Han, J.H.4
Kim, D.S.5
-
12
-
-
33646570905
-
Direct role of NF-κB activation in Toll-like receptor-triggered HLA-DRA expression
-
Lee, K. W., Lee, Y., Kim, D. S. and Kwon, H. J. (2006) Direct role of NF-κB activation in Toll-like receptor-triggered HLA-DRA expression. Eur. J. Immunol. 36, 1254-1266.
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 1254-1266
-
-
Lee, K.W.1
Lee, Y.2
Kim, D.S.3
Kwon, H.J.4
-
13
-
-
70449718869
-
Expression of human β-defensin-2 gene induced by CpG-DNA in human B cells
-
Han, S. H., Kim, Y. E., Park, J. A., Park, J. B., Kim, Y. S., Lee, Y., Choi, I. G. and Kwon, H. J. (2009) Expression of human β-defensin-2 gene induced by CpG-DNA in human B cells. Biochem. Biophys. Res. Commun. 389, 443-448.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.389
, pp. 443-448
-
-
Han, S.H.1
Kim, Y.E.2
Park, J.A.3
Park, J.B.4
Kim, Y.S.5
Lee, Y.6
Choi, I.G.7
Kwon, H.J.8
-
14
-
-
0024296609
-
Physicochemical properties of phosphorothioate oligodeoxynucleotides
-
Stein, C. A., Subasinghe, C., Shinozuka, K. and Cohen, J. S. (1988) Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res. 16, 3209-3221
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 3209-3221
-
-
Stein, C.A.1
Subasinghe, C.2
Shinozuka, K.3
Cohen, J.S.4
-
15
-
-
0027325137
-
Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides
-
Zhao, Q., Matson, S., Herrera, C. J., Fisher, E., Yu, H. and Krieg, A. M. (1993) Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides. Antisense Res. Dev. 3, 53-66.
-
(1993)
Antisense Res. Dev.
, vol.3
, pp. 53-66
-
-
Zhao, Q.1
Matson, S.2
Herrera, C.J.3
Fisher, E.4
Yu, H.5
Krieg, A.M.6
-
16
-
-
0027985329
-
Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors
-
Zhao, Q., Waldschmidt, T., Fisher, E., Herrera, C. J. and Krieg, A.M. (1994) Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors. Blood 84, 3660-3666.
-
(1994)
Blood
, vol.84
, pp. 3660-3666
-
-
Zhao, Q.1
Waldschmidt, T.2
Fisher, E.3
Herrera, C.J.4
Krieg, A.M.5
-
17
-
-
0035501012
-
Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs
-
Ballas, Z. K., Krieg, A. M., Warren, T. L., Rasmussen, W. L., Davis, H. L., Waldschmidt, M. and Weiner, G. J. (2001) Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J. Immunol. 167, 4878-4886.
-
(2001)
J. Immunol.
, vol.167
, pp. 4878-4886
-
-
Ballas, Z.K.1
Krieg, A.M.2
Warren, T.L.3
Rasmussen, W.L.4
Davis, H.L.5
Waldschmidt, M.6
Weiner, G.J.7
-
18
-
-
0032534602
-
Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
-
Broide, D., Schwarze, J., Tighe, H., Gifford, T., M. Nguyen, Malek, D. S., Van Uden, J., Martin-Orozco, E., Gelfand, E. W. and Raz, E. (1998) Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J. Immunol. 161, 7054-7062.
-
(1998)
J. Immunol.
, vol.161
, pp. 7054-7062
-
-
Broide, D.1
Schwarze, J.2
Tighe, H.3
Gifford, T.4
Nguyen, M.5
Malek, D.S.6
Van Uden, J.7
Martin-Orozco, E.8
Gelfand, E.W.9
Raz, E.10
-
19
-
-
0032521881
-
CpG oli-godeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
-
Zimmermann, S., Egeter, O., Hausmann, S., Lipford, G. B., Rocken, M., Wagner, H. and Heeg, K. (1998) CpG oli-godeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160, 3627-3630.
