메뉴 건너뛰기




Volumn 64, Issue 23, 2004, Pages 8754-8760

Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CATIONIC LIPOSOME CYTOSINE PHOSPHOROTHIOATE GUANINE OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 12; INTERLEUKIN 4; LIPOSOME; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OVALBUMIN; TOLL LIKE RECEPTOR 9; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNMETHYLATED CYTOSINE PHOSPHOROTHIOATE GUANINE OLIGODEOXYNUCLEOTIDE;

EID: 9244230628     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1691     Document Type: Article
Times cited : (117)

References (63)
  • 1
    • 0035889647 scopus 로고    scopus 로고
    • Active immunization against cancer with dendritic cells: The near future
    • Steinman RM, Dhodapkar M. Active immunization against cancer with dendritic cells: the near future. Int J Cancer 2001;94:459-73.
    • (2001) Int J Cancer , vol.94 , pp. 459-473
    • Steinman, R.M.1    Dhodapkar, M.2
  • 2
    • 0035347549 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity: Enhancing the efficiency of antigen presentation
    • Steinman RM. Dendritic cells and the control of immunity: enhancing the efficiency of antigen presentation. Mt Sinai J Med 2001;68:106-66.
    • (2001) Mt Sinai J Med , vol.68 , pp. 106-166
    • Steinman, R.M.1
  • 3
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3:133-46.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 4
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 5
    • 0348013202 scopus 로고    scopus 로고
    • The NKT cell system: Bridging innate and acquired immunity
    • Taniguchi M, Seino K, Nakayama T. The NKT cell system: bridging innate and acquired immunity. Nat Immunol 2003;4;1164-5.
    • (2003) Nat Immunol , vol.4 , pp. 1164-1165
    • Taniguchi, M.1    Seino, K.2    Nakayama, T.3
  • 6
  • 8
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994;84:4008-27.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 9
    • 0033526066 scopus 로고    scopus 로고
    • The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
    • Kitamura H, Iwakabe K, Yahata T, et al. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med 1999;189:1121-8.
    • (1999) J Exp Med , vol.189 , pp. 1121-1128
    • Kitamura, H.1    Iwakabe, K.2    Yahata, T.3
  • 12
    • 1842477227 scopus 로고    scopus 로고
    • A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells
    • Dillon S, Agrawal A, Van Dyke T, et al. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 2004;172:4733-43.
    • (2004) J Immunol , vol.172 , pp. 4733-4743
    • Dillon, S.1    Agrawal, A.2    Van Dyke, T.3
  • 13
    • 0032934504 scopus 로고    scopus 로고
    • Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
    • Kodama T, Takeda K, Shimozato O, et al. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12. Eur J Immunol 1999;29:1390-6.
    • (1999) Eur J Immunol , vol.29 , pp. 1390-1396
    • Kodama, T.1    Takeda, K.2    Shimozato, O.3
  • 15
    • 0034786013 scopus 로고    scopus 로고
    • The natural killer T-cell ligand α-galactosyl-ceramide prevents autoimmune diabetes in non-obese diabetic mice
    • Hong S, Wilson MT, Serizawa I, et al. The natural killer T-cell ligand α-galactosyl-ceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 2001;7:1052-6.
    • (2001) Nat Med , vol.7 , pp. 1052-1056
    • Hong, S.1    Wilson, M.T.2    Serizawa, I.3
  • 16
    • 0034569025 scopus 로고    scopus 로고
    • NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
    • Terabe M, Matsui S, Noben-Trauth N, et al. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol 2000;1:515-20.
    • (2000) Nat Immunol , vol.1 , pp. 515-520
    • Terabe, M.1    Matsui, S.2    Noben-Trauth, N.3
  • 17
    • 0034572835 scopus 로고    scopus 로고
    • NKT cells and tumor immunity - A double-edged sword
    • Smyth MJ, Godfrey DI. NKT cells and tumor immunity - a double-edged sword. Nat Immunol 2000;1:459-60.
    • (2000) Nat Immunol , vol.1 , pp. 459-460
    • Smyth, M.J.1    Godfrey, D.I.2
  • 18
    • 0036735859 scopus 로고    scopus 로고
    • Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide-loaded DCs
    • Fujii S, Shimizu K, Kronenberg M, Steinman RM. Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide- loaded DCs. Nat Immunol 2002;3:867-74.
