Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 22, 2010, Pages 10184-10189

  Young, Nathan P ^a   Jacks, Tyler ^a,b  

^a KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

BMI1; Chromatin; Ink4a Arf; SNF5; Tumor suppression

Indexed keywords

ARF PROTEIN; K RAS PROTEIN; PROTEIN P19; TRANSCRIPTION FACTOR SNF; CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; NONHISTONE PROTEIN; PRIMER DNA; SMARCB1 PROTEIN, MOUSE;

ARTICLE; CARCINOGENESIS; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA; TISSUE SPECIFICITY; UPREGULATION; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CELL TRANSFORMATION; DRUG ANTAGONISM; FEMALE; GENETICS; MALE; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

MUS;

ANIMALS; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA PRIMERS; FEMALE; GENES, RAS; GENES, TUMOR SUPPRESSOR; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; ORGAN SPECIFICITY; RNA INTERFERENCE; SARCOMA, EXPERIMENTAL; SIGNAL TRANSDUCTION;

EID: 77953389461     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004796107     Document Type: Article

References (36)

1. Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432:307-315.
2. Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence: Halting on the road to cancer. N Engl J Med 355:1037-1046.
3. Collado M, Serrano M (2006) The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 6:472-476.
4. Lowe SW, Sherr CJ (2003) Tumor suppression by Ink4a-Arf: Progress and puzzles. Curr Opin Genet Dev 13:77-83.
5. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602. (Pubitemid 27152402)
6. Collado M, et al. (2005) Tumour biology: Senescence in premalignant tumours. Nature 436:642. (Pubitemid 41117258)
7. Palmero I, Pantoja C, Serrano M (1998) p19ARF links the tumour suppressor p53 to Ras. Nature 395:125-126. (Pubitemid 28425643)
8. Johnson L, et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410:1111-1116. (Pubitemid 32391044)
9. Woods D, et al. (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17:5598-5611. (Pubitemid 27357656)
10. Tuveson DA, et al. (2004) Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5:375-387.
11. Sarkisian CJ, et al. (2007) Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9:493-505.
12. Murphy DJ, et al. (2008) Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14:447-457.
13. Bracken AP, et al. (2007) The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21:525-530.
14. Chen H, et al. (2009) Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 23:975-985.
15. Dhawan S, Tschen SI, Bhushan A (2009) Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev 23:906-911.
16. Miyazaki M, et al. (2008) Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity 28:231-245. (Pubitemid 351215231)
17. Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M (2004) Stem cells and cancer: The polycomb connection. Cell 118:409-418. (Pubitemid 39485661)
18. Volanakis EJ, Williams RT, Sherr CJ (2009) Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia. Blood 114:4451-4459.
19. Williams RT, Sherr CJ (2007) The ARF tumor suppressor in acute leukemias: Insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. Adv Exp Med Biol 604:107-114.
20. Gebuhr TC, Bultman SJ, Magnuson T (2000) Pc-G/trx-G and the SWI/SNF connection: Developmental gene regulation through chromatin remodeling. Genesis 26:189-197.
21. Tamkun JW, et al. (1992) brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell 68:561-572.
22. Zindy F, et al. (2003) Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci USA 100:15930-15935. (Pubitemid 38021092)
23. Kirsch DG, et al. (2007) A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13:992-997.
24. Jackson EL, et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15:3243-3248.
25. Stott FJ, et al. (1998) The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 17:5001-5014.
26. Jackson EL, et al. (2005) The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 65:10280-10288.
27. Gil J, Peters G (2006) Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all. Nat Rev Mol Cell Biol 7:667-677. (Pubitemid 44268212)
28. Ventura A, et al. (2007) Restoration of p53 function leads to tumour regression in vivo. Nature 445:661-665. (Pubitemid 46232887)
29. Raymond CS, Soriano P (2007) High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One 2:e162.
30. Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP (2008) SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol 28:3457-3464. (Pubitemid 351657107)
31. Dovey JS, Zacharek SJ, Kim CF, Lees JA (2008) Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci USA 105:11857-11862.
32. Wong ES, et al. (2009) p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Dev Cell 17:142-149.
33. Voncken JW, et al. (2005) MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J Biol Chem 280:5178-5187.
34. Williams RT, Sherr CJ (2008) The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias. Cold Spring Harb Symp Quant Biol 73:461-467.
35. Ventura A, et al. (2004) Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA 101:10380-10385. (Pubitemid 38924934)
36. Rubinson DA, et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33:401-406. (Pubitemid 36278858)