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Volumn 299, Issue 1, 2010, Pages

Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids

Author keywords

Lipid overflow; Lipid oxidation; Metabolic flexibility; Mitochondria

Indexed keywords

CARBON DIOXIDE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; FATTY ACID; GLUCOSE; LIPID; OLEIC ACID;

EID: 77953470349     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00187.2010     Document Type: Article
Times cited : (23)

References (43)
  • 2
    • 0016723939 scopus 로고
    • Percutaneous needle biopsy of skeletal muscle in physiological and clinical research
    • Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35: 609-616, 1975.
    • (1975) Scand J Clin Lab Invest , vol.35 , pp. 609-616
    • Bergstrom, J.1
  • 3
    • 2942722772 scopus 로고    scopus 로고
    • Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
    • Blaak EE. Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus. Proc Nutr Soc 63: 323-330, 2004.
    • (2004) Proc Nutr Soc , vol.63 , pp. 323-330
    • Blaak, E.E.1
  • 6
    • 0035405847 scopus 로고    scopus 로고
    • Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
    • Boden G, Lebed B, Schatz M, Homko C, Lemieux S. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50: 1612-1617, 2001. (Pubitemid 33639602)
    • (2001) Diabetes , vol.50 , Issue.7 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 10
    • 61349153606 scopus 로고    scopus 로고
    • Metabolic flexibility in the development of insulin resistance and type 2 diabetes: Effects of lifestyle
    • Corpeleijn E, Saris WH, Blaak EE. Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obes Rev 10: 178-193, 2009.
    • (2009) Obes Rev , vol.10 , pp. 178-193
    • Corpeleijn, E.1    Saris, W.H.2    Blaak, E.E.3
  • 13
    • 64549139279 scopus 로고    scopus 로고
    • Reduced lipid oxidation in myotubes established from obese and type 2 diabetic subjects
    • Gaster M. Reduced lipid oxidation in myotubes established from obese and type 2 diabetic subjects. Biochem Biophys Res Commun 382: 766-770, 2009.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 766-770
    • Gaster, M.1
  • 14
    • 68549136467 scopus 로고    scopus 로고
    • Reduced TCA flux in diabetic myotubes: A governing influence on the diabetic phenotype?
    • Gaster M. Reduced TCA flux in diabetic myotubes: a governing influence on the diabetic phenotype? Biochem Biophys Res Commun 387: 651-655, 2009.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 651-655
    • Gaster, M.1
  • 15
    • 33646065654 scopus 로고    scopus 로고
    • Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects
    • Gaster M, Beck-Nielsen H. Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects. Biochim Biophys Acta 1761: 100-110, 2006.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 100-110
    • Gaster, M.1    Beck-Nielsen, H.2
  • 16
    • 0035675446 scopus 로고    scopus 로고
    • Proliferation conditions for human satellite cells. The fractional content of satellite cells
    • Gaster M, Beck-Nielsen H, Schrøder HD. Proliferation conditions for human satellite cells. The fractional content of satellite cells. APMIS 109: 726-734, 2001.
    • (2001) APMIS , vol.109 , pp. 726-734
    • Gaster, M.1    Beck-Nielsen, H.2    Schrøder, H.D.3
  • 17
    • 0035672377 scopus 로고    scopus 로고
    • A cellular model system of differentiated human myotubes
    • Gaster M, Kristensen SR, Beck-Nielsen H, Schrøder HD. A cellular model system of differentiated human myotubes. APMIS 109: 735-744, 2001. (Pubitemid 34015455)
    • (2001) APMIS , vol.109 , Issue.11 , pp. 735-744
    • Gaster, M.1    Kristensen, S.R.2    Beck-Nielsen, H.3    Schroder, H.D.4
  • 18
    • 0036224284 scopus 로고    scopus 로고
    • The diabetic phenotype is conserved in myotubes established from diabetic subjects: Evidence for primary defects in glucose transport and glycogen synthase activity
    • Gaster M, Petersen I, Højlund K, Poulsen P, Beck-Nielsen H. The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity. Diabetes 51: 921-927, 2002. (Pubitemid 34438332)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 921-927
    • Gaster, M.1    Petersen, I.2    Hojlund, K.3    Poulsen, P.4    Beck-Nielsen, H.5
  • 19
    • 1442326017 scopus 로고    scopus 로고
    • Reduced Lipid Oxidation in Skeletal Muscle from Type 2 Diabetic Subjects May Be of Genetic Origin: Evidence from Cultured Myotubes
    • DOI 10.2337/diabetes.53.3.542
    • Gaster M, Rustan AC, Aas V, Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes 53: 542-548, 2004. (Pubitemid 38270621)
    • (2004) Diabetes , vol.53 , Issue.3 , pp. 542-548
    • Gaster, M.1    Rustan, A.C.2    Aas, V.3    Beck-Nielsen, H.4
  • 20
    • 14644435061 scopus 로고    scopus 로고
    • Differential utilization of saturated palmitate and unsaturated oleate: Evidence from cultured myotubes
    • DOI 10.2337/diabetes.54.3.648
    • Gaster M, Rustan AC, Beck-Nielsen H. Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes. Diabetes 54: 648-656, 2005. (Pubitemid 40322066)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 648-656
    • Gaster, M.1    Rustan, A.C.2    Beck-Nielsen, H.3
  • 21
    • 33646504856 scopus 로고    scopus 로고
    • Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes
    • Højlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski JF, Beck-Nielsen H. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia 49: 1283-1291, 2006.
    • (2006) Diabetologia , vol.49 , pp. 1283-1291
    • Højlund, K.1    Frystyk, J.2    Levin, K.3    Flyvbjerg, A.4    Wojtaszewski, J.F.5    Beck-Nielsen, H.6
  • 22
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51: 2005-2011, 2002.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 23
    • 42949140834 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    • Jocken JW, Blaak EE. Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity. Physiol Behav 94: 219-230, 2008.
    • (2008) Physiol Behav , vol.94 , pp. 219-230
    • Jocken, J.W.1    Blaak, E.E.2
  • 24
    • 40149106348 scopus 로고    scopus 로고
    • Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    • DOI 10.1152/physiolgenomics.00194.2007
    • Katterle Y, Keipert S, Hof J, Klaus S. Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1. Physiol Genomics 32: 352-359, 2008. (Pubitemid 351328558)
    • (2008) Physiological Genomics , vol.32 , Issue.3 , pp. 352-359
    • Katterle, Y.1    Keipert, S.2    Hof, J.3    Klaus, S.4
  • 25
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol Endocrinol Metab 277: E1130-E1141, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 26
    • 0035514950 scopus 로고    scopus 로고
    • Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes
    • Mensink M, Blaak EE, van Baak MA, Wagenmakers AJ, Saris WH. Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes 50: 2548-2554, 2001. (Pubitemid 33642773)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2548-2554
    • Mensink, M.1    Blaak, E.E.2    Van Baak, M.A.3    Wagenmakers, A.J.M.4    Saris, W.H.M.5
  • 28
    • 38949161524 scopus 로고    scopus 로고
    • Determinants of intramyocellular triglyceride turnover: Implications for insulin sensitivity
    • Moro C, Bajpeyi S, Smith SR. Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab 294: E203-E213, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Moro, C.1    Bajpeyi, S.2    Smith, S.R.3
  • 29
    • 20444463198 scopus 로고    scopus 로고
    • Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: Evidence for an intrinsic oxidative enzyme defect
    • Ortenblad N, Mogensen M, Petersen I, Hojlund K, Levin K, Sahlin K, Beck-Nielsen H, Gaster M. Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect. Biochim Biophys Acta 1741: 206-214, 2005.
    • (2005) Biochim Biophys Acta , vol.1741 , pp. 206-214
    • Ortenblad, N.1    Mogensen, M.2    Petersen, I.3    Hojlund, K.4    Levin, K.5    Sahlin, K.6    Beck-Nielsen, H.7    Gaster, M.8
  • 31
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350: 664-671, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 34
    • 0026781585 scopus 로고
    • Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: The Baltimore Longitudinal Study on Aging
    • Seidell JC, Muller DC, Sorkin JD, Andres R. Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes Relat Metab Disord 16: 667-674, 1992.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 667-674
    • Seidell, J.C.1    Muller, D.C.2    Sorkin, J.D.3    Andres, R.4
  • 36
    • 1642367438 scopus 로고    scopus 로고
    • Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes
    • Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA. Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab 89: 1301-1311, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1301-1311
    • Storgaard, H.1    Jensen, C.B.2    Björnholm, M.3    Song, X.M.4    Madsbad, S.5    Zierath, J.R.6    Vaag, A.A.7
  • 37
    • 22144472218 scopus 로고    scopus 로고
    • Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor
    • Ukropcova B, McNeil M, Sereda O, de Jonge L, Xie H, Bray GA, Smith SR. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest 115: 1934-1941, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 1934-1941
    • Ukropcova, B.1    McNeil, M.2    Sereda, O.3    De Jonge, L.4    Xie, H.5    Bray, G.A.6    Smith, S.R.7
  • 39
    • 0037903050 scopus 로고    scopus 로고
    • Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise
    • Watt MJ, Heigenhauser GJ, O'Neill M, Spriet LL. Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise. J Appl Physiol 95: 314-321, 2003.
    • (2003) J Appl Physiol , vol.95 , pp. 314-321
    • Watt, M.J.1    Heigenhauser, G.J.2    O'Neill, M.3    Spriet, L.L.4
  • 40
    • 62749121588 scopus 로고    scopus 로고
    • Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: Effects of tetradecylthioacetic acid and eicosapentaenoic acid
    • Wensaas AJ, Rustan AC, Just M, Berge RK, Drevon CA, Gaster M. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes 58: 527-535, 2009.
    • (2009) Diabetes , vol.58 , pp. 527-535
    • Wensaas, A.J.1    Rustan, A.C.2    Just, M.3    Berge, R.K.4    Drevon, C.A.5    Gaster, M.6
  • 42
    • 0021962623 scopus 로고
    • Evidence for a substrate regulation of triglyceride lipolysis in human skeletal muscle
    • Wicklmayr M, Dietze G, Rett K, Mehnert H. Evidence for a substrate regulation of triglyceride lipolysis in human skeletal muscle. Horm Metab Res 17: 471-475, 1985.
    • (1985) Horm Metab Res , vol.17 , pp. 471-475
    • Wicklmayr, M.1    Dietze, G.2    Rett, K.3    Mehnert, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.