Expression of human β-defensin-2 gene induced by CpG-DNA in human B cells

Biochemical and Biophysical Research Communications

Volumn 389, Issue 3, 2009, Pages 443-448

  Han, Su Ho ^a   Kim, Young Eun ^b   Park, Jeong A ^b   Park, Jae Bong ^a   Kim, Yong Sun ^a   Lee, Younghee ^b   Choi, Ihn Geun ^a   Kwon, Hyung Joo ^a  

^a Hallym University   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

B cells; CpG DNA; hBD 2; Lymphocytes; NF B

Indexed keywords

ALPHA DEFENSIN; BETA ACTIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; BETA DEFENSIN 4; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOROTHIOIC ACID; BETA DEFENSIN; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; DEFB4 PROTEIN, HUMAN; OLIGODEOXYRIBONUCLEOTIDE;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CPG ISLAND; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION; CELL LINE; DRUG EFFECT; GENETICS; IMMUNOLOGY;

BACTERIA (MICROORGANISMS); FUNGI;

B-LYMPHOCYTES; BETA-DEFENSINS; CELL LINE; GENE EXPRESSION; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; UP-REGULATION;

EID: 70449718869     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.162     Document Type: Article

References (33)

1. R.I. Lehrer, A.K. Lichtenstein, T. Ganz, Defensins: antimicrobial and cytotoxic peptides of mammalian cells, Annu. Rev. Immunol. 11 (1993) 105-128.
2. T. Ganz, Defensins: antimicrobial peptides of innate immunity, Nat. Rev. Immunol. 3 (2003) 710-720.
3. Y.Q. Tang, J. Yuan, G. Osapay, K. Osapay, D. Tran, C.J. Miller, A.J. Ouellette, M.E. Selsted, A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins, Science 286 (1999) 498-502.
4. S.H. White, W.C. Wimley, M.E. Selsted, Structure, function, and membrane integration of defensins, Curr. Opin. Struct. Biol. 5 (1995) 521-527.
5. O. Chertov, D.F. Michiel, L. Xu, J.M. Wang, K. Tani, W.J. Murphy, D.L. Longo, D.D. Taub, J.J. Oppenheim, Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils, J. Biol. Chem. 271 (1996) 2935-2940.
6. D.E. Jones, C.L. Bevins, Paneth cells of the human small intestine express an antimicrobial peptide gene, J. Biol. Chem. 267 (1992) 23216-23225.
7. D.E. Jones, C.L. Bevins, Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel, FEBS Lett. 315 (1993) 187-192.
8. J. Harder, J. Bartels, E. Christophers, J.M. Schroeder, A peptide antibiotic from human skin, Nature 387 (1997) 861.
9. P. Schmid, O. Grenet, J. Medina, S.D. Chibout, C. Osborne, D.A. Cox, An intrinsic antibiotic mechanism in wounds and tissue-engineered skin, J. Invest. Dermatol. 116 (2001) 471-472.
10. J. Butmarc, T. Yufit, P. Carson, V. Falanga, Human β-defensin-2 expression is increased in chronic wounds, Wound Repair Regen. 12 (2004) 439-443.
11. D.A. O0Neil, E.M. Porter, D. Elewaut, G.M. Anderson, L. Eckmann, T. Ganz, M.F. Kagnoff, Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium, J. Immunol. 163 (1999) 6718-6724.
12. M. Frye, J. Bargon, B. Lembcke, T.O. Wagner, R. Gropp, Differential expression of human α-and β-defensins mRNA in gastrointestinal epithelia, Eur. J. Clin. Invest. 30 (2000) 695-701.
13. R. Bals, X. Wang, Z. Wu, T. Freeman, V. Bafna, M. Zasloff, J.M. Wilson, Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung, J. Clin. Invest. 102 (1998) 874-880.
14. P.K. Singh, H.P. Jia, K. Wiles, J. Hesselberth, L. Liu, B.A. Conway, E.P. Greenberg, E.V. Valore, M.J. Welsh, T. Ganz, B.F. Tack, P.B. McCray Jr., Production of β-defensins by human airway epithelia, Proc. Natl. Acad. Sci. USA 95 (1998) 14961-14966.
15. S. Krisanaprakornkit, J.R. Kimball, A. Weinberg, R.P. Darveau, B.W. Bainbridge, B.A. Dale, Inducible expression of human β-defensin-2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier, Infect. Immun. 68 (2000) 2907-2915.