    • (2002) Nat Immunol , vol.3 , pp. 867-874
    • Fujii, S.1    Shimizu, K.2    Kronenberg, M.3    Steinman, R.M.4
  • 19
    • 0035112622 scopus 로고    scopus 로고
    • Potentiation of antitumor effect of NKT cell ligand, α- galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells
    • Nakui M, Ohta A, Sekimoto M, et al. Potentiation of antitumor effect of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells. Clin Exp Metastasis 2000;18:147-53.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 147-153
    • Nakui, M.1    Ohta, A.2    Sekimoto, M.3
  • 20
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002;20:709-60.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 21
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv Immunol 1999;73:329-68.
    • (1999) Adv Immunol , vol.73 , pp. 329-368
    • Wagner, H.1
  • 22
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
    • Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc Natl Acad Sci USA 1996;93:2879-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 23
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg AM, Love-Homan L, Yi AK, Harty JT. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 1998;161:2428-34.
    • (1998) J Immunol , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.K.3    Harty, J.T.4
  • 24
    • 0033790347 scopus 로고    scopus 로고
    • Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA
    • Krieg AM, Wagner H. Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA. Immunol Today 2000;21:521-6.
    • (2000) Immunol Today , vol.21 , pp. 521-526
    • Krieg, A.M.1    Wagner, H.2
  • 25
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-5.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 26
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P, Hacker H, Rutz M, Bauer S, Vabulas RM, Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 2002;32:1958-68.
    • (2002) Eur J Immunol , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 27
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • Gursel I, Gursel M, Ishii KJ, Klinman DM. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J Immunol 2001;167:3324-8.
    • (2001) J Immunol , vol.167 , pp. 3324-3328
    • Gursel, I.1    Gursel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 29
    • 0036555126 scopus 로고    scopus 로고
    • Liposomal delivery of CTL epitopes to dendritic cells
    • Chikh G, Schutze-Redelmeier MP. Liposomal delivery of CTL epitopes to dendritic cells. Biosci Rep 2002;22:339-53.
    • (2002) Biosci Rep , vol.22 , pp. 339-353
    • Chikh, G.1    Schutze-Redelmeier, M.P.2
  • 30
  • 31
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Homung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002;168:4531-7.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Homung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 32
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996;157:1840-5.
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 33
    • 0032433054 scopus 로고    scopus 로고
    • Type 1 interferon-mediated stimulation of T cells by CpG DNA
    • Sun S, Zhang X, Tough DF, Sprent J. Type 1 interferon-mediated stimulation of T cells by CpG DNA. J Exp Med 1998;188:2335-42.
    • (1998) J Exp Med , vol.188 , pp. 2335-2342
    • Sun, S.1    Zhang, X.2    Tough, D.F.3    Sprent, J.4
  • 34
    • 0026322151 scopus 로고
    • A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    • van der Bruggen P, Traversari C, Chomez P, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991;254:1643-7.
    • (1991) Science , vol.254 , pp. 1643-1647
    • Van Der Bruggen, P.1    Traversari, C.2    Chomez, P.3
  • 35
    • 0036813331 scopus 로고    scopus 로고
    • Cancer/testis antigens: An expanding family of targets for cancer immunotherapy
    • Scanlan MJ, Gure AO, Jungbluth AA, Old LJ, Chen YT. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev 2002;188:22-32.
    • (2002) Immunol Rev , vol.188 , pp. 22-32
    • Scanlan, M.J.1    Gure, A.O.2    Jungbluth, A.A.3    Old, L.J.4    Chen, Y.T.5
  • 36
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
    • Thurner B, Haendle I, Röder C, et al. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 1999;190:1669-78.
    • (1999) J Exp Med , vol.190 , pp. 1669-1678
    • Thurner, B.1    Haendle, I.2    Röder, C.3
  • 37
    • 0033485764 scopus 로고    scopus 로고
    • Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression
    • Lee KH, Wang E, Nielsen MB, et al. Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression. J Immunol 1999;163:6292-300.