-
(1998)
J. Immunol.
, vol.160
, pp. 3627-3630
-
-
Zimmermann, S.1
Egeter, O.2
Hausmann, S.3
Lipford, G.B.4
Rocken, M.5
Wagner, H.6
Heeg, K.7
-
20
-
-
0344436049
-
Immunostimulatory CpG oli-godeoxynucleotides cause extramedullary murine hemopoiesis
-
Sparwasser, T., Hultner, L., Koch, E. S., Luz, A., Lipford, G. B. and Wagner, H. (1999) Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J. Immunol. 162, 2368-2374.
-
(1999)
J. Immunol.
, vol.162
, pp. 2368-2374
-
-
Sparwasser, T.1
Hultner, L.2
Koch, E.S.3
Luz, A.4
Lipford, G.B.5
Wagner, H.6
-
21
-
-
0842343142
-
Lymphoid follicle destruction and immuno suppression after repeated CpG oligodeoxynucleotide administration
-
Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R. and Aguzzi, A. (2004) Lymphoid follicle destruction and immuno suppression after repeated CpG oligodeoxynucleotide administration. Nat. Med. 10, 187-192.
-
(2004)
Nat. Med.
, vol.10
, pp. 187-192
-
-
Heikenwalder, M.1
Polymenidou, M.2
Junt, T.3
Sigurdson, C.4
Wagner, H.5
Akira, S.6
Zinkernagel, R.7
Aguzzi, A.8
-
22
-
-
0033038486
-
Intra-articularly localized bacte-rial DNA containing CpG motifs induces arthritis
-
Deng, G. M., Nilsson, I. M., Verdrengh, M., Collins, L. V. and Tarkowski, A. (1999) Intra-articularly localized bacte-rial DNA containing CpG motifs induces arthritis. Nat. Med. 5, 702-705.
-
(1999)
Nat. Med.
, vol.5
, pp. 702-705
-
-
Deng, G.M.1
Nilsson, I.M.2
Verdrengh, M.3
Collins, L.V.4
Tarkowski, A.5
-
23
-
-
58149513750
-
Immunostimu-lation and anti-DNA antibody production by backbone modified CpG-DNA
-
Kim, D., Rhee, J. W., Kwon, S., Sohn, W. J., Lee, Y., Kim, D. W., Kim, D. S. and Kwon, H. J. (2009) Immunostimu-lation and anti-DNA antibody production by backbone modified CpG-DNA. Biochem. Biophys. Res. Commun. 379, 362-367.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.379
, pp. 362-367
-
-
Kim, D.1
Rhee, J.W.2
Kwon, S.3
Sohn, W.J.4
Lee, Y.5
Kim, D.W.6
Kim, D.S.7
Kwon, H.J.8
-
24
-
-
33645851635
-
Immunostimulatory oligodeoxynucleotide isolated from genome wide screening of Mycobacterium bovis chromosomal DNA
-
Lee, K. W., Jung, J., Lee, Y., Kim, T. Y., Choi, S. Y., Park, J., Kim, D. S. and Kwon, H. J. (2006) Immunostimulatory oligodeoxynucleotide isolated from genome wide screening of Mycobacterium bovis chromosomal DNA. Mol. Immunol. 43, 2107-2118.
-
(2006)
Mol. Immunol.
, vol.43
, pp. 2107-2118
-
-
Lee, K.W.1
Jung, J.2
Lee, Y.3
Kim, T.Y.4
Choi, S.Y.5
Park, J.6
Kim, D.S.7
Kwon, H.J.8
-
25
-
-
18644383289
-
Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
-
Yasuda, K., Yu, P., Kirschning, C. J., Schlatter, B., Schmitz, F., Heit, A., Bauer, S., Hochrein, H. and Wagner, H. (2005) Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 174, 6129-6136.
-
(2005)
J. Immunol.
, vol.174
, pp. 6129-6136
-
-
Yasuda, K.1
Yu, P.2
Kirschning, C.J.3
Schlatter, B.4
Schmitz, F.5
Heit, A.6
Bauer, S.7
Hochrein, H.8
Wagner, H.9
-
26
-
-
34250850725
-
Natural DNA repetitive extragenic sequences from Gramnegative pathogens strongly stimulate TLR9
-
Magnusson, M., Tobes, R., Sancho, J. and Pareja, E. (2007) Natural DNA repetitive extragenic sequences from Gramnegative pathogens strongly stimulate TLR9. J. Immunol. 179, 31-35.