16. J. Wehkamp, J. Harder, K. Wehkamp, B. Wehkamp-von Meissner, M. Schlee, C. Enders, U. Sonnenborn, S. Nuding, S. Bengmark, K. Fellermann, J.M. Schroder, E.F. Stange, NF-κB-and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium, Infect. Immun. 72 (2004) 5750-5758.
17. P. Mendez-Samperio, E. Miranda, A. Trejo, Regulation of human β-defensin-2 by Mycobacterium bovis bacillus Calmette-Guerin (BCG): involvement of PKC, JNK, and PI3K in human lung epithelial cell line (A549), Peptides 29 (2008) 1657-1663.
18. A. Takahashi, A. Wada, K. Ogushi, K. Maeda, T. Kawahara, K. Mawatari, H. Kurazono, J. Moss, T. Hirayama, Y. Nakaya, Production of β-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein, FEBS Lett. 508 (2001) 484-488.
19. Y. Tsutsumi-Ishii, I. Nagaoka, NF-κB-mediated transcriptional regulation of human β-defensin-2 gene following lipopolysaccharide stimulation, J. Leukoc. Biol. 71 (2002) 154-162.
20. J. Platz, C. Beisswenger, A. Dalpke, R. Koczulla, O. Pinkenburg, C. Vogelmeier, R. Bals, Microbial DNA induces a host defense reaction of human respiratory epithelial cells, J. Immunol. 173 (2004) 1219-1223.
21. P. Vora, A. Youdim, L.S. Thomas, M. Fukata, S.Y. Tesfay, K. Lukasek, K.S. Michelsen, A. Wada, T. Hirayama, M. Arditi, M.T. Abreu, D-Defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells, J. Immunol. 173 (2004) 5398-5405.
22. H.J. Kwon, K.W. Lee, S.H. Yu, J.H. Han, D.S. Kim, NF-κB-dependent regulation of tumor necrosis factor-a gene expression by CpG-oligodeoxynucleotides, Biochem. Biophys. Res. Commun. 311 (2003) 129-138.
23. H.J. Kwon, D.S. Kim, Regulation of macrophage inflammatory protein-2 gene expression in response to oligodeoxynucleotide containing CpG motifs in RAW 264.7 cells, Biochem. Biophys. Res. Commun. 308 (2003) 608-613.
24. J.W. Rhee, K.W. Lee, W.J. Sohn, Y. Lee, O.H. Jeon, H.J. Kwon, D.S. Kim, Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-κB in response to CpG-oligodeoxynucleotides in RAW 264.7 cells, Mol. Immunol. 44 (2007) 1393-1400.
25. K.W. Lee, Y. Lee, D.S. Kim, H.J. Kwon, Direct role of NF-κB activation in toll-like receptor-triggered HLA-DRA expression, Eur. J. Immunol. 36 (2006) 1254-1266.
26. W.J. Sohn, D. Kim, K.W. Lee, M.S. Kim, S. Kwon, Y. Lee, D.S. Kim, H.J. Kwon, Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation, Mol. Immunol. 44 (2007) 3273-3282.
27. K.W. Lee, J. Jung, Y. Lee, T.Y. Kim, S.Y. Choi, J. Park, D.S. Kim, H.J. Kwon, Immunostimulatory oligodeoxynucleotide isolated from genome wide screening of Mycobacterium bovis chromosomal DNA, Mol. Immunol. 43 (2006) 2107-2118.
28. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, S. Akira, A. Toll-like, Receptor recognizes bacterial DNA, Nature 408 (2000) 740-745.
29. A.M. Krieg, Therapeutic potential of toll-like receptor 9 activation, Nat. Rev. Drug. Discov. 5 (2006) 471-484.
30. K. Yasuda, P. Kirschning, C.J. Schlatter, B. Schmitz, F. Heit, A. Bauer, S. Hochrein, H. Wagner, Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways, J. Immunol. 174 (2005) 6129-6136.
31. M. Magnusson, R. Tobes, J. Sancho, E. Pareja, Natural DNA repetitive extragenic sequences from Gram-negative pathogens strongly stimulate TLR9, J. Immunol. 179 (2007) 31-35.
32. D.E. Frigo, Y. Tang, B.S. Beckman, A.B. Scandurro, J. Alam, M.E. Burow, J.A. McLachlan, Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway, Carcinogenesis 25 (2004) 249-261.
33. P.P. Roux, J. Blenis, ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions, Microbiol. Mol. Biol. Rev. 68 (2004) 320-344.