    • (1999) J Immunol , vol.163 , pp. 6292-6300
    • Lee, K.H.1    Wang, E.2    Nielsen, M.B.3
  • 38
    • 0033034333 scopus 로고    scopus 로고
    • Down-regulation of HLA class 1 antigen-processing molecules in malignant melanoma: Association with disease progression
    • Kageshita T, Hirai S, Ono T, Hicklin DJ, Ferrone S. Down-regulation of HLA class 1 antigen-processing molecules in malignant melanoma: association with disease progression. Am J Pathol 1999;154:745-54.
    • (1999) Am J Pathol , vol.154 , pp. 745-754
    • Kageshita, T.1    Hirai, S.2    Ono, T.3    Hicklin, D.J.4    Ferrone, S.5
  • 39
    • 0037446966 scopus 로고    scopus 로고
    • Transforming growth factor β inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines
    • Kobie JJ, Wu RS, Kurt RA, et al. Transforming growth factor β inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Res 2003;63:1860-4.
    • (2003) Cancer Res , vol.63 , pp. 1860-1864
    • Kobie, J.J.1    Wu, R.S.2    Kurt, R.A.3
  • 40
    • 0346888498 scopus 로고    scopus 로고
    • Control of autoimmunity by naturally arising regulatory CD4+ T cells
    • Hori S, Takahashi T, Sakaguchi S. Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol 2003;81:331-71.
    • (2003) Adv Immunol , vol.81 , pp. 331-371
    • Hori, S.1    Takahashi, T.2    Sakaguchi, S.3
  • 41
    • 0029841427 scopus 로고    scopus 로고
    • Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses
    • Otsuji M, Kimura Y, Aoe T, Okamoto Y, Saito T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 1996;93:13119-24.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13119-13124
    • Otsuji, M.1    Kimura, Y.2    Aoe, T.3    Okamoto, Y.4    Saito, T.5
  • 42
    • 0032858174 scopus 로고    scopus 로고
    • Distinct role of antigen-specific T helper type I (Th1) and Th2 cells in tumor eradication in vivo
    • Nishimura T, Iwakabe K, Sekimoto M, et al. Distinct role of antigen-specific T helper type I (Th1) and Th2 cells in tumor eradication in vivo. J Exp Med 1999;190:617-27.
    • (1999) J Exp Med , vol.190 , pp. 617-627
    • Nishimura, T.1    Iwakabe, K.2    Sekimoto, M.3
  • 43
    • 9144239842 scopus 로고    scopus 로고
    • Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells
    • Chamoto K, Tsuji T, Funamoto H, et al. Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells. Cancer Res 2004;64:386-90.
    • (2004) Cancer Res , vol.64 , pp. 386-390
    • Chamoto, K.1    Tsuji, T.2    Funamoto, H.3
  • 44
    • 10744225529 scopus 로고    scopus 로고
    • Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor
    • Gyobu H, Tsuji T, Suzuki Y, et al. Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor. Cancer Res 2004;64:1490-5.
    • (2004) Cancer Res , vol.64 , pp. 1490-1495
    • Gyobu, H.1    Tsuji, T.2    Suzuki, Y.3
  • 45
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 46
    • 0033854136 scopus 로고    scopus 로고
    • The interface between innate and acquired immunity: Glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes
    • Nishimura T, Kitamura H, Iwakabe K, et al. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol 2000;12:987-94.
    • (2000) Int Immunol , vol.12 , pp. 987-994
    • Nishimura, T.1    Kitamura, H.2    Iwakabe, K.3
  • 47
    • 0034627985 scopus 로고    scopus 로고
    • α-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells
    • Kitamura H, Ohta A, Sekimoto M, et al. α-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell Immunol 2000;199:37-42.
    • (2000) Cell Immunol , vol.199 , pp. 37-42
    • Kitamura, H.1    Ohta, A.2    Sekimoto, M.3
  • 49
    • 1642443984 scopus 로고    scopus 로고
    • Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-γ synthesis
    • Gould MP, Greene JA, Bhoj V, DeVecchio JL, Heinzel FP. Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-γ synthesis. J Immunol 2004;172:1754-62.
