-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414:782-7.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
2
-
-
0037497326
-
The double puzzle of diabetes
-
Diamond J. The double puzzle of diabetes. Nature 2003; 423:599-602.
-
(2003)
Nature
, vol.423
, pp. 599-602
-
-
Diamond, J.1
-
3
-
-
0030596338
-
Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulindependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance
-
Polonsky KS, Sturis J, Bell GI. Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulindependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 1996; 334:777-83.
-
(1996)
N Engl J Med
, vol.334
, pp. 777-783
-
-
Polonsky, K.S.1
Sturis, J.2
Bell, G.I.3
-
4
-
-
0037283601
-
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
-
Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003; 46:3-19.
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
5
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444:840-6.
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
6
-
-
67349228410
-
The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality
-
Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009; 52:1003-12.
-
(2009)
Diabetologia
, vol.52
, pp. 1003-1012
-
-
Kahn, S.E.1
Zraika, S.2
Utzschneider, K.M.3
Hull, R.L.4
-
7
-
-
0024495665
-
Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents
-
Guest PC, Rhodes CJ, Hutton JC. Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J 1989; 257:431-7.
-
(1989)
Biochem J
, vol.257
, pp. 431-437
-
-
Guest, P.C.1
Rhodes, C.J.2
Hutton, J.C.3
-
8
-
-
0033948498
-
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells
-
Seissler J, Nguyen TB, Aust G, Steinbrenner H, Scherbaum WA. Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells. Diabetes 2000; 49:1137-41.
-
(2000)
Diabetes
, vol.49
, pp. 1137-1141
-
-
Seissler, J.1
Nguyen, T.B.2
Aust, G.3
Steinbrenner, H.4
Scherbaum, W.A.5
-
10
-
-
0027418977
-
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
-
Alarcon C, Lincoln B, Rhodes CJ. The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 1993; 268:4276-80.
-
(1993)
J Biol Chem
, vol.268
, pp. 4276-4280
-
-
Alarcon, C.1
Lincoln, B.2
Rhodes, C.J.3
-
11
-
-
0028099196
-
Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans
-
Martin SK, Carroll R, Benig M, Steiner DF. Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans. FEBS Lett 1994; 356:279-82.
-
(1994)
FEBS Lett
, vol.356
, pp. 279-282
-
-
Martin, S.K.1
Carroll, R.2
Benig, M.3
Steiner, D.F.4
-
12
-
-
0019311577
-
Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content
-
Halban PA, Wollheim CB. Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. J Biol Chem 1980; 255:6003-6.
-
(1980)
J Biol Chem
, vol.255
, pp. 6003-6006
-
-
Halban, P.A.1
Wollheim, C.B.2
-
13
-
-
33646270192
-
Intracellular degradation of insulin and crinophagy are maintained by nitric oxide and cyclo-oxygenase 2 activity in isolated pancreatic islets
-
Sandberg M, Borg LA. Intracellular degradation of insulin and crinophagy are maintained by nitric oxide and cyclo-oxygenase 2 activity in isolated pancreatic islets. Biol Cell 2006; 98:307-15.
-
(2006)
Biol Cell
, vol.98
, pp. 307-315
-
-
Sandberg, M.1
Borg, L.A.2
-
14
-
-
1542399886
-
Polypyrimidine tractbinding protein promotes insulin secretory granule biogenesis
-
Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkruger A, Verkade P, et al. Polypyrimidine tractbinding protein promotes insulin secretory granule biogenesis. Nat Cell Biol 2004; 6:207-14.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 207-214
-
-
Knoch, K.P.1
Bergert, H.2
Borgonovo, B.3
Saeger, H.D.4
Altkruger, A.5
Verkade, P.6
-
15
-
-
0036391939
-
Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidinerich insulin mRNA 3'-untranslated region
-
Tillmar L, Welsh N. Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidinerich insulin mRNA 3'-untranslated region. Mol Med 2002; 8:263-72.
-
(2002)
Mol Med
, vol.8
, pp. 263-272
-
-
Tillmar, L.1
Welsh, N.2
-
16
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102-10.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
17
-
-
0028057533
-
Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
-
Fernandez-Alvarez J, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse WJ. Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1994; 37:177-81.
-
(1994)
Diabetologia
, vol.37
, pp. 177-181
-
-
Fernandez-Alvarez, J.1
Conget, I.2
Rasschaert, J.3
Sener, A.4
Gomis, R.5
Malaisse, W.J.6
-
18
-
-
0036228455
-
Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes
-
Lin JM, Fabregat ME, Gomis R, Bergsten P. Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes. Diabetes 2002; 51:988-93.