-
(2007)
J. Immunol.
, vol.179
, pp. 31-35
-
-
Magnusson, M.1
Tobes, R.2
Sancho, J.3
Pareja, E.4
-
27
-
-
33845390434
-
Identification of immunostimulatory oligodeoxynucleo-tides from Escherichia coli genomic DNA
-
Choi, Y. J., Lee, K. W., Kwon, H. J. and Kim, D. S. (2006) Identification of immunostimulatory oligodeoxynucleo-tides from Escherichia coli genomic DNA. J. Biochem. Mol. Biol. 39, 788-793.
-
(2006)
J. Biochem. Mol. Biol.
, vol.39
, pp. 788-793
-
-
Choi, Y.J.1
Lee, K.W.2
Kwon, H.J.3
Kim, D.S.4
-
28
-
-
0036555126
-
Liposo mal delivery of CTL epitope to dendritic cells
-
Chikh, G. and Schutze-Redelmeier, M. P. (2002) Liposo mal delivery of CTL epitope to dendritic cells. Bioscience Reports 22, 339-353.
-
(2002)
Bioscience Reports
, vol.22
, pp. 339-353
-
-
Chikh, G.1
Schutze-Redelmeier, M.P.2
-
29
-
-
9244234954
-
Liposomes and virosomes as delivery system for antigens, nucleic acids and drugs
-
Felnerova, D., Viret, J. F., Gluck, R. and Moser, C. (2004) Liposomes and virosomes as delivery system for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 15, 518-529.
-
(2004)
Curr. Opin. Biotechnol.
, vol.15
, pp. 518-529
-
-
Felnerova, D.1
Viret, J.F.2
Gluck, R.3
Moser, C.4
-
30
-
-
0030613651
-
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
-
Chu, R. S., Targoni, O. S., Krieg, A. M., Lehmann, P. V. and Harding, C. V. (1997) CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186, 1623-1631.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1623-1631
-
-
Chu, R.S.1
Targoni, O.S.2
Krieg, A.M.3
Lehmann, P.V.4
Harding, C.V.5
-
31
-
-
0031964257
-
CpG-DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
-
Davis, H. L., Weeratna, R., Waldschmidt, T. J., Tygrett, L., Schorr, J. and Krieg, A. M. (1998) CpG-DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160, 870-876.
-
(1998)
J. Immunol.
, vol.160
, pp. 870-876
-
-
Davis, H.L.1
Weeratna, R.2
Waldschmidt, T.J.3
Tygrett, L.4
Schorr, J.5
Krieg, A.M.6
-
32
-
-
9244230628
-
Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity
-
Suzuki, Y., Wakita, D., Chamoto, K., Narita, Y., Tsuji, T., Takeshima, T., Gyobu, H., Kawarada, Y., Kondo, S., Akira, S., Katoh, H., Ikeda, H. and Nishimura, T. (2004) Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. Cancer Res. 64, 8754-8760.
-
(2004)
Cancer Res.
, vol.64
, pp. 8754-8760
-
-
Suzuki, Y.1
Wakita, D.2
Chamoto, K.3
Narita, Y.4
Tsuji, T.5
Takeshima, T.6
Gyobu, H.7
Kawarada, Y.8
Kondo, S.9
Akira, S.10
Katoh, H.11
Ikeda, H.12
Nishimura, T.13
-
33
-
-
66549084491
-
Inhibitory effects of flavonoids on TNF-α-induced IL-8 gene expression in HEK 293 cells
-
Lee, S., Kim, Y. J., Kwon, S., Lee, Y., Choi, S. Y., Park, J. and Kwon, H. J. (2009) Inhibitory effects of flavonoids on TNF-α-induced IL-8 gene expression in HEK 293 cells. BMB Rep. 42, 265-270.
-
(2009)
BMB Rep.
, vol.42
, pp. 265-270
-
-
Lee, S.1
Kim, Y.J.2
Kwon, S.3
Lee, Y.4
Choi, S.Y.5
Park, J.6
Kwon, H.J.7
|