    • (2004) J Immunol , vol.172 , pp. 1754-1762
    • Gould, M.P.1    Greene, J.A.2    Bhoj, V.3    DeVecchio, J.L.4    Heinzel, F.P.5
  • 50
    • 0034951434 scopus 로고    scopus 로고
    • Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
    • Amakata Y, Fujiyama Y, Andoh A, Hodohara K, Bamba T. Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes. Clin Exp Immunol 2001;124:214-22.
    • (2001) Clin Exp Immunol , vol.124 , pp. 214-222
    • Amakata, Y.1    Fujiyama, Y.2    Andoh, A.3    Hodohara, K.4    Bamba, T.5
  • 51
    • 0033198183 scopus 로고    scopus 로고
    • Cutting edge: Activation of NK T cells by CD1d and α- galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype
    • Singh N, Hong S, Scherer DC, et al. Cutting edge: activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol 1999;163:2373-7.
    • (1999) J Immunol , vol.163 , pp. 2373-2377
    • Singh, N.1    Hong, S.2    Scherer, D.C.3
  • 52
    • 4043169040 scopus 로고    scopus 로고
    • 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine
    • Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 2004;112:559-66.
    • (2004) Immunology , vol.112 , pp. 559-566
    • Munks, M.W.1    Mourich, D.V.2    Mittler, R.S.3    Weinberg, A.D.4    Hill, A.B.5
  • 53
    • 0141609073 scopus 로고    scopus 로고
    • Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?
    • Croft M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol 2003;3:609-20.
    • (2003) Nat Rev Immunol , vol.3 , pp. 609-620
    • Croft, M.1
  • 54
    • 0034235701 scopus 로고    scopus 로고
    • Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity
    • Davila E, Celis E. Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity. J Immunol 2000;165:539-47.
    • (2000) J Immunol , vol.165 , pp. 539-547
    • Davila, E.1    Celis, E.2
  • 55
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 1997;94:10833-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10833-10837
    • Weiner, G.J.1    Liu, H.M.2    Wooldridge, J.E.3    Dahle, C.E.4    Krieg, A.M.5
  • 56
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila E, Kennedy R, Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res 2003;63:3281-8.
    • (2003) Cancer Res , vol.63 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 57
    • 2142806632 scopus 로고    scopus 로고
    • Autoreactive T cells persist in rats protected against experimental autoimmune encephalomyelitis and can be activated through stimulation of innate immunity
    • Conant SB, Swanborg RH. Autoreactive T cells persist in rats protected against experimental autoimmune encephalomyelitis and can be activated through stimulation of innate immunity. J Immunol 2004;172:5322-8.
    • (2004) J Immunol , vol.172 , pp. 5322-5328
    • Conant, S.B.1    Swanborg, R.H.2
  • 58
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CDS T cell memory
    • Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CDS T cell memory. Science 2003;300:337-9.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 59
    • 0037432776 scopus 로고    scopus 로고
    • Defective CDS T cell memory following acute infection without CD4 T cell help
    • Sun JC, Bevan MJ. Defective CDS T cell memory following acute infection without CD4 T cell help. Science 2003;300:339-42.
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 60
    • 0037432736 scopus 로고    scopus 로고
    • Immunology. CD8 T cells remember with a little help
    • Kaech SM, Ahmed R. Immunology. CD8 T cells remember with a little help. Science 2003;300:263-5.
    • (2003) Science , vol.300 , pp. 263-265
    • Kaech, S.M.1    Ahmed, R.2
  • 61
    • 0842343142 scopus 로고    scopus 로고
    • Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    • Heikenwalder M, Polymenidou M, Junt T, et al. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med 2004;10:187-92.
    • (2004) Nat Med , vol.10 , pp. 187-192
    • Heikenwalder, M.1    Polymenidou, M.2    Junt, T.3
  • 62
    • 0035831629 scopus 로고    scopus 로고
    • Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes
    • Loisel S, Le Gall C, Doucet L, Ferec C, Floch V. Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes. Hum Gene Ther 2001;12:685-96.
    • (2001) Hum Gene Ther , vol.12 , pp. 685-696
    • Loisel, S.1    Le Gall, C.2    Doucet, L.3    Ferec, C.4    Floch, V.5
  • 63
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 2004;4:249-58.
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.