-
(2002)
Diabetes
, vol.51
, pp. 988-993
-
-
Lin, J.M.1
Fabregat, M.E.2
Gomis, R.3
Bergsten, P.4
-
19
-
-
10744222060
-
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
-
Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, et al. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 2004; 53:624-32.
-
(2004)
Diabetes
, vol.53
, pp. 624-632
-
-
Deng, S.1
Vatamaniuk, M.2
Huang, X.3
Doliba, N.4
Lian, M.M.5
Frank, A.6
-
20
-
-
8744272467
-
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
-
Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 2004; 89:5535-41.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5535-5541
-
-
Marchetti, P.1
Del Guerra, S.2
Marselli, L.3
Lupi, R.4
Masini, M.5
Pollera, M.6
-
21
-
-
20044390365
-
Functional and molecular defects of pancreatic islets in human type 2 diabetes
-
Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, et al. Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 2005; 54:727-35.
-
(2005)
Diabetes
, vol.54
, pp. 727-735
-
-
Del Guerra, S.1
Lupi, R.2
Marselli, L.3
Masini, M.4
Bugliani, M.5
Sbrana, S.6
-
22
-
-
20244376316
-
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
-
Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005; 48:282-9.
-
(2005)
Diabetologia
, vol.48
, pp. 282-289
-
-
Anello, M.1
Lupi, R.2
Spampinato, D.3
Piro, S.4
Masini, M.5
Boggi, U.6
-
24
-
-
0008231376
-
The secretion of newly synthesized insulin in vitro
-
Howell SL, Taylor KW. The secretion of newly synthesized insulin in vitro. Biochem J 1967; 102:922-7.
-
(1967)
Biochem J
, vol.102
, pp. 922-927
-
-
Howell, S.L.1
Taylor, K.W.2
-
25
-
-
0015621380
-
Dynamic synthesis and release of insulin and proinsulin from perifused islets
-
Sando H, Grodsky GM. Dynamic synthesis and release of insulin and proinsulin from perifused islets. Diabetes 1973; 22:354-60.
-
(1973)
Diabetes
, vol.22
, pp. 354-360
-
-
Sando, H.1
Grodsky, G.M.2
-
26
-
-
0020121342
-
Differential rates of release of newly synthesized and of stored insulin from pancreatic islets
-
Halban PA. Differential rates of release of newly synthesized and of stored insulin from pancreatic islets. Endocrinology 1982; 110:1183-8.
-
(1982)
Endocrinology
, vol.110
, pp. 1183-1188
-
-
Halban, P.A.1
-
27
-
-
0019971028
-
Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin
-
Gold G, Gishizky ML, Grodsky GM. Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin. Science 1982; 218:56-8.
-
(1982)
Science
, vol.218
, pp. 56-58
-
-
Gold, G.1
Gishizky, M.L.2
Grodsky, G.M.3
-
28
-
-
0037435034
-
Functional and spatial segregation of secretory vesicle pools according to vesicle age
-
Duncan RR, Greaves J, Wiegand UK, Matskevich I, Bodammer G, Apps DK, et al. Functional and spatial segregation of secretory vesicle pools according to vesicle age. Nature 2003; 422:176-80.
-
(2003)
Nature
, vol.422
, pp. 176-180
-
-
Duncan, R.R.1
Greaves, J.2
Wiegand, U.K.3
Matskevich, I.4
Bodammer, G.5
Apps, D.K.6
-
29
-
-
33645089191
-
cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells
-
Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkruger A, Wegbrod C, et al. cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells. Cell Metab 2006; 3:123-34.
-
(2006)
Cell Metab
, vol.3
, pp. 123-134
-
-
Knoch, K.P.1
Meisterfeld, R.2
Kersting, S.3
Bergert, H.4
Altkruger, A.5
Wegbrod, C.6
-
30
-
-
77953408986
-
Polymorphism rs11085226 in the gene encoding Polypyrimdine-tract-binding protein 1 negatively affects glucose-stimulated insulin secretion
-
submitted
-
Heni M, Haupt A, Schäfer SA, Guthoff M, Kirchhoff K, Ketterer C, et al. Polymorphism rs11085226 in the gene encoding Polypyrimdine-tract-binding protein 1 negatively affects glucose-stimulated insulin secretion. 2009; submitted.
-
(2009)
-
-
Heni, M.1
Haupt, A.2
Schäfer, S.A.3
Guthoff, M.4
Kirchhoff, K.5
Ketterer, C.6
|